{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T00:12:30Z","timestamp":1776730350586,"version":"3.51.2"},"reference-count":49,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2021,2,20]],"date-time":"2021-02-20T00:00:00Z","timestamp":1613779200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>To analyze the middle latency auditory evoked potential index (MLAEPi), compared to the standard bispectral index (BIS), as a method for evaluating the sedation level in drug-induced sleep endoscopy (DISE). In this controlled clinical study on a sample of 99 obstructive sleep apnea (OSA) or snoring patients, we compared the MLAEPi with the BIS after propofol infusion during the standard DISE technique in order to define the MLAEPi values within the observational window of the procedure. The DISE procedure was divided into eight steps, and we collected both MLAEPi and BIS data values from the same patient in every step. The MLAEPi showed a faster response than the BIS after propofol infusion during DISE. Therefore, the clinical use of the MLAEPi in evaluating the sedation level seems to be a good alternative to the current technological standards.<\/jats:p>","DOI":"10.3390\/ijerph18042070","type":"journal-article","created":{"date-parts":[[2021,2,21]],"date-time":"2021-02-21T21:15:01Z","timestamp":1613942101000},"page":"2070","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The Use of Middle Latency Auditory Evoked Potentials (MLAEP) as Methodology for Evaluating Sedation Level in Propofol-Drug Induced Sleep Endoscopy (DISE) Procedure"],"prefix":"10.3390","volume":"18","author":[{"given":"Michele","family":"Arigliani","sequence":"first","affiliation":[{"name":"ENT Unit, \u201cV.Fazzi\u201d Hospital, 73100 ASL Lecce, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Domenico M.","family":"Toraldo","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation, Cardiorespiratory Rehabilitation Unit, \u201cV.Fazzi\u201d Hospital, 73100 ASL Lecce, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrico","family":"Ciavolino","sequence":"additional","affiliation":[{"name":"Department of History, Society and Human Studies, University of Salento, 73100 Lecce, Italy"},{"name":"Wy\u017csza Szko\u0142a Bankowa w Gda\u0144sku, aleja Grunwaldzka 238A, 80-266 Gda\u0144sk, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caterina","family":"Lattante","sequence":"additional","affiliation":[{"name":"Anesthesia and Intensive Care Department, \u201cV.Fazzi\u201d Hospital, 73100 ASL Lecce, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8741-3478","authenticated-orcid":false,"given":"Luana","family":"Conte","sequence":"additional","affiliation":[{"name":"Laboratory of Interdisciplinary Research Applied to Medicine (DReAM), University of Salento and ASL (Local Health Authority) at the \u201cV Fazzi\u201d Hospital, 73100 Lecce, Italy"},{"name":"Laboratory of Advanced Data Analysis for Medicine (ADAM), Department of Mathematics and Physics \u201cE. De Giorgi\u201d, University of Salento, 73100 Lecce, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serena","family":"Arima","sequence":"additional","affiliation":[{"name":"Department of History, Society and Human Studies, University of Salento, 73100 Lecce, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caterina","family":"Arigliani","sequence":"additional","affiliation":[{"name":"General Medicine Department, Univerzita Pavla Jozefa Safarika, 04001 Kosiciach, Slovakia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Palumbo","sequence":"additional","affiliation":[{"name":"ENT Unit, \u201cV.Fazzi\u201d Hospital, 73100 ASL Lecce, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"De Benedetto","sequence":"additional","affiliation":[{"name":"ENT Unit, \u201cV.Fazzi\u201d Hospital, 73100 ASL Lecce, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,2,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1056\/NEJM199601113340207","article-title":"Obstructive Sleep Apnea","volume":"334","author":"Strollo","year":"1996","journal-title":"N. 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