{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T04:19:32Z","timestamp":1789791572430,"version":"4.0.1"},"reference-count":82,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2020,5,28]],"date-time":"2020-05-28T00:00:00Z","timestamp":1590624000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI17\/01743"],"award-info":[{"award-number":["PI17\/01743"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Aim: To analyze the levels of chronic fatigue in Spanish women with endometriosis and its relationship with their psychosocial status and quality of life (QoL). Methods: A total of 230 Spanish women with a clinical diagnosis of endometriosis were recruited. Chronic fatigue (Piper Fatigue Scale) and pelvic pain (Numeric Rating Scale) were evaluated. An on-line battery of validated scales was used to assess psychosocial status [Hospital Anxiety and Depression Scale, Scale for Mood Assessment, Pain Catastrophizing Scale, Pittsburgh Sleep Quality Index, Gastrointestinal Quality of Life Index, Female Sexual Function Index and Medical Outcomes Study-Social Support Survey] and QoL [Endometriosis-Health Profile questionnaire-30]. Associations between fatigue and both psychosocial and QoL outcomes were explored through multivariate regression models. Results: One-third and one-half of women showed moderate and severe fatigue, respectively. Fatigue was associated with higher anxiety and depression, poorer sleep quality, poorer sexual functioning, worse gastrointestinal health, higher catastrophizing thoughts, higher anger\/hostility scores and lower QoL (p-values &lt; 0.050). Moreover, fatigue and catastrophizing thoughts showed a mediating effect on the association between pelvic pain and QoL. Conclusion: This work reveals the important role of fatigue in the association between pain, psychosocial status, and QoL of Spanish women with endometriosis.<\/jats:p>","DOI":"10.3390\/ijerph17113831","type":"journal-article","created":{"date-parts":[[2020,5,28]],"date-time":"2020-05-28T10:02:45Z","timestamp":1590660165000},"page":"3831","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Contribution of Chronic Fatigue to Psychosocial Status and Quality of Life in Spanish Women Diagnosed with Endometriosis"],"prefix":"10.3390","volume":"17","author":[{"given":"Antonio","family":"Mundo-L\u00f3pez","sequence":"first","affiliation":[{"name":"Department of Radiology and Physical Medicine, University of Granada, E-18016 Granada, Spain"},{"name":"Clinic Psychology Center Alarc\u00f3n (CPCA), E-18004 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Oc\u00f3n-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Biohealth Research Institute in Granada (ibs.GRANADA), E-18012 Granada, Spain"},{"name":"Gynaecology and Obstetrics Unit, \u2018San Cecilio\u2019 University Hospital, E-18016 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ainhoa P.","family":"San-Sebasti\u00e1n","sequence":"additional","affiliation":[{"name":"Department of Radiology and Physical Medicine, University of Granada, E-18016 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6825-4213","authenticated-orcid":false,"given":"Noelia","family":"Galiano-Castillo","sequence":"additional","affiliation":[{"name":"Biohealth Research Institute in Granada (ibs.GRANADA), E-18012 Granada, Spain"},{"name":"Department of Physiotherapy, University of Granada, E-18016 Granada, Spain"},{"name":"\u201cCu\u00eddate\u201d Support Unit for Oncology Patients (UAPO), Sport and Health University Research Institute (iMUDS), E-18016 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Rodr\u00edguez-P\u00e9rez","sequence":"additional","affiliation":[{"name":"Department of Radiology and Physical Medicine, University of Granada, E-18016 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda S.","family":"Arroyo-Luque","sequence":"additional","affiliation":[{"name":"Department of Radiology and Physical Medicine, University of Granada, E-18016 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Arroyo-Morales","sequence":"additional","affiliation":[{"name":"Biohealth Research Institute in Granada (ibs.GRANADA), E-18012 Granada, Spain"},{"name":"Department of Physiotherapy, University of Granada, E-18016 Granada, 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Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,5,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/nrendo.2013.255","article-title":"Endometriosis: Pathogenesis and treatment","volume":"10","author":"Vercellini","year":"2014","journal-title":"Nat. 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