{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:27:01Z","timestamp":1790872021458,"version":"4.1.0"},"reference-count":51,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Purpose: Comparison of the activity of 11beta-hydroxysteroid dehydrogenase type 2 in the placenta and the umbilical cord blood cortisol level between caesarean sections with or without uterine contraction and vaginal delivery groups. Cortisol is the main stress hormone responsible for the normal adaptation of the neonate to extrauterine life. The disorders resulting from a dysfunction of the 11\u03b2-HSD 2\u2013cortisol system can explain the higher risk of developing diseases in children born by caesarean section. Methods: 111 healthy, pregnant women in singular pregnancy at term of delivery were included into the study. The study comprised 11\u03b2-HSD 2 in placental tissue from 49 pregnant women delivering by elective caesarean section and 46 pregnant women delivering by vagina. In 16 cases of the elective caesarean section, regular uterine contractions were declared. Cortisol level was estimated in umbilical cord blood directly after delivery. Results: We found no statistically significant differences in the activity of 11\u03b2-HSD 2 in placentas delivered via caesarean sections (29.61 on average in elective caesarean sections and 26.65 on average in intrapartum caesarean sections) compared to vaginal deliveries (31.94 on average, p = 0.381), while umbilical cord blood cortisol in the elective caesarean sections group was significantly lower (29.86 on average) compared to the vaginal deliveries (55.50 on average, p &lt; 0.001) and intrapartum caesarean sections (52.27 on average, p &lt; 0.001). Conclusions: The model of placental 11\u03b2-HSD 2 activity and umbilical cord blood cortisol concentration seems to be significant in conditions of stress associated with natural uterine contractions in labour.<\/jats:p>","DOI":"10.3390\/ijerph17155566","type":"journal-article","created":{"date-parts":[[2020,8,3]],"date-time":"2020-08-03T06:16:47Z","timestamp":1596435407000},"page":"5566","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Does the Caesarean Section Impact on 11\u03b2 HSD2 and Fetal Cortisol?"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7146-6295","authenticated-orcid":false,"given":"Aneta","family":"S\u0142abuszewska-J\u00f3\u017cwiak","sequence":"first","affiliation":[{"name":"First Department of Obstetrics and Gynaecology, Centre of Postgraduate Medical Education, \u017belazna 90 Street, 01-004 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1545-2547","authenticated-orcid":false,"given":"Marta","family":"W\u0142odarczyk","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Pharmacogenomics, Faculty of Pharmacy, Medical University of Warsaw, Banacha 1 Street, 02-097 Warsaw, Poland"},{"name":"Center for Preclinical Research, Medical University of Warsaw, Banacha 1 Street, 02-097 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3812-3917","authenticated-orcid":false,"given":"Krzysztof","family":"Kilian","sequence":"additional","affiliation":[{"name":"Heavy Ion Laboratory, University of Warsaw, Pasteura 5a Street, 02-093 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zbigniew","family":"Rogulski","sequence":"additional","affiliation":[{"name":"Radiochemistry for Medicine and Industry, Biological and Chemical Research Centre, University of Warsaw, Banacha 1 Street, 02-097 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5780-5983","authenticated-orcid":false,"given":"Micha\u0142","family":"Ciebiera","sequence":"additional","affiliation":[{"name":"Second Department of Obstetrics and Gynaecology, Centre of Postgraduate Medical Education, Ceg\u0142owska 80 Street, 01-809 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7607-7643","authenticated-orcid":false,"given":"Jolanta","family":"Szyma\u0144ska-Majchrzak","sequence":"additional","affiliation":[{"name":"Chair and Department of Biochemistry, Medical University of Warsaw, Banacha 1 Street, 02-097 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8262-4380","authenticated-orcid":false,"given":"Kornelia","family":"Zar\u0119ba","sequence":"additional","affiliation":[{"name":"First Department of Obstetrics and Gynaecology, Centre of Postgraduate Medical Education, \u017belazna 90 Street, 01-004 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1118-7013","authenticated-orcid":false,"given":"Jacek Krzysztof","family":"Szyma\u0144ski","sequence":"additional","affiliation":[{"name":"First Department of Obstetrics and Gynaecology, Centre of Postgraduate Medical Education, \u017belazna 90 Street, 01-004 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3517-6711","authenticated-orcid":false,"given":"Dorota","family":"Raczkiewicz","sequence":"additional","affiliation":[{"name":"Institute of Statistics and Demography, Collegium of Economic Analysis, SGH Warsaw School of Economics, Madali\u0144skiego 6\/8 Street, 02-513 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gra\u017cyna","family":"Nowicka","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Pharmacogenomics, Faculty of Pharmacy, Medical University of Warsaw, Banacha 1 Street, 02-097 Warsaw, Poland"},{"name":"Center for Preclinical Research, Medical University of Warsaw, Banacha 1 Street, 02-097 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6094-2273","authenticated-orcid":false,"given":"Grzegorz","family":"Jakiel","sequence":"additional","affiliation":[{"name":"First Department of Obstetrics and Gynaecology, Centre of Postgraduate Medical Education, \u017belazna 90 Street, 01-004 Warsaw, 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