{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T16:12:49Z","timestamp":1765728769023,"version":"build-2065373602"},"reference-count":19,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2020,3,26]],"date-time":"2020-03-26T00:00:00Z","timestamp":1585180800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Objectives: Herpes zoster (HZ) infection has been associated with disease burdens such as infection and depression. However, the relationship between chronic interstitial cystitis (CIC) and HZ is unknown. This study investigated HZ risk in patients with CIC. Patients and Methods: The Longitudinal Health Insurance Database, which is a subset of the Taiwan National Health Insurance Research Database, was used in the study. The case cohort consisted of patients with newly diagnosed CIC between 2000 and 2012. Each patient with CIC was matched to four controls by age and index year. All participants were traced from the index date to HZ diagnosis, and loss to follow-up or death, or to the end of the study (31 December 2013). Results: A total of 1096 patients with CIC and 4384 controls were enrolled. The incidence rate of HZ in patients with CIC was 10.8 per 1000 person-years, whereas that for controls was 7.25 per 1000 person-years. HZ risk for the case cohort was 1.48 times that for the control cohort. Among participants aged \u226449 years, patients with CIC had a 1.91-fold-increased HZ risk compared to those without CIC. Conclusion: Patients with CIC had a higher risk of HZ than those without CIC. CIC should not be ignored, particularly in young adults.<\/jats:p>","DOI":"10.3390\/ijerph17072228","type":"journal-article","created":{"date-parts":[[2020,3,31]],"date-time":"2020-03-31T10:29:38Z","timestamp":1585650578000},"page":"2228","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Association between Chronic Interstitial Cystitis and Herpes Zoster"],"prefix":"10.3390","volume":"17","author":[{"given":"Chao-Yu","family":"Hsu","sequence":"first","affiliation":[{"name":"Department of Medical Education and Research, Puli Christian Hospital, Puli 545, Taiwan"},{"name":"Department of Family Medicine, Puli Christian Hospital, Puli 545, Taiwan"},{"name":"Department of Optometry, Central Taiwan University of Science and Technology, Taichung 40601, Taiwan"},{"name":"Center for General Education, National Taichung University of Science and Technology, Taichung 404, Taiwan"},{"name":"The General Education Center, Chaoyang University of Technology, Taichung 413, Taiwan"},{"name":"Department of General Education, National Chin-Yi University of Technology, Taichung 41170, Taiwan"},{"name":"Center for General Education, National Chi Nan University, Puli 54561, Taiwan"},{"name":"Rural Generalist Program Japan, genepro, Asahi Shi 289-2505, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng-Li","family":"Lin","sequence":"additional","affiliation":[{"name":"Management Office for Health Data, China Medical University Hospital, Taichung 40447, Taiwan"},{"name":"School of Medicine, College of Medicine, China Medical University, Taichung 40447, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6368-3676","authenticated-orcid":false,"given":"Chia-Hung","family":"Kao","sequence":"additional","affiliation":[{"name":"Graduate Institute of Biomedical Sciences, China Medical University, Taichung 40447, Taiwan"},{"name":"Department of Nuclear Medicine and PET Center, China Medical University Hospital, Taichung 40447, Taiwan"},{"name":"Department of Bioinformatics and Medical Engineering, Asia University, Taichung 40447, Taiwan"},{"name":"Center of Augmented Intelligence in Healthcare, China Medical University Hospital, Taichung 40447, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,3,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1007\/s00404-017-4364-2","article-title":"Etiology, pathophysiology and biomarkers of interstitial cystitis\/painful bladder syndrome","volume":"295","author":"Patnaik","year":"2017","journal-title":"Arch. Gynecol. Obstet."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.ejogrb.2013.12.041","article-title":"Interstitial cystitis\/painful bladder syndrome: Epidemiology, pathophysiology and evidence-based treatment options","volume":"175","author":"Davis","year":"2014","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Boil."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1002\/nau.23421","article-title":"Psychosocial co-morbidities in Interstitial Cystitis\/Bladder Pain syndrome (IC\/BPS): A systematic review","volume":"37","author":"McKernan","year":"2017","journal-title":"Neurourol. Urodynamics"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"b1369","DOI":"10.1080\/14656566.2018.1505865","article-title":"Bridging pharmacotherapy and minimally invasive surgery in interstitial cystitis\/bladder pain syndrome treatment","volume":"19","author":"Dellis","year":"2018","journal-title":"Expert Opin. Pharmacother."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"e004833","DOI":"10.1136\/bmjopen-2014-004833","article-title":"Systematic review of incidence and complications of herpes zoster: Towards a global perspective","volume":"4","author":"Kawai","year":"2014","journal-title":"BMJ Open"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1007\/s10096-015-2314-0","article-title":"Balanitis is a risk factor for herpes zoster","volume":"34","author":"Hsu","year":"2015","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1111\/jdv.13175","article-title":"Dyshidrosis is a risk factor for herpes zoster","volume":"29","author":"Hsu","year":"2015","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"e1099","DOI":"10.4088\/JCP.14m09311","article-title":"High Prevalence of Herpes Zoster in Patients With Depression","volume":"76","author":"Liao","year":"2015","journal-title":"J. Clin. Psychiatr."},{"key":"ref_9","first-page":"506","article-title":"Interstitial cystitis\/painful bladder syndrome: The influence of modern diagnostic criteria on epidemiology and on Internet search activity by the public","volume":"4","author":"Davis","year":"2015","journal-title":"Transl. Androl. Urol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/j.juro.2011.10.048","article-title":"Gender Specific Pelvic Pain Severity in Neurogenic Cystitis","volume":"187","author":"Rudick","year":"2012","journal-title":"J. Urol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/1476-9255-6-23","article-title":"Gender-based reciprocal expression of transforming growth factor-beta1 and the inducible nitric oxide synthase in a rat model of cyclophosphamide-induced cystitis","volume":"6","author":"Tyagi","year":"2009","journal-title":"J. Inflamm."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"40","DOI":"10.5213\/inj.1836182.091","article-title":"Risk Factors for Interstitial Cystitis in the General Population and in Individuals With Depression","volume":"23","author":"Cepeda","year":"2019","journal-title":"Int. Neurourol. J."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1007\/s00192-008-0712-x","article-title":"Depression, abuse and its relationship to interstitial cystitis","volume":"19","author":"Goldstein","year":"2008","journal-title":"Int. Urogynecology J."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/s11255-014-0908-6","article-title":"Increased risks of healthcare-seeking behaviors of anxiety, depression and insomnia among patients with bladder pain syndrome\/interstitial cystitis: A nationwide population-based study","volume":"47","author":"Chuang","year":"2015","journal-title":"Int. Urol. Nephrol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1097\/01.ju.0000169258.31345.5d","article-title":"Risk of irritable bowel syndrome and depression in women with interstitial cystitis: A case-control study","volume":"174","author":"Novi","year":"2005","journal-title":"J. Urol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1300\/J013v31n04_05","article-title":"Pain and depression experienced by women with interstitial cystitis","volume":"31","author":"Rabin","year":"2000","journal-title":"Women Heal."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"383","DOI":"10.5489\/cuaj.3892","article-title":"Depression and catastrophizing predict suicidal ideation in tertiary care patients with interstitial cystitis\/bladder pain syndrome","volume":"10","author":"Tripp","year":"2016","journal-title":"Can. Urol. Assoc. J."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1097\/PSY.0000000000000051","article-title":"Risk of Depressive Disorder Among Patients With Herpes Zoster","volume":"76","author":"Chen","year":"2014","journal-title":"Psychosom. Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"e17430","DOI":"10.1097\/MD.0000000000017430","article-title":"The risk of herpes zoster virus infection in patients with depression: A longitudinal follow-up study using a national sample cohort","volume":"98","author":"Choi","year":"2019","journal-title":"Medicine"}],"container-title":["International Journal of Environmental Research and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-4601\/17\/7\/2228\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T09:11:56Z","timestamp":1760173916000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-4601\/17\/7\/2228"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,26]]},"references-count":19,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2020,4]]}},"alternative-id":["ijerph17072228"],"URL":"https:\/\/doi.org\/10.3390\/ijerph17072228","relation":{},"ISSN":["1660-4601"],"issn-type":[{"type":"electronic","value":"1660-4601"}],"subject":[],"published":{"date-parts":[[2020,3,26]]}}}