{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T21:01:53Z","timestamp":1790715713245,"version":"4.1.0"},"reference-count":27,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2020,8,30]],"date-time":"2020-08-30T00:00:00Z","timestamp":1598745600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>The study aimed to determine if oral hygiene influences not only oral health but also potentially metabolic disorders such as overweight or obesity. Participants were 94 patients: 40 with increased body mass and 54 with normal body mass. The methods included dental examination, a questionnaire concerning hygienic habits and an assessment of selected salivary inflammatory markers. The new parameter named \u201ccleaning index\u201d (describing the interaction between average time of tooth brushing in minutes and its frequency per day) significantly correlated with Body Mass Index (RSpearman = 0.300). The multivariate regression model incorporating cleaning index, approximal plaque index, receptor 1 for tumor necrosis factor-alpha (TNF\u03b1-R1) and interleukin-15 (IL-15) had a high power to predict overweight or obesity (AUC = 0.894). Patients with poor oral hygiene (approximal plaque index &gt;40%) were more than eight times more likely to suffer from obesity than patients with good oral hygiene. Cleaning index higher than 4 decreased the odds by about 85%. Oral hygiene habits, adjusted by salivary concentrations of selected inflammatory markers may allow predicting effectively overweight or obesity risk. Early proper dental prophylaxis and treatment could lead to the better prevention of metabolic disorders.<\/jats:p>","DOI":"10.3390\/ijerph17176310","type":"journal-article","created":{"date-parts":[[2020,8,30]],"date-time":"2020-08-30T22:00:17Z","timestamp":1598824817000},"page":"6310","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Poor Oral Hygiene and High Levels of Inflammatory Cytokines in Saliva Predict the Risk of Overweight and Obesity"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5042-5985","authenticated-orcid":false,"given":"Kacper","family":"Nijakowski","sequence":"first","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, Poznan University of Medical Sciences, 61-701 Pozna\u0144, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Lehmann","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, Poznan University of Medical Sciences, 61-701 Pozna\u0144, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafa\u0142","family":"Rutkowski","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, Poznan University of Medical Sciences, 61-701 Pozna\u0144, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6291-0814","authenticated-orcid":false,"given":"Katarzyna","family":"Korybalska","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, Poznan University of Medical Sciences, 61-701 Pozna\u0144, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janusz","family":"Witowski","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, Poznan University of Medical Sciences, 61-701 Pozna\u0144, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9952-0230","authenticated-orcid":false,"given":"Anna","family":"Surdacka","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, Poznan University of Medical Sciences, 61-701 Pozna\u0144, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,8,30]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2000). Obesity: Preventing and Managing the Global Epidemic, World Health Organization."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1111\/jebm.12363","article-title":"Association between obesity and adipokines levels in saliva and gingival crevicular fluid: A systematic review and meta-analysis","volume":"12","author":"Duffles","year":"2019","journal-title":"J. Evid. Based Med."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Goodson, J.M., Kantarci, A., Hartman, M.-L., Denis, G.V., Stephens, D., Hasturk, H., Yaskell, T., Vargas, J., Wang, X., and Cugini, M. (2014). Metabolic Disease Risk in Children by Salivary Biomarker Analysis. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0098799"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.peptides.2011.11.007","article-title":"Measurement of salivary resistin, visfatin and adiponectin levels","volume":"33","author":"Mamali","year":"2012","journal-title":"Peptides"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.peptides.2014.11.007","article-title":"Evaluation of salivary adiponectin profile in obese patients","volume":"63","author":"Nigro","year":"2015","journal-title":"Peptides"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/1758-5996-6-19","article-title":"Comparison of salivary and plasma adiponectin and leptin in patients with metabolic syndrome","volume":"6","author":"Thanakun","year":"2014","journal-title":"Diabetol. Metab. Syndr."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Kim, J.S., Kim, S.Y., Byon, M.J., Lee, J.H., Jeong, S.H., and Kim, J.B. (2019). Association between Periodontitis and Metabolic Syndrome in a Korean Nationally Representative Sample of Adults Aged 35\u201379 Years. Int. J. Environ. Res. Public Health, 16.","DOI":"10.3390\/ijerph16162930"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1590\/1413-81232014196.13482013","article-title":"Obesity and periodontitis: Systematic review and meta-analysis","volume":"19","author":"Marsicano","year":"2014","journal-title":"Cien. Saude Colet."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1111\/prd.12239","article-title":"Periodontal complications with obesity","volume":"78","author":"Suvan","year":"2018","journal-title":"Periodontol. 2000"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1177\/0022034509338353","article-title":"Is Obesity an Oral Bacterial Disease?","volume":"88","author":"Goodson","year":"2009","journal-title":"J. Dent. Res."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Andreeva, V.A., Egnell, M., Galan, P., Feron, G., Hercberg, S., and Julia, C. (2019). Association of the Dietary Index Underpinning the Nutri-Score Label with Oral Health: Preliminary Evidence from a Large, Population-Based Sample. Nutrients, 11.","DOI":"10.3390\/nu11091998"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"S136","DOI":"10.1111\/jphd.12227","article-title":"Healthy Futures: Engaging the oral health community in childhood obesity prevention\u2014Conference summary and recommendations","volume":"77","author":"Garcia","year":"2017","journal-title":"J. Public Health Dent."},{"key":"ref_13","first-page":"137","article-title":"Obesity and dental caries\u2014A systematic review","volume":"4","author":"Kantovitz","year":"2006","journal-title":"Oral Health Prev. Dent."},{"key":"ref_14","first-page":"2","article-title":"Associations of the Oral Microbiota with Obesity and Menarche in Inner City Girls","volume":"4","author":"Mervish","year":"2019","journal-title":"J. Child. Obes."},{"key":"ref_15","first-page":"297","article-title":"Characteristics of salivary inflammation profile in obesity","volume":"130","author":"Lehmann","year":"2020","journal-title":"Pol. Arch. Intern. Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"20466","DOI":"10.1073\/pnas.0710335105","article-title":"Diet-induced obesity in mice causes changes in immune responses and bone loss manifested by bacterial challenge","volume":"104","author":"Amar","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2367","DOI":"10.1038\/oby.2010.63","article-title":"Association Between Obesity, Flow Rate of Whole Saliva, and Dental Caries in Adolescents","volume":"18","author":"Blomberg","year":"2010","journal-title":"Obesity"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"280","DOI":"10.25100\/cm.v49i4.3919","article-title":"Obesity, salivary glands and oral pathology","volume":"49","author":"Roa","year":"2018","journal-title":"Colomb. Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1111\/j.1600-051X.2012.01913.x","article-title":"Salivary proteome modifications associated with periodontitis in obese patients","volume":"39","author":"Huchon","year":"2012","journal-title":"J. Clin. Periodontol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2016\/4801418","article-title":"Cytokine Profile in Chronic Periodontitis Patients with and without Obesity: A Systematic Review and Meta-Analysis","volume":"2016","author":"Akram","year":"2016","journal-title":"Dis. Markers"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1111\/j.1600-051X.2006.00954.x","article-title":"Spurious associations in oral epidemiological research: The case of dental flossing and obesity","volume":"33","author":"Hujoel","year":"2006","journal-title":"J. Clin. Periodontol."},{"key":"ref_22","first-page":"189","article-title":"Body Mass Index and selected periodontal clinical parameters","volume":"48","author":"Konopka","year":"2011","journal-title":"Dent. Med. Probl."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"3093","DOI":"10.3892\/etm.2016.3697","article-title":"Obesity in relation to oral health behaviors: An analysis of the Korea National Health and Nutrition Examination Survey 2008\u20132010","volume":"12","author":"Park","year":"2016","journal-title":"Exp. Ther. Med."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1111\/j.1600-051X.2011.01770.x","article-title":"Poor oral hygiene and gingivitis are associated with obesity and overweight status in paediatric subjects","volume":"38","author":"Franchini","year":"2011","journal-title":"J. Clin. Periodontol."},{"key":"ref_25","first-page":"253","article-title":"Association between childhood obesity and oral hygiene status","volume":"30","author":"Ferraz","year":"2014","journal-title":"Nutr. Hosp."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.cyto.2018.05.006","article-title":"Salivary fingerprint of simple obesity","volume":"110","author":"Miechowicz","year":"2018","journal-title":"Cytokine"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"e1437","DOI":"10.1590\/0102-672020190001e1437","article-title":"Oral Health Promotion in Patients with Morbid Obesity After Gastroplasty: A Randomized Clinical Trial","volume":"32","author":"Porcelli","year":"2019","journal-title":"Arq. Bras. Cir. 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