{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T04:15:49Z","timestamp":1791605749761,"version":"4.3.4"},"reference-count":48,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2020,6,16]],"date-time":"2020-06-16T00:00:00Z","timestamp":1592265600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Thyroid diseases are characterized by a wide range of physical and mental symptoms that can affect biological function, emotional and social life of patients. However, their impact on work functioning is not yet fully understood. Therefore, this review aims to address the way in which thyroid diseases can affect occupational outcomes, i.e., the employment rate, sick leave, working capacity and work income of patients. A systematic review of Pubmed, Scopus and ISI Web of Knowledge databases has been performed. Although it is not possible to extrapolate precise data for benign pathologies, about a third of the survivors of thyroid cancer could be unemployed. Hyperthyroid and hypothyroid patients presented a greater risk of long-term sick leave than controls, depending on the severity of the disease. Hyperthyroidism impaired working ability in about a third of affected patients, particularly in cases complicated by orbitopathy with diplopia. A possible influence of thyroid diseases on various occupational outcomes emerged from our review, however further research seems necessary to understand the relationship between work problems, specific pathological characteristics over time and risk factors in the workplace. This may support a comprehensive, interdisciplinary management of thyroid disorders, with benefits for patients\u2019 personal, social and professional life.<\/jats:p>","DOI":"10.3390\/ijerph17124295","type":"journal-article","created":{"date-parts":[[2020,6,16]],"date-time":"2020-06-16T13:20:43Z","timestamp":1592313643000},"page":"4295","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["The Impact of Thyroid Diseases on the Working Life of Patients: A Systematic Review"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3039-2856","authenticated-orcid":false,"given":"Veruscka","family":"Leso","sequence":"first","affiliation":[{"name":"Section of Occupational Medicine, Department of Public Health, University of Naples Federico II, Via S. Pansini 5, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8374-4774","authenticated-orcid":false,"given":"Ilaria","family":"Vetrani","sequence":"additional","affiliation":[{"name":"Section of Occupational Medicine, Department of Public Health, University of Naples Federico II, Via S. Pansini 5, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"De Cicco","sequence":"additional","affiliation":[{"name":"Section of Occupational Medicine, Department of Public Health, University of Naples Federico II, Via S. Pansini 5, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Cardelia","sequence":"additional","affiliation":[{"name":"Section of Occupational Medicine, Department of Public Health, University of Naples Federico II, Via S. Pansini 5, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Fontana","sequence":"additional","affiliation":[{"name":"Section of Occupational Medicine, Department of Public Health, University of Naples Federico II, Via S. Pansini 5, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaetano","family":"Buonocore","sequence":"additional","affiliation":[{"name":"Clinical Directorate, University Hospital Federico II, Via S. Pansini 5, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0444-3792","authenticated-orcid":false,"given":"Ivo","family":"Iavicoli","sequence":"additional","affiliation":[{"name":"Section of Occupational Medicine, Department of Public Health, University of Naples Federico II, Via S. 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Thyroid J."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1530\/EJE-13-0708","article-title":"Hyperthyroidism and psychiatric morbidity: Evidence from a Danish nationwide register study","volume":"170","author":"Brandt","year":"2013","journal-title":"Eur. J. Endocrinol."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Thvilum, M., Brandt, F., Almind, D., Christensen, K., Brix, T.H., and Heged\u00fcs, L. (2013). Type and extent of somatic morbidity before and after the diagnosis of hypothyroidism. A nationwide register study. PLoS ONE, 8.","DOI":"10.1530\/endoabs.32.P986"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1089\/thy.2005.15.700","article-title":"Increased risk of developing affective disorder in patients with hypothyroidism: A register-based study","volume":"15","author":"Thomsen","year":"2005","journal-title":"Thyroid"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"3129","DOI":"10.1210\/jc.2014-1407","article-title":"Hypothyroidism is a predictor of disability pension and loss of labor market income: A Danish register-based study","volume":"99","author":"Thvilum","year":"2014","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1007\/s11136-014-0896-0","article-title":"Thyroid-specific questions on work ability showed known-groups validity among Danes with thyroid diseases","volume":"24","author":"Nexo","year":"2015","journal-title":"Qual. Life Res."},{"key":"ref_8","unstructured":"World Health Organization (2020, May 07). 2011 International Classification of Functioning, Disability and Health. Available online: www.who.int\/classifications\/icf\/icf_more\/en."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/s10926-010-9269-x","article-title":"The concept of work ability","volume":"21","author":"Tengland","year":"2011","journal-title":"J. Occup. Rehabil."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"3184","DOI":"10.1210\/jc.2013-4468","article-title":"Increased risk of long-term sickness absence, lower rate of return to work, and higher risk of unemployment and disability pensioning for thyroid patients: A Danish register-based cohort study","volume":"99","author":"Nexo","year":"2014","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1089\/thy.2015.0031","article-title":"Prevalence, Phenotype, and Psychosocial Well-Being in Euthyroid\/Hypothyroid Thyroid-Associated Orbitopathy","volume":"25","author":"Ponto","year":"2015","journal-title":"Thyroid"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1093\/occmed\/50.7.473","article-title":"Designing and managing healthy work for older workers","volume":"50","author":"Griffiths","year":"2000","journal-title":"Occup. Med. (Lond.)"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1002\/(SICI)1097-0274(199909)36:1+<21::AID-AJIM8>3.0.CO;2-S","article-title":"Promotion of work ability during ageing","volume":"1","author":"Ilmarinen","year":"1999","journal-title":"Am. J. Ind. Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.ijsu.2010.02.007","article-title":"PRISMA Group Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement","volume":"8","author":"Moher","year":"2010","journal-title":"Int. J. Surg."},{"key":"ref_15","unstructured":"Wells, G.A., Shea, B., O\u2019Connell, D., Peterson, J., Welch, V., Losos, M., and Tugwell, P. (2020, January 28). The Newcastle-Ottawa Scale (NOS) for Assessing the Quality of Nonrandomized Studies in Meta-Analysis 2020. Available online: www.ohri.ca\/programs\/clinical_epidemiology\/oxford.asp."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.ijcard.2017.02.022","article-title":"Is cardiac autonomic function associated with cardiorespiratory fitness and physical activity in children and adolescents? A systematic review of cross-sectional studies","volume":"236","author":"Oliveira","year":"2017","journal-title":"Int. J. Cardiol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2613","DOI":"10.1016\/j.ejca.2005.05.017","article-title":"Quality of life among long-term breast cancer survivors: A systematic review","volume":"41","author":"Mols","year":"2005","journal-title":"Eur. J. Cancer"},{"key":"ref_18","first-page":"283","article-title":"Quality of life and occupational disability in endocrine orbitopathy","volume":"106","author":"Ponto","year":"2009","journal-title":"Dtsch. Arztebl. Int."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0306-4530(99)00050-5","article-title":"Long-term residual complaints and psychosocial sequelae after remission of hyperthyroidism","volume":"25","author":"Fahrenfort","year":"2000","journal-title":"Psychoneuroendocrinology"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1016\/j.ejca.2012.01.029","article-title":"Carcinoma of endocrine organs: Results of the RARECARE project","volume":"48","author":"Mallone","year":"2012","journal-title":"Eur. J. Cancer"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1002\/pon.1522","article-title":"Long-term cancer survivors experience work changes after diagnosis: Results of a population-based study","volume":"18","author":"Mols","year":"2009","journal-title":"Psychooncology"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"144","DOI":"10.5271\/sjweh.3199","article-title":"Breast cancer survivors\u2019 views of factors that influence the return-to-work process\u2014A qualitative study","volume":"38","author":"Tamminga","year":"2012","journal-title":"Scand. J. Work Environ. Health"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.3109\/09638288.2014.982830","article-title":"Workplace support after breast cancer treatment: Recognition of vulnerability","volume":"37","author":"Tiedtke","year":"2015","journal-title":"Disabil. Rehabil."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s11764-008-0053-2","article-title":"Cancer\u2019s impact on employment and earnings\u2014A population-based study from Norway","volume":"2","author":"Syse","year":"2008","journal-title":"J. Cancer Surviv."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1055\/s-0029-1234086","article-title":"The use of thyrogen in the treatment of differentiated thyroid carcinoma: An intraindividual comparison of clinical effects and implications of daily life","volume":"118","author":"Dueren","year":"2010","journal-title":"Exp. Clin. Endocrinol. Diabetes"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1097\/MLG.0b013e31802e3739","article-title":"Health-related quality of life in thyroid cancer survivors","volume":"117","author":"Tan","year":"2007","journal-title":"Laryngoscope"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1002\/hed.10217","article-title":"Health profiles and quality of life of 518 survivors of thyroid cancer","volume":"25","author":"Schultz","year":"2003","journal-title":"Head Neck"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1530\/EJE-06-0724","article-title":"Sick leave for follow-up control in thyroid cancer patients: Comparison between stimulation with Thyrogen and thyroid hormone withdrawal","volume":"156","author":"Borget","year":"2007","journal-title":"Eur. J. Endocrinol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1007\/s11136-015-1135-z","article-title":"Employment and insurance outcomes and factors associated with employment among long-term thyroid cancer survivors: A population-based study from the PROFILES registry","volume":"25","author":"Tamminga","year":"2016","journal-title":"Qual. Life Res."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1089\/thy.2005.15.1147","article-title":"Thyroid hormone withdrawal in patients with differentiated thyroid carcinoma: A one hundred thirty-patient pilot survey on consequences of hypothyroidism and a pharmacoeconomic comparison to recombinant thyrotropin administration","volume":"15","author":"Luster","year":"2005","journal-title":"Thyroid"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1089\/thy.2015.0608","article-title":"Unemployment Risk and Decreased Income Two and Four Years after Thyroid Cancer Diagnosis: A Population-Based Study","volume":"26","author":"Ratzon","year":"2016","journal-title":"Thyroid"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.1002\/cncr.31985","article-title":"Lasting effects of cancer and its treatment on employment and finances in adolescent and young adult cancer survivors","volume":"125","author":"Ketterl","year":"2019","journal-title":"Cancer"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.surg.2019.11.014","article-title":"Financial burden and quality of life among thyroid cancer survivors","volume":"167","author":"Mongelli","year":"2020","journal-title":"Surgery"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1002\/pon.4154","article-title":"Work ability and return to work in thyroid cancer patients and their partners: A pilot study","volume":"26","author":"Neudeck","year":"2017","journal-title":"Psychooncology"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1089\/thy.2016.0541","article-title":"An Exploratory Study of Fatigue and Physical Activity in Canadian Thyroid Cancer Patients","volume":"27","author":"Alhashemi","year":"2017","journal-title":"Thyroid"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1210\/jc.2012-3119","article-title":"Public health relevance of Graves\u2019 orbitopathy","volume":"98","author":"Ponto","year":"2013","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_37","first-page":"2986","article-title":"Graves\u2019 hyperthyroidism: Treatment with antithyroid drugs, surgery, or radioiodine\u2014A prospective, randomized study. Thyroid Study Group","volume":"81","author":"Tallstedt","year":"1996","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/S0002-9394(14)70439-8","article-title":"Chronology of Graves\u2019 ophthalmopathy in an incidence cohort","volume":"121","author":"Bartley","year":"1996","journal-title":"Am. J. Ophthalmol."},{"key":"ref_39","first-page":"289","article-title":"Balancing demands of cancer surveillance among survivors of thyroid cancer","volume":"5","author":"Dow","year":"1997","journal-title":"Cancer Pract."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1210\/jc.2005-2064","article-title":"A comparison of short-term changes in health-related quality of life in thyroid carcinoma patients undergoing diagnostic evaluation with recombinant humanthyrotropin compared with thyroid hormone withdrawal","volume":"91","author":"Schroeder","year":"2006","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1097\/RLU.0000000000002420","article-title":"Fast-track Radioiodine Ablation Therapy After Thyroidectomy Reduces Sick Leave in Patients With Differentiated Thyroid Cancer (FASTHYNA Trial)","volume":"44","author":"Waissi","year":"2019","journal-title":"Clin. Nucl. Med."},{"key":"ref_42","first-page":"437","article-title":"Effect of complicated thyroid surgical procedures on personal and professional life of patients","volume":"84","year":"2012","journal-title":"Pol. J. Surg."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1089\/thy.1998.8.653","article-title":"Quality of life aspects and costs in treatment of Graves\u2019 hyperthyroidism with antithyroid drugs, surgery, or radioiodine: Results from a prospective, randomized study","volume":"8","author":"Ljunggren","year":"1998","journal-title":"Thyroid"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1089\/thy.2013.0015","article-title":"Fatigue among short- and long-term thyroid cancer survivors: Results from the population-based PROFILES registry","volume":"23","author":"Husson","year":"2013","journal-title":"Thyroid"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"128","DOI":"10.3109\/0284186X.2012.723822","article-title":"High level of distress in long-term survivors of thyroid carcinoma: Results of rapid screening using the distress thermometer","volume":"52","author":"Roerink","year":"2013","journal-title":"Acta Oncol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1530\/EJE-15-0306","article-title":"Hyperthyroidism is associated with work disability and loss of labour market income. A Danish register-based study in singletons and disease-discordant twin pairs","volume":"173","author":"Brandt","year":"2015","journal-title":"Eur. J. Endocrinol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1002\/pon.1633","article-title":"Experiences and concerns about \u2018returning to work\u2019 for women breast cancer survivors: A literature review","volume":"19","author":"Tiedtke","year":"2010","journal-title":"Psychooncology"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1038\/nrendo.2018.18","article-title":"Global epidemiology of hyperthyroidism and hypothyroidism","volume":"14","author":"Taylor","year":"2018","journal-title":"Nat. Rev. Endocrinol."}],"container-title":["International Journal of Environmental Research and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-4601\/17\/12\/4295\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T09:39:32Z","timestamp":1760175572000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-4601\/17\/12\/4295"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,16]]},"references-count":48,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2020,6]]}},"alternative-id":["ijerph17124295"],"URL":"https:\/\/doi.org\/10.3390\/ijerph17124295","relation":{},"ISSN":["1660-4601"],"issn-type":[{"value":"1660-4601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,16]]}}}