{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T13:57:08Z","timestamp":1790517428781,"version":"4.1.0"},"reference-count":44,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2020,4,7]],"date-time":"2020-04-07T00:00:00Z","timestamp":1586217600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>The association of Helicobacter pylori (H. pylori) infection with functional dyspepsia has been well studied. However, the data on the relationship between H. pylori infection and irritable bowel syndrome (IBS) are conflicting. This study aims to elucidate the association between H. pylori infection and IBS. PubMed, Cochrane Library, CINAHL and SCOPUS databases were searched to identify eligible English articles published up to December 2019. Cross-sectional studies, case\u2013control studies and cohort studies reporting both prevalence of H. pylori infection and IBS were selected for the detailed review. The pooled odds ratio (ORs) and their 95% confidence interval (CI) were calculated. A total of 7269 individuals in four cross-sectional studies and six case-control studies were included. The prevalence of H. pylori infection ranged from 12.8% to 73.4% in the control group, and 9.7% to 72.1% in the IBS group. The combined OR for H. pylori infection was 1.10 (95% CI: 0.93\u20131.29, I2: 37.5%). In a subgroup analysis of IBS defined according to Rome criteria, the OR for H. pylori infection was 1.10 (95% CI: 0.93\u20131.30, I2 = 31.7%). In this meta-analysis, H. pylori infection was not significantly associated with IBS. Well-designed studies are needed to identify the relationship between H. pylori infection and IBS.<\/jats:p>","DOI":"10.3390\/ijerph17072524","type":"journal-article","created":{"date-parts":[[2020,4,8]],"date-time":"2020-04-08T05:59:47Z","timestamp":1586325587000},"page":"2524","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["The Association between Helicobacter pylori Infection and Irritable Bowel Syndrome: A Meta-Analysis"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0743-4680","authenticated-orcid":false,"given":"Yun-A","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Family Medicine, Daegu Catholic University School of Medicine, Daegu 42472, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0960-5976","authenticated-orcid":false,"given":"Yoon Jeong","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, Daegu Catholic University School of Medicine, Daegu 42472, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Gyu","family":"Kwak","sequence":"additional","affiliation":[{"name":"Department of Medical Statistics, Daegu Catholic University School of Medicine, Daegu 42472, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,4,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1053\/j.gastro.2006.03.008","article-title":"The functional gastrointestinal disorders and the Rome III process","volume":"130","author":"Drossman","year":"2006","journal-title":"Gastroenterology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"ITC81","DOI":"10.7326\/AITC201706060","article-title":"Irritable bowel syndrome","volume":"166","author":"Sultan","year":"2017","journal-title":"Ann. Intern. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"213","DOI":"10.23736\/S0031-0808.18.03541-3","article-title":"Irritable bowel syndrome: The clinical approach","volume":"60","author":"Adriani","year":"2018","journal-title":"Panminerva Medica"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1007\/s10620-007-9930-1","article-title":"A survey about irritable bowel syndrome in South Korea: Prevalence and observable organic abnormalities in IBS patients","volume":"53","author":"Park","year":"2008","journal-title":"Dig. Dis. Sci."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2566","DOI":"10.1056\/NEJMra1607547","article-title":"Irritable bowel syndrome","volume":"376","author":"Ford","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2248","DOI":"10.1007\/BF02071408","article-title":"Impact of irritable bowel syndrome on quality of life","volume":"41","author":"Whitehead","year":"1996","journal-title":"Dig. Dis. Sci."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"860","DOI":"10.7326\/0003-4819-134-9_Part_2-200105011-00010","article-title":"Health-related quality of life and health care costs in severe, refractory irritable bowel syndrome","volume":"134","author":"Creed","year":"2001","journal-title":"Ann. Intern. Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1056\/NEJMcp1001110","article-title":"Clinical practice. Helicobacter pylori infection","volume":"362","author":"McColl","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"142","DOI":"10.3904\/kjm.2015.89.2.142","article-title":"Helicobacter pylori infection and related gastrointestinal diseases","volume":"89","author":"Bang","year":"2015","journal-title":"Korean J. Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/S1473-3099(08)70066-5","article-title":"Helicobacter species and liver diseases: Association or causation?","volume":"8","author":"Pellicano","year":"2008","journal-title":"Lancet Infect. Dis."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"464","DOI":"10.23736\/S0026-4806.19.05942-1","article-title":"Helicobacter pylori infection and the risk of colorectal carcinoma: A systematic review and meta-analysis","volume":"110","author":"Yang","year":"2019","journal-title":"Minerva Medica"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"38","DOI":"10.3109\/00365529609094532","article-title":"Helicobacter pylori infection and dyspepsia","volume":"215","author":"Armstrong","year":"1996","journal-title":"Scand. J. Gastroenterol. Suppl."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1111\/j.1523-5378.2007.00520.x","article-title":"Systematic review and meta-analysis from Chinese literature: The association between Helicobacter pylori eradication and improvement of functional dyspepsia","volume":"12","author":"Jin","year":"2007","journal-title":"Helicobacter"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2082","DOI":"10.1111\/j.1572-0241.1998.00597.x","article-title":"Patterns of symptoms in functional dyspepsia: Role of Helicobacter pylori infection and delayed gastric emptying","volume":"93","author":"Perri","year":"1998","journal-title":"Am. J. Gastroenterol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1111\/jgh.13756","article-title":"Overlap between irritable bowel syndrome and functional dyspepsia including subtype analyses","volume":"32","author":"Choi","year":"2017","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1080\/09674845.2012.11669914","article-title":"Virulence markers of Helicobacter pylori in patients with diarrhoea-dominant irritable bowel syndrome","volume":"69","author":"Yakoob","year":"2012","journal-title":"Br. J. Biomed. Sci."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1159\/000050673","article-title":"H. pylori infection and visceral hypersensitivity in patients with irritable bowel syndrome","volume":"19","author":"Gerards","year":"2001","journal-title":"Dig. Dis."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"3059201","DOI":"10.1155\/2016\/3059201","article-title":"Lack of Association found between Helicobacter pylori infection and diarrhea-predominant irritable bowel syndrome: A multicenter retrospective study","volume":"2016","author":"Xiong","year":"2016","journal-title":"Gastroenterol. Res. Pract."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.1111\/j.1572-0241.2000.02251.x","article-title":"Helicobacter pylori and dyspepsia: A population-based study of the organism and host","volume":"95","author":"Locke","year":"2000","journal-title":"Am. J. Gastroenterol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2276","DOI":"10.1128\/JCM.02017-05","article-title":"Nongastric Helicobacter species detected in the intestinal tract of children","volume":"44","author":"Zhang","year":"2006","journal-title":"J. Clin. Microbiol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1111\/j.1365-2036.2010.04376.x","article-title":"Dyspepsia and irritable bowel syndrome in China: A population-based endoscopy study of prevalence and impact","volume":"32","author":"Zhao","year":"2010","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"521","DOI":"10.5056\/jnm.2013.19.4.521","article-title":"Irritable bowel syndrome is associated with gastroesophageal reflux symptom but not erosive esophagitis","volume":"19","author":"Nam","year":"2013","journal-title":"J. Neurogastroenterol. Motil."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1111\/j.1572-0241.2007.01740.x","article-title":"Irritable bowel syndrome: A 10-yr natural history of symptoms and factors that influence consultation behavior","volume":"103","author":"Ford","year":"2008","journal-title":"Am. J. Gastroenterol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1136\/gut.2006.099846","article-title":"Initial poor quality of life and new onset of dyspepsia: Results from a longitudinal 10-year follow-up study","volume":"56","author":"Ford","year":"2007","journal-title":"Gut"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","article-title":"Measuring inconsistency in meta-analyses","volume":"327","author":"Higgins","year":"2003","journal-title":"BMJ"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/0140-6736(91)90201-Y","article-title":"Publication bias in clinical research","volume":"337","author":"Easterbrook","year":"1991","journal-title":"Lancet"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"752","DOI":"10.3109\/00365529509096323","article-title":"Helicobacter pylori seropositivity among Swedish adults with and without abdominal symptoms. A population-based epidemiologic study","volume":"30","author":"Agreus","year":"1995","journal-title":"Scand. J. Gastroenterol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1007\/s002590050404","article-title":"Altered gastric emptying in patients with irritable bowel syndrome","volume":"26","year":"1999","journal-title":"Eur. J. Nucl. Med."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1111\/j.1572-0241.2004.30040.x","article-title":"Impact of coexisting irritable bowel syndrome on symptoms and pathophysiological mechanisms in functional dyspepsia","volume":"99","author":"Corsetti","year":"2004","journal-title":"Am. J. Gastroenterol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"486","DOI":"10.5958\/0976-5506.2018.01884.3","article-title":"Association of helicobacter pylori and irritable bowel syndrome","volume":"9","year":"2018","journal-title":"Indian J. Public Health Res. Dev."},{"key":"ref_31","first-page":"184","article-title":"Irritable bowel syndrome in Egyptian patients: Plausible risk factors and association with intestinal protozoa","volume":"49","author":"Salem","year":"2019","journal-title":"Trop. Dr."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2236","DOI":"10.5958\/0976-5506.2019.03187.5","article-title":"Exploration of potential link between prevalence of irritable bowel syndrome and seropositivity for Helicobacter pylori","volume":"10","author":"Odhar","year":"2019","journal-title":"Indian J. Public Health Res. Dev."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"5702","DOI":"10.3748\/wjg.v25.i37.5702","article-title":"Is there an association between Helicobacter pylori infection and irritable bowel syndrome? A meta-analysis","volume":"25","author":"Ng","year":"2019","journal-title":"World J. Gastroenterol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1136\/gutjnl-2012-302084","article-title":"Management of Helicobacter pylori infection\u2014The Maastricht IV\/Florence Consensus Report","volume":"61","author":"Malfertheiner","year":"2012","journal-title":"Gut"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1136\/bmj.321.7262.659","article-title":"Systematic review and economic evaluation of Helicobacter pylori eradication treatment for non-ulcer dyspepsia. Dyspepsia Review Group","volume":"321","author":"Moayyedi","year":"2000","journal-title":"BMJ"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1900","DOI":"10.1111\/j.1572-0241.2000.02252.x","article-title":"The association between Helicobacter pylori infection and functional dyspepsia in patients with irritable bowel syndrome","volume":"95","author":"Su","year":"2000","journal-title":"Am. J. Gastroenterol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1136\/bmj.319.7216.1040","article-title":"Is Helicobacter pylori associated with non-ulcer dyspepsia and will eradication improve symptoms? A meta-analysis","volume":"319","author":"Jaakkimainen","year":"1999","journal-title":"BMJ"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1038\/ajg.2017.154","article-title":"ACG and CAG clinical guideline: Management of dyspepsia","volume":"112","author":"Moayyedi","year":"2017","journal-title":"Am. J. Gastroenterol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1056\/NEJMra1501505","article-title":"Functional dyspepsia","volume":"373","author":"Talley","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1159\/000485408","article-title":"Functional dyspepsia and irritable bowel syndrome: Beyond Rome IV","volume":"35","author":"Stanghellini","year":"2017","journal-title":"Dig. Dis."},{"key":"ref_41","first-page":"401","article-title":"Systematic review and meta-analysis of the prevalence of irritable bowel syndrome in individuals with dyspepsia","volume":"8","author":"Ford","year":"2010","journal-title":"Clin. Gastroenterol. Hepatol. Off. Clin. Pract. J. Am. Gastroenterol. Assoc."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1111\/eci.12548","article-title":"Immune dysregulation in the functional gastrointestinal disorders","volume":"45","author":"Keely","year":"2015","journal-title":"Eur. J. Clin. Investig."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s11894-017-0554-0","article-title":"Update on Rome IV Criteria for Colorectal Disorders: Implications for Clinical Practice","volume":"19","author":"Simren","year":"2017","journal-title":"Curr. Gastroenterol. Rep."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/s12664-013-0365-7","article-title":"Comparison of Manning, Rome I, II, and III, and Asian diagnostic criteria: Report of the Multicentric Indian Irritable Bowel Syndrome (MIIBS) study","volume":"32","author":"Ghoshal","year":"2013","journal-title":"Indian J. Gastroenterol. Off. J. Indian Soc. Gastroenterol."}],"container-title":["International Journal of Environmental Research and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-4601\/17\/7\/2524\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T09:16:12Z","timestamp":1760174172000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-4601\/17\/7\/2524"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,7]]},"references-count":44,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2020,4]]}},"alternative-id":["ijerph17072524"],"URL":"https:\/\/doi.org\/10.3390\/ijerph17072524","relation":{},"ISSN":["1660-4601"],"issn-type":[{"value":"1660-4601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,7]]}}}