{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T23:44:35Z","timestamp":1787442275209,"version":"build-2736575974"},"reference-count":31,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2020,3,17]],"date-time":"2020-03-17T00:00:00Z","timestamp":1584403200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Pemphigus is a chronic dermatological disorder caused by an autoimmune response and is associated with a high proportion of comorbidities and fatalities. The aim of this study was to investigate the risk of depression in patients with pemphigus. Data were derived from the National Health Insurance Research Database recorded during the period 2000\u20132010 in Taiwan. Multivariate Cox proportional hazards regression models were used to analyze the data and assess the effects of pemphigus on the risk of depression after adjusting for demographic characteristics and comorbidities. Patients with pemphigus were 1.98 times more likely to suffer from depression than the control group (pemphigus, adjusted HR: 1.99, 95% CI = 1.37\u20132.86). People aged \u226565 years were 1.69 times more likely to suffer from depression than those aged 20\u201349 years (\u226565 years, adjusted HR: 1.42, 95% CI = 0.92\u20132.21). Female and male patients with pemphigus were respectively 2.02 and 1.91 times more likely to suffer from depression than the control group (female, adjusted HR: 2.09, 95% CI = 1.24\u20133.54; male, adjusted HR: 1.87, 95% CI = 0.97\u20133.60). People with HTN, hyperlipidemia, asthma\/COPD, and chronic liver disease were respectively 1.73, 2.3, 2.2, and 1.69 times more likely to suffer from depression than those without these comorbidities (HTN, adjusted HR: 0.75, 95% CI = 0.41\u20131.42; hyperlipidemia, adjusted HR: 1.48, 95% CI = 0.78\u20132.82; asthma\/COPD, adjusted HR: 1.4, 95% CI = 0.72\u20132.69; and chronic liver disease, adjusted HR: 1.61, 95% CI = 1.07\u20132.43). There was a significant association between pemphigus and increased risk of depression. Female patients had a higher incidence of depression.<\/jats:p>","DOI":"10.3390\/ijerph17061983","type":"journal-article","created":{"date-parts":[[2020,3,18]],"date-time":"2020-03-18T08:20:44Z","timestamp":1584519644000},"page":"1983","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["The Risk of Depression in Patients with Pemphigus: A Nationwide Cohort Study in Taiwan"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9821-3746","authenticated-orcid":false,"given":"Yi-Min","family":"Hsu","sequence":"first","affiliation":[{"name":"Department of Public Health, China Medical University, Taichung 40447, Taiwan"},{"name":"Department of Nursing, China Medical University Hospital, Taichung 40447, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsin-Yu","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of dermatology, China Medical University Hospital, Taichung 40447, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Li","family":"Lin","sequence":"additional","affiliation":[{"name":"Management Office for Health Data, China Medical University Hospital, Taichung 40447, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shwn-Huey","family":"Shieh","sequence":"additional","affiliation":[{"name":"Department of Health Services Administration, China Medical University, Taichung 40447, Taiwan"},{"name":"Department of Nursing, Asia University, Taichung 41354, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,3,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"491","DOI":"10.2340\/0001555562491496","article-title":"Pemphigus: An epidemiological study of patients treated in Finnish hospitals between 1969 and 1978","volume":"62","author":"Hietanen","year":"1982","journal-title":"Acta Derm. 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