{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T20:35:04Z","timestamp":1792442104344,"version":"4.5.0"},"reference-count":39,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2020,6,18]],"date-time":"2020-06-18T00:00:00Z","timestamp":1592438400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2018-R1D1A1A0-2085328"],"award-info":[{"award-number":["2018-R1D1A1A0-2085328"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>The aim of the present study was to investigate the association between periodontitis and chronic gastritis\/peptic ulcer using a cross-sectional study design. The present prospective cohort study used epidemiological data from the Korean Genome and Epidemiology Study (KoGES) recorded from 2004 to 2016. Among 173,209 participants, 9983 with periodontitis and 125,336 with no periodontitis were selected. Histories of chronic gastritis and peptic ulcer between periodontitis and no periodontitis participants were analyzed. The participants were questioned around any history of hypertension, diabetes mellitus, hyperlipidemia, cerebral stroke, ischemic heart disease, periodontitis, body mass index, smoking, alcohol consumption, nutritional intake, and financial income. Chi-square tests, independent t-tests, two-tailed analyses were used in statistical analysis of the data. The adjusted odds ratio of chronic gastritis was 2.22 (95% confidence interval [CI] = 2.10\u20132.34, p &lt; 0.001) and that of peptic ulcer was 1.86 (95% CI = 1.74\u20131.98, p &lt; 0.001) in model 2. This study demonstrated that periodontitis was associated with an increased risk of chronic gastritis\/peptic ulcer. These findings provide additional evidence for an association between periodontitis and chronic gastritis\/peptic ulcer.<\/jats:p>","DOI":"10.3390\/ijerph17124387","type":"journal-article","created":{"date-parts":[[2020,6,18]],"date-time":"2020-06-18T11:00:56Z","timestamp":1592478056000},"page":"4387","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Analysis of the Relation between Periodontitis and Chronic Gastritis\/Peptic Ulcer: A Cross-Sectional Study Using KoGES HEXA Data"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0739-7971","authenticated-orcid":false,"given":"Soo Hwan","family":"Byun","sequence":"first","affiliation":[{"name":"Department of Oral &amp; Maxillofacial Surgery, Dentistry, Sacred Heart Hospital, Hallym University College of Medicine, Anyang 14068, Korea"},{"name":"Research Center of Clinical Dentistry, Hallym University Clinical Dentistry Graduate School, Chuncheon 24252, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0629-9299","authenticated-orcid":false,"given":"Chanyang","family":"Min","sequence":"additional","affiliation":[{"name":"Hallym Data Science Laboratory, Hallym University College of Medicine, Anyang 14068, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9061-0552","authenticated-orcid":false,"given":"Seok Jin","family":"Hong","sequence":"additional","affiliation":[{"name":"Research Center of Clinical Dentistry, Hallym University Clinical Dentistry Graduate School, Chuncheon 24252, Korea"},{"name":"Department of Otorhinolaryngology-Head &amp; Neck Surgery, Dongtan Sacred Heart Hospital, Hallym University College of Medicine, Hwaseong 18450, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1655-9549","authenticated-orcid":false,"given":"Hyo Geun","family":"Choi","sequence":"additional","affiliation":[{"name":"Research Center of Clinical Dentistry, Hallym University Clinical Dentistry Graduate School, Chuncheon 24252, Korea"},{"name":"Hallym Data Science Laboratory, Hallym University College of Medicine, Anyang 14068, Korea"},{"name":"Department of Otorhinolaryngology-Head &amp; Neck Surgery, Sacred Heart Hospital, Hallym University College of Medicine, Anyang 14068, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2078-5805","authenticated-orcid":false,"given":"Dong Hee","family":"Koh","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Dongtan Sacred Heart Hospital, Hallym University College of Medicine, Hwaseong 18450, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,6,18]]},"reference":[{"key":"ref_1","first-page":"219","article-title":"Peptic Ulcer Disease and Helicobacter pylori infection","volume":"115","author":"Narayanan","year":"2018","journal-title":"Mo. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/S0140-6736(16)32404-7","article-title":"Peptic ulcer disease","volume":"390","author":"Lanas","year":"2017","journal-title":"Lancet"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1111\/j.1365-2036.2010.04563.x","article-title":"The changing face of hospitalisation due to gastrointestinal bleeding and perforation","volume":"33","author":"Lanas","year":"2011","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1111\/apt.12380","article-title":"Review article: Historic changes of Helicobacter pylori-associated diseases","volume":"38","author":"Sonnenberg","year":"2013","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1111\/apt.12620","article-title":"Incidence and complications of peptic ulcer disease requiring hospitalisation have markedly decreased in Finland","volume":"39","author":"Malmi","year":"2014","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1038\/ajg.2016.166","article-title":"We Are Using Too Many PPIs, and We Need to Stop: A European Perspective","volume":"111","author":"Lanas","year":"2016","journal-title":"Am. J. Gastroenterol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.amjmed.2017.12.024","article-title":"Helicobacter pylori Infection: An Update for the Internist in the Age of Increasing Global Antibiotic Resistance","volume":"131","author":"Siddique","year":"2018","journal-title":"Am. J. Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1016\/S0016-5085(96)70056-2","article-title":"The effect of environmental pH on the proton motive force of Helicobacter pylori","volume":"111","author":"Scott","year":"1996","journal-title":"Gastroenterology"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"G715","DOI":"10.1152\/ajpgi.00187.2012","article-title":"H. pylori acutely inhibits gastric secretion by activating CGRP sensory neurons coupled to stimulation of somatostatin and inhibition of histamine secretion","volume":"304","author":"Zaki","year":"2013","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0016-5085(97)70075-1","article-title":"Helicobacter pylori infection and chronic gastric acid hyposecretion","volume":"113","author":"Oien","year":"1997","journal-title":"Gastroenterology"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1016\/0140-6736(92)92816-X","article-title":"Effect of Helicobacter pylori on gastric somatostatin in duodenal ulcer disease","volume":"340","author":"Moss","year":"1992","journal-title":"Lancet"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.gtc.2009.03.004","article-title":"Helicobacter pylori-negative nonsteroidal anti-inflammatory drug-negative ulcer","volume":"38","author":"McColl","year":"2009","journal-title":"Gastroenterol. Clin. North. Am."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1177\/0022034517693566","article-title":"Global, Regional, and National Prevalence, Incidence, and Disability-Adjusted Life Years for Oral Conditions for 195 Countries, 1990-2015: A Systematic Analysis for the Global Burden of Diseases, Injuries, and Risk Factors","volume":"96","author":"Kassebaum","year":"2017","journal-title":"J. Dent. Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/j.1600-0757.2009.00326.x","article-title":"Epidemiologic patterns of chronic and aggressive periodontitis","volume":"53","author":"Demmer","year":"2010","journal-title":"Periodontol. 2000"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1902\/jop.2016.150682","article-title":"Associations Between Periodontitis and Chronic Obstructive Pulmonary Disease: The 2010 to 2012 Korean National Health and Nutrition Examination Survey","volume":"87","author":"Chung","year":"2016","journal-title":"J. Periodontol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1111\/j.1600-0579.2010.00620.x","article-title":"Periodontal health in Europe: Future trends based on treatment needs and the provision of periodontal services--position paper 1","volume":"14","author":"Konig","year":"2010","journal-title":"Eur J. Dent. Educ."},{"key":"ref_17","unstructured":"Dye, B.A., Tan, S., Smith, V., Lewis, B.G., Barker, L.K., Thornton-Evans, G., Eke, P.I., Beltran-Aguilar, E.D., Horowitz, A.M., and Li, C.H. (2007). Trends in oral health status: United States, 1988\u20131994 and 1999\u20132004. Vital Health Stat. 11, 1\u201392."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1177\/154405910408300213","article-title":"Periodontal disease and biomarkers related to cardiovascular disease","volume":"83","author":"Joshipura","year":"2004","journal-title":"J. Dent. Res."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"349","DOI":"10.4103\/ccd.ccd_652_18","article-title":"Prevalence of Periodontal Disease in Type 2 Diabetes Mellitus Patients: A Cross-sectional Study","volume":"10","author":"Singh","year":"2019","journal-title":"Contemp. Clin. Dent."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.adaj.2018.03.030","article-title":"Promoting oral health care because of its possible effect on systemic disease is premature and may be misleading","volume":"149","author":"Pihlstrom","year":"2018","journal-title":"J. Am. Dent. Assoc."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.it.2013.09.001","article-title":"Immunomicrobial pathogenesis of periodontitis: Keystones, pathobionts, and host response","volume":"35","author":"Hajishengallis","year":"2014","journal-title":"Trends Immunol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1111\/jcpe.13224","article-title":"Periodontal pathogens and their role in cardiovascular outcome","volume":"47","author":"Schulz","year":"2020","journal-title":"J. Clin. Periodontol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1902\/jop.2003.74.1.129","article-title":"High prevalence of Helicobacter pylori detected by PCR in the oral cavities of periodontitis patients","volume":"74","author":"Umeda","year":"2003","journal-title":"J. Periodontol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"e49","DOI":"10.1038\/ctg.2013.14","article-title":"A prospective study of periodontal disease and risk of gastric and duodenal ulcer in male health professionals","volume":"5","author":"Boylan","year":"2014","journal-title":"Clin. Transl. Gastroenterol."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Yu, H.C., Chen, T.P., Wei, C.Y., and Chang, Y.C. (2018). Association between Peptic Ulcer Disease and Periodontitis: A Nationwide Population-Based Case-Control Study in Taiwan. Int. J. Environ. Res. Public Health, 15.","DOI":"10.3390\/ijerph15050912"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1093\/ije\/dyx105","article-title":"Cohort Profile: The Korean Genome and Epidemiology Study (KoGES) Consortium","volume":"46","author":"Kim","year":"2017","journal-title":"Int. J. Epidemiol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1038\/sj.ejcn.1602657","article-title":"Validation and reproducibility of food frequency questionnaire for Korean genome epidemiologic study","volume":"61","author":"Ahn","year":"2007","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1111\/jcpe.12015","article-title":"Effect of periodontal therapy on prevention of gastric Helicobacter pylori recurrence: A systematic review and meta-analysis","volume":"39","author":"Bouziane","year":"2012","journal-title":"J. Clin. Periodontol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1155\/2009\/950527","article-title":"Is the presence of Helicobacter pylori in dental plaque of patients with chronic periodontitis a risk factor for gastric infection?","volume":"23","author":"Anil","year":"2009","journal-title":"Can. J. Gastroenterol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"167","DOI":"10.2478\/v10039-010-0032-5","article-title":"The occurrence of Helicobacter pylori antigens in dental plaque; an association with oral health status and oral hygiene practices","volume":"55","author":"Namiot","year":"2010","journal-title":"Adv. Med. Sci."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1007\/s11596-011-0391-6","article-title":"Correlation between distribution of Helicobacter pylori in oral cavity and chronic stomach conditions","volume":"31","author":"Gao","year":"2011","journal-title":"J. Huazhong Univ. Sci. Technolog. Med. Sci."},{"key":"ref_32","first-page":"196","article-title":"Correlation of Helicobacter pylori in dental plaque and gastric mucosa of dyspeptic patients","volume":"52","author":"Butt","year":"2002","journal-title":"J. Pak. Med. Assoc."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1177\/0022034509344559","article-title":"Periodontal therapy improves gastric Helicobacter pylori eradication","volume":"88","author":"Zaric","year":"2009","journal-title":"J. Dent. Res."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"S51","DOI":"10.1902\/jop.2013.134006","article-title":"Inflammatory mechanisms linking periodontal diseases to cardiovascular diseases","volume":"84","author":"Schenkein","year":"2013","journal-title":"J. Periodontol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1902\/jop.2000.71.10.1528","article-title":"Elevation of systemic markers related to cardiovascular diseases in the peripheral blood of periodontitis patients","volume":"71","author":"Loos","year":"2000","journal-title":"J. Periodontol."},{"key":"ref_36","first-page":"e1","article-title":"C-reactive protein as a marker of periodontal disease","volume":"60","author":"Kanaparthy","year":"2012","journal-title":"Gen. Dent."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1111\/j.1365-2249.1997.270-ce1162.x","article-title":"Systemic acute-phase reactants, C-reactive protein and haptoglobin, in adult periodontitis","volume":"107","author":"Ebersole","year":"1997","journal-title":"Clin. Exp. Immunol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1093\/jnci\/djk021","article-title":"A prospective study of periodontal disease and pancreatic cancer in US male health professionals","volume":"99","author":"Michaud","year":"2007","journal-title":"J. Natl. Cancer. Inst."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/S1470-2045(08)70106-2","article-title":"Periodontal disease, tooth loss, and cancer risk in male health professionals: A prospective cohort study","volume":"9","author":"Michaud","year":"2008","journal-title":"Lancet. Oncol."}],"container-title":["International Journal of Environmental Research and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-4601\/17\/12\/4387\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T09:40:27Z","timestamp":1760175627000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-4601\/17\/12\/4387"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,18]]},"references-count":39,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2020,6]]}},"alternative-id":["ijerph17124387"],"URL":"https:\/\/doi.org\/10.3390\/ijerph17124387","relation":{},"ISSN":["1660-4601"],"issn-type":[{"value":"1660-4601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,18]]}}}