{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T11:34:18Z","timestamp":1791891258138,"version":"4.3.4"},"reference-count":18,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2021,2,18]],"date-time":"2021-02-18T00:00:00Z","timestamp":1613606400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>A necessary condition for public health maintenance is regular physical activity. A significant increase in the number of musculoskeletal injuries, occurring during physical education and sport activities, actualizes the development of effective measures for their prevention. Early diagnosis of injury predisposition, based on identification of connective tissue dysplasia indicators specific for different age periods, is of particular importance for the prevention of such injuries. The study, performed in accordance to STROBE guidelines, included 78 persons separated into two age subgroups: Group 1 (age 22\u201335) and Group 2 (age 36\u201347). Morphometric signs of connective tissue dysplasia and clinical symptoms associated with predisposition to chronic injury were assessed. For persons in Group 1, these indicators included: asthenic body type, joint hypermobility, thin elastic skin, keloid scars, and soft auricles. For the second group: kyphosis, skin hyperpigmentation above the spine, flatfeet, valgus installation, rectus muscles diastasis, atrophic striae, recurrent hernias, and lower-limb varicosity. Universal pathognomonic indicators, such as \u201ccrunching\u201d in the temporomandibular joint, gothic palate, altered chest shape, scoliosis, and X- and O-shaped legs are significant at any age. The established pathognomonic indicators will promote early diagnosis of injury predisposition help, and develop effective measures of their prevention and public health preservation during physical activity.<\/jats:p>","DOI":"10.3390\/ijerph18041989","type":"journal-article","created":{"date-parts":[[2021,2,18]],"date-time":"2021-02-18T20:56:21Z","timestamp":1613681781000},"page":"1989","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Age Pathognomonic Indicators of Injury Predisposition as a Basis for Public Health Preservation during Physical Activity"],"prefix":"10.3390","volume":"18","author":[{"given":"Maria V.","family":"Sankova","sequence":"first","affiliation":[{"name":"Department of Human Anatomy, First Moscow State Medical University Named after I.M.Sechenov (Sechenov University), st. Trubetskaya, 8, bld. 2, 119991 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir N.","family":"Nikolenko","sequence":"additional","affiliation":[{"name":"Department of Human Anatomy, First Moscow State Medical University Named after I.M.Sechenov (Sechenov University), st. Trubetskaya, 8, bld. 2, 119991 Moscow, Russia"},{"name":"Department of Human Anatomy, Lomonosov Moscow State University, Leninskie Gory, 1, 119991 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6432-5179","authenticated-orcid":false,"given":"Marine V.","family":"Oganesyan","sequence":"additional","affiliation":[{"name":"Department of Human Anatomy, First Moscow State Medical University Named after I.M.Sechenov (Sechenov University), st. Trubetskaya, 8, bld. 2, 119991 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andjela D.","family":"Vovkogon","sequence":"additional","affiliation":[{"name":"Department of Human Anatomy, First Moscow State Medical University Named after I.M.Sechenov (Sechenov University), st. Trubetskaya, 8, bld. 2, 119991 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekaterina L.","family":"Chirkova","sequence":"additional","affiliation":[{"name":"Department of Human Anatomy, First Moscow State Medical University Named after I.M.Sechenov (Sechenov University), st. Trubetskaya, 8, bld. 2, 119991 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0862-6011","authenticated-orcid":false,"given":"Mikhail Y.","family":"Sinelnikov","sequence":"additional","affiliation":[{"name":"Department of Human Anatomy, First Moscow State Medical University Named after I.M.Sechenov (Sechenov University), st. Trubetskaya, 8, bld. 2, 119991 Moscow, Russia"},{"name":"Research Institute of Human Morphology, Curupa, 3, 117418 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,2,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0140-6736(12)61031-9","article-title":"Effect of physical inactivity on major non-communicable diseases worldwide: An analysis of burden of disease and life expectancy","volume":"380","author":"Lee","year":"2012","journal-title":"Lancet"},{"key":"ref_2","first-page":"166","article-title":"Connective tissue dysplasia","volume":"7","year":"2012","journal-title":"Lik. Sprav."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1177\/1941738118814247","article-title":"Preventing Sports Injuries\/EM. Wojtys","volume":"11","author":"Wojtys","year":"2019","journal-title":"Sports Health"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Nikolenko, V.N., Oganesyan, M.V., Vovkogon, A.D., Cao, Y., Churganova, A.A., Zolotareva, M.A., Achkasov, E.E., Sankova, M.V., Rizaeva, N.A., and Sinelnikov, M.Y. (2020). Morphological signs of connective tissue dysplasia as predictors of frequent post-exercise musculoskeletal disorders. BMC Musculoskelet. Disord., 21.","DOI":"10.1186\/s12891-020-03698-0"},{"key":"ref_5","first-page":"19","article-title":"Manifestations of unclassified connective tissue dysplasia depending on age: Prognosis","volume":"47","author":"Dotsenko","year":"2012","journal-title":"Ukr. Rheumatol. J."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1097\/MOP.0000000000000541","article-title":"Contemporary approach to joint hypermobility and related disorders","volume":"29","author":"Castori","year":"2017","journal-title":"Curr. Opin. Pediatr."},{"key":"ref_7","first-page":"30","article-title":"\u0414\u0438\u0441\u043f\u043b\u0430\u0437\u0438\u044f \u0441o\u0435\u0434\u0438\u043d\u0438\u0442\u0435\u043b\u044c\u043do\u0439 \u0442\u043a\u0430\u043d\u0438","volume":"2","year":"2020","journal-title":"\u0423\u043d\u0438\u0432\u0435\u0440\u0441\u0438\u0442\u0435\u0442\u0441\u043a\u0438\u0439 \u0422\u0435\u0440\u0430\u043f\u0435\u0432\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u0439 \u0412\u0435\u0441\u0442\u043d\u0438\u043a."},{"key":"ref_8","first-page":"18","article-title":"Clinico-morphological and molecular-genetic characteristic of the miometrium with failure of the uterine scar after the Cesarean section at women with undifferentiated forms of connective tissue dysplasia","volume":"74","author":"Demura","year":"2012","journal-title":"Arkhiv. Patol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1002\/humu.22977","article-title":"Marfan Syndrome and Related Disorders: 25 Years of Gene Discovery","volume":"37","author":"Verstraeten","year":"2016","journal-title":"Hum Mutat."},{"key":"ref_10","first-page":"130","article-title":"Diagnostics Features of Dysplastic Syndromes and Phenotypes in Persons of Older Age Groups","volume":"3","author":"Vyutrih","year":"2011","journal-title":"Bull. St. Petersburg. Med. Acad. Postgrad. Educ."},{"key":"ref_11","first-page":"61","article-title":"Connective tissue dysplasia as a reason of recurrent inguinal hernia","volume":"9","author":"Dzheng","year":"2014","journal-title":"Khirurgiia"},{"key":"ref_12","first-page":"36","article-title":"Vascular pathology in the aspect of sudden death in young adults and connective tissue dysplasia: Anatomical, physiological, and morphological parallels","volume":"23","author":"Pigolkin","year":"2017","journal-title":"Angiol. Sosud. Khir."},{"key":"ref_13","first-page":"4","article-title":"The syndrome of undifferentiated dysplasia of the connective tissue","volume":"112","author":"Pizova","year":"2012","journal-title":"Zh. Nevrol. Psikhiatr. Im. SS Korsakova"},{"key":"ref_14","first-page":"97","article-title":"Lower limb varicose veins as a manifestation of undifferentiated connective tissue dysplasia","volume":"22","author":"Potapov","year":"2016","journal-title":"Angiol. Sosud. Khir."},{"key":"ref_15","first-page":"14","article-title":"Functional diseases of the digestive organs in patients with the connective tissue dysplasia","volume":"7","author":"Lialiukova","year":"2013","journal-title":"Eksp. Klin. Gastroenterol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"146","DOI":"10.21164\/pomjlifesci.69","article-title":"Sclera as the target tissue in progressive myopia","volume":"61","author":"Iomdina","year":"2015","journal-title":"Pomeranian J. Life Sci."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.36740\/WLek202007134","article-title":"The frequency of visceral and phenotypic markers in patients with the combination of undifferentiated connective tissue disease and gastroesophageal reflux disease","volume":"73","author":"Romash","year":"2020","journal-title":"Wiad Lek."},{"key":"ref_18","first-page":"743","article-title":"Best Uses of Osteopathic Manipulation\/Westfall","volume":"66","author":"Slattengren","year":"2017","journal-title":"J. Fam. Pract."}],"container-title":["International Journal of Environmental Research and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-4601\/18\/4\/1989\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T05:25:56Z","timestamp":1760160356000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-4601\/18\/4\/1989"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,18]]},"references-count":18,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2021,2]]}},"alternative-id":["ijerph18041989"],"URL":"https:\/\/doi.org\/10.3390\/ijerph18041989","relation":{},"ISSN":["1660-4601"],"issn-type":[{"value":"1660-4601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,18]]}}}