{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T05:48:54Z","timestamp":1774331334139,"version":"3.50.1"},"reference-count":37,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2020,5,21]],"date-time":"2020-05-21T00:00:00Z","timestamp":1590019200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002920","name":"Research Grants Council, University Grants Committee","doi-asserted-by":"publisher","award":["HKU 769408 M"],"award-info":[{"award-number":["HKU 769408 M"]}],"id":[{"id":"10.13039\/501100002920","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>This study aimed to investigate the relationships among sicca symptoms, oral health conditions, salivary profiles and oral Candida in Sj\u00f6gren\u2019s syndrome (SS) patients. Eighty-five SS patients (mean age = 50.5) and 40 healthy non-SS individuals (mean age = 51.4) were recruited. They self-completed the Sicca Symptoms Inventory (SSI). Decayed, missing and filled surface (DMFS) scores, salivary flow rates, pH and oral Candida colonization were determined. Mean SSI summary scores of SS patients and non-SS individuals were 11.1 and 5.4 respectively (p &lt; 0.001). The most prevalent sicca symptoms in SS patients were eye irritation (93%), dry throat or nose (88%) and need of fluid for mouth wetting (88%). SS patients had significantly lower whole salivary flow rates than the non-SS individuals. Candida strains were isolated from over 60% of SS patients but not in non-SS patients. C. albicans was the predominant species. SSI summary score was negatively correlated to salivary flow rates while SSI summary and domain scores were positively correlated to the number of filled surfaces (FS) and DMFS scores and oral Candida counts. In conclusion, SS patients had more severe sicca symptoms than non-SS individuals. SSI scores were negatively correlated to the salivary flow rates but positively correlated to caries experience and oral Candida colonization.<\/jats:p>","DOI":"10.3390\/ijerph17103625","type":"journal-article","created":{"date-parts":[[2020,5,22]],"date-time":"2020-05-22T10:18:18Z","timestamp":1590142698000},"page":"3625","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Sicca Symptoms, Oral Health Conditions, Salivary Flow and Oral Candida in Sj\u00f6gren\u2019s Syndrome Patients"],"prefix":"10.3390","volume":"17","author":[{"given":"Weini","family":"Xin","sequence":"first","affiliation":[{"name":"Department of Stomatology, Shantou University Medical College, Shantou 515041, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine Chiu Man","family":"Leung","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, The University of Hong Kong, Pok Fu Lam, Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward Chin Man","family":"Lo","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, The University of Hong Kong, Pok Fu Lam, Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mo Yin","family":"Mok","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, City University of Hong Kong, Kowloon, Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2720-1825","authenticated-orcid":false,"given":"Moon Ho","family":"Leung","sequence":"additional","affiliation":[{"name":"Department of Medicine, Queen Elizabeth Hospital, Hong Kong SAR, Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,5,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.jaut.2013.12.010","article-title":"Outcome measures for primary Sj\u00f6gren\u2019s syndrome: A comprehensive review","volume":"51","author":"Seror","year":"2014","journal-title":"J. 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