{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T21:35:42Z","timestamp":1771018542412,"version":"3.50.1"},"reference-count":27,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2020,11,9]],"date-time":"2020-11-09T00:00:00Z","timestamp":1604880000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Science and Technology and the Ministry of Science, ICT &amp; Future Planning NRF","award":["2017R1A2B2003575"],"award-info":[{"award-number":["2017R1A2B2003575"]}]},{"name":"Korea Health Industry Development Institute (KHIDI) by the Ministry of Health &amp; Welfare","award":["HI17C0387"],"award-info":[{"award-number":["HI17C0387"]}]},{"name":"a Korea University grant and a grant of Korea University Medical Center and Anam Hospital","award":["O1905011"],"award-info":[{"award-number":["O1905011"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Chronic rhinosinusitis is known to be influenced by cigarette exposure; however, this relationship is based on the presence of nasal polyps, and objective measurements of cigarette exposure in chronic rhinosinusitis are not well established. This study aimed to estimate the association between chronic rhinosinusitis and smoking status based on self-reported questionnaires and urinary cotinine levels according to the presence of nasal polyps. We analyzed a total of 23,621 participants who participated from the fifth Korea National Health and Nutrition Examination Survey (2010\u20132012). Serum total and specific IgE level were measured. Higher prevalence of chronic rhinosinusitis with nasal polyps was associated with current smoking status (OR = 1.43, 95% CI = 1.00\u20132.03). This association was prevalent in participants aged \u2264 50 years (OR = 1.76, 95% CI = 1.01\u20133.05), and higher urinary cotinine level showed correlation with higher prevalence of chronic rhinosinusitis with nasal polyps in this age group (OR = 1.04, 95% CI = 1.00\u20131.08). In addition, positive correlation between serum total IgE and urinary cotinine levels was greater in patients with chronic rhinosinusitis (\u03b2 = 0.493, 95% CI = 0.071\u20130.916) than in controls (\u03b2 = 0.062, 95% CI = 0.021\u20130.103). Aggressive smoking interventions should be performed in patients with chronic rhinosinusitis with nasal polyp, especially in cases of young adults or high serum IgE levels.<\/jats:p>","DOI":"10.3390\/ijerph17218291","type":"journal-article","created":{"date-parts":[[2020,11,9]],"date-time":"2020-11-09T19:08:29Z","timestamp":1604948909000},"page":"8291","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Association of Cotinine-Verified Cigarette Exposure with Chronic Rhinosinusitis in Korean Adults"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9799-662X","authenticated-orcid":false,"given":"Kijeong","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology-Head &amp; Neck Surgery, College of Medicine, Korea University, Seoul 02841, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"In Hak","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology-Head &amp; Neck Surgery, College of Medicine, Korea University, Seoul 02841, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hoyoung","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology-Head &amp; Neck Surgery, College of Medicine, Korea University, Seoul 02841, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soojeong","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology-Head &amp; Neck Surgery, College of Medicine, Korea University, Seoul 02841, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang Hag","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology-Head &amp; Neck Surgery, College of Medicine, Korea University, Seoul 02841, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tae Hoon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology-Head &amp; Neck Surgery, College of Medicine, Korea University, Seoul 02841, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,11,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4193\/Rhino12.000","article-title":"EPOS 2012: European position paper on rhinosinusitis and nasal polyps 2012. A summary for otorhinolaryngologists","volume":"50","author":"Fokkens","year":"2012","journal-title":"Rhinology"},{"key":"ref_2","first-page":"1","article-title":"Summary health statistics for U.S. adults: National health interview survey, 2012","volume":"260","author":"Blackwell","year":"2014","journal-title":"Vital Health Stat."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1111\/j.1398-9995.2011.02646.x","article-title":"Chronic rhinosinusitis in Europe\u2014An underestimated disease. A GA(2)LEN study","volume":"66","author":"Hastan","year":"2011","journal-title":"Allergy"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1097\/00005537-200307000-00016","article-title":"The epidemiology of chronic rhinosinusitis in Canadians","volume":"113","author":"Chen","year":"2003","journal-title":"Laryngoscope"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1146\/annurev-pathol-052016-100401","article-title":"Immunopathogenesis of Chronic Rhinosinusitis and Nasal Polyposis","volume":"12","author":"Schleimer","year":"2017","journal-title":"Annu. Rev. Pathol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2269","DOI":"10.1002\/lary.20223","article-title":"Cigarette smoke condensate inhibits transepithelial chloride transport and ciliary beat frequency","volume":"119","author":"Cohen","year":"2009","journal-title":"Laryngoscope"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"226","DOI":"10.2500\/ajra.2011.25.3623","article-title":"The effect of passive smoking on the levels of matrix metalloproteinase 9 in nasal secretions of children","volume":"25","author":"De","year":"2011","journal-title":"Am. J. Rhinol. Allergy"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1177\/0194599810394302","article-title":"Clinical factors associated with bacterial biofilm formation in chronic rhinosinusitis","volume":"144","author":"Zhang","year":"2011","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1002\/alr.21626","article-title":"Impact of cigarette smoking on the middle meatus microbiome in health and chronic rhinosinusitis","volume":"5","author":"Ramakrishnan","year":"2015","journal-title":"Int. Forum Allergy Rhinol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1177\/0194599818757697","article-title":"A Systematic Review of the Association between Cigarette Smoke Exposure and Chronic Rhinosinusitis","volume":"158","author":"Christensen","year":"2018","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1177\/0194599817717960","article-title":"Reversal of Smoking Effects on Chronic Rhinosinusitis after Smoking Cessation","volume":"157","author":"Phillips","year":"2017","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Benowitz, N.L., Hukkanen, J., and Jacob, P. (2009). Nicotine chemistry, metabolism, kinetics and biomarkers. Handbook of Experimental Pharmacology, Springer. [3rd ed.].","DOI":"10.1007\/978-3-540-69248-5_2"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Paci, E., Pigini, D., Bauleo, L., Ancona, C., Forastiere, F., and Tranfo, G. (2018). Urinary Cotinine Concentration and Self-Reported Smoking Status in 1075 Subjects Living in Central Italy. Int. J. Environ. Res. Public Health, 15.","DOI":"10.3390\/ijerph15040804"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1001\/archotol.126.8.940","article-title":"Confirmations and surprises in the association of tobacco use with sinusitis","volume":"126","author":"Lieu","year":"2000","journal-title":"Arch. Otolaryngol. Head Neck Surg."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Xie, L., Liu, A.G., Peng, L.Y., Wang, S.J., Zhang, Y.P., and Wang, X.S. (2018). Expression of E-prostanoid receptors in nasal polyp tissues of smoking and nonsmoking patients with chronic rhinosinusitis. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0200989"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1002\/alr.21955","article-title":"Impact of tobacco smoke on upper airway dendritic cell accumulation and regulation by sinonasal epithelial cells","volume":"7","author":"Mulligan","year":"2017","journal-title":"Int. Forum Allergy Rhinol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/1465-9921-9-42","article-title":"Cigarette smoke enhances Th-2 driven airway inflammation and delays inhalational tolerance","volume":"9","author":"Moerloose","year":"2008","journal-title":"Respir. Res."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1016\/j.jaci.2011.12.002","article-title":"Age-related differences in the pathogenesis of chronic rhinosinusitis","volume":"129","author":"Cho","year":"2012","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1001\/archoto.2010.43","article-title":"Secondhand smoke as a potential cause of chronic rhinosinusitis: A case-control study","volume":"136","author":"Tammemagi","year":"2010","journal-title":"Arch. Otolaryngol. Head Neck Surg."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1093\/ntr\/ntx247","article-title":"Dose-Dependent Effect of Cotinine-Verified Tobacco Smoking on Serum Immunoglobulin E Levels in Korean Adult Males","volume":"21","author":"Dong","year":"2019","journal-title":"Nicotine Tob. Res. Off. J. Soc. Res. Nicotine Tob."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.tox.2011.10.013","article-title":"Environmental cigarette smoke exposure modulates IgE levels of Pb-exposed children","volume":"291","author":"Lutz","year":"2012","journal-title":"Toxicology"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1164\/ajrccm.161.4.9905027","article-title":"Relationships of active and passive smoking to total IgE in adults of the Epidemiological Study of the Genetics and Environment of Asthma, Bronchial Hyperresponsiveness, and Atopy (EGEA)","volume":"161","author":"Oryszczyn","year":"2000","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.pupt.2012.05.005","article-title":"Cigarette smoke-induced inflammation and respiratory host defense: Insights from animal models","volume":"25","author":"Nikota","year":"2012","journal-title":"Pulm. Pharmacol. Ther."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"117ra119","DOI":"10.1126\/scitranslmed.3003041","article-title":"Cigarette smoke induction of osteopontin (SPP1) mediates T(H)17 inflammation in human and experimental emphysema","volume":"4","author":"Shan","year":"2012","journal-title":"Sci. Transl. Med."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"57","DOI":"10.4193\/Rhin18.131","article-title":"Impact of cigarette smoke and IL-17A activation on asthmatic patients with chronic rhinosinusitis","volume":"57","author":"Huang","year":"2019","journal-title":"Rhinology"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"e5432","DOI":"10.1097\/MD.0000000000005432","article-title":"Association between cigarette smoking and interleukin-17A expression in nasal tissues of patients with chronic rhinosinusitis and asthma","volume":"95","author":"Huang","year":"2016","journal-title":"Medicine"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"2621","DOI":"10.1038\/jid.2010.175","article-title":"Interleukin-17A promotes IgE production in human B cells","volume":"130","author":"Milovanovic","year":"2010","journal-title":"J. Investig. Dermatol."}],"container-title":["International Journal of Environmental Research and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-4601\/17\/21\/8291\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T10:31:21Z","timestamp":1760178681000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-4601\/17\/21\/8291"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,9]]},"references-count":27,"journal-issue":{"issue":"21","published-online":{"date-parts":[[2020,11]]}},"alternative-id":["ijerph17218291"],"URL":"https:\/\/doi.org\/10.3390\/ijerph17218291","relation":{},"ISSN":["1660-4601"],"issn-type":[{"value":"1660-4601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,9]]}}}