{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T06:59:21Z","timestamp":1772953161348,"version":"3.50.1"},"reference-count":32,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2021,4,7]],"date-time":"2021-04-07T00:00:00Z","timestamp":1617753600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"SAES Getter S.p.A.","award":["SAES Getters S.p.A. in agreement with University of Siena, in a contract dated 13 and 14\/5\/2020"],"award-info":[{"award-number":["SAES Getters S.p.A. in agreement with University of Siena, in a contract dated 13 and 14\/5\/2020"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>The coronavirus SARS-CoV-2 pandemic has become a global health burden. Surface sanitation is one of the key points to reduce the risk of transmission both in healthcare and other public spaces. UVC light is already used in hospital and laboratory infection control, and some recent studies have shown its effectiveness on SARS-CoV-2. An innovative UV chip technology, described in Part I of this study, has recently appeared able to overcome the limits of old lamps and is proposed as a valid alternative to LEDs. This study was designed to test the virucidal activity on SARS-CoV-2 of a device based on the new UV chip technology. Via an initial concentration of virus suspension of 107.2 TCID50\/mL, the tests revealed a viral charge reduction of more than 99.9% after 3 min; the maximum detectable attenuation value of Log10 = 5.7 was measured at 10 min of UV exposure.<\/jats:p>","DOI":"10.3390\/ijerph18083873","type":"journal-article","created":{"date-parts":[[2021,4,7]],"date-time":"2021-04-07T11:31:59Z","timestamp":1617795119000},"page":"3873","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["An Emerging Innovative UV Disinfection Technology (Part II): Virucide Activity on SARS-CoV-2"],"prefix":"10.3390","volume":"18","author":[{"given":"Gabriele","family":"Messina","sequence":"first","affiliation":[{"name":"Department of Molecular and Developmental Medicine, University of Siena, 53100 Siena, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Della Camera","sequence":"additional","affiliation":[{"name":"Department of Molecular and Developmental Medicine, Post Graduate School of Public Health, University of Siena, 53100 Siena, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8814-783X","authenticated-orcid":false,"given":"Pietro","family":"Ferraro","sequence":"additional","affiliation":[{"name":"Department of Molecular and Developmental Medicine, University of Siena, 53100 Siena, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davide","family":"Amodeo","sequence":"additional","affiliation":[{"name":"Department of Molecular and Developmental Medicine, University of Siena, 53100 Siena, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2797-2171","authenticated-orcid":false,"given":"Alessio","family":"Corazza","sequence":"additional","affiliation":[{"name":"SAES Getters S.p.A., Viale Italia 77, 20020 Lainate, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2040-9562","authenticated-orcid":false,"given":"Nicola","family":"Nante","sequence":"additional","affiliation":[{"name":"Department of Molecular and Developmental Medicine, University of Siena, 53100 Siena, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriele","family":"Cevenini","sequence":"additional","affiliation":[{"name":"Department of Medical Biotechnologies, University of Siena, 53100 Siena, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,4,7]]},"reference":[{"key":"ref_1","unstructured":"WHO (2021, April 03). Coronavirus Disease (COVID-19) Dashboard. Available online: https:\/\/covid19.who.int."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Li, Q., Guan, X., Wu, P., Wang, X., Zhou, L., Tong, Y., Ren, R., Leung, K.S.M., Lau, E.H.Y., and Wong, J.Y. (2020). Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus\u2013Infected Pneumonia. N. Engl. J. Med.","DOI":"10.1056\/NEJMoa2001316"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.ijid.2020.04.044","article-title":"Preliminary Estimates of the Reproduction Number of the Coronavirus Disease (COVID-19) Outbreak in Republic of Korea and Italy by 5 March 2020","volume":"95","author":"Zhuang","year":"2020","journal-title":"Int. J. Infect. Dis."},{"key":"ref_4","unstructured":"(2020, December 04). Report 34\u2014COVID-19 Infection Fatality Ratio Estimates from Seroprevalence. Available online: http:\/\/www.imperial.ac.uk\/medicine\/departments\/school-public-health\/infectious-disease-epidemiology\/mrc-global-infectious-disease-analysis\/covid-19\/report-34-ifr\/."},{"key":"ref_5","unstructured":"He\u00dfling, M., H\u00f6nes, K., Vatter, P., and Lingenfelder, C. (2020). Ultraviolet Irradiation Doses for Coronavirus Inactivation\u2014Review and Analysis of Coronavirus Photoinactivation Studies. GMS Hyg. Infect. Control, 15."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1631\/jzus.B2000083","article-title":"An Overview of COVID-19","volume":"21","author":"Shi","year":"2020","journal-title":"J. Zhejiang Univ. Sci. B"},{"key":"ref_7","unstructured":"(2020, August 18). Transmission of COVID-19. Available online: https:\/\/www.ecdc.europa.eu\/en\/covid-19\/latest-evidence\/transmission."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1056\/NEJMc2004973","article-title":"Aerosol and Surface Stability of SARS-CoV-2 as Compared with SARS-CoV-1","volume":"382","author":"Bushmaker","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e10","DOI":"10.1016\/S2666-5247(20)30003-3","article-title":"Stability of SARS-CoV-2 in Different Environmental Conditions","volume":"1","author":"Chin","year":"2020","journal-title":"Lancet Microbe"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Kasloff, S.B., Strong, J.E., Funk, D., and Cutts, T.A. (2020). Stability of SARS-CoV-2 on Critical Personal Protective Equipment. medRxiv.","DOI":"10.1101\/2020.06.11.20128884"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Aboubakr, H.A., Sharafeldin, T.A., and Goyal, S.M. (2020). Stability of SARS-CoV-2 and Other Coronaviruses in the Environment and on Common Touch Surfaces and the Influence of Climatic Conditions: A Review. Transbound. Emerg. Dis.","DOI":"10.31219\/osf.io\/y2rth"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2276","DOI":"10.3201\/eid2609.202267","article-title":"Effect of Environmental Conditions on SARS-CoV-2 Stability in Human Nasal Mucus and Sputum","volume":"26","author":"Matson","year":"2020","journal-title":"Emerg. Infect. Dis. J."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Pastorino, B., Touret, F., Gilles, M., de Lamballerie, X., and Charrel, R.N. (2020). Prolonged Infectivity of SARS-CoV-2 in Fomites. Emerg. Infect. Dis. J., 26.","DOI":"10.31219\/osf.io\/7etga"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Derraik, J.G.B., Anderson, W.A., Connelly, E.A., and Anderson, Y.C. (2020). Rapid Review of SARS-CoV-1 and SARS-CoV-2 Viability, Susceptibility to Treatment, and the Disinfection and Reuse of PPE, Particularly Filtering Facepiece Respirators. Int. J. Environ. Res. Public Health, 17.","DOI":"10.3390\/ijerph17176117"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1973","DOI":"10.1016\/S0140-6736(20)31142-9","article-title":"Physical Distancing, Face Masks, and Eye Protection to Prevent Person-to-Person Transmission of SARS-CoV-2 and COVID-19: A Systematic Review and Meta-Analysis","volume":"395","author":"Chu","year":"2020","journal-title":"Lancet"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Kratzel, A., Todt, D., V\u2019kovski, P., Steiner, S., Gultom, M., Thao, T.T.N., Ebert, N., Holwerda, M., Steinmann, J., and Niemeyer, D. (2020). Inactivation of Severe Acute Respiratory Syndrome Coronavirus 2 by WHO-Recommended Hand Rub Formulations and Alcohols. Emerg. Infect. Dis. J., 26.","DOI":"10.1101\/2020.03.10.986711"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1007\/s40258-020-00596-3","article-title":"The Efficacy of Lockdown against COVID-19: A Cross-Country Panel Analysis","volume":"18","author":"Alfano","year":"2020","journal-title":"Appl. Health Econ. Health Policy"},{"key":"ref_18","unstructured":"(2020, December 09). Contact Tracing in the Context of COVID-19. Available online: https:\/\/www.who.int\/publications-detail-redirect\/contact-tracing-in-the-context-of-covid-19."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Heilingloh, C.S., Aufderhorst, U.W., Schipper, L., Dittmer, U., Witzke, O., Yang, D., Zheng, X., Sutter, K., Trilling, M., and Alt, M. (2020). Susceptibility of SARS-CoV-2 to UV Irradiation. Am. J. Infect. Control.","DOI":"10.1016\/j.ajic.2020.07.031"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Sharafi, S.M., Ebrahimpour, K., and Nafez, A. (2020). Environmental Disinfection against COVID-19 in Different Areas of Health Care Facilities: A Review. Rev. Environ. Health.","DOI":"10.1515\/reveh-2020-0075"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Patterson, E.I., Prince, T., Anderson, E.R., Casas-Sanchez, A., Smith, S.L., Cansado-Utrilla, C., Solomon, T., Griffiths, M.J., Acosta-Serrano, \u00c1., and Turtle, L. (2020). Methods of Inactivation of SARS-CoV-2 for Downstream Biological Assays. J. Infect. Dis.","DOI":"10.1101\/2020.05.21.108035"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1080\/22221751.2020.1796529","article-title":"Rapid Inactivation of SARS-CoV-2 with Deep-UV LED Irradiation","volume":"9","author":"Inagaki","year":"2020","journal-title":"Emerg. Microbes Infect."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"e00944-18","DOI":"10.1128\/AEM.00944-18","article-title":"UVC LED Irradiation Effectively Inactivates Aerosolized Viruses, Bacteria, and Fungi in a Chamber-Type Air Disinfection System","volume":"84","author":"Kim","year":"2018","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"10285","DOI":"10.1038\/s41598-020-67211-2","article-title":"Far-UVC Light (222 Nm) Efficiently and Safely Inactivates Airborne Human Coronaviruses","volume":"10","author":"Buonanno","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_25","unstructured":"(2020, December 16). 2020 Deadline Phasing Out Mercury-Added Products. Available online: http:\/\/mercuryconvention.org\/News\/fromtheConvention\/2020deadlinephasingoutmercuryaddedproducts\/tabid\/8479\/language\/en-US\/Default.aspx."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1017\/ice.2020.399","article-title":"Deactivation of SARS-CoV-2 with Pulsed-Xenon Ultraviolet Light: Implications for Environmental COVID-19 Control","volume":"42","author":"Simmons","year":"2020","journal-title":"Infect. Control Hosp. Epidemiol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"112044","DOI":"10.1016\/j.jphotobiol.2020.112044","article-title":"UV-LED Disinfection of Coronavirus: Wavelength Effect","volume":"212","author":"Gerchman","year":"2020","journal-title":"J. Photochem. Photobiol. B Biol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1007\/BF01863914","article-title":"Beitrag zur kollektiven Behandlung pharmakologischer Reihenversuche","volume":"162","year":"1931","journal-title":"Archiv. Exp. Pathol. Pharmakol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1111\/j.2044-8295.1908.tb00176.x","article-title":"The Method of \u2018Right and Wrong Cases\u2019 (\u2018Constant Stimuli\u2019) without Gauss\u2019s Formulae","volume":"2","author":"Spearman","year":"1908","journal-title":"Br. J. Psychol. 1904\u20131920"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.3201\/eid2609.201524","article-title":"Effectiveness of N95 Respirator Decontamination and Reuse against SARS-CoV-2 Virus","volume":"26","author":"Fischer","year":"2020","journal-title":"Emerg. Infect. 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