{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T00:30:25Z","timestamp":1790901025550,"version":"4.1.0"},"reference-count":74,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2020,9,15]],"date-time":"2020-09-15T00:00:00Z","timestamp":1600128000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-16-CE34-0004-01"],"award-info":[{"award-number":["ANR-16-CE34-0004-01"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>We aimed to identify high-priority organophosphorus flame retardants for action and research. We thus critically reviewed literature between 2000 and 2019 investigating organophosphorus flame retardants\u2019 presence indoors and human exposure in Europe, as well as epidemiological evidence of human effects. The most concentrated compounds indoors were tris(2-butoxyethyl)phosphate (TBOEP), tris(1-chloro-2-propyl)phosphate (TCIPP), tris(2,3-dichloropropyl)phosphate (TDCIPP). TBOEP and TCIPP were the most consistently detected compounds in humans\u2019 urine, hair or breast milk as well as tris (butyl) phosphate (TNBP) and tris (phenyl) phosphate (TPHP). Notably, epidemiological evidence concerned reprotoxicity, neurotoxicity, respiratory effects and eczema risk for TDCIPP, eczema increase for TBOEP, and neurodevelopmental outcomes for Isopropylated triarylphosphate isomers (ITPs). Given the ubiquitous presence indoors and the prevalence of exposure, the growing health concern seems justified. TDCIPP and TPHP seem to be of particular concern due to a high prevalence of exposure and epidemiological evidence. TBOEP and TNBP require epidemiological studies regarding outcomes other than respiratory or dermal ones.<\/jats:p>","DOI":"10.3390\/ijerph17186713","type":"journal-article","created":{"date-parts":[[2020,9,15]],"date-time":"2020-09-15T10:24:09Z","timestamp":1600165449000},"page":"6713","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":113,"title":["Organophosphorus Flame Retardants: A Global Review of Indoor Contamination and Human Exposure in Europe and Epidemiological Evidence"],"prefix":"10.3390","volume":"17","author":[{"given":"Zohra","family":"Chupeau","sequence":"first","affiliation":[{"name":"INSERM\u2014Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, F-75000 Paris, France"},{"name":"IRSET\u2014Institut de Recherche en Sant\u00e9, Environnement et Travail, UMR1085, F-35000 Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Bonvallot","sequence":"additional","affiliation":[{"name":"IRSET\u2014Institut de Recherche en Sant\u00e9, Environnement et Travail, UMR1085, F-35000 Rennes, France"},{"name":"EHESP\u2014Ecole des Hautes Etudes en Sant\u00e9 Publique, F-35000 Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9523-4277","authenticated-orcid":false,"given":"Fabien","family":"Mercier","sequence":"additional","affiliation":[{"name":"IRSET\u2014Institut de Recherche en Sant\u00e9, Environnement et Travail, UMR1085, F-35000 Rennes, France"},{"name":"EHESP\u2014Ecole des Hautes Etudes en Sant\u00e9 Publique, F-35000 Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Le Bot","sequence":"additional","affiliation":[{"name":"IRSET\u2014Institut de Recherche en Sant\u00e9, Environnement et Travail, UMR1085, F-35000 Rennes, France"},{"name":"EHESP\u2014Ecole des Hautes Etudes en Sant\u00e9 Publique, F-35000 Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecile","family":"Chevrier","sequence":"additional","affiliation":[{"name":"INSERM\u2014Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, F-75000 Paris, France"},{"name":"IRSET\u2014Institut de Recherche en Sant\u00e9, Environnement et Travail, UMR1085, F-35000 Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4450-0878","authenticated-orcid":false,"given":"Philippe","family":"Glorennec","sequence":"additional","affiliation":[{"name":"IRSET\u2014Institut de Recherche en Sant\u00e9, Environnement et Travail, UMR1085, F-35000 Rennes, France"},{"name":"EHESP\u2014Ecole des Hautes Etudes en Sant\u00e9 Publique, F-35000 Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,9,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"5485","DOI":"10.1016\/j.atmosenv.2003.09.025","article-title":"Emissions of organophosphate and brominated flame retardants from selected consumer products and building materials","volume":"37","author":"Kemmlein","year":"2003","journal-title":"Atmos. 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