{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T20:47:48Z","timestamp":1793047668865,"version":"4.5.0"},"reference-count":27,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2020,11,26]],"date-time":"2020-11-26T00:00:00Z","timestamp":1606348800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>The purpose of this study was to confirm the success rate of surgical treatment of medication-related osteonecrosis of the jaw (MRONJ) in patients at a single institution (Association of Oral and Maxillofacial Surgery (AAOMS) stages 1, 2, or 3), and to identify the factors that influence treatment outcomes. As a result of analyzing the outcomes of treatment, surgical \u201csuccess\u201d was achieved in 93.97% (109) of cases, and \u201cfailure\u201d was observed at 6.03% (7) cases. Analysis of patient factors that potentially affect treatment outcomes showed that zoledronate dose (p = 0.005) and the IV (intravenous) injection of drugs (p = 0.044) had significant negative impacts.<\/jats:p>","DOI":"10.3390\/ijerph17238801","type":"journal-article","created":{"date-parts":[[2020,11,26]],"date-time":"2020-11-26T22:00:33Z","timestamp":1606428033000},"page":"8801","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Surgical Treatment of Medication-Related Osteonecrosis of the Jaw: A Retrospective Study"],"prefix":"10.3390","volume":"17","author":[{"given":"Na Rae","family":"Choi","sequence":"first","affiliation":[{"name":"Department of Oral Maxillofacial Surgery, School of Dentistry, Pusan National University, Yangsan 50612, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Han","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Oral Maxillofacial Surgery, School of Dentistry, Pusan National University, Yangsan 50612, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Young","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Oral Maxillofacial Surgery, School of Dentistry, Pusan National University, Yangsan 50612, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6899-1769","authenticated-orcid":false,"given":"Dae Seok","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Oral Maxillofacial Surgery, School of Dentistry, Pusan National University, Yangsan 50612, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,11,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.tripleo.2007.01.008","article-title":"Biphosphonate-associated osteonecrosis can be controlled by nonsurgical management","volume":"104","author":"Montebugnoli","year":"2007","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1016\/j.joms.2014.04.031","article-title":"American Association of Oral and Maxillofacial Surgeons position paper on medication-related osteonecrosis of the jaw\u20142014 update","volume":"72","author":"Ruggiero","year":"2014","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1007\/s00520-009-0688-1","article-title":"Osteotomy and primary wound closure in bisphosphonate-associated osteonecrosis of the jaw: A prospective clinical study with 12 months follow-up. Supportive care in cancer","volume":"18","author":"Stockmann","year":"2010","journal-title":"Off. J. Multinatl. Assoc. Supportive Care Cancer"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1111\/j.1600-0714.2011.01091.x","article-title":"Bisphosphonates-related osteonecrosis of the jaws: A concise review of the literature and a report of a single-centre experience with 151 patients","volume":"41","author":"Vescovi","year":"2012","journal-title":"J. Oral Pathol. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.tripleo.2010.04.015","article-title":"The role of surgical therapy in the management of intravenous bisphosphonates-related osteonecrosis of the jaw","volume":"111","author":"Wilde","year":"2011","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"American Association of Oral and Maxillofacial Surgeons (2015). Updated position paper. Dent. Abstr., 60, 72\u201375.","DOI":"10.1016\/j.denabs.2015.01.011"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/s00774-010-0162-7","article-title":"Bisphosphonate-related osteonecrosis of the jaw: Position paper from the Allied Task Force Committee of Japanese Society for Bone and Mineral Research, Japan Osteoporosis Society, Japanese Society of Periodontology, Japanese Society for Oral and Maxillofacial Radiology, and Japanese Society of Oral and Maxillofacial Surgeons","volume":"28","author":"Yoneda","year":"2010","journal-title":"J. Bone Miner. Metab."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.adaj.2017.04.002","article-title":"Effectiveness of treatments for medication-related osteonecrosis of the jaw: A systematic review and meta-analysis","volume":"148","author":"Sgro","year":"2017","journal-title":"J. Am. Dent. Assoc."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2022","DOI":"10.1002\/jbmr.3191","article-title":"Evaluation of the treatment strategies for medication-related osteonecrosis of the jaws (MRONJ) and the factors affecting treatment outcome: A multicenter retrospective study with propensity score matching analysis","volume":"32","author":"Hayashida","year":"2017","journal-title":"J. Bone Miner. Res."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.ijom.2015.01.026","article-title":"Treatment strategies and outcomes of bisphosphonate-related osteonecrosis of the jaw (BRONJ) with characterization of patients: A systematic review","volume":"44","author":"Fliefel","year":"2015","journal-title":"Int. J. Oral. Maxillofac. Surg."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/j.tripleo.2011.07.004","article-title":"A prospective clinical trial for assessing the efficacy of a minimally invasive protocol in patients with bisphosphonate-associated osteonecrosis of the jaws","volume":"112","author":"Moretti","year":"2011","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"9","DOI":"10.5125\/jkaoms.2013.39.1.9","article-title":"Bisphosphonates-related osteonecrosis of the jaw in Korea: A preliminary report","volume":"39","author":"Lee","year":"2013","journal-title":"J. Korean Assoc. Oral Maxillofac. Surg."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Staderini, E., Patini, R., Guglielmi, F., Camodeca, A., and Gallenzi, P. (2019). How to manage impacted third molars: Germectomy or delayed removal? A systematic literature review. Medicina, 55.","DOI":"10.3390\/medicina55030079"},{"key":"ref_14","first-page":"e788","article-title":"The assessment of surgical and non-surgical treatment of stage II medication-related osteonecrosis of the jaw","volume":"22","author":"Eguchi","year":"2017","journal-title":"Med. Oral Patol. Oral Cir. Bucal."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/j.oraloncology.2013.05.012","article-title":"Conservative management of bisphosphonate-related osteonecrosis of the jaws: Staging and treatment outcomes","volume":"49","author":"Lerman","year":"2013","journal-title":"Oral Oncol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"151","DOI":"10.11005\/jbm.2015.22.4.151","article-title":"Medication related osteonecrosis of the jaw: 2015 position statement of the Korean society for bone and mineral research and the Korean association of oral and maxillofacial surgeons","volume":"22","author":"Kim","year":"2015","journal-title":"J. Bone Metab."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.bone.2016.06.011","article-title":"Osteonecrosis of the jaws (ONJ) in mice after extraction of teeth with periradicular disease","volume":"90","author":"Soundia","year":"2016","journal-title":"Bone"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"17349","DOI":"10.1074\/jbc.M115.652305","article-title":"Osteonecrosis of the jaw developed in mice: Disease variants regulated by \u03b3\u03b4 T cells in oral mucosal barrier immunity","volume":"290","author":"Park","year":"2015","journal-title":"J. Biol. Chem."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"20602","DOI":"10.1074\/jbc.M116.735795","article-title":"Plasticity of myeloid cells during oral barrier wound healing and the development of bisphosphonate-related osteonecrosis of the jaw","volume":"291","author":"Sun","year":"2016","journal-title":"J. Biol. Chem."},{"key":"ref_20","first-page":"5161","article-title":"A novel model of bisphosphonate-related osteonecrosis of the jaw in rats","volume":"8","author":"Yang","year":"2015","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1111\/ger.12416","article-title":"Medication-related osteonecrosis of the jaw-like lesions in rodents: A comprehensive systematic review and meta-analysis","volume":"36","author":"Kuroshima","year":"2019","journal-title":"Gerodontology"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1111\/odi.12632","article-title":"Time to onset of bisphosphonate-related osteonecrosis of the jaws: A multicentre retrospective cohort study","volume":"23","author":"Fung","year":"2017","journal-title":"Oral Dis."},{"key":"ref_23","first-page":"e326","article-title":"Medication-related osteonecrosis of the jaws (MRONJ) in cancer patients treated with denosumab vs. zoledronic acid: A systematic review and meta-analysis","volume":"25","author":"Limones","year":"2020","journal-title":"Med. Oral Patol. Oral Cir. Bucal."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.bone.2011.04.022","article-title":"Bisphosphonates: The first 40 years","volume":"49","author":"Russell","year":"2011","journal-title":"Bone"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/j.beem.2008.07.001","article-title":"Bisphosphonates: How do they work?","volume":"22","author":"Papapoulos","year":"2008","journal-title":"Best Pract. Res. Clin. Endocrinol. Metab."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"2465","DOI":"10.1007\/s00198-017-4063-7","article-title":"A multicenter retrospective study of the risk factors associated with medication-related osteonecrosis of the jaw after tooth extraction in patients receiving oral bisphosphonate therapy: Can primary wound closure and a drug holiday really prevent MRONJ?","volume":"28","author":"Hasegawa","year":"2017","journal-title":"Osteoporos. Int."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Patini, R., Staderini, E., Camodeca, A., Guglielmi, F., and Gallenzi, P. (2019). Case reports in pediatric dentistry journals: A systematic review about their effect on impact factor and future investigations. Dent. J., 7.","DOI":"10.3390\/dj7040103"}],"container-title":["International Journal of Environmental Research and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-4601\/17\/23\/8801\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T10:37:58Z","timestamp":1760179078000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-4601\/17\/23\/8801"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,26]]},"references-count":27,"journal-issue":{"issue":"23","published-online":{"date-parts":[[2020,12]]}},"alternative-id":["ijerph17238801"],"URL":"https:\/\/doi.org\/10.3390\/ijerph17238801","relation":{},"ISSN":["1660-4601"],"issn-type":[{"value":"1660-4601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,26]]}}}