{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T15:15:14Z","timestamp":1791472514427,"version":"4.3.4"},"reference-count":79,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2020,8,3]],"date-time":"2020-08-03T00:00:00Z","timestamp":1596412800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Women with schizophrenia show sex-specific health needs that differ according to stage of life. The aim of this narrative review is to resolve important questions concerning the treatment of women with schizophrenia at different periods of their life\u2014paying special attention to reproductive and post-reproductive stages. Review results suggest that menstrual cycle-dependent treatments may be a useful option for many women and that recommendations re contraceptive options need always to be part of care provision. The pregnancy and the postpartum periods\u2014while constituting vulnerable time periods for the mother\u2014require special attention to antipsychotic effects on the fetus and neonate. Menopause and aging are further vulnerable times, with extra challenges posed by associated health risks. Pregnancy complications, neurodevelopmental difficulties of offspring, cancer risk and cognitive defects are indirect results of the interplay of hormones and antipsychotic treatment of women over the course of the lifespan. The literature recommends that health promotion strategies need to be directed at lifestyle modifications, prevention of medical comorbidities and increased psychosocial support. Careful monitoring of pharmacological treatment has been shown to be critical during periods of hormonal transition. Not only does treatment of women with schizophrenia often need to be different than that of their male peers, but it also needs to vary over the course of life.<\/jats:p>","DOI":"10.3390\/ijerph17155594","type":"journal-article","created":{"date-parts":[[2020,8,3]],"date-time":"2020-08-03T07:45:57Z","timestamp":1596440757000},"page":"5594","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Women with Schizophrenia over the Life Span: Health Promotion, Treatment and Outcomes"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1855-8566","authenticated-orcid":false,"given":"Alexandre","family":"Gonz\u00e1lez-Rodr\u00edguez","sequence":"first","affiliation":[{"name":"Department of Mental Health, Parc Taul\u00ed University Hospital, Institut d\u2019Investigaci\u00f3 i Innovaci\u00f3 Parc Taul\u00ed (I3PT), Autonomous University of Barcelona (UAB), 08280 Sabadell, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armand","family":"Gu\u00e0rdia","sequence":"additional","affiliation":[{"name":"Department of Mental Health, Parc Taul\u00ed University Hospital, 08280 Sabadell, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aida","family":"\u00c1lvarez Pedrero","sequence":"additional","affiliation":[{"name":"Department of Mental Health, Parc Taul\u00ed University Hospital, Institut d\u2019Investigaci\u00f3 i Innovaci\u00f3 Parc Taul\u00ed (I3PT), Autonomous University of Barcelona (UAB), 08280 Sabadell, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Betriu","sequence":"additional","affiliation":[{"name":"Department of Mental Health, Parc Taul\u00ed University Hospital, 08280 Sabadell, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2032-9343","authenticated-orcid":false,"given":"Jes\u00fas","family":"Cobo","sequence":"additional","affiliation":[{"name":"Department of Mental Health, Parc Taul\u00ed University Hospital, Institut d\u2019Investigaci\u00f3 i Innovaci\u00f3 Parc Taul\u00ed (I3PT), Autonomous University of Barcelona (UAB), 08280 Sabadell, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sidharta","family":"Acebillo","sequence":"additional","affiliation":[{"name":"Department of Mental Health, Parc Taul\u00ed University Hospital, Institut d\u2019Investigaci\u00f3 i Innovaci\u00f3 Parc Taul\u00ed (I3PT), Autonomous University of Barcelona (UAB), 08280 Sabadell, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Antonio","family":"Monreal","sequence":"additional","affiliation":[{"name":"Department of Mental Health, Parc Taul\u00ed University Hospital, Institut d\u2019Investigaci\u00f3 i Innovaci\u00f3 Parc Taul\u00ed (I3PT), Autonomous University of Barcelona (UAB), 08280 Sabadell, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6797-3382","authenticated-orcid":false,"given":"Mary V.","family":"Seeman","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Toronto, Toronto, ON M5P 3L6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Palao","sequence":"additional","affiliation":[{"name":"Department of Mental Health, Parc Taul\u00ed University Hospital, Institut d\u2019Investigaci\u00f3 i Innovaci\u00f3 Parc Taul\u00ed (I3PT), Autonomous University of Barcelona (UAB), 08280 Sabadell, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Labad","sequence":"additional","affiliation":[{"name":"Department of Mental Health, Parc Taul\u00ed University Hospital, Institut d\u2019Investigaci\u00f3 i Innovaci\u00f3 Parc Taul\u00ed (I3PT), Autonomous University of Barcelona (UAB), 08280 Sabadell, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,8,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1093\/schbul\/sby058","article-title":"Global epidemiology and burden of schizophrenia: Findings from the global burden of disease study","volume":"44","author":"Charlson","year":"2018","journal-title":"Schizophr. 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