{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T16:26:36Z","timestamp":1790007996374,"version":"4.0.1"},"reference-count":43,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2020,8,13]],"date-time":"2020-08-13T00:00:00Z","timestamp":1597276800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Italian Ministery of Health","award":["RF-2013-02355242"],"award-info":[{"award-number":["RF-2013-02355242"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Postural orthostatic tachycardia syndrome (POTS) is a multifactorial condition capable of chronically reducing the quality of life and the work ability of patients. The study aim was to assess the burden of autonomic symptoms in a cohort of POTS patients over 2 years. Patients\u2019 clinical profiles were assessed by the 31-item Composite Autonomic Symptom Score questionnaire (COMPASS 31) and a visual analog scale (VAS). One-way ANOVA for repeated measures followed by Dunnett\u2019s post-hoc test were used to compare symptoms at baseline and at 1 and 2 years. Out of 42 enrolled patients, 25 had a 1-year follow-up and 12 had a 2-year follow-up. At baseline, the reported burden of autonomic symptoms was high (overall COMPASS 31 = 49.9 \u00b1 14.3 \/100). Main complaints were related to orthostatic intolerance according to both COMPASS 31 and VAS. Fourteen patients were rendered inactive because of symptoms. At 1-year follow-up, a statistically significant improvement in pupillomotor function and overall score was detected by the COMPASS 31. These findings were confirmed at 2 years, together with a significant reduction in quality of life impairment, assessed by VAS. However, these improvements did not change patients\u2019 occupational status. Awareness of POTS diagnosis, patient monitoring, and tailored therapies can help to improve patients\u2019 condition.<\/jats:p>","DOI":"10.3390\/ijerph17165872","type":"journal-article","created":{"date-parts":[[2020,8,13]],"date-time":"2020-08-13T09:23:44Z","timestamp":1597310624000},"page":"5872","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Time Course of Autonomic Symptoms in Postural Orthostatic Tachycardia Syndrome (POTS) Patients: Two-Year Follow-Up Results"],"prefix":"10.3390","volume":"17","author":[{"given":"Franca","family":"Dipaola","sequence":"first","affiliation":[{"name":"Internal Medicine, Humanitas Clinical and Research Center\u2014IRCCS, Rozzano, 20089 Milan, Italy"},{"name":"Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, 20090 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5197-4484","authenticated-orcid":false,"given":"Caterina","family":"Barberi","sequence":"additional","affiliation":[{"name":"Internal Medicine, Humanitas Clinical and Research Center\u2014IRCCS, Rozzano, 20089 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Castelnuovo","sequence":"additional","affiliation":[{"name":"Internal Medicine, Humanitas Clinical and Research Center\u2014IRCCS, Rozzano, 20089 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maura","family":"Minonzio","sequence":"additional","affiliation":[{"name":"Internal Medicine, Humanitas Clinical and Research Center\u2014IRCCS, Rozzano, 20089 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Fornerone","sequence":"additional","affiliation":[{"name":"Internal Medicine, Humanitas Clinical and Research Center\u2014IRCCS, Rozzano, 20089 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana","family":"Shiffer","sequence":"additional","affiliation":[{"name":"Internal Medicine, Humanitas Clinical and Research Center\u2014IRCCS, Rozzano, 20089 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3396-6883","authenticated-orcid":false,"given":"Beatrice","family":"Cairo","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences for Health, University of Milan, 20122 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7480-3047","authenticated-orcid":false,"given":"Antonio Roberto","family":"Zamuner","sequence":"additional","affiliation":[{"name":"Departamento de Kinesiolog\u00eda, Universidad Cat\u00f3lica del Maule, 3605 Talca, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8283-1988","authenticated-orcid":false,"given":"Franca","family":"Barbic","sequence":"additional","affiliation":[{"name":"Internal Medicine, Humanitas Clinical and Research Center\u2014IRCCS, Rozzano, 20089 Milan, Italy"},{"name":"Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, 20090 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5209-6786","authenticated-orcid":false,"given":"Raffaello","family":"Furlan","sequence":"additional","affiliation":[{"name":"Internal Medicine, Humanitas Clinical and Research Center\u2014IRCCS, Rozzano, 20089 Milan, Italy"},{"name":"Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, 20090 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,8,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e41","DOI":"10.1016\/j.hrthm.2015.03.029","article-title":"2015 heart rhythm society expert consensus statement on the diagnosis and treatment of postural tachycardia syndrome, inappropriate sinus tachycardia, and vasovagal syncope","volume":"12","author":"Sheldon","year":"2015","journal-title":"Heart Rhythm"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1016\/j.mayocp.2012.08.013","article-title":"Postural tachycardia syndrome: a heterogeneous and multifactorial disorder","volume":"87","author":"Benarroch","year":"2012","journal-title":"Mayo Clin. 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