{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T16:39:33Z","timestamp":1772123973064,"version":"3.50.1"},"reference-count":40,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2020,11,13]],"date-time":"2020-11-13T00:00:00Z","timestamp":1605225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2018-R1D1A1A02085328 and 2020R1A2C4002594"],"award-info":[{"award-number":["NRF-2018-R1D1A1A02085328 and 2020R1A2C4002594"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>The association between thyroid disease and sudden sensorineural hearing loss (SSNHL) has not been evaluated. We investigated the association of goiter, hypothyroidism, thyroiditis, and hyperthyroidism with sudden sensorineural hearing loss (SSNHL). Data from the Korean National Health Insurance Service-Health Screening Cohort were used. The 8658 SSNHL patients were matched in a 1:4 ratio with 34,632 controls for age, sex, and region of residence. Histories of goiter, hypothyroidism, thyroiditis, hyperthyroidism, and Levothyroxine medication were explored as possible factors influencing SSNHL development. Associations were estimated using conditional logistic regression analyses, adjusted for Levothyroxine medication use. Subgroup analyses were conducted according to age, sex, income, and region of residence. SSNHL patients had a higher rate of goiter occurrence (4.4% vs. 3.7 %, p = 0.001) and hypothyroidism (4.0% vs. 3.2 %, p &lt; 0.001) than controls. Goiter and hypothyroidism were positively associated with SSNHL (adjusted OR =1.14 (95% CI =1.01\u20131.28), p = 0.043 for goiter and 1.17 (95% CI =1.03\u20131.33), p = 0.016 for hypothyroidism). In subgroup analyses, hypothyroidism or goiter was more prevalent in SSNHL patients than in controls. Lower-income subgroups showed associations of hypothyroidism and goiter with SSNHL. SSNHL patients were more likely to have goiter and hypothyroidism than normal individuals.<\/jats:p>","DOI":"10.3390\/ijerph17228419","type":"journal-article","created":{"date-parts":[[2020,11,13]],"date-time":"2020-11-13T10:32:47Z","timestamp":1605263567000},"page":"8419","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Association between SSNHL and Thyroid Diseases"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7361-4930","authenticated-orcid":false,"given":"So Young","family":"Kim","sequence":"first","affiliation":[{"name":"CHA Bundang Medical Center, Department of Otorhinolaryngology-Head &amp; Neck Surgery, CHA University, Seongnam 13496, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young Shin","family":"Song","sequence":"additional","affiliation":[{"name":"CHA Bundang Medical Center, Department of Internal Medicine, CHA University, Seongnam 13496, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6513-7011","authenticated-orcid":false,"given":"Jee Hye","family":"Wee","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology-Head &amp; Neck Surgery, Hallym University College of Medicine, Anyang 14068, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0629-9299","authenticated-orcid":false,"given":"Chanyang","family":"Min","sequence":"additional","affiliation":[{"name":"Hallym Data Science Laboratory, Hallym University College of Medicine, Anyang 14068, Korea"},{"name":"Graduate School of Public Health, Seoul National University, Seoul 08826, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2511-5536","authenticated-orcid":false,"given":"Dae Myoung","family":"Yoo","sequence":"additional","affiliation":[{"name":"Hallym Data Science Laboratory, Hallym University College of Medicine, Anyang 14068, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1655-9549","authenticated-orcid":false,"given":"Hyo Geun","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology-Head &amp; Neck Surgery, Hallym University College of Medicine, Anyang 14068, Korea"},{"name":"Hallym Data Science Laboratory, Hallym University College of Medicine, Anyang 14068, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,11,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"15758","DOI":"10.1073\/pnas.95.26.15758","article-title":"Thyroid hormone receptor -dependent expression of a potassium conductance in inner hair cells at the onset of hearing","volume":"95","author":"Erway","year":"1998","journal-title":"Proc. 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