{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T15:50:26Z","timestamp":1790783426252,"version":"4.1.0"},"reference-count":29,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2020,3,27]],"date-time":"2020-03-27T00:00:00Z","timestamp":1585267200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>There is little information on Thogoto virus (THOV) and Dhori virus (DHOV)infection in Spain. A total of 283 serum samples from 150 human subjects (78 males, 72 females) bitten by ticks, as well as samples from 120 sheep (one per animal), were studied by immunofluorescence assay. All human and animal subjects were from the province of Palencia in northern Spain. Eight human subjects had antibodies against THOV (seroprevalence: 5.3%) and six had antibodies against DHOV (seroprevalence: 4%); titers ranged between 1\/32\u20131\/256 and 1\/32\u20131\/128, respectively. No significant differences were seen in seroprevalence in terms of gender or age, although people with antibodies were significantly more likely to have had contact with livestock for professional reasons. One subject with an acute infection had IgM antibodies to both viruses and seroconverted to IgG. For the sheep, 24 serum samples were positive for antibodies to THOV (seroprevalence: 20%) and 32 for antibodies to DHOV (seroprevalence: 26.8%); titers ranged between 1\/16 and 1\/128. The seroprevalence of both viruses was significantly higher in animals &lt; 4 years of age. Together, these results reveal the circulation of DHOV and THOV in humans and sheep in the province of Palencia. Sheep might be used as indicators of the presence of these organisms.<\/jats:p>","DOI":"10.3390\/ijerph17072254","type":"journal-article","created":{"date-parts":[[2020,3,31]],"date-time":"2020-03-31T10:29:38Z","timestamp":1585650578000},"page":"2254","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Epidemiological Study of Thogoto and Dhori Virus Infection in People Bitten by Ticks, and in Sheep, in an Area of Northern Spain"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5387-6792","authenticated-orcid":false,"given":"Lourdes","family":"Lled\u00f3","sequence":"first","affiliation":[{"name":"Departamento de Biomedicina y Biotecnolog\u00eda, Universidad de Alcal\u00e1, 28801 Alcal\u00e1 de Henares, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Consuelo","family":"Gim\u00e9nez-Pardo","sequence":"additional","affiliation":[{"name":"Departamento de Biomedicina y Biotecnolog\u00eda, Universidad de Alcal\u00e1, 28801 Alcal\u00e1 de Henares, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Isabel","family":"Geg\u00fandez","sequence":"additional","affiliation":[{"name":"Departamento de Biomedicina y Biotecnolog\u00eda, Universidad de Alcal\u00e1, 28801 Alcal\u00e1 de Henares, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,3,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1080\/00034983.1975.11686983","article-title":"Arthropod-borne viral infections of man in Nigeria, 1964\u20131970","volume":"69","author":"Moore","year":"1975","journal-title":"Ann. 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