{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T18:14:00Z","timestamp":1771265640273,"version":"3.50.1"},"reference-count":66,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2021,1,19]],"date-time":"2021-01-19T00:00:00Z","timestamp":1611014400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Consejo Nacional de Ciencia y Tecnolog\u00eda (CONACyT)","award":["PDCPN2014-01\/248982"],"award-info":[{"award-number":["PDCPN2014-01\/248982"]}]},{"name":"Consejo Nacional de Ciencia y Tecnolog\u00eda (CONACyT)","award":["493874"],"award-info":[{"award-number":["493874"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Background: Reports in a northwestern Mexico state linked arsenic (As) in drinking water to DNA damage in people from indigenous communities. However, this correlation remains under discussion due to unknown variables related to nutrition, customs, and the potential presence of other metal(oid)s. Methods: To determine this association, we sampled water from three Yaqui towns (C\u00f3corit, V\u00edcam, and P\u00f3tam), and analyzed the metals by ICP-OES. We exposed four separate groups, with five male CD-1 mice each, to provide further insight into the potential effects of untreated drinking water. Results: The maximum concentrations of each metal(oid) in \u00b5g\u00b7L\u22121 were Sr(819) &gt; Zn(135) &gt; As(75) &gt; Ba(57) &gt; Mo(56) &gt; Cu(17) &gt; Al(14) &gt; Mn(12) &gt; Se(19). Histological studies revealed brain cells with angulation, satellitosis, and reactive gliosis with significant statistical correlation with Mn and As. Furthermore, the liver cells presented hepatocellular degeneration. Despite the early response, there is no occurrence of both statistical and significative changes in hematological parameters. Conclusions: The obtained results provide experimental insights to understand the potential effects of untreated water with low As and Mn contents in murine models. This fact is noteworthy because of the development of histological changes on both the brain and liver at subchronic exposure.<\/jats:p>","DOI":"10.3390\/ijerph18020805","type":"journal-article","created":{"date-parts":[[2021,1,19]],"date-time":"2021-01-19T04:55:31Z","timestamp":1611032131000},"page":"805","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Effects of Untreated Drinking Water at Three Indigenous Yaqui Towns in Mexico: Insights from a Murine Model"],"prefix":"10.3390","volume":"18","author":[{"given":"Sofia","family":"Navarro-Espinoza","sequence":"first","affiliation":[{"name":"Department of Geology, University of Sonora, Rosales and Encinas, Hermosillo 83000, Sonora, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8934-0321","authenticated-orcid":false,"given":"Aracely","family":"Angulo-Molina","sequence":"additional","affiliation":[{"name":"Department of Physics Research, University of Sonora, Rosales and Encinas, Hermosillo 83000, Sonora, Mexico"},{"name":"Department of Biological Chemical Sciences, University of Sonora, Rosales and Encinas, Hermosillo 83000, Sonora, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8586-3387","authenticated-orcid":false,"given":"Diana","family":"Meza-Figueroa","sequence":"additional","affiliation":[{"name":"Department of Geology, University of Sonora, Rosales and Encinas, Hermosillo 83000, Sonora, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillermo","family":"L\u00f3pez-Cervantes","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Sonora, Rosales and Encinas, Hermosillo 83000, Sonora, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mercedes","family":"Meza-Montenegro","sequence":"additional","affiliation":[{"name":"Department of Natural Resources, Sonora Technological Institute, 5 de Febrero 818 Sur, Obregon City 85000, Sonora, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aurora","family":"Armienta","sequence":"additional","affiliation":[{"name":"Institute of Geophysics, National Autonomous University of Mexico-UNAM, Coyoac\u00e1n 04510, Ciudad de Mexico, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3604-1421","authenticated-orcid":false,"given":"Diego","family":"Soto-Puebla","sequence":"additional","affiliation":[{"name":"Department of Biological Chemical Sciences, University of Sonora, Rosales and Encinas, Hermosillo 83000, Sonora, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erika","family":"Silva-Campa","sequence":"additional","affiliation":[{"name":"Department of Biological Chemical Sciences, University of Sonora, Rosales and Encinas, Hermosillo 83000, Sonora, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3461-0029","authenticated-orcid":false,"given":"Alexel","family":"Burgara-Estrella","sequence":"additional","affiliation":[{"name":"Department of Biological Chemical Sciences, University of Sonora, Rosales and Encinas, Hermosillo 83000, Sonora, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osiris","family":"\u00c1lvarez-Bajo","sequence":"additional","affiliation":[{"name":"Department of Biological Chemical Sciences, University of Sonora, Rosales and Encinas, Hermosillo 83000, Sonora, Mexico"},{"name":"Consejo Nacional de Ciencia y Tecnolog\u00eda CONACyT, Insurgentes 1582, Benito Ju\u00e1rez 03940, Ciudad de Mexico, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4190-6477","authenticated-orcid":false,"given":"Mart\u00edn","family":"Pedroza-Montero","sequence":"additional","affiliation":[{"name":"Department of Biological Chemical Sciences, University of Sonora, Rosales and Encinas, Hermosillo 83000, Sonora, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,1,19]]},"reference":[{"key":"ref_1","unstructured":"Bundschuh, J., Garcia, M.E., Birkle, P., Cumbal, L.H., Bhattacharya, P., and Matschullat, J. 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