{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T03:14:27Z","timestamp":1760238867176,"version":"build-2065373602"},"reference-count":53,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2020,9,9]],"date-time":"2020-09-09T00:00:00Z","timestamp":1599609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Even though vitamin D is widely acknowledged as having a potential immunomodulatory role in asthma, its exact beneficial mechanisms are yet to be clarified. An optimal serum 25-hydroxy-vitamin D (25-OH-VitD) level in pediatric asthma patients might not rely solely on the effect of dose-dependent vitamin D3 intake, but might also be influenced by factors related to insufficient asthma control. We aimed to survey the prevalence of serum 25-OH-VitD deficiency and analyze whether suboptimal levels were associated with asthma severity factors. The current cross-sectional study enrolled 131 pediatric asthma or asthma-suggestive recurrent wheezing patients, for whom serum 25-OH-VitD, IgE, and eosinophil count were assessed. The prevalence of suboptimal serum 25-OH-VitD was 58.8%. A suboptimal vitamin D status was associated with asthma exacerbation in the previous month (p = 0.02). Even under seasonal oral vitamin D3 supplementation, patients with a positive history of asthma attack in the previous four weeks presented significantly lower serum 25-OH-VitD concentrations, compared to their peers with no disease exacerbation. In conclusion, sequential measurements of serum 25-OH-VitD might prove useful for future studies evaluating the dynamic changes in vitamin D3 status in regard to asthma, especially in symptomatic patients.<\/jats:p>","DOI":"10.3390\/ijerph17186545","type":"journal-article","created":{"date-parts":[[2020,9,9]],"date-time":"2020-09-09T09:01:09Z","timestamp":1599642069000},"page":"6545","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Suboptimal Serum 25-Hydroxy-Vitamin D Is Associated with a History of Recent Disease Exacerbation in Pediatric Patients with Bronchial Asthma or Asthma-Suggestive Recurrent Wheezing"],"prefix":"10.3390","volume":"17","author":[{"given":"Teodora-Irina","family":"Adam-Bonci","sequence":"first","affiliation":[{"name":"Pathophysiology, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania"},{"name":"3rd Pediatrics Clinic, Children\u2019s Emergency Hospital Cluj-Napoca, 400217 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paraschiva","family":"Chereche\u0219-Pan\u021ba","sequence":"additional","affiliation":[{"name":"3rd Pediatrics Clinic, Children\u2019s Emergency Hospital Cluj-Napoca, 400217 Cluj-Napoca, Romania"},{"name":"3rd Pediatrics Clinic, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy, 400217 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5119-0906","authenticated-orcid":false,"given":"Eduard-Alexandru","family":"Bonci","sequence":"additional","affiliation":[{"name":"Oncological Surgery and Gynecologic Oncology, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy, 400015 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sorin Claudiu","family":"Man","sequence":"additional","affiliation":[{"name":"3rd Pediatrics Clinic, Children\u2019s Emergency Hospital Cluj-Napoca, 400217 Cluj-Napoca, Romania"},{"name":"3rd Pediatrics Clinic, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy, 400217 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ancu\u021ba","family":"Cuta\u0219-Benedec","sequence":"additional","affiliation":[{"name":"Medical Informatics and Biostatistics, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0097-262X","authenticated-orcid":false,"given":"Tudor","family":"Drugan","sequence":"additional","affiliation":[{"name":"Medical Informatics and Biostatistics, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1899-5977","authenticated-orcid":false,"given":"Raluca Maria","family":"Pop","sequence":"additional","affiliation":[{"name":"Pharmacology, Toxicology and Clinical Pharmacology, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy, 400337 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandru","family":"Irimie","sequence":"additional","affiliation":[{"name":"Oncological Surgery and Gynecologic Oncology, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy, 400015 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,9,9]]},"reference":[{"key":"ref_1","first-page":"1","article-title":"Pediatric Asthma: A Global Epidemic","volume":"85","author":"Serebrisky","year":"2019","journal-title":"Ann. 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