{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T23:27:26Z","timestamp":1769124446976,"version":"3.49.0"},"reference-count":36,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2021,2,23]],"date-time":"2021-02-23T00:00:00Z","timestamp":1614038400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["P2GEP3_191584"],"award-info":[{"award-number":["P2GEP3_191584"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>The impact of COVID-19 lockdown on prehospital stroke care is largely unknown. We aimed to compare stroke care patterns before and during a state-wide lockdown. Thus, we analysed prospective data of stroke alerts referred to our stroke centre between 1 December 2019 and 16 June 2020, and compared them between two periods\u201415 weeks before and 13 weeks during the state-wide lockdown declared in Lithuania on 16 March 2020. Among 719 referrals for suspected stroke, there was a decrease in stroke alerts (rate ratio 0.61, 95% CI (0.52\u20130.71)), stroke admissions (0.63, 95% CI (0.52\u20130.76)), and decrease in prehospital stroke triage quality (positive predictive value 72.1% vs. 79.9%, p = 0.042) during the lockdown. The onset-to-door time was longer (153.0 vs. 120.5 min, p = 0.049) and seizures and intracranial tumours were more common among stroke mimics (16.9% vs. 6.7%, p = 0.012 and 9.6% vs. 3.0%, p = 0.037, respectively). We conclude that there was a decline in prehospital stroke triage quality during the lockdown despite low COVID-19 incidence in the country. Moreover, we observed an increase in hospital arrival delays and severe conditions presenting as stroke mimics. Our findings suggest that improved strategies are required to maintain optimal neurological care during public health emergencies.<\/jats:p>","DOI":"10.3390\/ijerph18042150","type":"journal-article","created":{"date-parts":[[2021,2,23]],"date-time":"2021-02-23T00:50:27Z","timestamp":1614041427000},"page":"2150","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Changes in Prehospital Stroke Care and Stroke Mimic Patterns during the COVID-19 Lockdown"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4413-0635","authenticated-orcid":false,"given":"Kazimieras","family":"Melaika","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Vilnius University, 03101 Vilnius, Lithuania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8015-7929","authenticated-orcid":false,"given":"Lukas","family":"Sveikata","sequence":"additional","affiliation":[{"name":"J. Philip Kistler Stroke Research Center, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02109, USA"},{"name":"Institute of Cardiology, Medical Academy, Lithuanian University of Health Sciences, 50161 Kaunas, Lithuania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5839-0126","authenticated-orcid":false,"given":"Adam","family":"Wi\u015bniewski","sequence":"additional","affiliation":[{"name":"Department of Neurology, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, 85-094 Bydgoszcz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8927-7377","authenticated-orcid":false,"given":"Altynshash","family":"Jaxybayeva","sequence":"additional","affiliation":[{"name":"Department of Neurology, Astana Medical University, Nur-Sultan 010000, Kazakhstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2069-8744","authenticated-orcid":false,"given":"Aleksandra","family":"Ekkert","sequence":"additional","affiliation":[{"name":"Center of Neurology, Vilnius University, 08661 Vilnius, Lithuania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6159-4795","authenticated-orcid":false,"given":"Dalius","family":"Jatu\u017eis","sequence":"additional","affiliation":[{"name":"Center of Neurology, Vilnius University, 08661 Vilnius, Lithuania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8033-9682","authenticated-orcid":false,"given":"Rytis","family":"Masili\u016bnas","sequence":"additional","affiliation":[{"name":"Center of Neurology, Vilnius University, 08661 Vilnius, Lithuania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,2,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Price, C.I., Rae, V., Duckett, J., Wood, R., Gray, J., McMeekin, P., Rodgers, H., Portas, K., and Ford, G.A. (2013). An Observational Study of Patient Characteristics Associated with the Mode of Admission to Acute Stroke Services in North East, England. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0076997"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1136\/svn-2019-000277","article-title":"Emergency Medical Services Use and Its Association with Acute Ischaemic Stroke Evaluation and Treatment in Singapore","volume":"5","author":"Xu","year":"2020","journal-title":"Stroke Vasc. Neurol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1161\/01.STR.0000044170.46643.5E","article-title":"Diagnostic Accuracy of Stroke Referrals From Primary Care, Emergency Room Physicians, and Ambulance Staff Using the Face Arm Speech Test","volume":"34","author":"Harbison","year":"2003","journal-title":"Stroke"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1111\/ene.13539","article-title":"European Academy of Neurology and European Stroke Organization Consensus Statement and Practical Guidance for Pre-hospital Management of Stroke","volume":"25","author":"Kobayashi","year":"2018","journal-title":"Eur. J. Neurol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1016\/S0140-6736(14)60584-5","article-title":"Effect of Treatment Delay, Age, and Stroke Severity on the Effects of Intravenous Thrombolysis with Alteplase for Acute Ischaemic Stroke: A Meta-Analysis of Individual Patient Data from Randomised Trials","volume":"384","author":"Emberson","year":"2014","journal-title":"Lancet"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1097\/WCO.0000000000000620","article-title":"Stroke Mimics and Chameleons","volume":"32","author":"Moulin","year":"2019","journal-title":"Curr. Opin. Neurol."},{"key":"ref_7","first-page":"530","article-title":"The Accuracy of Prehospital Diagnosis of Acute Cerebrovascular Accidents: An Observational Study","volume":"11","author":"Gluszkiewicz","year":"2015","journal-title":"Arch. Med. Sci. AMS"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2263","DOI":"10.1161\/STROKEAHA.120.030340","article-title":"Prehospital Triage of Acute Stroke Patients during the COVID-19 Pandemic","volume":"51","author":"Goyal","year":"2020","journal-title":"Stroke"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1996","DOI":"10.1161\/STROKEAHA.120.030225","article-title":"Impact of the COVID-19 Epidemic on Stroke Care and Potential Solutions","volume":"51","author":"Zhao","year":"2020","journal-title":"Stroke"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2491","DOI":"10.1111\/ene.14467","article-title":"Impact of COVID-19 Outbreak in Reperfusion Therapies of Acute Ischaemic Stroke in Northwest Spain","volume":"27","author":"Meza","year":"2020","journal-title":"Eur. J. Neurol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1161\/STROKEAHA.120.030106","article-title":"Break in the Stroke Chain of Survival Due to COVID-19","volume":"51","author":"Montaner","year":"2020","journal-title":"Stroke"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1136\/svn-2020-000441","article-title":"Decline in Stroke Alerts and Hospitalisations during the COVID-19 Pandemic","volume":"5","author":"Sharma","year":"2020","journal-title":"Stroke Vasc. Neurol."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Leira, E.C., Russman, A.N., Biller, J., Brown, D.L., Bushnell, C.D., Caso, V., Chamorro, A., Creutzfeldt, C.J., Cruz-Flores, S., and Elkind, M.S.V. (2020). Preserving Stroke Care during the COVID-19 Pandemic: Potential Issues and Solutions. Neurology.","DOI":"10.1212\/WNL.0000000000009713"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"On Behalf of the AHA\/ASA Stroke Council Leadership (2020). Temporary Emergency Guidance to US Stroke Centers during the COVID-19 Pandemic. Stroke, 51, 1910\u20131912.","DOI":"10.1161\/STROKEAHA.120.030023"},{"key":"ref_15","unstructured":"The Office of the Government of the Republic of Lithuania (2020, December 09). Quarantine Announced throughout the Territory of the Republic of Lithuania (Attached Resolution). Available online: https:\/\/lrv.lt\/en\/news\/quarantine-announced-throughout-the-territory-of-the-republic-of-lithuania-attached-resolution."},{"key":"ref_16","unstructured":"(2020, December 12). Lithuanian National Public Health Center. Available online: ftp:\/\/atviriduomenys.nvsc.lt\/."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Katsouras, C., Karapanayiotides, T., Papafaklis, M., Giannopoulos, S., Ziakas, A., Sianos, G., Papagiannopoulou, G., Koutroulou, I., Varytimiadi, E., and Kosmidou, M. (2020). Greater Decline of Acute Stroke Admissions Compared with Acute Coronary Syndromes during COVID-19 Outbreak in Greece: Cerebro\/Cardiovascular Implications amidst a Second Wave Surge. Eur. J. Neurol.","DOI":"10.1111\/ene.14666"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"407","DOI":"10.5853\/jos.2020.02292","article-title":"Maintenance of Stroke Care Quality amid the Coronavirus Disease 2019 Outbreak in Taiwan","volume":"22","author":"Chen","year":"2020","journal-title":"J. Stroke"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1016\/S0140-6736(07)61602-X","article-title":"The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) Statement: Guidelines for Reporting Observational Studies","volume":"370","author":"Altman","year":"2007","journal-title":"Lancet"},{"key":"ref_20","unstructured":"(2020, December 11). Google Trends. Available online: https:\/\/trends.google.com\/."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.bbi.2020.04.073","article-title":"Google Trends Provides a Tool to Monitor Population Concerns and Information Needs during COVID-19 Pandemic","volume":"87","author":"Springer","year":"2020","journal-title":"Brain Behav Immun"},{"key":"ref_22","unstructured":"(2020, December 12). Financial Times Coronavirus Tracked: See How Your Country Compares. Available online: Ft.com\/covid19."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1080\/10903129808958866","article-title":"Accuracy of Paramedic Identification of Stroke and Transient Ischemic Attack in the Field","volume":"2","author":"Smith","year":"2009","journal-title":"Prehosp. Emerg. Care"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/S1052-3057(98)80130-4","article-title":"Accuracy of Paramedic Diagnosis of Stroke","volume":"7","author":"Zweifler","year":"1998","journal-title":"J. Stroke Cerebrovasc. Dis."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"McClelland, G., Wilson, N., Shaw, L., Grayling, M., Haworth, D., and Price, C.I. (2020). Ambulance Documentation of Stroke Symptoms during the UK COVID-19 \u2018Stay at Home\u2019 Message. Emerg. Med. J.","DOI":"10.1136\/emermed-2020-210319"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"e23594","DOI":"10.2196\/23594","article-title":"Asynchronous Distance Learning of the National Institutes of Health Stroke Scale during the COVID-19 Pandemic (E-Learning vs. Video): Randomized Controlled Trial","volume":"23","author":"Suppan","year":"2021","journal-title":"J. Med. Internet Res."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"114","DOI":"10.4997\/JRCPE.2013.205","article-title":"The Differential Diagnosis of Suspected Stroke: A Systematic Review","volume":"43","author":"Gibson","year":"2013","journal-title":"J. R. Coll. Physicians Edinb."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Kozera-Strzeli\u0144ska, D., Karli\u0144ski, M., Rak, G., Wojdacz, M., Sienkiewicz-Jarosz, H., and Kurkowska-Jastrz\u0119bska, I. (2018). Stroke and TIA Mimics in Patients Referred to a Neurological Emergency Department by Non-Ambulance Physicians, Ambulance Physicians and Paramedics. Neurol. Neurochir. Pol.","DOI":"10.5603\/PJNNS.a2019.0002"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1007\/s00405-019-05313-y","article-title":"Diagnosis and Treatment Choices of Suspected Benign Paroxysmal Positional Vertigo: Current Approach of General Practitioners, Neurologists, and ENT Physicians","volume":"276","author":"Lesinskas","year":"2019","journal-title":"Eur. Arch. Oto-Rhino-Laryngol."},{"key":"ref_30","unstructured":"(2020, December 14). Ministry of Health of The Republic of Lithuania. Available online: https:\/\/e-seimas.lrs.lt\/portal\/legalAct\/lt\/TAD\/24591240ff0411e993cb8c8daaf8ff8a?jfwid=-kyrux7o2c."},{"key":"ref_31","unstructured":"de Leci\u00f1ana, M.A., Castellanos, M., Ayo-Mart\u00edn, \u00d3., Morales, A., and Neurology, S.G.-S.S. (2020). Of Stroke Care during the COVID-19 Outbreak in Spain: The Experience of Spanish Stroke Units. Stroke Vasc. Neurol."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Etherton, M.R., Zachrison, K.S., Yan, Z., Sveikata, L., Bretzner, M., Estrada, J., Viswanathan, A., Singhal, A.B., and Schwamm, L.H. (2021). Regional Changes in Patterns of Stroke Presentation during the COVID-19 Pandemic. Stroke, 52.","DOI":"10.1161\/str.52.suppl_1.P126"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1136\/svn-2020-000514","article-title":"Impact of COVID-2019 on Stroke Services in China: Survey from the Chinese Stroke Association","volume":"5","author":"Wang","year":"2020","journal-title":"Stroke Vasc. Neurol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"105479","DOI":"10.1016\/j.jstrokecerebrovasdis.2020.105479","article-title":"Understanding and Informing Community Emergency Cardiovascular Disease Preparedness during the COVID-19 Pandemic: Stroke Ready","volume":"30","author":"Robles","year":"2020","journal-title":"J. Stroke Cerebrovasc. Dis."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Puteikis, K., Jasionis, A., and Mameni\u0161kien\u0117, R. (2020). Recalling the COVID-19 Lockdown: Insights from Patients with Epilepsy. Epilepsy Behav., 107573.","DOI":"10.1016\/j.yebeh.2020.107573"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/S1470-2045(20)30388-0","article-title":"The Impact of the COVID-19 Pandemic on Cancer Deaths Due to Delays in Diagnosis in England, UK: A National, Population-Based, Modelling Study","volume":"21","author":"Maringe","year":"2020","journal-title":"Lancet Oncol."}],"container-title":["International Journal of Environmental Research and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-4601\/18\/4\/2150\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T05:26:43Z","timestamp":1760160403000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-4601\/18\/4\/2150"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,23]]},"references-count":36,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2021,2]]}},"alternative-id":["ijerph18042150"],"URL":"https:\/\/doi.org\/10.3390\/ijerph18042150","relation":{},"ISSN":["1660-4601"],"issn-type":[{"value":"1660-4601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,23]]}}}