{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T18:58:17Z","timestamp":1777661897454,"version":"3.51.4"},"reference-count":27,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2021,1,23]],"date-time":"2021-01-23T00:00:00Z","timestamp":1611360000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"European Regional Development Fund (ERDF)","award":["DOCM 19\/02\/20"],"award-info":[{"award-number":["DOCM 19\/02\/20"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Oral mucositis (OM) is a common side effect of cancer therapies. It causes ulcerative, painful lesions in the oral cavity that can provoke malnutrition, increased risk of infection, longer hospital stays, and seriously affect the quality of life. Cooling the mucosa with oral cryotherapy (OC) during and\/or after chemotherapy is the most accessible and tolerable intervention available. The aim of this study is to define the efficacy of OC for preventing OM induced by chemotherapy\/radiotherapy in adult patients with cancer. Secondary endpoints include associated problems as pain. A systematic search was performed using the Pubmed, WOS (Web of Science), Cochrane Library, CINAHL, and BVS databases for articles published up to 2010. After inclusion and exclusion criteria were applied, a total of eight articles were analyzed in this review. In seven of the eight articles, the incidence of OM of all grades was significantly lower in the OC group compared with the no-OC group. Use of opioids and level of pain were also significantly reduced. OC is an effective intervention to reduce the incidence of OM induced by chemotherapy as well as the associated severity and pain. Based on these results, OC with only water or with chamomile, associated or not with other mouthwash therapies, is an effective intervention to reduce the incidence of OM induced by chemotherapy as well as the associated severity and pain.<\/jats:p>","DOI":"10.3390\/ijerph18030994","type":"journal-article","created":{"date-parts":[[2021,1,25]],"date-time":"2021-01-25T02:07:00Z","timestamp":1611540420000},"page":"994","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Eficacy of Cryotherapy in the Prevention of Oral Mucosistis in Adult Patients with Chemotherapy"],"prefix":"10.3390","volume":"18","author":[{"given":"\u00c1ngel","family":"L\u00f3pez-Gonz\u00e1lez","sequence":"first","affiliation":[{"name":"Department of Nursing, Physiotherapy and Occupational Therapy, Facultad de Enfermer\u00eda, Universidad de Castilla-La Mancha, Campus Univesitario s\/n, 02071 Albacete, Spain"},{"name":"Group of Preventive Activities in the University Health Sciences Setting, Universidad de Castilla-La Mancha\/UCLM, 13001 Ciudad Real, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Garc\u00eda-Quintanilla","sequence":"additional","affiliation":[{"name":"Department of Nursing, Physiotherapy and Occupational Therapy, Facultad de Enfermer\u00eda, Universidad de Castilla-La Mancha, Campus Univesitario s\/n, 02071 Albacete, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen Mar\u00eda","family":"Guerrero-Agenjo","sequence":"additional","affiliation":[{"name":"Castilla-La Mancha Health Service (Servicio de Salud de Castilla-La Mancha\/SESCAM), Universidad de Castilla-La Mancha\/UCLM, 02071 Albacete, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaime L\u00f3pez","family":"Tendero","sequence":"additional","affiliation":[{"name":"Castilla-La Mancha Health Service (Servicio de Salud de Castilla-La Mancha\/SESCAM), Universidad de Castilla-La Mancha\/UCLM, 02071 Albacete, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6365-9070","authenticated-orcid":false,"given":"Isabel Mar\u00eda","family":"Guisado-Requena","sequence":"additional","affiliation":[{"name":"Department of Nursing, Physiotherapy and Occupational Therapy, Facultad de Enfermer\u00eda, Universidad de Castilla-La Mancha, Campus Univesitario s\/n, 02071 Albacete, Spain"},{"name":"Group of Preventive Activities in the University Health Sciences Setting, Universidad de Castilla-La Mancha\/UCLM, 13001 Ciudad Real, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6649-4395","authenticated-orcid":false,"given":"Joseba","family":"Rabanales-Sotos","sequence":"additional","affiliation":[{"name":"Department of Nursing, Physiotherapy and Occupational Therapy, Facultad de Enfermer\u00eda, Universidad de Castilla-La Mancha, Campus Univesitario s\/n, 02071 Albacete, Spain"},{"name":"Group of Preventive Activities in the University Health Sciences Setting, Universidad de Castilla-La Mancha\/UCLM, 13001 Ciudad Real, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,1,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Daug\u0117lait\u0117, G., U\u017ekuraityt\u0117, K., Jagelavi\u010dien\u0117, E., and Filipauskas, A. 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