{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T18:54:09Z","timestamp":1770749649397,"version":"3.50.0"},"reference-count":47,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2020,12,22]],"date-time":"2020-12-22T00:00:00Z","timestamp":1608595200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["41907390"],"award-info":[{"award-number":["41907390"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["41671500"],"award-info":[{"award-number":["41671500"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"the Second Tibetan Plateau Scientific Expedition and Research","award":["2019QZKK0607"],"award-info":[{"award-number":["2019QZKK0607"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Kashin-Beck Disease (KBD) is one of major endemic diseases in China. In this study, we estimated the health loss from KBD in Qamdo district of Tibet using the years lived with disability (YLD) metric and investigated the influence of environmental selenium (Se) on it by multiple regression model. The results showed that YLD rates produced a different ranking of health loss of KBD from that produced by prevalence rates between Basu and Luolong County, with higher health loss from KBD (43.61 YLD\/1000) but lower prevalence (17.86%) in Basu County. YLD rates in two counites were both highest for the 45\u201364 years age group. Compared with the prevalence rate, the YLD rate had a closer relation to environmental Se and was significantly negatively correlated with Se in both soil and highland barley. The multiple linear regression further revealed that Se contents in cultivated soil and highland barley were main influencing factors for the health loss of KBD, which could explain 90.5% of the variation in YLD rates. The information obtained highlights the significance of the YLD metric in exploring the environmental etiology of KBD and provides important information on which to base decisions on future prevention and control of endemic diseases.<\/jats:p>","DOI":"10.3390\/ijerph18010011","type":"journal-article","created":{"date-parts":[[2020,12,22]],"date-time":"2020-12-22T12:42:28Z","timestamp":1608640948000},"page":"11","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Assessing the Health Loss from Kashin-Beck Disease and Its Relationship with Environmental Selenium in Qamdo District of Tibet, China"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2382-3336","authenticated-orcid":false,"given":"Jing","family":"Wang","sequence":"first","affiliation":[{"name":"Key Laboratory for Geographical Process Analysis &amp; Simulation, Research Institute of Sustainable Development, Central China Normal University, Wuhan 430079, China"},{"name":"Key Laboratory of Land Surface Pattern and Simulation, Institute of Geographical Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing 100101, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shengcheng","family":"Zhao","sequence":"additional","affiliation":[{"name":"Tibet Center of Disease Control and Prevention, Lhasa 850030, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9603-6507","authenticated-orcid":false,"given":"Linsheng","family":"Yang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Land Surface Pattern and Simulation, Institute of Geographical Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing 100101, China"},{"name":"College of Resources and Environment, University of Chinese Academy of Sciences, Beijing 100049, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongqiang","family":"Gong","sequence":"additional","affiliation":[{"name":"Tibet Center of Disease Control and Prevention, Lhasa 850030, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hairong","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Land Surface Pattern and Simulation, Institute of Geographical Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing 100101, China"},{"name":"College of Resources and Environment, University of Chinese Academy of Sciences, Beijing 100049, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cangjue","family":"Nima","sequence":"additional","affiliation":[{"name":"Tibet Center of Disease Control and Prevention, Lhasa 850030, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,12,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1016\/B978-0-323-09138-1.00185-6","article-title":"185-Rare osteoarthritis: Ochronosis and Kashin-Beck disease","volume":"2","author":"Kraus","year":"2015","journal-title":"Rheumatology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/j.joca.2007.09.002","article-title":"Articular cartilage metabolism in patients with Kashin-Beck Disease: An endemic osteoarthropathy in China","volume":"16","author":"Cao","year":"2008","journal-title":"Osteoarthr. Cartil."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1016\/j.joca.2014.07.023","article-title":"Recent advances in the research of an endemic osteochondropathy in China: Kashin-Beck disease","volume":"22","author":"Guo","year":"2014","journal-title":"Osteoarthr. Cartil."},{"key":"ref_4","first-page":"97","article-title":"Pattern of joints involvement in Kashin-Beck disease: A local osteochondropathy in China","volume":"22","author":"Farooq","year":"2010","journal-title":"J. Ayub. Med. Coll. Abbottabad."},{"key":"ref_5","first-page":"155","article-title":"Surveillance report of Kashin Beck disease in Tibet in 2017","volume":"34","author":"Zhao","year":"2019","journal-title":"Chin. J. Ctrl. Endem. Dis."},{"key":"ref_6","unstructured":"National Health Commission (2018). China Health Statistics Yearbook 2018, Beijing Union Medical University Press."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1126\/science.274.5288.740","article-title":"Evidence-based health policy-lessons from the Global Burden of Disease Study","volume":"274","author":"Murray","year":"1996","journal-title":"Science"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.1016\/S0140-6736(12)61729-2","article-title":"Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990\u20132010: A systematic analysis for the Global Burden of Disease Study 2010","volume":"380","author":"Vos","year":"2012","journal-title":"Lancet"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1016\/S0140-6736(18)32279-7","article-title":"Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990\u20132017: A systematic analysis for the Global Burden of Disease Study 2017","volume":"392","author":"James","year":"2018","journal-title":"Lancet"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1001\/jamaoncol.2016.5688","article-title":"Global, regional, and national cancer incidence, mortality, years of life lost, years lived with disability, and disability-adjusted life-years for 32 cancer groups, 1990 to 2015: A systematic analysis for the Global Burden of Disease Study","volume":"3","author":"Fitzmaurice","year":"2017","journal-title":"JAMA Oncol."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Spronk, I., Edgar, D.W., Baar, M.E., Wood, F.M., Van Loey, N.E.E., Middelkoop, E., and Nieuwenhuis, M. (2020). Improved and standardized method for assessing years lived with disability after burns and its application to estimate the non-fatal burden of disease of burn injuries in Australia, New Zealand and the Netherlands. BMC Public Health, 20.","DOI":"10.1186\/s12889-020-8233-8"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2471","DOI":"10.1038\/s41598-019-39792-0","article-title":"Ecological analysis of Kashin-Beck osteoarthropathy risk factors in Tibet\u2019s Qamdo City, China","volume":"9","author":"Zha","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Preedy, V.R. (2015). Selenium and Kashin-Beck Disease. Selenium: Chemistry, Analysis, Function and Effects, Royal Society of Chemistry.","DOI":"10.1039\/9781782622215"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S0048-9697(01)00889-0","article-title":"Selenium in soil and endemic diseases in China","volume":"284","author":"Tan","year":"2020","journal-title":"Sci. Total Environ."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1007\/s11783-009-0009-4","article-title":"Soil selenium concentration and Kashin-Beck disease prevalence in Tibet, China","volume":"3","author":"Li","year":"2009","journal-title":"Front. Environ. Sci. Eng."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1007\/s10653-010-9366-y","article-title":"Environmental selenium in the Kaschin\u2013Beck disease area, Tibetan Plateau, China","volume":"33","author":"Zhang","year":"2011","journal-title":"Environ. Geochem. Health"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/s12011-013-9822-5","article-title":"Speciation, distribution and bioavailability of soil selenium in the Tibetan Plateau Kashin\u2013Beck disease area\u2014A case study in Songpan County, Sichuan Province, China","volume":"156","author":"Wang","year":"2013","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_18","first-page":"40","article-title":"Observations on effect of Kashin-Beck disease prevention by supplying selenium for 20 years in JingChuan County, Gansu Province","volume":"17","author":"Bai","year":"2002","journal-title":"Endem. Dis. Bull."},{"key":"ref_19","first-page":"710","article-title":"The investigation on effect of supplement selenium in KBD-affected area of Linzhou and Sangri County, Tibet","volume":"26","author":"Bai","year":"2007","journal-title":"Chin. J. Endemiol."},{"key":"ref_20","first-page":"659","article-title":"Analyzing the effect of Se-I salt on Kashin-Beck disease by mathematical statistics method","volume":"23","author":"Li","year":"2007","journal-title":"Med. Anim. Prev."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12011-013-9686-8","article-title":"Selenium: A protective factor for Kaschin-Beck disease in Qing-Tibet plateau","volume":"153","author":"Zhao","year":"2013","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1093\/ajcn\/33.2.303","article-title":"Selenium in human health and disease with emphasis on those aspects peculiar to New Zealand","volume":"33","author":"Thomson","year":"1980","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_23","first-page":"433","article-title":"Annual variation of serum selenium in patients with gynaecological cancer during 1978\u20131983 in Finland, a low selenium area","volume":"55","year":"1985","journal-title":"Int. J. Vitam. Nutr. Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.18306\/dlkxjz.2020.10.007","article-title":"Selenium levels in the environment, food, and human hair in Kashin-Beck Disease endemic areas of the Qinghai-Tibet Plateau","volume":"39","author":"Wang","year":"2020","journal-title":"Prog. Geogr."},{"key":"ref_25","first-page":"270","article-title":"Monitoring report of Kashin-Beck disease in Changdu region of Tibet in 2014","volume":"36","author":"Gong","year":"2015","journal-title":"Foreign Med. Sci. Sect. Medgeogr."},{"key":"ref_26","unstructured":"Wang, X.L. (2015). Statistical bulletin of national economic and social development of Qamdo City. Changdu Yearbook, Chinese Cultural and Historical Press."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.scitotenv.2018.03.190","article-title":"Effects of topography and soil properties on soil selenium distribution and bioavailability (phosphate extraction): A case study in Yongjia County, China","volume":"633","author":"Xu","year":"2018","journal-title":"Sci. Total Environ."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Maredza, M., Bertram, M.Y., and Tollman, S.M. (2015). Disease burden of stroke in rural South Africa: An estimate of incidence, mortality and disability adjusted life years. BMC Neurol., 15.","DOI":"10.1186\/s12883-015-0311-7"},{"key":"ref_29","first-page":"243","article-title":"Burden of disease in schistosomiasis japonica I Calculation and evaluation of years lived with disability of chronic schistosomiasis","volume":"23","author":"Jia","year":"2011","journal-title":"Chin. J. Schisto. Control"},{"key":"ref_30","unstructured":"Mathers, C.D., Vos, T., Lopez, A.D., Salomon, J., and Ezzati, M. (2001). National Burden of Disease Studies: A Practical Guide, World Health Organization. [2nd ed.]. Available online: https:\/\/www.who.int\/healthinfo\/nationalburdenofdiseasemanual.pdf?ua=1."},{"key":"ref_31","unstructured":"Duoji, Z.D. (2015). Statistics Bureau of Tibet Autonomous Region. Tibet Statistical Yearbook, China Statistical Press."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"458","DOI":"10.2471\/BLT.06.033035","article-title":"Assessment of the age-specific disability weight of chronic schistosomiasis japonica","volume":"85","author":"Jia","year":"2007","journal-title":"Bull. World Health Organ."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Yang, L.P., Liang, S.Y., Wang, X.J., Li, X.J., Wu, Y.L., and Ma, W. (2015). Burden of disease measured by disability-adjusted life years and a disease forecasting time series model of scrub typhus in Laiwu, China. PLoS Negl. Trop. Dis., 9.","DOI":"10.1371\/journal.pntd.0003420"},{"key":"ref_34","first-page":"45","article-title":"Study on burden of stroke in Shilin county of Kunming","volume":"23","author":"Cai","year":"2007","journal-title":"Chin. J. Public Health"},{"key":"ref_35","first-page":"195","article-title":"Differential diagnosis of Kashin-Beck disease and rheumatoid arthritis","volume":"24","author":"Liu","year":"2009","journal-title":"Chin. J. Ctrl. Endem. Dis."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1038\/s41598-017-00522-z","article-title":"Comparison of micro RNA expression profiles of Kashin-Beck disease, osteoarthritis and rheumatoid arthritis","volume":"7","author":"Wu","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_37","unstructured":"Global Burden of Disease Collaborative Network (2018). Global Burden of Disease Study 2017 (GBD 2017) Disability Weights, Institute for Health Metrics and Evaluation (IHME). Available online: http:\/\/ghdx.healthdata.org\/record\/ihme-data\/gbd-2017-disability-weights."},{"key":"ref_38","unstructured":"World Health Organization (WHO) (2020, November 22). YLD Template. Available online: https:\/\/www.who.int\/healthinfo\/global_burden_disease\/tools_national\/en\/."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1016\/j.envsoft.2004.09.001","article-title":"Principal component and multiple regression analysis in modelling of ground-level ozone and factors affecting its concentrations","volume":"20","author":"Bakheit","year":"2005","journal-title":"Environ. Modell. Softw."},{"key":"ref_40","first-page":"590","article-title":"Prediction of body weight from testicular and morphological characteristics in indigenous Mengali sheep of Pakistan: Using factor analysis scores in multiple linear regression analysis","volume":"14","author":"Tariq","year":"2012","journal-title":"Int. J. Agric. Biol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1016\/j.puhe.2012.08.012","article-title":"Measuring the burden of disease and injury in Spain using disability-adjusted life years: An updated and policy-oriented overview","volume":"126","year":"2012","journal-title":"Public Health"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1177\/003335491212700309","article-title":"Using disability-adjusted life years to assess the burden of disease and injury in Rhode Island","volume":"127","author":"Jiang","year":"2012","journal-title":"Public Health Rep."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1093\/pubmed\/fdn015","article-title":"Measuring burden of disease in two inner London boroughs using disability adjusted life years","volume":"30","author":"Dodhia","year":"2008","journal-title":"J. Public Health"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0033-3549(04)50125-5","article-title":"Assessing the burden of disease and injury in Los Angeles County using disability-adjusted life years","volume":"117","author":"Kominski","year":"2002","journal-title":"Public Health Rep."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0140-6736(00)02490-9","article-title":"The importance of selenium to human health","volume":"356","author":"Rayman","year":"2000","journal-title":"Lancet"},{"key":"ref_46","unstructured":"Christopher, J., Murray, L., and Lopez, A.D. (1996). The Global Burden of Disease: A Comprehensive Assessment of Mortality and Disability from Diseases, Injuries and Risk Factors in 1990 and Projected to 2020: Summary, Harvard University Press. Available online: https:\/\/extranet.who.int\/iris\/restricted\/handle\/10665\/41864."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/S0167-6296(97)00005-2","article-title":"Disability-adjusted life years: A critical review","volume":"16","author":"Anand","year":"1997","journal-title":"J. Health Econ."}],"container-title":["International Journal of Environmental Research and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-4601\/18\/1\/11\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T10:48:22Z","timestamp":1760179702000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-4601\/18\/1\/11"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,22]]},"references-count":47,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,1]]}},"alternative-id":["ijerph18010011"],"URL":"https:\/\/doi.org\/10.3390\/ijerph18010011","relation":{},"ISSN":["1660-4601"],"issn-type":[{"value":"1660-4601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,22]]}}}