{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T12:55:36Z","timestamp":1787748936821,"version":"build-2784847793"},"reference-count":78,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2021,1,22]],"date-time":"2021-01-22T00:00:00Z","timestamp":1611273600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Nitric oxide (NO) is formed during the oxidation of L-arginine to L-citrulline by the action of multiple isoenzymes of NO synthase (NOS): neuronal NOS (nNOS), endotelial NOS (eNOS), and inducible NOS (iNOS). NO plays a relevant role in the vascular endothelium, in central and peripheral neurons, and in immunity and inflammatory systems. In addition, several authors showed a consistent contribution of NO to different aspects of the reproductive physiology. The aim of the present review is to analyse the published data on the role of NO within the ovary. It has been demonstrated that the multiple isoenzymes of NOS are expressed and localized in the ovary of different species. More to the point, a consistent role was ascribed to NO in the processes of steroidogenesis, folliculogenesis, and oocyte meiotic maturation in in vitro and in vivo studies using animal models. Unfortunately, there are few nitric oxide data for humans; there are preliminary data on the implication of nitric oxide for oocyte\/embryo quality and in-vitro fertilization\/embryo transfer (IVF\/ET) parameters. NO plays a remarkable role in the ovary, but more investigation is needed, in particular in the context of human ovarian physiology.<\/jats:p>","DOI":"10.3390\/ijerph18030980","type":"journal-article","created":{"date-parts":[[2021,1,25]],"date-time":"2021-01-25T02:07:00Z","timestamp":1611540420000},"page":"980","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Novel Insights on the Role of Nitric Oxide in the Ovary: A Review of the Literature"],"prefix":"10.3390","volume":"18","author":[{"given":"Maria Cristina","family":"Budani","sequence":"first","affiliation":[{"name":"Department of Medicine and Aging Sciences, University \u201cG. d\u2019Annunzio\u201d Chieti-Pescara, Via Dei Vestini 31, 66100 Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3030-5230","authenticated-orcid":false,"given":"Gian Mario","family":"Tiboni","sequence":"additional","affiliation":[{"name":"Department of Medical, Oral and Biotechnological Sciences, University \u201cG. d\u2019Annunzio\u201d Chieti-Pescara, Via Dei Vestini 31, 66100 Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,1,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/bj3360001","article-title":"Arginine metabolism: Nitric oxide and beyond","volume":"15","author":"Wu","year":"1998","journal-title":"Biochem. J."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"R1","DOI":"10.1530\/REP-14-0524","article-title":"Nitric oxide in follicle development and oocyte competence","volume":"150","author":"Basini","year":"2015","journal-title":"Reproduction"},{"key":"ref_3","first-page":"E829","article-title":"New insights into the regulation of inducible nitric oxide synthesis","volume":"266","author":"Morris","year":"1994","journal-title":"Am. J. Physiol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1023\/A:1015459029397","article-title":"Nitric oxide and its role in blastocyst implantation","volume":"3","author":"Khorram","year":"2002","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1093\/humupd\/4.1.3","article-title":"Role of nitric oxide in the biology, physiology and pathophysiology of reproduction","volume":"4","author":"Rosselli","year":"1998","journal-title":"Hum. Reprod. Update"},{"key":"ref_6","first-page":"469","article-title":"Nitric oxide and superoxide in inflammation and immune regulation","volume":"54","author":"Guzik","year":"2003","journal-title":"J. Physiol. Pharmacol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1385\/ENDO:8:2:185","article-title":"Regulation of human luteal steroidogenesis in vitro by nitric oxide","volume":"8","author":"Vega","year":"1998","journal-title":"Endocrine"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"69","DOI":"10.4103\/0253-7613.15105","article-title":"Recent trends in the nitrergic nervous system","volume":"37","author":"Roy","year":"2005","journal-title":"Ind. J. Pharmacol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1530\/JOE-11-0034","article-title":"eNOS activation and NO function: Differential control of steroidogenesis by nitric oxide and its adaptation with hypoxia","volume":"210","author":"Ducsay","year":"2011","journal-title":"J. Endocrinol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1042\/cs0920277","article-title":"Evidence that nitric oxide inhibits steroidogenesis in cultured rat granulosa cells","volume":"92","author":"Dave","year":"1997","journal-title":"Clin. Sci."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.ygcen.2018.09.008","article-title":"Physiological relevance of nitric oxide in ovarian functions: An overview","volume":"279","author":"Nath","year":"2019","journal-title":"Gen. Comp. Endocrinol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S0739-7240(01)00096-0","article-title":"Nitric oxide synthase expression and nitric oxide\/cyclic GMP pathway in swine granulosa cells","volume":"20","author":"Grasselli","year":"2001","journal-title":"Domest. Anim. Endocrinol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1210\/endo.135.5.7525252","article-title":"Nitric oxide: An autocrine regulator of human granulosa-luteal cell steroidogenesis","volume":"135","author":"Dunn","year":"1994","journal-title":"Endocrinology"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1530\/eje.0.1370293","article-title":"Interactions between interleukin-1 beta, nitric oxide and prostaglandin E2 in the rat ovary: Effects on steroidogenesis","volume":"137","author":"Ahsan","year":"1997","journal-title":"Eur. J. Endocrinol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2537","DOI":"10.1093\/humrep\/14.10.2537","article-title":"Effects of a nitric oxide donor and nitric oxide synthase inhibitors on luteinizing hormone-induced ovulation in the ex-vivo perfused rat ovary","volume":"14","author":"Mitsube","year":"1999","journal-title":"Hum. Reprod."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/humrep\/14.1.27","article-title":"Nitric oxide reverses prostaglandin-induced inhibition in ovarian progesterone secretion in rats","volume":"14","author":"Dong","year":"1999","journal-title":"Hum. Reprod."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1530\/eje.0.1440303","article-title":"Effects of nitric oxide on steroidogenesis in porcine granulosa cells during different stages of follicular development","volume":"144","author":"Masuda","year":"2001","journal-title":"Eur. J. Endocrinol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1093\/molehr\/5.5.396","article-title":"Inhibitory effects of nitric oxide on the expression and activity of aromatase in human granulosa cells","volume":"5","author":"Kagabu","year":"1999","journal-title":"Mol. Hum. Reprod."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0090-6980(01)00156-3","article-title":"Interrelationship between nitric oxide and prostaglandins in bovine granulosa cells","volume":"66","author":"Basini","year":"2001","journal-title":"Prostaglandins. Other. Lipid. Mediat."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/0092-8674(93)90666-E","article-title":"CPLA2 is phosphorylated and activated by MAP Kinase","volume":"72","author":"Lin","year":"1993","journal-title":"Cell"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2719","DOI":"10.1172\/JCI118339","article-title":"Expression and localization of inducible and endothelial nitric oxide synthase in the rat ovary. Effects of gonadotropin stimulation in vivo","volume":"96","author":"Moore","year":"1995","journal-title":"J. Clin. Investig."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1210\/endo.138.1.4884","article-title":"Hormonal regulation of nitric oxide synthases and their cell-specific expression during follicular development in the rat ovary","volume":"138","author":"Olson","year":"1997","journal-title":"Endocrinology"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1071\/RD98114","article-title":"Is nitric oxide an autocrine modulator of bovine granulosa cell function?","volume":"10","author":"Basini","year":"1998","journal-title":"Reprod. Fertil. Dev."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1507\/endocrj.45.745","article-title":"Evidence for an inverse relationship between apoptosis and inducible nitric oxide synthase expression in rat granulosa cells: A possible role of nitric oxide in ovarian follicle atresia","volume":"45","author":"Matsumi","year":"1998","journal-title":"Endocr. J."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1210\/en.2004-0579","article-title":"Cross-Talk between Fas\/Fas ligand system and nitric oxide in the pathway subserving granulosa cell apoptosis: A possible regulatory mechanism for ovarian follicle atresia","volume":"146","author":"Chen","year":"2005","journal-title":"Endocrinology"},{"key":"ref_26","first-page":"45","article-title":"Nitric oxide stimulates the production of atrial natriuretic peptide and progesterone by human granulosa luteinized cells with an antiapoptotic effect","volume":"42","author":"Dineva","year":"2008","journal-title":"Endocr. Regul."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.mce.2011.01.013","article-title":"Regulation of inducible nitric oxide synthase expression in bovine ovarian granulosa cells","volume":"335","author":"Zamberlam","year":"2011","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1095\/biolreprod63.1.141","article-title":"Regulation of nitric oxide synthase to promote cytostasis in ovarian follicular development","volume":"63","author":"Matsumi","year":"2000","journal-title":"Biol. Reprod."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/nrm3531","article-title":"The road to maturation: Somatic cell interaction and self-organization of the mammalian oocyte","volume":"14","author":"Rong","year":"2013","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/S1472-6483(10)62159-1","article-title":"Origins and manifestations of oocyte maturation competencies","volume":"6","author":"Albertini","year":"2003","journal-title":"Reprod. Biomed. Online"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/bs.ctdb.2018.12.006","article-title":"Gametogenesis: A journey from inception to conception","volume":"132","author":"Larose","year":"2019","journal-title":"Curr. Top. Dev. Biol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1095\/biolreprod.102.005264","article-title":"Nitric oxide inhibits oocyte meiotic maturation","volume":"67","author":"Nakamura","year":"2002","journal-title":"Biol. Reprod."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1677\/jme.0.0240065","article-title":"FSH suppression of nitric oxide synthesis in porcine oocytes","volume":"24","author":"Hattori","year":"2000","journal-title":"J. Mol. Endocrinol."},{"key":"ref_34","first-page":"219","article-title":"Alterations in nitrate\/nitrite and nitric oxide synthase in preovulatory follicles in gonadotropin-primed immature rat","volume":"49","author":"Yamagata","year":"2002","journal-title":"Endocrinology"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2944","DOI":"10.1210\/endo.139.6.6054","article-title":"The role of nitric oxide in oocyte meiotic maturation and ovulation: Meiotic abnormalities of endothelial nitric oxide synthase knock-out mouse oocytes","volume":"139","author":"Olson","year":"1998","journal-title":"Endocrinology"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1177\/107155769900600208","article-title":"Inhibitors of nitric oxide synthase influence oocyte maturation in rats","volume":"6","author":"Basuray","year":"1999","journal-title":"J. Soc. Gynecol. Investig."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1002\/(SICI)1098-2795(200004)55:4<412::AID-MRD9>3.0.CO;2-W","article-title":"Nitric oxide is essential for optimal meiotic maturation of murine cumulus-oocyte complexes in vitro","volume":"55","author":"Olson","year":"2000","journal-title":"Mol. Reprod. Dev."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1002\/1098-2795(200103)58:3<262::AID-MRD3>3.0.CO;2-8","article-title":"Requirement of nitric oxide for murine oocyte maturation, embryo development and trophoblast outgrowth in vitro","volume":"58","author":"Sengoku","year":"2001","journal-title":"Mol. Reprod. Dev."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.mce.2004.04.014","article-title":"Immunohistochemical localization of inducible and endothelial nitric oxide synthase in porcine ovaries and effects of NO on antrum formation and oocyte meiotic maturation","volume":"222","author":"Tao","year":"2004","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/S0967199404002953","article-title":"Effects of nitric oxide synthase inhibitors on porcine oocyte meiotic maturation","volume":"13","author":"Tao","year":"2005","journal-title":"Zygote"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1530\/rep.1.0542","article-title":"Inducible nitric oxide synthase-derived nitric oxide regulates germinal vesicle breakdown and first polar body emission in the mouse oocyte","volume":"129","author":"Huo","year":"2005","journal-title":"Reproduction"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1177\/1535370214545024","article-title":"Reduction of nitric oxide level leads to spontaneous resumption of meiosis in diplotene-arrested rat oocytes cultured in vitro","volume":"240","author":"Pandey","year":"2015","journal-title":"Exp. Biol. Med."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0303-7207(03)00213-2","article-title":"Dual effects of nitric oxide on meiotic maturation of mouse cumulus cell-enclosed oocytes in vitro","volume":"207","author":"Bu","year":"2003","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1080\/10715760802695985","article-title":"Intracellular levels of hydrogen peroxide and nitric oxide in oocytes at various stages of meiotic cell cycle and apoptosis","volume":"43","author":"Tripathi","year":"2009","journal-title":"Free Radic. Res."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.mce.2004.04.015","article-title":"Nitric oxide influences the maturation of cumulus cell-enclosed mouse oocytes cultured in spontaneous maturation medium and hypoxanthine-supplemented medium through different signaling pathways","volume":"223","author":"Bu","year":"2004","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.theriogenology.2007.05.063","article-title":"Effects of manipulating the nitric oxide\/cyclic GMP pathway on bovine oocyte meiotic resumption in vitro","volume":"15","author":"Goeseels","year":"2007","journal-title":"Theriogenology"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1017\/S096719941700017X","article-title":"Influence of nitric oxide and phosphodiesterases during in vitro maturation of bovine oocytes on meiotic resumption and embryo production","volume":"25","author":"Botigelli","year":"2017","journal-title":"Zygote"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1095\/biolreprod.107.065490","article-title":"Inhibition of rat oocyte maturation and ovulation by nitric oxide: Mechanism of action","volume":"78","author":"Galiani","year":"2008","journal-title":"Biol. Reprod."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1007\/BF02980052","article-title":"Involvement of nitric oxide during in vitro fertilization and early embryonic development in mice","volume":"27","author":"Kim","year":"2004","journal-title":"Arch. Pharm. Res."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1002\/mrd.22387","article-title":"Supplementation of bovine embryo culture medium with L-arginine improves embryo quality via nitric oxide production","volume":"81","author":"Santana","year":"2014","journal-title":"Mol. Reprod. Dev."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1093\/molehr\/4.5.503","article-title":"Nitric oxide inhibits development of embryos and implantation in mice","volume":"4","author":"Barroso","year":"1998","journal-title":"Mol. Hum. Reprod."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1095\/biolreprod.102.009282","article-title":"Nitric oxide synthase production and nitric oxide regulation of preimplantation embryo development","volume":"68","author":"Tranguch","year":"2003","journal-title":"Biol. Reprod."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1095\/biolreprod58.4.875","article-title":"Nitric oxide as a regulator of embryonic development","volume":"58","author":"Gouge","year":"1998","journal-title":"Biol. Reprod."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1016\/S0015-0282(01)01780-0","article-title":"Nitric oxide as a regulator in preimplantation embryo development and apoptosis","volume":"75","author":"Chen","year":"2001","journal-title":"Fertil. Steril."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1023\/B:JARG.0000006706.21588.0d","article-title":"Embryonic production of nitric oxide and its role in Implantation: A pilot study","volume":"20","author":"Battaglia","year":"2003","journal-title":"J. Assist. Reprod. Genet."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1016\/j.fertnstert.2008.01.108","article-title":"Nitric Oxide Metabolite Production in the Human Preimplantation Embryo and Successful Blastocyst Formation","volume":"91","author":"Lipari","year":"2009","journal-title":"Fertil. Steril."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.ejogrb.2008.09.005","article-title":"Nitric oxide as an early marker of human embryo metabolic cleavage in ART using fresh and thawed oocytes","volume":"142","author":"Gallinelli","year":"2009","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"2615","DOI":"10.1093\/humrep\/17.10.2615","article-title":"Nitric oxide donors for patients undergoing IVF. A prospective, double-blind, randomized, placebo-controlled trial","volume":"17","author":"Ohl","year":"2002","journal-title":"Hum. Reprod."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1023\/A:1009495913119","article-title":"Relationships between concentrations of tumor necrosis factor-alpha and nitric oxide in follicular fluid and oocyte quality","volume":"17","author":"Lee","year":"2000","journal-title":"J. Assist. Reprod. Genet."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.fertnstert.2004.02.097","article-title":"Nitric oxide is associated with poor embryo quality and pregnancy outcome in in vitro fertilization cycles","volume":"82","author":"Lee","year":"2004","journal-title":"Fertil. Steril."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/s00404-007-0445-y","article-title":"Follicular fluid nitric oxide (NO) concentrations in stimulated cycles: The relationship to embryo grading","volume":"277","author":"Vignini","year":"2008","journal-title":"Arch. Gynecol. Obstet."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1177\/1933719114525268","article-title":"Inducible nitric oxide synthase and heme oxygenase 1 are expressed in human cumulus cells and may be used as biomarkers of oocyte competence","volume":"21","author":"Bergandi","year":"2014","journal-title":"Reprod. Sci."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1095\/biolreprod60.4.959","article-title":"Ovarian hormone secretory response to gonadotropins and nitric oxide following chronic nitric oxide deficiency in the rat","volume":"60","author":"Dunnam","year":"1999","journal-title":"Biol. Reprod."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1093\/molehr\/6.5.397","article-title":"Evidence for nitric oxide acting as a luteolytic factor in the human corpus luteum","volume":"6","author":"Runesson","year":"2000","journal-title":"Mol. Hum. Reprod."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"E262","DOI":"10.1210\/jc.2014-2886","article-title":"Nitric oxide and cGMP induce COX-2 expression and PGE2 production in human granulosa cells through CREB signaling pathway","volume":"100","author":"Fang","year":"2015","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/j.fertnstert.2013.04.030","article-title":"Peroxynitrite affects the cumulus cell defense of metaphase II mouse oocytes leading to disruption of the spindle structure in vitro","volume":"100","author":"Banerjee","year":"2013","journal-title":"Fertil. Steril."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.freeradbiomed.2015.12.033","article-title":"Peroxynitrite deteriorates oocyte quality through disassembly of microtubule organizing centers","volume":"91","author":"Khan","year":"2016","journal-title":"Free Radic. Biol. Med."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.niox.2016.02.002","article-title":"Nitric oxide signaling in human ovarian cancer: A potential therapeutic target","volume":"54","author":"Postovit","year":"2016","journal-title":"Nitric Oxide"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1007\/s00428-010-0929-1","article-title":"Proangiogenetic molecules, hypoxia-inducible factor-1\u03b1 and nitric oxide synthase isoforms in ovarian endometriotic cysts","volume":"456","author":"Goteri","year":"2010","journal-title":"Virchows Arch."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"4083","DOI":"10.1177\/0300060519864493","article-title":"Nitric oxide (NO) levels in patients with polycystic ovary syndrome (PCOS): A meta-analysis","volume":"47","author":"Meng","year":"2019","journal-title":"J. Int. Med. Res."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0009-8981(00)00340-5","article-title":"Influence of sex and age on serum nitrite\/nitrate concentration in healthy subjects","volume":"301","author":"Watanabe","year":"2000","journal-title":"Clin. Chim. Acta."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.lfs.2008.06.010","article-title":"Serum nitric oxide metabolite levels in a general healthy population: Relation to sex and age","volume":"83","author":"Ghasemi","year":"2008","journal-title":"Life Sci."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1111\/aogs.12655","article-title":"Association between serum concentrations of nitric oxide and transition to menopause","volume":"94","author":"Tehrani","year":"2015","journal-title":"Acta. Obstet. Gynecol. Scand."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"787","DOI":"10.3109\/09513590.2012.671395","article-title":"Nitric oxide and pro-inflammatory cytokine serum levels in postmenopausal women with the metabolic syndrome","volume":"28","author":"Chedraui","year":"2012","journal-title":"Gynecol. Endocrinol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1002\/mnfr.201400286","article-title":"Nitrate and nitrite in the diet: How to assess their benefit and risk for human health","volume":"59","author":"Habermeyer","year":"2015","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1093\/cvr\/cvq325","article-title":"Roles of dietary inorganic nitrate in cardiovascular health and disease","volume":"89","author":"Lundberg","year":"2011","journal-title":"Cardiovasc. Res."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"c4229","DOI":"10.1136\/bmj.c4229","article-title":"Fruit and vegetable intake and incidence of type 2 diabetes mellitus: Systematic review and meta-analysis","volume":"341","author":"Carter","year":"2010","journal-title":"Brit. Med. J."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1161\/HYPERTENSIONAHA.110.153536","article-title":"Inorganic nitrate supplementation lowers blood pressure in humans: Role for nitrite-derived NO","volume":"56","author":"Kapil","year":"2010","journal-title":"Hypertension"}],"container-title":["International Journal of Environmental Research and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-4601\/18\/3\/980\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T05:14:18Z","timestamp":1760159658000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-4601\/18\/3\/980"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,22]]},"references-count":78,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2021,2]]}},"alternative-id":["ijerph18030980"],"URL":"https:\/\/doi.org\/10.3390\/ijerph18030980","relation":{},"ISSN":["1660-4601"],"issn-type":[{"value":"1660-4601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,22]]}}}