{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T05:54:05Z","timestamp":1768715645192,"version":"3.49.0"},"reference-count":43,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2021,4,10]],"date-time":"2021-04-10T00:00:00Z","timestamp":1618012800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Cardiovascular Medical Research and Education Fund (CMREF)","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]},{"name":"Ministry of education and science of the Kyrgyz Republic","award":["0005823"],"award-info":[{"award-number":["0005823"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Chronic hypoxia-induced sustained pulmonary vasoconstriction and vascular remodeling lead to mild-to-moderate elevation of pulmonary artery pressure in high-altitude residents. However, in some of them, severe pulmonary hypertension may develop. Besides hypoxia, high-altitude residents also face other environmental challenges such as low ambient temperatures. We describe a case of a 49-year-old woman of Kyrgyz ethnicity with abnormally increased pulmonary artery pressure, revealed by Doppler echocardiography. Significantly elevated pulmonary artery pressure was detected in late winter and this was not associated with right ventricular hypertrophy or right ventricular dysfunction. Repeat echocardiography performed in late summer disclosed a significant attenuation of pulmonary artery pressure elevation, with no changes in right ventricular performance parameters. This case illustrates that, in susceptible individuals, long-term cold exposure could induce an abnormal pulmonary artery pressure rise, which can be reversed during warm seasons as in our patient. In certain circumstances, however, additional factors could contribute to a sustained pulmonary artery pressure increase and the development of persistent pulmonary hypertension, which often leads to right heart failure and premature death.<\/jats:p>","DOI":"10.3390\/ijerph18083984","type":"journal-article","created":{"date-parts":[[2021,4,12]],"date-time":"2021-04-12T03:04:06Z","timestamp":1618196646000},"page":"3984","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["An Exaggerated Rise in Pulmonary Artery Pressure in a High-Altitude Dweller during the Cold Season"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8122-7033","authenticated-orcid":false,"given":"Akylbek","family":"Sydykov","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Excellence Cluster Cardio-Pulmonary Institute (CPI), Member of the German Center for Lung Research (DZL), Justus Liebig University of Giessen, 35392 Giessen, Germany"},{"name":"Department of Mountain and Sleep Medicine and Pulmonary Hypertension, National Center of Cardiology and Internal Medicine, Bishkek 720040, Kyrgyzstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdirashit","family":"Maripov","sequence":"additional","affiliation":[{"name":"Department of Mountain and Sleep Medicine and Pulmonary Hypertension, National Center of Cardiology and Internal Medicine, Bishkek 720040, Kyrgyzstan"},{"name":"Kyrgyz-Indian Mountain Biomedical Research Center, Bishkek 720040, Kyrgyzstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6874-7125","authenticated-orcid":false,"given":"Nadira","family":"Kushubakova","sequence":"additional","affiliation":[{"name":"Department of Mountain and Sleep Medicine and Pulmonary Hypertension, National Center of Cardiology and Internal Medicine, Bishkek 720040, Kyrgyzstan"},{"name":"Kyrgyz-Indian Mountain Biomedical Research Center, Bishkek 720040, Kyrgyzstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kubatbek","family":"Muratali Uulu","sequence":"additional","affiliation":[{"name":"Department of Mountain and Sleep Medicine and Pulmonary Hypertension, National Center of Cardiology and Internal Medicine, Bishkek 720040, Kyrgyzstan"},{"name":"Kyrgyz-Indian Mountain Biomedical Research Center, Bishkek 720040, Kyrgyzstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samatbek","family":"Satybaldyev","sequence":"additional","affiliation":[{"name":"Department of Mountain and Sleep Medicine and Pulmonary Hypertension, National Center of Cardiology and Internal Medicine, Bishkek 720040, Kyrgyzstan"},{"name":"Kyrgyz-Indian Mountain Biomedical Research Center, Bishkek 720040, Kyrgyzstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cholpon","family":"Kulchoroeva","sequence":"additional","affiliation":[{"name":"Department of Mountain and Sleep Medicine and Pulmonary Hypertension, National Center of Cardiology and Internal Medicine, Bishkek 720040, Kyrgyzstan"},{"name":"Kyrgyz-Indian Mountain Biomedical Research Center, Bishkek 720040, Kyrgyzstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Djuro","family":"Kosanovic","sequence":"additional","affiliation":[{"name":"Department of Pulmonology, Sechenov First Moscow State Medical University (Sechenov University), 119992 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akpay","family":"Sarybaev","sequence":"additional","affiliation":[{"name":"Department of Mountain and Sleep Medicine and Pulmonary Hypertension, National Center of Cardiology and Internal Medicine, Bishkek 720040, Kyrgyzstan"},{"name":"Kyrgyz-Indian Mountain Biomedical Research Center, Bishkek 720040, Kyrgyzstan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,4,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Sydykov, A., Mamazhakypov, A., Maripov, A., Kosanovic, D., Weissmann, N., Ghofrani, H.A., Sarybaev, A.S., and Schermuly, R.T. 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