{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T21:08:43Z","timestamp":1776114523431,"version":"3.50.1"},"reference-count":46,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2020,9,26]],"date-time":"2020-09-26T00:00:00Z","timestamp":1601078400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>This cross-sectional study aimed to translate, culturally adapt, validate, and apply a Celiac Disease Quality of Life (CD-QoL) questionnaire to a representative sample of Argentina\u2019s celiac population. A previously developed and validated questionnaire (Celiac Disease Questionnaire: CDQ) was chosen as a tool for assessing the health-related quality of Life (HRQoL) of adult celiac patients in Argentina. Therefore, the study was performed in four stages: (a) translation and re-translation of the CDQ to Argentinian-Spanish language; (b) cultural adaptation and semantic evaluation; based on the Delphi method (c) validation of the CDQ by applying it to a representative sample of Argentinian celiac patients; (d) statistical analysis of the data. The result of stages (a) and (b) was a translated and culturally adapted an Argentinian-Spanish version of the CDQ, which was generated after reaching consensus between the corresponding four (phase a) and 10 (phase b) professionals involved in the different phases of this process. Among them, we can cite bilingual healthcare professionals with extensive experience in research and celiac disease, celiac patients, gastroenterologists, general practitioners, dieticians, and psychologists. The resulting CDQ proved to be an appropriate measuring tool to assess the HRQoL of Argentinian celiac patients confirmed by a good fit in the confirmatory factor validity analysis (RMSEA &lt; 0.001 and \u03c72 = 267.325, df = 313, p = 0.971) and high values of internal consistency (Cronbach\u2019s alpha &gt; 0.7). A total of 191 participants accessed the questionnaire, and 171 individuals from 20 out of 23 Argentinian states completed the questionnaire. There was no correlation between higher educational level nor marital status with QoL. Individuals on a strict gluten-free diet (GFD) and those who do not take antidepressants showed higher QoL. Male gender also presented better HRQoL. There was no correlation between differences in HRQoL and age of the respondent, age at diagnosis, symptoms at diagnosis, or having other chronic diseases. However, a significantly higher score of HRQoL was reported among those individuals who disclosed having knowledge of CD related national regulations and benefits. This study highlights the importance of maintaining current public health regulations that support chronic disease patients, such as celiac patients.<\/jats:p>","DOI":"10.3390\/ijerph17197051","type":"journal-article","created":{"date-parts":[[2020,9,27]],"date-time":"2020-09-27T22:24:42Z","timestamp":1601245482000},"page":"7051","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Evaluation of Quality of Life of Adult Patients with Celiac Disease in Argentina: From Questionnaire Validation to Assessment"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6790-829X","authenticated-orcid":false,"given":"Nicole","family":"Selleski","sequence":"first","affiliation":[{"name":"Interdisciplinary Laboratory of Biosciences and Celiac Disease Research Center, School of Medicine, University of Brasilia, Brasilia, DF 70910-900, Brazil"},{"name":"Post-Graduate Program in Health Sciences, School of Health Sciences, University of Brasilia, Brasilia, DF 70910-900, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0370-3089","authenticated-orcid":false,"given":"Renata Puppin","family":"Zandonadi","sequence":"additional","affiliation":[{"name":"Department of Nutrition, School of Health Sciences, University of Brasilia, Brasilia, DF 70910-900, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura B.","family":"Milde","sequence":"additional","affiliation":[{"name":"Department of Food Science and Technology, School of Exact Sciences, Chemistry and Natural Sciences, University of Misiones, 3300 Posadas, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lenora","family":"Gandolfi","sequence":"additional","affiliation":[{"name":"Interdisciplinary Laboratory of Biosciences and Celiac Disease Research Center, School of Medicine, University of Brasilia, Brasilia, DF 70910-900, Brazil"},{"name":"Post-Graduate Program in Health Sciences, School of Health Sciences, University of Brasilia, Brasilia, DF 70910-900, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6372-9024","authenticated-orcid":false,"given":"Riccardo","family":"Pratesi","sequence":"additional","affiliation":[{"name":"Interdisciplinary Laboratory of Biosciences and Celiac Disease Research Center, School of Medicine, University of Brasilia, Brasilia, DF 70910-900, Brazil"},{"name":"Post-Graduate Program in Health Sciences, School of Health Sciences, University of Brasilia, Brasilia, DF 70910-900, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3742-729X","authenticated-orcid":false,"given":"Winfred","family":"H\u00e4user","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, Klinikum Saarbr\u00fccken, 66119 Saarbr\u00fccken, Germany"},{"name":"Department of Psychosomatic Medicine and Psychotherapy, Technische Universit\u00e4t M\u00fcnchen, 80333 M\u00fcnchen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2352-4355","authenticated-orcid":false,"given":"Rosa Harumi","family":"Uenishi","sequence":"additional","affiliation":[{"name":"Interdisciplinary Laboratory of Biosciences and Celiac Disease Research Center, School of Medicine, University of Brasilia, Brasilia, DF 70910-900, Brazil"},{"name":"Post-Graduate Program in Health Sciences, School of Health Sciences, University of Brasilia, Brasilia, DF 70910-900, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9071-8512","authenticated-orcid":false,"given":"Eduardo Yoshio","family":"Nakano","sequence":"additional","affiliation":[{"name":"Department of Statistics, University of Brasilia, Brasilia, DF 70910-900, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2752-4296","authenticated-orcid":false,"given":"Claudia B.","family":"Pratesi","sequence":"additional","affiliation":[{"name":"Interdisciplinary Laboratory of Biosciences and Celiac Disease Research Center, School of Medicine, University of Brasilia, Brasilia, DF 70910-900, Brazil"},{"name":"College of Population Health, University of New Mexico, Albuquerque, NM 87131, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,9,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Itzlinger, A., Branchi, F., Elli, L., Schumann, M., Itzlinger, A., Branchi, F., Elli, L., and Schumann, M. 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