{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T21:00:59Z","timestamp":1780347659587,"version":"3.54.1"},"reference-count":32,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2021,1,21]],"date-time":"2021-01-21T00:00:00Z","timestamp":1611187200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>In bone regeneration, obtaining a vital bone as similar as possible to native bone is sought. This review aimed to evaluate the efficacy of stem cells in maxillary bone regeneration for implant rehabilitation and to review the different techniques for obtaining and processing these cells. A systematic review and meta-analysis were performed using the Pubmed\/Medline (NCBI), Cochrane, Scielo, and Scopus databases, without restriction on the publication date. The following Mesh terms were used, combined by the Boolean operator \u201cAND\u201d: \u201cdental implants\u201d AND \u201cstem cells\u201d AND \u201cbioengineering\u201d. Applying inclusion and exclusion criteria, five articles were obtained and three were added after manual search. The results from the meta-analysis (18 patients) did not provide significant differences despite the percentage of bone formed in the maxillary sinus, favoring the stem cell group, and the analysis of the percentage of residual Bio-Oss\u00ae showed results favoring the control group. Stem cell regeneration usually shows positive vascular and viable bone formation. In conclusion, using mesenchymal stem cells in bone regeneration provides benefits in the quality of bone, similar or even superior to autologous bone, all this through a minimally invasive procedure.<\/jats:p>","DOI":"10.3390\/ijerph18030894","type":"journal-article","created":{"date-parts":[[2021,1,21]],"date-time":"2021-01-21T00:53:41Z","timestamp":1611190421000},"page":"894","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Clinical Efficacy of Mesenchymal Stem Cells in Bone Regeneration in Oral Implantology. Systematic Review and Meta-Analysis"],"prefix":"10.3390","volume":"18","author":[{"given":"Sonia","family":"Egido-Moreno","sequence":"first","affiliation":[{"name":"Department of Odontoestomatology, Faculty of Medicine and Health Sciences, School of Dentistry, University of Barcelona\u2014Campus Bellvitge, 08907 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan","family":"Valls-Roca-Umbert","sequence":"additional","affiliation":[{"name":"Department of Odontoestomatology, Faculty of Medicine and Health Sciences, School of Dentistry, University of Barcelona\u2014Campus Bellvitge, 08907 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Manuel","family":"C\u00e9spedes-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Department of Odontoestomatology, Faculty of Medicine and Health Sciences, School of Dentistry, University of Barcelona\u2014Campus Bellvitge, 08907 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8035-4412","authenticated-orcid":false,"given":"Jos\u00e9","family":"L\u00f3pez-L\u00f3pez","sequence":"additional","affiliation":[{"name":"Department of Odontoestomatology, Faculty of Medicine and Health Sciences, School of Dentistry, University of Barcelona\u2014Campus Bellvitge, 08907 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugenio","family":"Velasco-Ortega","sequence":"additional","affiliation":[{"name":"Department of Stomatology, Faculty of Dentistry, University of Seville, 41013 Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,1,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1111\/j.1834-7819.2000.tb00552.x","article-title":"Tooth loss and implant replacement","volume":"45","author":"Henry","year":"2000","journal-title":"Aust. 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