{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T13:29:25Z","timestamp":1767706165965,"version":"build-2065373602"},"reference-count":138,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2020,8,14]],"date-time":"2020-08-14T00:00:00Z","timestamp":1597363200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Currently, a global pandemic era of public health concerns is going on with the Coronavirus Disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). The first case of COVID-19 was reported from Wuhan\u2019s Huanan seafood market in China late December 2019. Bats, pangolins, and snakes have been nominated as salient carriers of the virus. Thanks to its high pathogenicity, it can cause severe respiratory infections. Fever, dry cough, sore throat, pneumonia, septic shock, and ground-glass opacities are the foremost clinical manifestations of COVID-19. Immunocompromised patients are at high risk for COVID-19 infection and may lead to death. Scientist and government agencies around the globe are putting forward their best efforts and resources for the effective treatment of human coronavirus infections; however, neither vaccines nor antiviral drugs are available for the treatment of human coronaviruses (HCoV) infections such as SARS (severe acute respiratory syndrome), MERS (Middle Eastern respiratory syndrome), and COVID-19. Since the outbreak, a plethora of research and review articles have been published. Moreover, the mass media has bombarded the public with conflicting opinions about the pandemic. There is a dire need for accurate and reliable information concerning this pandemic. In this review, we have compiled the up to date information about the origins, evolution, epidemiology, and pathogenesis of this disease. Moreover, very few reports have addressed the clinical features and current status of treatment for COVID-19; we have adequately addressed these topics in detail in this review. Finally, a detailed account of clinical trials of vaccines and other therapeutics currently in progress has been delineated.<\/jats:p>","DOI":"10.3390\/ijerph17165904","type":"journal-article","created":{"date-parts":[[2020,8,14]],"date-time":"2020-08-14T08:28:35Z","timestamp":1597393715000},"page":"5904","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Understanding COVID-19: From Origin to Potential Therapeutics"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4707-5440","authenticated-orcid":false,"given":"Muhammad","family":"Moazzam","sequence":"first","affiliation":[{"name":"Faculty of Pharmacy, University of Central Punjab, Lahore 54700, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6502-1740","authenticated-orcid":false,"given":"Muhammad Imran","family":"Sajid","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, University of Central Punjab, Lahore 54700, Pakistan"},{"name":"Center for Targeted Drug Delivery, Department of Biomedical and Pharmaceutical Sciences, Chapman University School of Pharmacy, Harry and Diane Rinker Health Science Campus, Irvine, CA 92618, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamza","family":"Shahid","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, University of Central Punjab, Lahore 54700, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jahanzaib","family":"Butt","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, University of Central Punjab, Lahore 54700, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irfan","family":"Bashir","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, University of Central Punjab, Lahore 54700, Pakistan"},{"name":"Foundation for Young Researchers, Lahore 54700, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad","family":"Jamshaid","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, University of Central Punjab, Lahore 54700, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amir Nasrolahi","family":"Shirazi","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, College of Pharmacy, Marshall B. Ketchum University, Fullerton, CA 92831, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3701-4548","authenticated-orcid":false,"given":"Rakesh Kumar","family":"Tiwari","sequence":"additional","affiliation":[{"name":"Center for Targeted Drug Delivery, Department of Biomedical and Pharmaceutical Sciences, Chapman University School of Pharmacy, Harry and Diane Rinker Health Science Campus, Irvine, CA 92618, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,8,14]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2020, May 20). Coronavirus Disease (COVID-19) Situation Report 121, Data as Received by WHO from National Authorities by 10:00 CEST. Available online: https:\/\/www.who.int\/docs\/default-source\/coronaviruse\/situation-reports\/20200520-covid-19-sitrep-121.pdf?sfvrsn=c4be2ec6_4."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Liu, Y., Gayle, A.A., Wilder-Smith, A., and Rockl\u00f6v, J. (2020). The reproductive number of COVID-19 is higher compared to SARS coronavirus. J. Travel Med., 27.","DOI":"10.1093\/jtm\/taaa021"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Gorbalenya, A.E. (2020). Severe acute respiratory syndrome-related coronavirus\u2014The species and its viruses, a statement of the Coronavirus Study Group. BioRxiv.","DOI":"10.1101\/2020.02.07.937862"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.drudis.2020.01.015","article-title":"Recent discovery and development of inhibitors targeting coronaviruses","volume":"25","author":"Pillaiyar","year":"2020","journal-title":"Drug Discov. Today"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1038\/nrmicro3143","article-title":"A decade after SARS: Strategies for controlling emerging coronaviruses","volume":"11","author":"Graham","year":"2013","journal-title":"Nat. Rev. Genet."},{"key":"ref_6","unstructured":"National Institute of Health (2020, July 17). COVID-19 Treatment Guidelines, Available online: https:\/\/covid19treatmentguidelines.nih.gov\/introduction\/."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Di Gennaro, F., Pizzol, D., Marotta, C., Antunes, M., Racalbuto, V., Veronese, N., and Smith, L. (2020). Coronavirus diseases (COVID-19) current status and future perspectives: A narrative review. J. Environ. Res. Public Health, 17.","DOI":"10.3390\/ijerph17082690"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1097\/CM9.0000000000000722","article-title":"Identification of a novel coronavirus causing severe pneumonia in human: A descriptive study","volume":"133","author":"Ren","year":"2020","journal-title":"Chin. Med. J."},{"key":"ref_9","unstructured":"World Health Organization (2020). Laboratory Testing for Coronavirus Disease 2019 (COVID-19) in Suspected Human Cases: Interim Guidance, 2 March 2020, WHO Press."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.ijsu.2020.02.034","article-title":"World Health Organization declares global emergency: A review of the 2019 novel coronavirus (COVID-19)","volume":"76","author":"Sohrabi","year":"2020","journal-title":"Int. J. Surg."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/s41586-020-2012-7","article-title":"A pneumonia outbreak associated with a new coronavirus of probable bat origin","volume":"579","author":"Zhou","year":"2020","journal-title":"Nature"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1986","DOI":"10.1056\/NEJMoa030685","article-title":"A major outbreak of severe acute respiratory syndrome in Hong Kong","volume":"348","author":"Lee","year":"2003","journal-title":"N. Engl. J. Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.1056\/NEJMoa1211721","article-title":"Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia","volume":"367","author":"Zaki","year":"2012","journal-title":"N. Engl. J. Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.3201\/eid1212.060401","article-title":"Review of bats and SARS","volume":"12","author":"Wang","year":"2006","journal-title":"Emerg. Infect. Dis."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"200463","DOI":"10.1148\/radiol.2020200463","article-title":"Chest CT findings in coronavirus disease-19 (COVID-19): Relationship to duration of infection","volume":"295","author":"Bernheim","year":"2020","journal-title":"Radiology"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1038\/cr.2013.92","article-title":"Structure of MERS-CoV spike receptor-binding domain complexed with human receptor DPP4","volume":"23","author":"Wang","year":"2013","journal-title":"Cell Res."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1016\/S0140-6736(03)14630-2","article-title":"Epidemiology and cause of severe acute respiratory syndrome (SARS) in Guangdong, People\u2019s Republic of China, in February, 2003","volume":"362","author":"Zhong","year":"2003","journal-title":"Lancet"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/nrmicro.2016.81","article-title":"SARS and MERS: Recent insights into emerging coronaviruses","volume":"14","author":"Falzarano","year":"2016","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"S36","DOI":"10.1046\/j.1440-1843.2003.00522.x","article-title":"SARS: Prognosis, outcome and sequelae","volume":"8","author":"Chan","year":"2003","journal-title":"Respirology"},{"key":"ref_20","unstructured":"World Health Organization (2020, January 17). Novel Coronavirus\u2014Japan (ex-China). Available online: https:\/\/www.who.int\/csr\/don\/17-january-2020-novel-coronavirus-japan-ex-china\/en\/."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/S0140-6736(20)30185-9","article-title":"A novel coronavirus outbreak of global health concern","volume":"395","author":"Wang","year":"2020","journal-title":"Lancet"},{"key":"ref_22","first-page":"1","article-title":"The origin, transmission and clinical therapies on coronavirus disease 2019 (COVID-19) outbreak\u2014An update on the status","volume":"7","author":"Guo","year":"2020","journal-title":"Mil. Med. Res."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"242","DOI":"10.4103\/1995-7645.281613","article-title":"The 2019 novel coronavirus disease (COVID-19) pandemic: A zoonotic prospective","volume":"13","author":"Chakraborty","year":"2020","journal-title":"Asian Pac. J. Trop. Med."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/s41591-020-0796-5","article-title":"Emergence of a novel human coronavirus threatening human health","volume":"26","author":"Poon","year":"2020","journal-title":"Nat. Med."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Zhang, T., Wu, Q., and Zhang, Z. (2020). Probable pangolin origin of 2019-nCoV associated with outbreak of COVID-19. SSRN Electron. J.","DOI":"10.2139\/ssrn.3542586"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1089\/nat.2020.0868","article-title":"Oligonucleotides and the COVID-19 Pandemic: A Perspective","volume":"30","author":"Rossi","year":"2020","journal-title":"Nucleic Acid Ther."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"980","DOI":"10.3390\/v4060980","article-title":"Recent progress in studies of arterivirus-and coronavirus-host interactions","volume":"4","author":"Zhong","year":"2012","journal-title":"Viruses"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1126\/science.1118391","article-title":"Bats Are Natural Reservoirs of SARS-Like Coronaviruses","volume":"310","author":"Li","year":"2005","journal-title":"Science"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Gralinski, L.E., and Menachery, V.D. (2020). Return of the Coronavirus: 2019-nCoV. Viruses, 12.","DOI":"10.3390\/v12020135"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/S0140-6736(20)30251-8","article-title":"Genomic characterisation and epidemiology of 2019 novel coronavirus: Implications for virus origins and receptor binding","volume":"395","author":"Lu","year":"2020","journal-title":"Lancet"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1093\/nsr\/nwaa036","article-title":"On the origin and continuing evolution of SARS-CoV-2","volume":"7","author":"Tang","year":"2020","journal-title":"Natl. Sci. Rev."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"100673","DOI":"10.1016\/j.nmni.2020.100673","article-title":"Mutated COVID-19, May Foretells Mankind in a Great Risk in the Future","volume":"35","author":"Dawood","year":"2020","journal-title":"New Microbes New Infect."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"104260","DOI":"10.1016\/j.meegid.2020.104260","article-title":"Genetic diversity and evolution of SARS-CoV-2","volume":"81","author":"Phan","year":"2020","journal-title":"Infect. Genet. Evol."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Wang, Q., Qiu, Y., Li, J.-Y., Zhou, Z.-J., Liao, C.-H., and Ge, X.-Y. (2020). A unique protease cleavage site predicted in the spike protein of the novel pneumonia coronavirus (2019-nCoV) potentially related to viral transmissibility. Virol. Sin., 1\u20133.","DOI":"10.1007\/s12250-020-00212-7"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Maty\u00e1\u0161ek, R., and Kova\u0159\u00edk, A. (2020). Mutation Patterns of Human SARS-CoV-2 and Bat RaTG13 Coronavirus Genomes Are Strongly Biased Towards C> U Transitions, Indicating Rapid Evolution in Their Hosts. Genes, 11.","DOI":"10.21203\/rs.3.rs-21377\/v1"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1056\/NEJMp2002125","article-title":"Defining the epidemiology of Covid-19\u2014Studies needed","volume":"382","author":"Lipsitch","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Yuan, H., Cao, X., Ji, X., Du, F., Zhou, X., He, J., Xie, Y., and Zhu, Y. (2020). A Current Emerging Respiratory Infection: Epidemiological and Clinical Characteristics, Diagnosis and Treatments of COVID-19. Diagnosis and Treatments of COVID-19. SSRN Electron. J.","DOI":"10.2139\/ssrn.3551344"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0140-6736(20)30183-5","article-title":"Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China","volume":"395","author":"Huang","year":"2020","journal-title":"Lancet"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"69","DOI":"10.5582\/bst.2020.01020","article-title":"Drug treatment options for the 2019-new coronavirus (2019-nCoV)","volume":"14","author":"Lu","year":"2020","journal-title":"Biosci. Trends"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Nishiura, H., Jung, S.-M., Linton, N.M., Kinoshita, R., Yang, Y., Hayashi, K., Kobayashi, T., Yuan, B., and Akhmetzhanov, A.R. (2020). The extent of transmission of novel coronavirus in Wuhan, China, 2020. J. Clin. Med., 9.","DOI":"10.3390\/jcm9020330"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"102433","DOI":"10.1016\/j.jaut.2020.102433","article-title":"The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak","volume":"109","author":"Rothan","year":"2020","journal-title":"J. Autoimmun."},{"key":"ref_42","unstructured":"Epidemiology Working Group for NCIP Epidemic Response, and Chinese Center for Disease Control and Prevention (2020). The epidemiological characteristics of an outbreak of 2019 novel coronavirus diseases (COVID-19) in China. Zhonghua Liu Xing Bing Xue Za Zhi, 41, 145."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/S1473-3099(20)30119-5","article-title":"Open access epidemiological data from the COVID-19 outbreak","volume":"20","author":"Xu","year":"2020","journal-title":"Lancet Infect. Dis."},{"key":"ref_44","unstructured":"(2020, April 22). Nature. Coronavirus: The First Three Months as It Happened. Available online: https:\/\/www.nature.com\/articles\/d41586-020-00154-w."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Read, M.C. (2020). EID: High Contagiousness and Rapid Spread of Severe Acute Respiratory Syndrome Coronavirus 2. Emerg. Infect. Dis., 26.","DOI":"10.3201\/eid2607.200282"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"102434","DOI":"10.1016\/j.jaut.2020.102434","article-title":"The deadly coronaviruses: The 2003 SARS pandemic and the 2020 novel coronavirus epidemic in China","volume":"109","author":"Yang","year":"2020","journal-title":"J. Autoimmun."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"9696","DOI":"10.1073\/pnas.2004911117","article-title":"Demographic science aids in understanding the spread and fatality rates of COVID-19","volume":"117","author":"Dowd","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1001\/jama.2020.2648","article-title":"Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: Summary of a report of 72 314 cases from the Chinese Center for Disease Control and Prevention","volume":"323","author":"Wu","year":"2020","journal-title":"JAMA"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"S88","DOI":"10.1038\/nm1143","article-title":"Severe acute respiratory syndrome","volume":"10","author":"Peiris","year":"2004","journal-title":"Nat. Med."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1","DOI":"10.31531\/2581-3080.1000140","article-title":"Coronavirus (COVID-19): History, Current Knowledge and Pipeline Medications","volume":"4","author":"Jahangir","year":"2020","journal-title":"Int. J. Pharm. Pharmacol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/j.bbrc.2004.09.106","article-title":"Receptor-binding domain of SARS-CoV spike protein induces highly potent neutralizing antibodies: Implication for developing subunit vaccine","volume":"324","author":"He","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"2738","DOI":"10.1007\/s00018-004-4242-5","article-title":"Angiotensin-converting enzyme 2: A functional receptor for SARS coronavirus","volume":"61","author":"Kuhn","year":"2004","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/s41586-020-2008-3","article-title":"A new coronavirus associated with human respiratory disease in China","volume":"579","author":"Wu","year":"2020","journal-title":"Nature"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"4240","DOI":"10.1073\/pnas.0306446101","article-title":"Characterization of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) spike glycoprotein-mediated viral entry","volume":"101","author":"Simmons","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"5871","DOI":"10.1073\/pnas.0809524106","article-title":"Activation of the SARS coronavirus spike protein via sequential proteolytic cleavage at two distinct sites","volume":"106","author":"Belouzard","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1038\/nrmicro2147","article-title":"Coronaviruses post-SARS: Update on replication and pathogenesis","volume":"7","author":"Perlman","year":"2009","journal-title":"Nat. Rev. Genet."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1056\/NEJMoa2002032","article-title":"Clinical characteristics of coronavirus disease 2019 in China","volume":"382","author":"Guan","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/S0140-6736(20)30628-0","article-title":"COVID-19: Consider cytokine storm syndromes and immunosuppression","volume":"395","author":"Mehta","year":"2020","journal-title":"Lancet"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.healun.2020.03.012","article-title":"COVID-19 illness in native and immunosuppressed states: A clinical-therapeutic staging proposal","volume":"39","author":"Siddiqi","year":"2020","journal-title":"J. Hear. Lung Transplant."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/s41577-020-0311-8","article-title":"The trinity of COVID-19: Immunity, inflammation and intervention","volume":"20","author":"Tay","year":"2020","journal-title":"Nat. Rev. Immunol."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Zhang, B., Zhou, X., Qiu, Y., Feng, F., Feng, J., Jia, Y., Zhu, H., Hu, K., Liu, J., and Liu, Z. (2020). Clinical characteristics of 82 death cases with COVID-19. medRxiv.","DOI":"10.1101\/2020.02.26.20028191"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1126\/science.367.6485.1412","article-title":"Race to find COVID-19 treatments accelerates","volume":"367","author":"Kupferschmidt","year":"2020","journal-title":"Science"},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Hatami, N., Ahi, S., Sadeghinikoo, A., Foroughian, M., Javdani, F., Kalani, N., Fereydoni, M., and Keshavarz, P. (2020). Worldwide ACE (I\/D) Polymorphism May Affect COVID-19 Recovery Rate: An Ecological Meta-Regression, Springer.","DOI":"10.1007\/s12020-020-02381-7"},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Backer, J.A., Klinkenberg, D., and Wallinga, J. (2020). Incubation period of 2019 novel coronavirus (2019-nCoV) infections among travellers from Wuhan, China, 20\u201328 January 2020. Eurosurveillance, 25.","DOI":"10.2807\/1560-7917.ES.2020.25.5.2000062"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"e200034","DOI":"10.1148\/ryct.2020200034","article-title":"Imaging profile of the COVID-19 infection: Radiologic findings and literature review","volume":"2","author":"Ng","year":"2020","journal-title":"Radiol. Cardiothorac. Imaging"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1002\/jmv.25748","article-title":"Unique epidemiological and clinical features of the emerging 2019 novel coronavirus pneumonia (COVID-19) implicate special control measures","volume":"92","author":"Wang","year":"2020","journal-title":"J. Med. Virol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1007\/s00134-020-06026-1","article-title":"Identification of a potential mechanism of acute kidney injury during the COVID-19 outbreak: A study based on single-cell transcriptome analysis","volume":"46","author":"Pan","year":"2020","journal-title":"Intensive Care Med."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"108393","DOI":"10.1016\/j.clim.2020.108393","article-title":"The use of anti-inflammatory drugs in the treatment of people with severe coronavirus disease 2019 (COVID-19): The experience of clinical immunologists from China","volume":"214","author":"Zhang","year":"2020","journal-title":"Clin. Immunol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1097\/CM9.0000000000000744","article-title":"Clinical characteristics of novel coronavirus cases in tertiary hospitals in Hubei Province","volume":"133","author":"Kui","year":"2020","journal-title":"Chin. Med. J."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Xu, J., Zhao, S., Teng, T., Abdalla, A.E., Zhu, W., Xie, L., Wang, Y., and Guo, X. (2020). Systematic comparison of two animal-to-human transmitted human coronaviruses: SARS-CoV-2 and SARS-CoV. Viruses, 12.","DOI":"10.3390\/v12020244"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1002\/lary.28692","article-title":"Anosmia and ageusia: Common findings in COVID-19 patients","volume":"130","author":"Vaira","year":"2020","journal-title":"Laryngoscope"},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Kaye, R., Chang, C.D., Kazahaya, K., Brereton, J., and Denneny, J.C. (2020). COVID-19 anosmia reporting tool: Initial findings. Otolaryngol. Neck Surg.","DOI":"10.1177\/0194599820922992"},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Klopfenstein, T., Toko, L., Royer, P.-Y., Lepiller, Q., Gendrin, V., and Zayet, S. (2020). Features of anosmia in COVID-19. M\u00e9decine et Maladies Infectieuses.","DOI":"10.1016\/j.medmal.2020.04.006"},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Manheim, D., and Denkenberger, D. (2020). Review of Potential High-Leverage and Inexpensive Mitigations for Reducing Risk in Epidemics and Pandemics. J. Glob. Health Rep., 4.","DOI":"10.29392\/001c.12530"},{"key":"ref_75","unstructured":"World Health Organization (2004). WHO Guidelines for the Global Surveillance of Severe Acute Respiratory Syndrome (SARS): Updated Recommendations, October 2004, WHO Press."},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Zu, Z.Y., Jiang, M.D., Xu, P.P., Chen, W., Ni, Q.Q., Lu, G.M., and Zhang, L.J. (2020). Coronavirus disease 2019 (COVID-19): A perspective from China. Radiology, 296.","DOI":"10.1148\/radiol.2020200490"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.1056\/NEJMoa1401505","article-title":"Evidence for camel-to-human transmission of MERS coronavirus","volume":"370","author":"Azhar","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"ref_78","unstructured":"World Health Organization (2020, March 11). Coronavirus Disease 2019: Situation Report, 51. Available online: https:\/\/www.who.int\/docs\/default-source\/coronaviruse\/situation-reports\/20200311-sitrep-51-covid-19.pdf?sfvrsn=1ba62e57_10."},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Peeling, R.W., Wedderburn, C.J., Garcia, P.J., Boeras, D., Fongwen, N., Nkengasong, J., Sall, A., Tanuri, A., and Heymann, D.L. (2020). Serology testing in the COVID-19 pandemic response. Lancet Infect. Dis.","DOI":"10.1016\/S1473-3099(20)30517-X"},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Zhao, J., Yuan, Q., Wang, H., Liu, W., Liao, X., Su, Y., Wang, X., Yuan, J., Li, T., and Li, J. (2020). Antibody responses to SARS-CoV-2 in patients of novel coronavirus disease 2019. Clin. Infect. Dis.","DOI":"10.1101\/2020.03.02.20030189"},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Deng, S.-Q., and Peng, H.-J. (2020). Characteristics of and public health responses to the coronavirus disease 2019 outbreak in China. J. Clin. Med., 9.","DOI":"10.3390\/jcm9020575"},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Yang, W., and Yan, F. (2020). Patients with RT-PCR confirmed COVID-19 and normal chest CT. Radiology, 295.","DOI":"10.1148\/radiol.2020200702"},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Chan, J.F.-W., Yip, C.C.-Y., To, K.K.-W., Tang, T.H.-C., Wong, S.C.-Y., Leung, K.-H., Fung, A.Y.-F., Ng, A.C.-K., Zou, Z., and Tsoi, H.-W. (2020). Improved molecular diagnosis of COVID-19 by the novel, highly sensitive and specific COVID-19-RdRp\/Hel real-time reverse transcription-polymerase chain reaction assay validated in vitro and with clinical specimens. J. Clin. Microbiol., 58.","DOI":"10.1128\/JCM.00310-20"},{"key":"ref_84","first-page":"43","article-title":"Laboratory parameters in detection of COVID-19 patients with positive RT-PCR; a diagnostic accuracy study","volume":"8","author":"Mardani","year":"2020","journal-title":"Arch. Acad. Emerg. Med."},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Qu, R., Ling, Y., Zhang, Y.H.Z., Wei, L.Y., Chen, X., Li, X.M., Liu, X.Y., Liu, H.M., Guo, Z., and Ren, H. (2020). Platelet-to-lymphocyte ratio is associated with prognosis in patients with coronavirus disease-19. J. Med. Virol.","DOI":"10.1002\/jmv.25767"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/S2213-2600(20)30079-5","article-title":"Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: A single-centered, retrospective, observational study","volume":"8","author":"Yang","year":"2020","journal-title":"Lancet Respir. Med."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"104364","DOI":"10.1016\/j.jcv.2020.104364","article-title":"Clinical features and short-term outcomes of 221 patients with COVID-19 in Wuhan, China","volume":"127","author":"Zhang","year":"2020","journal-title":"J. Clin. Virol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"101623","DOI":"10.1016\/j.tmaid.2020.101623","article-title":"Clinical, laboratory and imaging features of COVID-19: A systematic review and meta-analysis","volume":"34","year":"2020","journal-title":"Travel Med. Infect. Dis."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s12098-020-03263-6","article-title":"A review of coronavirus disease-2019 (COVID-19)","volume":"87","author":"Singhal","year":"2020","journal-title":"Indian J. Pediatr."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/s41422-020-0282-0","article-title":"Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro","volume":"30","author":"Wang","year":"2020","journal-title":"Cell Res."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1002\/eji.202070035","article-title":"COVID-19: Lessons from SARS and MERS","volume":"50","author":"Park","year":"2020","journal-title":"Eur. J. Immunol."},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Yan, Y., Shin, W.I., Pang, Y.X., Meng, Y., Lai, J., You, C., Zhao, H., Lester, E., Wu, T., and Pang, C.H. (2020). The First 75 Days of Novel Coronavirus (SARS-CoV-2) Outbreak: Recent Advances, Prevention, and Treatment. Int. J. Environ. Res. Public Health, 17.","DOI":"10.3390\/ijerph17072323"},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Merad, M., and Martin, J.C. (2020). Pathological inflammation in patients with COVID-19: A key role for monocytes and macrophages. Nat. Rev. Immunol., 1\u20138.","DOI":"10.1038\/s41577-020-0331-4"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.jinf.2020.03.037","article-title":"The pathogenesis and treatment of the Cytokine Storm\u2019in COVID-19","volume":"80","author":"Ye","year":"2020","journal-title":"J. Infect."},{"key":"ref_95","unstructured":"Ye, Q., Wang, B., and Mao, J. (2020). Cytokine storm in COVID-19 and treatment. J. Infect."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/ni1309","article-title":"Monocyte emigration from bone marrow during bacterial infection requires signals mediated by chemokine receptor CCR2","volume":"7","author":"Serbina","year":"2006","journal-title":"Nat. Immunol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/S1473-3099(20)30132-8","article-title":"COVID-19: Combining antiviral and anti-inflammatory treatments","volume":"20","author":"Stebbing","year":"2020","journal-title":"Lancet Infect. Dis."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1016\/S0140-6736(20)30858-8","article-title":"Trials of anti-tumour necrosis factor therapy for COVID-19 are urgently needed","volume":"395","author":"Feldmann","year":"2020","journal-title":"Lancet"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.jmii.2020.03.005","article-title":"TH17 responses in cytokine storm of COVID-19: An emerging target of JAK2 inhibitor Fedratinib","volume":"53","author":"Wu","year":"2020","journal-title":"J. Microbiol. Immunol. Infect."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"6771","DOI":"10.1073\/pnas.1922083117","article-title":"Prophylactic and therapeutic remdesivir (GS-5734) treatment in the rhesus macaque model of MERS-CoV infection","volume":"117","author":"Feldmann","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Parang, K., El-Sayed, N.S., Kazeminy, A.J., and Tiwari, R.K. (2020). Comparative Antiviral Activity of Remdesivir and Anti-HIV Nucleoside Analogs against Human Coronavirus 229E (HCoV-229E). Molecules, 25.","DOI":"10.3390\/molecules25102343"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1001\/jama.2020.0757","article-title":"Coronavirus infections\u2014More than just the common cold","volume":"323","author":"Paules","year":"2020","journal-title":"JAMA"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1093\/cid\/ciz281","article-title":"Influenza A reinfection in sequential human challenge: Implications for protective immunity and \u201cUniversal\u201d vaccine development","volume":"70","author":"Memoli","year":"2019","journal-title":"Clin. Infect. Dis."},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"McMullan, L.K. (2020). Clinical trials in an Ebola outbreak seek to find an evidence-based cure. EBioMedicine, 52.","DOI":"10.1016\/j.ebiom.2019.102614"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"2327","DOI":"10.1056\/NEJMoa2007016","article-title":"Compassionate Use of Remdesivir for Patients with Severe Covid-19","volume":"382","author":"Grein","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"ref_106","unstructured":"Food and Drug Administration (FDA) (2020, May 01). Coronavirus (COVID-19) Update: FDA Issues Emergency Use Authorization for Potential COVID-19 Treatment, Available online: https:\/\/www.fda.gov\/news-events\/press-announcements\/coronavirus-covid-19-update-fda-issues-emergency-use-authorization-potential-covid-19-treatment."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"58","DOI":"10.5582\/ddt.2020.01012","article-title":"Discovering drugs to treat coronavirus disease 2019 (COVID-19)","volume":"14","author":"Dong","year":"2020","journal-title":"Drug Discov. Ther."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1056\/NEJMoa2001282","article-title":"A trial of lopinavir\u2013ritonavir in adults hospitalized with severe Covid-19","volume":"382","author":"Cao","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/j.cjca.2020.04.010","article-title":"Management and Treatment of COVID-19: The Chinese Experience","volume":"36","author":"Peng","year":"2020","journal-title":"Can. J. Cardiol."},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"Tobaiqy, M., Qashqary, M., Al-Dahery, S., Mujallad, A., Hershan, A.A., Kamal, M.A., and Helmi, N. (2020). Therapeutic Management of COVID-19 Patients: A systematic review. Infect. Prev. Pract., 2.","DOI":"10.1101\/2020.04.02.20051029"},{"key":"ref_111","unstructured":"Theoharides, T., and Conti, P. (2020). Dexamethasone for COVID-19? Not so fast. J. Biol. Regul. Homeost. Agents, 34."},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Johnson, R.M., and Vinetz, J.M. (2020). Dexamethasone in the management of covid-19. Br. Med. J., 370.","DOI":"10.1136\/bmj.m2648"},{"key":"ref_113","unstructured":"Recovery Collaborative Group (2020). Dexamethasone in Hospitalized Patients with Covid-19\u2014Preliminary Report. N. Engl. J. Med."},{"key":"ref_114","unstructured":"Whitty, C. (2020, June 16). Dexamethasone in the Treatment of COVID-19: Implementation and Management of Supply for Treatment in Hospitals, Available online: https:\/\/www.cas.mhra.gov.uk\/ViewandAcknowledgment\/ViewAlert.aspx?AlertID=103054."},{"key":"ref_115","unstructured":"Bethesda, M. (2020, July 30). COVID-19 Treatment Guidelines, Available online: https:\/\/www.covid19treatmentguidelines.nih.gov\/dexamethasone\/."},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"Gautret, P., Lagier, J.-C., Parola, P., Meddeb, L., Mailhe, M., Doudier, B., Courjon, J., Giordanengo, V., Vieira, V.E., and Dupont, H.T. (2020). Hydroxychloroquine and azithromycin as a treatment of COVID-19: Results of an open-label non-randomized clinical trial. Int. J. Antimicrob. Agents, 105949.","DOI":"10.1101\/2020.03.16.20037135"},{"key":"ref_117","doi-asserted-by":"crossref","unstructured":"Yao, X., Ye, F., Zhang, M., Cui, C., Huang, B., Niu, P., Liu, X., Zhao, L., Dong, E., and Song, C. (2020). In vitro antiviral activity and projection of optimized dosing design of hydroxychloroquine for the treatment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Clin. Infect. Dis., 2.","DOI":"10.1093\/cid\/ciaa237"},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"Cavalcanti, A.B., Zampieri, F.G., Rosa, R.G., Azevedo, L.C., Veiga, V.C., Avezum, A., Damiani, L.P., Marcadenti, A., Kawano-Dourado, L., and Lisboa, T. (2020). Hydroxychloroquine with or without Azithromycin in Mild-to-Moderate Covid-19. N. Engl. J. Med.","DOI":"10.1056\/NEJMoa2019014"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.thromres.2020.04.013","article-title":"Incidence of thrombotic complications in critically ill ICU patients with COVID-19","volume":"191","author":"Klok","year":"2020","journal-title":"Thromb. Res."},{"key":"ref_120","doi-asserted-by":"crossref","unstructured":"Cattaneo, M., Bertinato, E.M., Birocchi, S., Brizio, C., Malavolta, D., Manzoni, M., Muscarella, G., and Orlandi, M. (2020). Pulmonary embolism or pulmonary thrombosis in COVID-19? Is the recommendation to use high-dose heparin for thromboprophylaxis justified?. Thromb. Haemost.","DOI":"10.1055\/s-0040-1712097"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"2060","DOI":"10.1111\/jth.14860","article-title":"ISTH interim guidance on recognition and management of coagulopathy in COVID-19: A Comment","volume":"18","author":"Barrett","year":"2020","journal-title":"J. Thromb. Haemost."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"693","DOI":"10.4103\/ijo.IJO_639_20","article-title":"Therapeutic opportunities to manage COVID-19\/SARS-CoV-2 infection: Present and future","volume":"68","author":"Shetty","year":"2020","journal-title":"Indian J. Ophthalmol."},{"key":"ref_123","doi-asserted-by":"crossref","unstructured":"Hoffmann, M., Schroeder, S., Kleine-Weber, H., M\u00fcller, M.A., Drosten, C., and P\u00f6hlmann, S. (2020). Nafamostat mesylate blocks activation of SARS-CoV-2: New treatment option for COVID-19. Antimicrob. Agents Chemother., 64.","DOI":"10.1128\/AAC.00754-20"},{"key":"ref_124","doi-asserted-by":"crossref","unstructured":"Molina, J.M., Delaugerre, C., Goff, J., Mela-Lima, B., Ponscarme, D., Goldwirt, L., and De Castro, N. (2020). No evidence of rapid antiviral clearance or clinical benefit with the combination of hydroxychloroquine and azithromycin in patients with severe COVID-19 infection. Med. Mal. Infect., 30085\u201330088.","DOI":"10.1016\/j.medmal.2020.03.006"},{"key":"ref_125","doi-asserted-by":"crossref","unstructured":"Jin, Y., Yang, H., Ji, W., Wu, W., Chen, S., Zhang, W., and Duan, G. (2020). Virology, epidemiology, pathogenesis, and control of COVID-19. Viruses, 12.","DOI":"10.3390\/v12040372"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1001\/jama.2020.4940","article-title":"Convalescent plasma to treat COVID-19: Possibilities and challenges","volume":"323","author":"Roback","year":"2020","journal-title":"JAMA"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.tips.2020.03.006","article-title":"Ongoing clinical trials for the management of the COVID-19 pandemic","volume":"41","author":"Lythgoe","year":"2020","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"109815","DOI":"10.1016\/j.mehy.2020.109815","article-title":"Does Zinc Supplementation Enhance the Clinical Efficacy of Chloroquine\/Hydroxychloroquine to Win Todays Battle Against COVID-19?","volume":"142","author":"Scholz","year":"2020","journal-title":"Med. Hypotheses"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"em235","DOI":"10.29333\/ejgm\/7926","article-title":"COVID-19 in Italy: An overview from the first case to date","volume":"17","author":"Santacroce","year":"2020","journal-title":"Electron. J. Gen. Med."},{"key":"ref_130","doi-asserted-by":"crossref","unstructured":"Connors, J.M., and Levy, J.H. (2020). Thromboinflammation and the hypercoagulability of COVID-19. J. Thromb. Haemost.","DOI":"10.1111\/jth.14849"},{"key":"ref_131","first-page":"212","article-title":"Clinical considerations for patients with diabetes in times of COVID-19 epidemic","volume":"14","author":"Gupta","year":"2020","journal-title":"Diabetes Metab. Syndr."},{"key":"ref_132","doi-asserted-by":"crossref","unstructured":"Grant, W.B., Lahore, H., McDonnell, S.L., Baggerly, C.A., French, C.B., Aliano, J.L., and Bhattoa, H.P. (2020). Evidence that vitamin D supplementation could reduce risk of influenza and COVID-19 infections and deaths. Nutrients, 12.","DOI":"10.20944\/preprints202003.0235.v2"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1038\/d41573-020-00151-8","article-title":"The COVID-19 vaccine development landscape","volume":"19","author":"Le","year":"2020","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_134","doi-asserted-by":"crossref","unstructured":"Ota, M. (2020). Will we see protection or reinfection in COVID-19?. Nat. Rev. Immunol.","DOI":"10.1038\/s41577-020-0316-3"},{"key":"ref_135","doi-asserted-by":"crossref","unstructured":"World Health Organization (2020). Rational Use of Personal Protective Equipment for Coronavirus Disease (COVID-19): Interim Guidance, 27 February 2020, WHO Press.","DOI":"10.15557\/PiMR.2020.0004"},{"key":"ref_136","doi-asserted-by":"crossref","unstructured":"Adams, J.G., and Walls, R.M. (2020). Supporting the health care workforce during the COVID-19 global epidemic. JAMA.","DOI":"10.1001\/jama.2020.3972"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1007\/s00259-020-04779-x","article-title":"Suggestions for safety and protection control in Department of Nuclear Medicine during the outbreak of COVID-19","volume":"47","author":"Zhang","year":"2020","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"100679","DOI":"10.1016\/j.nmni.2020.100679","article-title":"Noval coronavirus disease (COVID-19): A pandemic (Epidemiology, Pathogenesis and potential therapeutics)","volume":"35","author":"Hamid","year":"2020","journal-title":"New Microbes New Infect."}],"container-title":["International Journal of Environmental Research and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-4601\/17\/16\/5904\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T10:00:46Z","timestamp":1760176846000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-4601\/17\/16\/5904"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,14]]},"references-count":138,"journal-issue":{"issue":"16","published-online":{"date-parts":[[2020,8]]}},"alternative-id":["ijerph17165904"],"URL":"https:\/\/doi.org\/10.3390\/ijerph17165904","relation":{},"ISSN":["1660-4601"],"issn-type":[{"type":"electronic","value":"1660-4601"}],"subject":[],"published":{"date-parts":[[2020,8,14]]}}}