{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:45:24Z","timestamp":1787028324655,"version":"build-2736575974"},"reference-count":66,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2021,3,4]],"date-time":"2021-03-04T00:00:00Z","timestamp":1614816000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RGPIN-2018-04810"],"award-info":[{"award-number":["RGPIN-2018-04810"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Canada Research Chair","award":["950230679"],"award-info":[{"award-number":["950230679"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Uptake of the neurotoxicant monomethylmercury (MeHg) from fish and marine mammals continues to present a public health concern in Canada and elsewhere. However, fish and marine mammals are key diet items contributing to food security for some Indigenous populations in Canada. Mercury (Hg) exposure is estimated assuming that 100% of Hg is methylated, that 100% will be absorbed by the consumer and that cooking does not affect MeHg concentrations. Some of these assumptions do not correspond to our current state of knowledge. The aim of this study was to assess the impact of additional variables on Hg exposure equation using probabilistic risk analysis. New variables tested were (1) the proportion of methylated Hg compared to total Hg (pMeHg, %), (2) the relative absorption factor (RAF, %) expressed as bioaccessibility and (3) the mass loss factor (MLF, unitless) that represents the loss of moisture during cooking, known to increase MeHg concentration in fish and mammals. For the new variables, data from literature were used in order to set point estimate values that were further used in the probabilistic risk analysis. Modelling results for both fish and marine mammals indicate that adding these new variables significantly influenced estimates of MeHg exposure (Mood\u2019s median test, p &lt; 0.05). This study highlights that the evaluation of exposure to MeHg is sensitive to pMeHg, RAF and MLF, and the inclusion of these variables in risk assessment should be considered with care. Further research is needed to provide better food-dependent, population-specific estimates of RAF and MLF before formal inclusion in exposure estimates.<\/jats:p>","DOI":"10.3390\/ijerph18052565","type":"journal-article","created":{"date-parts":[[2021,3,4]],"date-time":"2021-03-04T21:58:07Z","timestamp":1614895087000},"page":"2565","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Effects of Speciation, Cooking and Changes in Bioaccessibility on Methylmercury Exposure Assessment for Contrasting Diets of Fish and Marine Mammals"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8375-067X","authenticated-orcid":false,"given":"Tania","family":"Charette","sequence":"first","affiliation":[{"name":"Groupe de Recherche Interuniversitaire en Limnologie (GRIL), Universit\u00e9 de Montr\u00e9al, D\u00e9partement de Sciences Biologiques, Complexe des Sciences, C.P. 6128, succ. Centre-Ville, Montr\u00e9al, QC H3C 3J7, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory","family":"Kaminski","sequence":"additional","affiliation":[{"name":"Health Canada, 269 Laurier West, Ottawa, ON K1A 0K9, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5420-3490","authenticated-orcid":false,"given":"Maikel","family":"Rosabal","sequence":"additional","affiliation":[{"name":"Groupe de Recherche Interuniversitaire en Limnologie (GRIL), D\u00e9partement des Sciences Biologiques, Universit\u00e9 du Qu\u00e9bec \u00e0 Montr\u00e9al (UQAM), 141 Avenue du Pr\u00e9sident-Kennedy, Montreal, QC H2X 1Y4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0340-3249","authenticated-orcid":false,"given":"Marc","family":"Amyot","sequence":"additional","affiliation":[{"name":"Groupe de Recherche Interuniversitaire en Limnologie (GRIL), Universit\u00e9 de Montr\u00e9al, D\u00e9partement de Sciences Biologiques, Complexe des Sciences, C.P. 6128, succ. Centre-Ville, Montr\u00e9al, QC H3C 3J7, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,3,4]]},"reference":[{"key":"ref_1","unstructured":"Joint Expert Committee on Food Additives (JECFA) (2004). Safety Evaluation of Certain Food Additives and Contaminants, WHO."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.scitotenv.2014.07.102","article-title":"Local country food sources of methylmercury, selenium and omega-3 fatty acids in Nunavik, Northern Quebec","volume":"509\u2013510","author":"Lemire","year":"2015","journal-title":"Sci. Total Environ."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Amin-Zaki, L., Elhassani, S., Majeed, M.A., Clarkson, T.W., Doherty, R.A., and Greenwood, M. (1974). Intra-uterine Methylmercury Poisoning in Iraq. 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