{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T16:21:19Z","timestamp":1777306879924,"version":"3.51.4"},"reference-count":31,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2021,1,29]],"date-time":"2021-01-29T00:00:00Z","timestamp":1611878400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Kawano Masanori Memorial Public Interest Incorporated Foundation for Promotion of Pediatrics","award":["Ippanwaku"],"award-info":[{"award-number":["Ippanwaku"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>We report a case of a preterm infant who developed cow\u2019s milk allergy. This male infant presented with recurrent ascites and was successfully treated with donated breast milk. He was born at 24 weeks\u2019 gestation with a birthweight of 506 g. From day 20, infant formula, soy protein-based formula, and casein-hydrolyzed formula were used due to insufficient maternal lactation. This resulted in abdominal distention, generalized edema, and recurrent ascites. We diagnosed him with cow\u2019s milk allergy since these symptoms improved on exclusive breast milk feeding. No recurrence of symptoms occurred when donated breast milk was used in combination with the mother\u2019s own milk. Ascites should be regarded as a clinical symptom of neonatal cow\u2019s milk allergy. Donated breast milk may be effective in the treatment of the allergy if breastfeeding is not available.<\/jats:p>","DOI":"10.3390\/ijerph18031187","type":"journal-article","created":{"date-parts":[[2021,1,29]],"date-time":"2021-01-29T02:58:21Z","timestamp":1611889101000},"page":"1187","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A Preterm Case of Cow\u2019s Milk Allergy Presenting with Recurrent Ascites Treated with Donor Breast Milk"],"prefix":"10.3390","volume":"18","author":[{"given":"Ruka","family":"Nakasone","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Graduate School of Medicine, Kobe University, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9913-6447","authenticated-orcid":false,"given":"Kazumichi","family":"Fujioka","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Graduate School of Medicine, Kobe University, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shutaro","family":"Suga","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Graduate School of Medicine, Kobe University, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5788-8675","authenticated-orcid":false,"given":"Shinya","family":"Abe","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Graduate School of Medicine, Kobe University, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariko","family":"Ashina","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Graduate School of Medicine, Kobe University, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kosuke","family":"Nishida","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Graduate School of Medicine, Kobe University, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Motoichiro","family":"Sakurai","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, School of Medicine, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8666, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6983-8851","authenticated-orcid":false,"given":"Katsumi","family":"Mizuno","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, School of Medicine, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8666, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0290-3137","authenticated-orcid":false,"given":"Kandai","family":"Nozu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Graduate School of Medicine, Kobe University, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazumoto","family":"Iijima","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Graduate School of Medicine, Kobe University, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,1,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1111\/all.12630","article-title":"Incidence and natural history of challenge-proven cow\u2019s milk allergy in European children--EuroPrevall birth cohort","volume":"70","author":"Schoemaker","year":"2015","journal-title":"Allergy"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1111\/all.12681","article-title":"Non-IgE mediated cow\u2019s milk allergy in EuroPrevall","volume":"70","author":"Koletzko","year":"2015","journal-title":"Allergy"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1097\/MPG.0000000000000933","article-title":"Manifestations of Cow\u2019s-Milk Protein Intolerance in Preterm Infants","volume":"62","author":"Cordova","year":"2016","journal-title":"J. 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