{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T14:12:15Z","timestamp":1770905535339,"version":"3.50.1"},"reference-count":63,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2021,3,25]],"date-time":"2021-03-25T00:00:00Z","timestamp":1616630400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The Research Council of Lithuania","award":["No. S-SEN-20-13"],"award-info":[{"award-number":["No. S-SEN-20-13"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Background: Individuals with insulin resistance (IR) have a high risk of diabetes or metabolic syndrome, and they are more likely to have depression. Furthermore, IR by itself is a major cardiovascular risk factor in healthy persons. Thus, we aimed to investigate IR in association with thyroid function, psychoemotional state, and cardiovascular risk factors among 45\u201384-year-old citizens of Palanga. Methods: A randomized epidemiological study was performed with 850 subjects. All participants were evaluated for sociodemographic, clinical, and cardiovascular risk factors and biochemical analysis. IR was evaluated by the homeostasis model assessment of IR (HOMA-IR). Results: All study participants were stratified into groups without IR (HOMA-IR \u2264 2.7) and with IR (HOMA-IR &gt; 2.7). The analysis of parameters between the two study groups showed some statistically significant relationships between IR and cardiovascular risk factors. The predictable accuracy was presented using receiver performance characteristic curves for HOMA-IR scores in women and men separately. If the HOMA-IR score is higher than 3.45, individuals are significantly more likely to have type 2 diabetes mellitus (T2DM). Conclusions: An increase of fasting glucose and more frequent incidence of metabolic syndrome, diabetes, and cardiovascular diseases in subjects with IR are associated with the prevalence of cardiovascular risk factors. There was no significant association between thyroid function and HOMA-IR. HOMA-IR cut-offs could predict the presence of T2DM.<\/jats:p>","DOI":"10.3390\/ijerph18073388","type":"journal-article","created":{"date-parts":[[2021,3,25]],"date-time":"2021-03-25T02:54:03Z","timestamp":1616640843000},"page":"3388","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Insulin Resistance in Association with Thyroid Function, Psychoemotional State, and Cardiovascular Risk Factors"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4268-5303","authenticated-orcid":false,"given":"Nijole","family":"Kazukauskiene","sequence":"first","affiliation":[{"name":"Laboratory of Behavioral Medicine, Neuroscience Institute, Lithuanian University of Health Sciences, LT-00135 Palanga, Lithuania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aurelija","family":"Podlipskyte","sequence":"additional","affiliation":[{"name":"Laboratory of Behavioral Medicine, Neuroscience Institute, Lithuanian University of Health Sciences, LT-00135 Palanga, Lithuania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giedrius","family":"Varoneckas","sequence":"additional","affiliation":[{"name":"Laboratory of Behavioral Medicine, Neuroscience Institute, Lithuanian University of Health Sciences, LT-00135 Palanga, Lithuania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Narseta","family":"Mickuviene","sequence":"additional","affiliation":[{"name":"Laboratory of Behavioral Medicine, Neuroscience Institute, Lithuanian University of Health Sciences, LT-00135 Palanga, Lithuania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,3,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1161\/CIRCULATIONAHA.109.192644","article-title":"Harmonizing the metabolic syndrome: A joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity","volume":"120","author":"Alberti","year":"2009","journal-title":"Circulation"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Farrugia, F., Aquilina, A., and Vassallo, J. 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