{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T16:50:04Z","timestamp":1781715004526,"version":"3.54.5"},"reference-count":28,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2021,4,20]],"date-time":"2021-04-20T00:00:00Z","timestamp":1618876800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>The purpose of our study was to determine the willingness to be vaccinated against COVID-19 and factors associated with vaccine hesitancy among people with epilepsy (PWE). In December 2020, we performed an online cross-sectional survey of PWE and their caregivers in Lithuania before the rollout of COVID-19 vaccines to the public. The study sample consisted of 111 respondents (44 (39.6%) male, median age 25 years (range 1 to 70)). From 58 PWE who personally responded to the survey, 27 (46.6%) would be willing to be vaccinated against COVID-19. Among the 53 caregivers, 18 (34.0%) would accept the person they care for to be vaccinated. Willingness to be vaccinated was associated with receiving an influenza shot in 2020 (odds ratio (OR) = 9.17, 95% confidence interval (CI = 1.15\u201373.47), the beliefs that vaccines are generally safe (OR = 7.90, 95% CI = 2.43\u201325.74) and that they are the only convenient way to gain immunity (OR = 3.91, 95% CI = 1.02\u201315.05). Respondents were hesitant to accept the COVID-19 vaccine if they thought it could cause the infection (OR = 0.14, 95% CI = 0.04\u20130.49). COVID-19 vaccine hesitancy is frequent among PWE and their caregivers. It is probably related to erroneous beliefs about their safety and mechanism of action.<\/jats:p>","DOI":"10.3390\/ijerph18084374","type":"journal-article","created":{"date-parts":[[2021,4,20]],"date-time":"2021-04-20T13:58:04Z","timestamp":1618927084000},"page":"4374","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Factors Associated with COVID-19 Vaccine Hesitancy among People with Epilepsy in Lithuania"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8527-3902","authenticated-orcid":false,"given":"Kristijonas","family":"Puteikis","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Vilnius University, 03101 Vilnius, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u016bta","family":"Mameni\u0161kien\u0117","sequence":"additional","affiliation":[{"name":"Center for Neurology, Vilnius University, 08661 Vilnius, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,4,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Alkhotani, A., Siddiqui, M.I., Almuntashri, F., and Baothman, R. (2020). The effect of COVID-19 pandemic on seizure control and self-reported stress on patient with epilepsy. Epilepsy Behav., 112.","DOI":"10.1016\/j.yebeh.2020.107323"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1884","DOI":"10.1111\/epi.16635","article-title":"COVID-19 outbreak: The impact of stress on seizures in patients with epilepsy","volume":"61","author":"Huang","year":"2020","journal-title":"Epilepsia"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1111\/ane.13335","article-title":"Epilepsy in time of COVID-19. a survey-based study","volume":"142","author":"Fonseca","year":"2020","journal-title":"Acta Neurol. Scand."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1111\/epi.16544","article-title":"Severe psychological distress among patients with epilepsy during the COVID-19 outbreak in southwest China","volume":"61","author":"Hao","year":"2020","journal-title":"Epilepsia"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"737","DOI":"10.3389\/fneur.2020.00737","article-title":"Epilepsy Care in the Time of COVID-19 Pandemic in Italy: Risk Factors for Seizure Worsening","volume":"11","author":"Assenza","year":"2020","journal-title":"Front. Neurol."},{"key":"ref_6","first-page":"415","article-title":"COVID-19, de novo seizures, and epilepsy: A systematic review","volume":"42","author":"Simani","year":"2020","journal-title":"Neurol. Sci."},{"key":"ref_7","first-page":"e1417","article-title":"Incidence and case fatality rate of COVID-19 in patients with active epilepsy","volume":"95","year":"2020","journal-title":"Neurology"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1177\/1535759720948549","article-title":"COVID-19 in Patients With Seizures and Epilepsy: Interpretation of Relevant Knowledge of Presenting Signs and Symptoms","volume":"20","author":"Hogan","year":"2020","journal-title":"Epilepsy Curr."},{"key":"ref_9","unstructured":"(2021, April 16). The Official Source of Information by the Government of the Republic of Lithuania on the Pandemic Situation in Lithuania. Available online: http:\/\/koronastop.lrv.lt\/en\/#information."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Sun, M., Ruan, X., Li, Y., Wang, P., Zheng, S., Shui, G., Li, L., and Zhang, H. (2020). Clinical characteristics of 30 COVID-19 patients with epilepsy: A retrospective study in Wuhan. Int. J. Infect. Dis.","DOI":"10.1016\/j.ijid.2020.09.1475"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1007\/s10654-020-00671-y","article-title":"Vaccine hesitancy: The next challenge in the fight against COVID-19","volume":"35","author":"Dror","year":"2020","journal-title":"Eur. J. Epidemiol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"4161","DOI":"10.1016\/j.vaccine.2015.04.036","article-title":"Vaccine hesitancy: Definition, scope and determinants","volume":"33","author":"MacDonald","year":"2015","journal-title":"Vaccine"},{"key":"ref_13","unstructured":"European Medicines Agency Comirnaty (COVID-19 mRNA Vaccine [Nucleoside Modified]) (2020, April 16). An Overview of Comirnaty and Why It Is Authorised in the EU. EMA\/695455\/2020, EMEA\/H\/C\/005735. Available online: https:\/\/www.ema.europa.eu\/en\/documents\/overview\/comirnaty-epar-medicine-overview_en.pdf."},{"key":"ref_14","unstructured":"U.S. Food and Drug Administration (2020, April 16). FDA Takes Additional Action in Fight against COVID-19 By Issuing Emergency Use Authorization for Second COVID-19 Vaccine, Available online: https:\/\/www.fda.gov\/news-events\/press-announcements\/fda-takes-additional-action-fight-against-covid-19-issuing-emergency-use-authorization-second-covid."},{"key":"ref_15","unstructured":"U.S. Food and Drug Administration (2020, April 16). FDA Takes Key Action in Fight Against COVID-19 by Issuing Emergency Use Authorization for First COVID-19 Vaccine, Available online: https:\/\/www.fda.gov\/news-events\/press-announcements\/fda-takes-key-action-fight-against-covid-19-issuing-emergency-use-authorization-first-covid-19."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"e0008961","DOI":"10.1371\/journal.pntd.0008961","article-title":"Understanding COVID-19 vaccine demand and hesitancy: A nationwide online survey in China","volume":"28","author":"Lin","year":"2020","journal-title":"PLoS Negl. Trop. Dis."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Sherman, S.M., Smith, L.E., Sim, J., Aml\u00f4t, R., Cutts, M., Dasch, H., Rubin, G.J., and Sevdalis, N. (2020). COVID-19 vaccination intention in the UK: Results from the COVID-19 vaccination acceptability study (CoVAccS), a nationally representative cross-sectional survey. Hum. Vaccines Immunother., 1\u201310.","DOI":"10.1101\/2020.08.13.20174045"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"3636","DOI":"10.1016\/j.vaccine.2015.06.009","article-title":"Risk of febrile seizure after measles-mumps-rubella-varicella vaccine: A systematic review and meta-analysis","volume":"33","author":"Ma","year":"2015","journal-title":"Vaccine"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1001\/jamapediatrics.2013.2745","article-title":"Effect of age on the risk of fever and seizures following immunization with measles-containing vaccines in children","volume":"167","author":"Fireman","year":"2013","journal-title":"JAMA Pediatr."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1097\/WCO.0b013e3280555160","article-title":"Vaccination, seizures and \u201cvaccine damage\u201d","volume":"20","author":"Brown","year":"2007","journal-title":"Curr. Opin. Neurol."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Top, K.A., Brna, P., Ye, L., and Smith, B. (2018). Risk of seizures after immunization in children with epilepsy: A risk interval analysis. BMC Pediatr., 18.","DOI":"10.1186\/s12887-018-1112-0"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Fisher, K.A., Bloomstone, S.J., Walder, J., Crawford, S., Fouayzi, H., and Mazor, K.M. (2020). Attitudes Toward a Potential SARS-CoV-2 Vaccine: A Survey of U.S. Adults. Ann. Intern. Med.","DOI":"10.7326\/M20-3569"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"e2025594","DOI":"10.1001\/jamanetworkopen.2020.25594","article-title":"Factors Associated With US Adults\u2019 Likelihood of Accepting COVID-19 Vaccination","volume":"3","author":"Kreps","year":"2020","journal-title":"JAMA Netw. Open"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Freeman, D., Loe, B.S., Chadwick, A., Vaccari, C., Waite, F., Rosebrock, L., Jenner, L., Petit, A., Lewandowsky, S., and Vanderslott, S. (2020). COVID-19 Vaccine Hesitancy in the UK: The Oxford Coronavirus Explanations, Attitudes, and Narratives Survey (OCEANS) II, Cambridge University Press.","DOI":"10.1017\/S0033291720005188"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Puteikis, K., and Mameni\u0161kien\u0117, R. (2021). Epilepsy care and COVID-19: A cross-sectional online survey from Lithuania. Acta Neurol. Scand.","DOI":"10.1111\/ane.13409"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1038\/s41586-020-2281-1","article-title":"The online competition between pro- and anti-vaccination views","volume":"582","author":"Johnson","year":"2020","journal-title":"Nature"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"4481","DOI":"10.1007\/s12325-020-01502-y","article-title":"Fact vs. Fallacy: The Anti-Vaccine Discussion Reloaded","volume":"37","author":"Stolle","year":"2020","journal-title":"Adv. Ther."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Costa, A.M., Marchi\u00f2, M., Bruni, G., Bernabei, S.M., Cavalieri, S., Bondi, M., and Biagini, G. (2021). Evaluation of e-health applications for paediatric patients with refractory epilepsy and maintained on ketogenic diet. 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