{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T05:05:40Z","timestamp":1773896740733,"version":"3.50.1"},"reference-count":28,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2021,2,4]],"date-time":"2021-02-04T00:00:00Z","timestamp":1612396800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Key Project of Natural Science Foundation of Hebei province of China","award":["H2017209233"],"award-info":[{"award-number":["H2017209233"]}]},{"name":"Leader talent cultivation plan of innovation team in Tangshan city","award":["14130225B"],"award-info":[{"award-number":["14130225B"]}]},{"name":"Leader talent cultivation plan of innovation team in Hebei province","award":["LJRC001"],"award-info":[{"award-number":["LJRC001"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81101483"],"award-info":[{"award-number":["81101483"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>XAB2 protein (xeroderma pigmentosum group A-binding protein 2) plays a significant role in the nucleotide excision repair pathway. Polymorphisms in the XAB2 gene may have an effect on the capability of DNA repair and further contribute to the risk of developing various cancers. In order to investigate the relationship between XAB2 genetic variants and the risk of gastric cancer, we performed a hospital-based case\u2013control study. XAB2 tagSNPs were selected and then genotyped by iPlex Gold Genotyping Assay and Sequenom MassArray. By performing logistic regression analysis, odds ratio (OR) and 95% confidence interval (CI) were used to estimate the association of XAB2 tagSNPs with the risk of gastric cancer. Our results showed that XAB2 rs794078AA genotype was associated with a significantly lower risk of gastric cancer compared with GG genotype with OR (95% CI) of 0.33 (0.12\u20130.91). Stratified analysis indicated a significantly decreased risk for gastric cancer among smokers with rs794078AA genotype compared with nonsmokers with GG genotype (OR = 0.11, 95% CI = 0.01\u20130.91, p = 0.040). The gene\u2013gene interactions by multifactor dimensionality reduction (MDR) showed that tagSNP rs794078 was the best predictive element for gastric cancers (Testing Bal. Acc = 51.68%, p = 0.055, cross-validation consistency = 9). Therefore, the XAB2 tagSNP rs794078 may play an important role in the development of gastric cancer.<\/jats:p>","DOI":"10.3390\/ijerph18041494","type":"journal-article","created":{"date-parts":[[2021,2,4]],"date-time":"2021-02-04T21:29:27Z","timestamp":1612474167000},"page":"1494","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["XAB2 TagSNP Is Associated with the Risk of Gastric Cancer in Chinese Population: A Case\u2013Control Study"],"prefix":"10.3390","volume":"18","author":[{"given":"Yuning","family":"Xie","sequence":"first","affiliation":[{"name":"School of Public Health, North China University of Science and Technology, Tangshan 063210, China"},{"name":"College of Life Science, North China University of Science and Technology, Tangshan 063210, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Yu","sequence":"additional","affiliation":[{"name":"College of Life Science, North China University of Science and Technology, Tangshan 063210, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongjiao","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Public Health, North China University of Science and Technology, Tangshan 063210, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Gao","sequence":"additional","affiliation":[{"name":"School of Public Health, North China University of Science and Technology, Tangshan 063210, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenbang","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, North China University of Science and Technology, Tangshan 063210, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, North China University of Science and Technology, Tangshan 063210, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuemei","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Public Health, North China University of Science and Technology, Tangshan 063210, China"},{"name":"College of Life Science, North China University of Science and Technology, Tangshan 063210, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,2,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.21147\/j.issn.1000-9604.2018.01.01","article-title":"Cancer incidence and mortality in China, 2014","volume":"30","author":"Chen","year":"2018","journal-title":"Chin. J. Cancer Res."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1158\/1055-9965.EPI-10-0437","article-title":"Global patterns of cancer incidence and mortality rates and trends","volume":"19","author":"Jemal","year":"2010","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1158\/1055-9965.EPI-13-1057","article-title":"Gastric cancer: Descriptive epidemiology, risk factors, screening, and prevention","volume":"23","author":"Karimi","year":"2014","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"e60","DOI":"10.1016\/S1470-2045(14)71016-2","article-title":"Familial gastric cancer: Genetic susceptibility, pathology, and implications for management","volume":"16","author":"Oliveira","year":"2015","journal-title":"Lancet Oncol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1136\/gutjnl-2015-309168","article-title":"Genetic variation and gastric cancer risk: A field synopsis and meta-analysis","volume":"64","author":"Mocellin","year":"2015","journal-title":"Gut"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.mrrev.2010.05.002","article-title":"Phenotyping for DNA repair capacity","volume":"705","author":"Decordier","year":"2010","journal-title":"Mutat. Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1002\/cncr.20135","article-title":"DNA repair and breast carcinoma susceptibility in women","volume":"100","author":"Ramos","year":"2004","journal-title":"Cancer"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/nrm3822","article-title":"Understanding nucleotide excision repair and its roles in cancer and ageing","volume":"15","author":"Marteijn","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1038\/35077232","article-title":"Genome maintenance mechanisms for preventing cancer","volume":"411","author":"Hoeijmakers","year":"2001","journal-title":"Nature"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/j.dnarep.2013.04.015","article-title":"DNA repair mechanisms in dividing and non-dividing cells","volume":"12","author":"Iyama","year":"2013","journal-title":"DNA Repair"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"3550","DOI":"10.1038\/emboj.2012.193","article-title":"Generation of DNA single-strand displacement by compromised nucleotide excision repair","volume":"31","author":"Godon","year":"2012","journal-title":"EMBO J."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.gene.2013.01.059","article-title":"Association of two ERCC4 tagSNPs with susceptibility to atrophic gastritis and gastric cancer in Chinese","volume":"519","author":"Gong","year":"2013","journal-title":"Gene"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.gene.2014.02.043","article-title":"Laryngeal cancer risk and common single nucleotide polymorphisms in nucleotide excision repair pathway genes ERCC1, ERCC2, ERCC3, ERCC4, ERCC5 and XPA","volume":"542","author":"Lu","year":"2014","journal-title":"Gene"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Du, H., Guo, N., Shi, B., Zhang, Q., Chen, Z., Lu, K., Shu, Y., Chen, T., and Zhu, L. (2014). The effect of XPD polymorphisms on digestive tract cancers risk: A meta-analysis. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0096301"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1074\/jbc.M706647200","article-title":"Isolation of XAB2 complex involved in pre-mRNA splicing, transcription, and transcription-coupled repair","volume":"283","author":"Kuraoka","year":"2008","journal-title":"J. Biol. Chem."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"34931","DOI":"10.1074\/jbc.M004936200","article-title":"XAB2, a novel tetratricopeptide repeat protein involved in transcription-coupled DNA repair and transcription","volume":"275","author":"Nakatsu","year":"2000","journal-title":"J. Biol. Chem."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.dnarep.2004.12.004","article-title":"Disruption of mouse XAB2 gene involved in pre-mRNA splicing, transcription and transcription-coupled DNA repair results in preimplantation lethality","volume":"4","author":"Yonemasu","year":"2005","journal-title":"DNA Repair"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/cr.2008.6","article-title":"Transcription-coupled nucleotide excision repair in mammalian cells: Molecular mechanisms and biological effects","volume":"18","author":"Fousteri","year":"2008","journal-title":"Cell Res."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1002\/gepi.10218","article-title":"Power of multifactor dimensionality reduction for detecting gene-gene interactions in the presence of genotyping error, missing data, phenocopy, and genetic heterogeneity","volume":"24","author":"Ritchie","year":"2003","journal-title":"Genet. Epidemiol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1158\/0008-5472.CAN-06-1638","article-title":"Knockdown of XAB2 enhances all-trans retinoic acid-induced cellular differentiation in all-trans retinoic acid-sensitive and -resistant cancer cells","volume":"67","author":"Morio","year":"2007","journal-title":"Cancer Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.molcel.2006.06.029","article-title":"Cockayne syndrome A and B proteins differentially regulate recruitment of chromatin remodeling and repair factors to stalled RNA polymerase II in vivo","volume":"23","author":"Fousteri","year":"2006","journal-title":"Mol. Cell"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.molimm.2014.10.006","article-title":"The tag SNP rs10746463 in decay-accelerating factor is associated with the susceptibility to gastric cancer","volume":"63","author":"Song","year":"2015","journal-title":"Mol. Immunol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2304","DOI":"10.1158\/1055-9965.EPI-09-0233","article-title":"Genetic variation in immune regulation and DNA repair pathways and stomach cancer in China","volume":"18","author":"Hussain","year":"2009","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1158\/1055-9965.EPI-13-0185","article-title":"Single-nucleotide polymorphisms in nucleotide excision repair genes, cigarette smoking, and the risk of head and neck cancer","volume":"22","author":"Wyss","year":"2013","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1002\/tox.21782","article-title":"Human DNA damage by the synergistic action of 4-aminobiphenyl and nitric oxide: An immunochemical study","volume":"29","author":"Dixit","year":"2014","journal-title":"Environ. Toxicol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1097\/EDE.0b013e31821092cd","article-title":"Tobacco smoking and esophageal and gastric cardia adenocarcinoma: A meta-analysis","volume":"22","author":"Tramacere","year":"2011","journal-title":"Epidemiology"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Yang, J.J., Ko, K.P., Cho, L.Y., Shin, A., Gwack, J., Chang, S.H., Shin, H.R., Yoo, K.Y., Kang, D., and Park, S.K. (2009). The role of TNF genetic variants and the interaction with cigarette smoking for gastric cancer risk: A nested case-control study. BMC Cancer, 9.","DOI":"10.1186\/1471-2407-9-238"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"8335","DOI":"10.1007\/s11033-012-1683-z","article-title":"Meta-analysis of the association of CYP1A1 polymorphisms with gastric cancer susceptibility and interaction with tobacco smoking","volume":"39","author":"Han","year":"2012","journal-title":"Mol. Biol. Rep."}],"container-title":["International Journal of Environmental Research and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-4601\/18\/4\/1494\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T05:20:25Z","timestamp":1760160025000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-4601\/18\/4\/1494"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,4]]},"references-count":28,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2021,2]]}},"alternative-id":["ijerph18041494"],"URL":"https:\/\/doi.org\/10.3390\/ijerph18041494","relation":{},"ISSN":["1660-4601"],"issn-type":[{"value":"1660-4601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,4]]}}}