{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T02:55:10Z","timestamp":1760237710080,"version":"build-2065373602"},"reference-count":43,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2020,6,17]],"date-time":"2020-06-17T00:00:00Z","timestamp":1592352000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"C\u00e1tedra Real Madrid - Universidad Europea de Madrid","award":["P2016\/RM25"],"award-info":[{"award-number":["P2016\/RM25"]}]},{"name":"Fondo de Investigaciones Sanitarias","award":["PI15\/00558","PI15\/01756","CP14\/00032","PI14\/00903"],"award-info":[{"award-number":["PI15\/00558","PI15\/01756","CP14\/00032","PI14\/00903"]}]},{"name":"Biomedical Research Networking Center on Frailty and Healthy Aging (CIBERFES) and FEDER funds from the European Union","award":["CB16\/10\/00477"],"award-info":[{"award-number":["CB16\/10\/00477"]}]},{"name":"Postdoctoral contract from the Government of Castilla-La Mancha","award":["2019\/9601"],"award-info":[{"award-number":["2019\/9601"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>McArdle disease (glycogenosis-V) is associated with exercise intolerance, however, how it affects an important marker of cardiometabolic health as it is adiposity remains unknown. We evaluated the association between physical activity (PA) and adiposity in patients with McArdle disease. We assessed 199 adults of both sexes (51 McArdle patients (36 \u00b1 11 years) and 148 healthy controls (35 \u00b1 10 years)). Body fat (BF) was determined using dual-energy X-ray absorptiometry (DXA) method and each patient\u2019s PA was assessed with the International PA Questionnaire (IPAQ). Although body mass index values did not differ between patients and controls, McArdle patients had significantly higher values of BF in all body regions (p &lt; 0.05) and higher risk of suffering obesity (odds ratio (OR): 2.54, 95% confidence interval (95% CI): 1.32\u20134.88). Male patients had higher BF and obesity risk (OR: 3.69, 95% CI: 1.46\u22129.34) than their sex-matched controls, but no differences were found within the female sex (p &lt; 0.05). In turn, active female patients had lower trunk BF than their inactive peers (p &lt; 0.05). Males with McArdle seem to have adiposity problems and a higher risk of developing obesity than people without the condition, while female patients show similar or even better levels in the trunk region with an active lifestyle. Therefore, special attention should be given to decrease adiposity and reduce obesity risk in males with McArdle disease.<\/jats:p>","DOI":"10.3390\/ijerph17124334","type":"journal-article","created":{"date-parts":[[2020,6,17]],"date-time":"2020-06-17T13:11:32Z","timestamp":1592399492000},"page":"4334","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Sex Differences and the Influence of an Active Lifestyle on Adiposity in Patients with McArdle Disease"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1622-7109","authenticated-orcid":false,"given":"Irene","family":"Rodr\u00edguez-G\u00f3mez","sequence":"first","affiliation":[{"name":"GENUD Toledo Research Group, Universidad de Castilla-La Mancha, 45071 Toledo, Spain"},{"name":"CIBER of Frailty and Healthy Aging (CIBERFES), 28029 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9418-0564","authenticated-orcid":false,"given":"Alfredo","family":"Santalla","sequence":"additional","affiliation":[{"name":"CIBER of Frailty and Healthy Aging (CIBERFES), 28029 Madrid, Spain"},{"name":"Department of Sport and Computer Science, Section of Physical Education and Sports, Faculty of Sport, Universidad Pablo de Olavide, 41013 Sevilla, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"Diez-Bermejo","sequence":"additional","affiliation":[{"name":"Research Institute Hospital 12 de Octubre, 28041 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7817-747X","authenticated-orcid":false,"given":"Diego","family":"Mungu\u00eda-Izquierdo","sequence":"additional","affiliation":[{"name":"CIBER of Frailty and Healthy Aging (CIBERFES), 28029 Madrid, Spain"},{"name":"Department of Sport and Computer Science, Section of Physical Education and Sports, Faculty of Sport, Universidad Pablo de Olavide, 41013 Sevilla, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4502-9275","authenticated-orcid":false,"given":"Luis M.","family":"Alegre","sequence":"additional","affiliation":[{"name":"GENUD Toledo Research Group, Universidad de Castilla-La Mancha, 45071 Toledo, Spain"},{"name":"CIBER of Frailty and Healthy Aging (CIBERFES), 28029 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gisela","family":"Nogales-Gadea","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Institut d\u2019Investigaci\u00f3 en Ci\u00e8ncies de la Salut Germans Trias i Pujol I Campus Can Ruti, Universitat Aut\u00f2noma de Barcelona, 08041 Badalona, Spain"},{"name":"CIBER of Rare Disorders (CIBERER), 28029 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joaqu\u00edn","family":"Arenas","sequence":"additional","affiliation":[{"name":"Research Institute Hospital 12 de Octubre, 28041 Madrid, Spain"},{"name":"CIBER of Rare Disorders (CIBERER), 28029 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4741-772X","authenticated-orcid":false,"given":"Miguel A.","family":"Mart\u00edn","sequence":"additional","affiliation":[{"name":"Research Institute Hospital 12 de Octubre, 28041 Madrid, Spain"},{"name":"CIBER of Rare Disorders (CIBERER), 28029 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandro","family":"Lucia","sequence":"additional","affiliation":[{"name":"CIBER of Frailty and Healthy Aging (CIBERFES), 28029 Madrid, Spain"},{"name":"School of Research and Doctorate Studies, Universidad Europea de Madrid, 28670 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2854-6684","authenticated-orcid":false,"given":"Ignacio","family":"Ara","sequence":"additional","affiliation":[{"name":"GENUD Toledo Research Group, Universidad de Castilla-La Mancha, 45071 Toledo, Spain"},{"name":"CIBER of Frailty and Healthy Aging (CIBERFES), 28029 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,6,17]]},"reference":[{"key":"ref_1","first-page":"13","article-title":"Myopathy due to a defect in muscle glycogen breakdown","volume":"10","author":"McArdle","year":"1951","journal-title":"Clin. 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