{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T06:19:27Z","timestamp":1772173167377,"version":"3.50.1"},"reference-count":49,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2020,5,12]],"date-time":"2020-05-12T00:00:00Z","timestamp":1589241600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI14\/00052"],"award-info":[{"award-number":["PI14\/00052"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Background: Adherence problems have negative effects on health, but there is little information on the magnitude of non-initiation and single dispensing. Objective: The aim of this study was to estimate the prevalence of non-initiation and single dispensation and identify associated predictive factors for the main treatments prescribed in Primary Care (PC) for cardiovascular disease (CVD) and diabetes. Methods: Cohort study with real-world data. Patients who received a first prescription (2013\u20132014) for insulins, platelet aggregation inhibitors, angiotensin-converting enzyme inhibitors (ACEI) or statins in Catalan PC were included. The prevalence of non-initiation and single dispensation was calculated. Factors that explained these behaviours were explored. Results: At three months, between 5.7% (ACEI) and 9.1% (antiplatelets) of patients did not initiate their treatment and between 10.6% (statins) and 18.4% (ACEI) filled a single prescription. Body mass index, previous CVD, place of origin and having a substitute prescriber, among others, influenced the risk of non-initiation and single dispensation. Conclusions: The prevalence of non-initiation and single dispensation of CVD medications and insulin prescribed in PC in is high. Patient and health-system factors, such as place of origin and type of prescriber, should be taken into consideration when prescribing new medications for CVD and diabetes.<\/jats:p>","DOI":"10.3390\/ijerph17103358","type":"journal-article","created":{"date-parts":[[2020,5,12]],"date-time":"2020-05-12T10:53:55Z","timestamp":1589280835000},"page":"3358","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Initiation and Single Dispensing in Cardiovascular and Insulin Medications: Prevalence and Explanatory Factors"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3780-4996","authenticated-orcid":false,"given":"Carles","family":"Vilaplana-Carnerero","sequence":"first","affiliation":[{"name":"Research and Development Unit, Institut de Recerca Sant Joan de D\u00e9u, 08830 Barcelona, Catalonia, Spain"},{"name":"School of Pharmacy, University of Barcelona, 08028 Barcelona, Catalonia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6780-5968","authenticated-orcid":false,"given":"Ignacio","family":"Aznar-Lou","sequence":"additional","affiliation":[{"name":"Research and Development Unit, Institut de Recerca Sant Joan de D\u00e9u, 08830 Barcelona, Catalonia, Spain"},{"name":"Consortium for Biomedical Research in Epidemiology &amp; Public Health (CIBER en Epidemiolog\u00eda y Salud P\u00fablica\u2014CIBERESP), 28029 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Teresa","family":"Pe\u00f1arrubia-Mar\u00eda","sequence":"additional","affiliation":[{"name":"Consortium for Biomedical Research in Epidemiology &amp; Public Health (CIBER en Epidemiolog\u00eda y Salud P\u00fablica\u2014CIBERESP), 28029 Madrid, Spain"},{"name":"Primary Care Research Institute (IDIAP Jordi Gol), 08007 Barcelona, Spain"},{"name":"Catalan Institute of Health, 08028 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6123-0633","authenticated-orcid":false,"given":"Antoni","family":"Serrano-Blanco","sequence":"additional","affiliation":[{"name":"Consortium for Biomedical Research in Epidemiology &amp; Public Health (CIBER en Epidemiolog\u00eda y Salud P\u00fablica\u2014CIBERESP), 28029 Madrid, Spain"},{"name":"Parc Sanitari Sant Joan de D\u00e9u, 08830 Sant Boi de Llobregat, Catalonia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rita","family":"Fern\u00e1ndez-Vergel","sequence":"additional","affiliation":[{"name":"Primary Care Research Institute (IDIAP Jordi Gol), 08007 Barcelona, Spain"},{"name":"Catalan Institute of Health, 08028 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dolors","family":"Petitb\u00f2-Ant\u00fanez","sequence":"additional","affiliation":[{"name":"Catalan Institute of Health, 08028 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Montserrat","family":"Gil-Girbau","sequence":"additional","affiliation":[{"name":"Research and Development Unit, Institut de Recerca Sant Joan de D\u00e9u, 08830 Barcelona, Catalonia, Spain"},{"name":"School of Pharmacy, University of Barcelona, 08028 Barcelona, Catalonia, Spain"},{"name":"Primary Care Prevention and Health Promotion Research Network, 08007 Barcelona, Catalonia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marian","family":"March-Pujol","sequence":"additional","affiliation":[{"name":"School of Pharmacy, University of Barcelona, 08028 Barcelona, Catalonia, Spain"},{"name":"Consortium for Biomedical Research in Epidemiology &amp; Public Health (CIBER en Epidemiolog\u00eda y Salud P\u00fablica\u2014CIBERESP), 28029 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8095-7707","authenticated-orcid":false,"given":"Juan Manuel","family":"Mendive","sequence":"additional","affiliation":[{"name":"Primary Care Research Institute (IDIAP Jordi Gol), 08007 Barcelona, Spain"},{"name":"Catalan Institute of Health, 08028 Barcelona, Spain"},{"name":"Primary Care Prevention and Health Promotion Research Network, 08007 Barcelona, Catalonia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alba","family":"S\u00e1nchez-Vi\u00f1as","sequence":"additional","affiliation":[{"name":"Research and Development Unit, Institut de Recerca Sant Joan de D\u00e9u, 08830 Barcelona, Catalonia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8794-5490","authenticated-orcid":false,"given":"Cristina","family":"Carbonell-Duacastella","sequence":"additional","affiliation":[{"name":"Research and Development Unit, Institut de Recerca Sant Joan de D\u00e9u, 08830 Barcelona, Catalonia, Spain"},{"name":"Consortium for Biomedical Research in Epidemiology &amp; Public Health (CIBER en Epidemiolog\u00eda y Salud P\u00fablica\u2014CIBERESP), 28029 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Rubio-Valera","sequence":"additional","affiliation":[{"name":"Consortium for Biomedical Research in Epidemiology &amp; Public Health (CIBER en Epidemiolog\u00eda y Salud P\u00fablica\u2014CIBERESP), 28029 Madrid, Spain"},{"name":"Parc Sanitari Sant Joan de D\u00e9u, 08830 Sant Boi de Llobregat, Catalonia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,5,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Gheorghe, A., Griffiths, U., Murphy, A., Legido-Quigley, H., Lamptey, P., and Perel, P. 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