{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T04:23:38Z","timestamp":1772252618813,"version":"3.50.1"},"reference-count":22,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2020,3,24]],"date-time":"2020-03-24T00:00:00Z","timestamp":1585008000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Various cohort studies document a lower glomerular filtration rate (GFR) in former extremely low birth weight (ELBW, &lt;1000 g) neonates throughout childhood when compared to term controls. The current aim is to pool these studies to describe the GFR pattern over the pediatric age range. To do so, we conducted a systematic review on studies reporting on GFR measurements in former ELBW cases while GFR data of healthy age-matched controls included in these studies were co-collected. Based on 248 hits, 6 case-control and 3 cohort studies were identified, with 444 GFR measurements in 380 former ELBW cases (median age 5.3\u201320.7 years). The majority were small (17\u201378 cases) single center studies, with heterogeneity in GFR measurement (inulin, cystatin C or creatinine estimated GFR formulae) tools. Despite this, the median GFR (mL\/min\/1.73 m2) within case-control studies was consistently lower (\u221213%, range \u22128% to \u221225%) in cases, so that a relevant minority (15\u201330%) has a eGFR&lt;90 mL\/min\/1.73 m2). Consequently, this pooled analysis describes a consistent pattern of reduced eGFR in former ELBW cases throughout childhood. Research should focus on perinatal risk factors for impaired GFR and long-term outcome, but is hampered by single center cohorts, study size and heterogeneity of GFR assessment tools.<\/jats:p>","DOI":"10.3390\/ijerph17062144","type":"journal-article","created":{"date-parts":[[2020,3,24]],"date-time":"2020-03-24T07:16:08Z","timestamp":1585034168000},"page":"2144","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Glomerular Filtration Rate in Former Extreme Low Birth Weight Infants over the Full Pediatric Age Range: A Pooled Analysis"],"prefix":"10.3390","volume":"17","author":[{"given":"Elise","family":"Goetschalckx","sequence":"first","affiliation":[{"name":"Department of Development and Regeneration, KU Leuven, Herestraat 49, 3000 Leuven, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Djalila","family":"Mekahli","sequence":"additional","affiliation":[{"name":"Department of Development and Regeneration, KU Leuven, Herestraat 49, 3000 Leuven, Belgium"},{"name":"Department of Pediatric Nephrology and Organ Transplantation, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Levtchenko","sequence":"additional","affiliation":[{"name":"Department of Development and Regeneration, KU Leuven, Herestraat 49, 3000 Leuven, Belgium"},{"name":"Department of Pediatric Nephrology and Organ Transplantation, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9921-5105","authenticated-orcid":false,"given":"Karel","family":"Allegaert","sequence":"additional","affiliation":[{"name":"Department of Development and Regeneration, KU Leuven, Herestraat 49, 3000 Leuven, Belgium"},{"name":"Department of Pharmacy and Pharmaceutical Sciences, KU Leuven, Herestraat 49, 3000 Leuven, Belgium"},{"name":"Department of Clinical Pharmacy, Wytemaweg Hospital Pharmacy Postbus 2040, Erasmus MC, Rotterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,3,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1001\/jama.2015.10244","article-title":"Trends in care practices, morbidity, and mortality of extremely preterm neonates, 1993\u20132012","volume":"314","author":"Stoll","year":"2015","journal-title":"JAMA"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"F36","DOI":"10.1136\/archdischild-2017-313697","article-title":"Wide variation in severe neonatal morbidity among very preterm infants in European regions","volume":"104","author":"Zeitlin","year":"2019","journal-title":"Arch. 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Res."}],"container-title":["International Journal of Environmental Research and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-4601\/17\/6\/2144\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T09:10:57Z","timestamp":1760173857000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-4601\/17\/6\/2144"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,24]]},"references-count":22,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2020,3]]}},"alternative-id":["ijerph17062144"],"URL":"https:\/\/doi.org\/10.3390\/ijerph17062144","relation":{"has-preprint":[{"id-type":"doi","id":"10.20944\/preprints202001.0213.v1","asserted-by":"object"}]},"ISSN":["1660-4601"],"issn-type":[{"value":"1660-4601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,24]]}}}