{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T19:09:31Z","timestamp":1790363371549,"version":"4.1.0"},"reference-count":45,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2020,11,6]],"date-time":"2020-11-06T00:00:00Z","timestamp":1604620800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Science and Technology in Taiwan","award":["MOST 106-2314-B-192-001-MY3"],"award-info":[{"award-number":["MOST 106-2314-B-192-001-MY3"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>The oxidative stress biomarker of urinary 8-hydroxy-2\u2032-deoxyguanosine (8-OHdG) was reported to be changed in patients with allergic diseases. Measurement of urinary oxidative products is noninvasive. However, correlations between the severity levels of atopic diseases and oxidative stress remain unclear. This study aimed to investigate the association among urinary 8-OHdG, atopic dermatitis (AD), and the phenotypes of atopic diseases in children. In a nested case-control study, participants of kindergarten children were enrolled from the Childhood Environment and Allergic Diseases Study (CEAS). Urinary analyses and urinary 8-OHdG were performed on samples from 200 children with AD as cases and 200 age- and sex-matched controls. Our study presents the following main findings: (1) The urinary 8-OHdG levels were significantly higher in cases than controls. Higher urinary 8-OHdG levels were associated with the risk of AD in a dose-response-manner; (2) Children\u2019s AD history was associated with higher risks of asthma, allergic rhinitis, and night pruritus; (3) For children with AD, urinary 8-OHdG levels of &gt;75th percentile were associated with higher risk of asthma, compared with the reference group of 0\u201325th percentiles. In summary, this study provides better understanding of the underlying mechanisms of AD and urinary 8-OHdG by analyzing a large-scale sample survey in Taiwan.<\/jats:p>","DOI":"10.3390\/ijerph17218207","type":"journal-article","created":{"date-parts":[[2020,11,6]],"date-time":"2020-11-06T09:03:04Z","timestamp":1604653384000},"page":"8207","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Associations between Levels of Urinary Oxidative Stress of 8-OHdG and Risk of Atopic Diseases in Children"],"prefix":"10.3390","volume":"17","author":[{"given":"Pang-Yen","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine, Mackay Memorial Hospital, Taipei 10449, Taiwan"},{"name":"Institute of Environmental and Occupational Health Sciences, School of Medicine, National Yang-Ming University, Taipei 112, Taiwan"},{"name":"Institute of Public Health, School of Medicine, National Yang-Ming University, Taipei 112, Taiwan"},{"name":"Department of Nursing, Yuanpei University of Medical Technology, Hsinchu 300, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien-Wei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology, Chang Gung Memorial Hospital Chiayi Branch, Chiayi 613, Taiwan"},{"name":"College of Medicine, Chang Gung University, Taoyuan 333, Taiwan"},{"name":"Institute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0218-1944","authenticated-orcid":false,"given":"Yu-Jang","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Mackay Memorial Hospital, Taipei 10449, Taiwan"},{"name":"Department of Medicine, Mackay Medical College, New Taipei City 252, Taiwan"},{"name":"Mackay Junior College of Medicine, Nursing, and Management, Taipei 11260, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Han","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Mackay Memorial Hospital, Taipei 10449, Taiwan"},{"name":"Department of Medicine, Mackay Medical College, New Taipei City 252, Taiwan"},{"name":"Mackay Junior College of Medicine, Nursing, and Management, Taipei 11260, Taiwan"},{"name":"Graduate Institute of Injury Prevention and Control, Taipei Medical University, Taipei 110, Taiwan"},{"name":"Institute of Mechatronic Engineering, National Taipei University of Technology, Taipei 106, Taiwan"},{"name":"Department of Emergency Medicine, School of Medicine, Taipei Medical University, Taipei 110, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Fong","family":"Kao","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, School of Medicine, Taipei Medical University, Taipei 110, Taiwan"},{"name":"Department of Emergency and Critical Care Medicine, Taipei Medical University Hospital, Taipei 110301, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen-Chang","family":"Yang","sequence":"additional","affiliation":[{"name":"Institute of Environmental and Occupational Health Sciences, School of Medicine, National Yang-Ming University, Taipei 112, Taiwan"},{"name":"Department of Internal Medicine, Taipei Veterans General Hospital, Taipei 112, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0091-258X","authenticated-orcid":false,"given":"I-Jen","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Environmental and Occupational Health Sciences, School of Medicine, National Yang-Ming University, Taipei 112, Taiwan"},{"name":"Department of Pediatrics, Taipei Hospital, Ministry of Health and Welfare, Taipei 242, Taiwan"},{"name":"College of Public Health, China Medical University, Taichung 404, Taiwan"},{"name":"National Taiwan University Hospital, National Taiwan University, Taipei 100, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,11,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"480","DOI":"10.2340\/00015555-1989","article-title":"Incidence, Serum IgE and TARC\/CCL17 Levels in Atopic Dermatitis Associated with Other Allergic Diseases: An Update from the Ishigaki Cohort","volume":"95","author":"Takeuchi","year":"2015","journal-title":"Acta Derm. 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