{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T01:56:44Z","timestamp":1760234204584,"version":"build-2065373602"},"reference-count":52,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2021,4,20]],"date-time":"2021-04-20T00:00:00Z","timestamp":1618876800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Tri-Service General Hospital, National Defense Medical Center","award":["TSGH-C108-067"],"award-info":[{"award-number":["TSGH-C108-067"]}]},{"name":"Ministry of National Defense-Medical Affairs Bureau","award":["MAB-108-018"],"award-info":[{"award-number":["MAB-108-018"]}]},{"name":"Cheng Hsin General Hospital","award":["CH-NDMC-109-16","CH-NDMC-110-6"],"award-info":[{"award-number":["CH-NDMC-109-16","CH-NDMC-110-6"]}]},{"name":"Ministry of Science and Technology","award":["MOST 107-2314-B-016-061","MOST 108-2314-B-016-047-MY3"],"award-info":[{"award-number":["MOST 107-2314-B-016-061","MOST 108-2314-B-016-047-MY3"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Previous studies have indicated that patients with migraine have a higher prevalence of risk factors known to be associated with cardiovascular diseases. There are also shared epidemiology and molecular mechanisms between migraine and abdominal aortic aneurysm (AAA). We hypothesized that patients with migraine could have an increased risk of AAA. To test this hypothesis, we used the National Health Insurance Research Database (NHIRD) to evaluate whether associations exist between migraine and AAA. The data for this nationwide population-based retrospective cohort study were obtained from the NHIRD in Taiwan. The assessed study outcome was the cumulative incidence of AAA in patients with migraine during a 15-year follow-up period. Among the 1,936,512 patients from the NHIRD, 53,668 (2.77%) patients were identified as having been diagnosed with migraine. The patients with migraine had a significantly higher cumulative risk of 3.558 of developing an AAA 5 years after the index date compared with the patients without migraine. At the end of the 15-year follow-up period, a significantly higher incidence of AAA (0.98%) was observed in the patients with migraine than in those without migraine (0.24%). We revealed an association between the development of migraine and AAA.<\/jats:p>","DOI":"10.3390\/ijerph18084389","type":"journal-article","created":{"date-parts":[[2021,4,20]],"date-time":"2021-04-20T13:58:04Z","timestamp":1618927084000},"page":"4389","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Association between Migraine and Abdominal Aortic Aneurysms: A Nationwide Population-Based Cohort Study"],"prefix":"10.3390","volume":"18","author":[{"given":"Jou-Yu","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Rehabilitation, Cheng Hsin General Hospital, Taipei 11220, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Che-Se","family":"Tung","sequence":"additional","affiliation":[{"name":"Division of Medical Research &amp; Education, Cheng Hsin General Hospital, Taipei 11220, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jen-Chun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei 11490, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3286-0780","authenticated-orcid":false,"given":"Wu-Chien","family":"Chien","sequence":"additional","affiliation":[{"name":"Department of Medical Research, Tri-Service General Hospital, National Defense Medical Center, Taipei 11490, Taiwan"},{"name":"School of Public Health, National Defense Medical Center, Taipei 11490, Taiwan"},{"name":"Taiwanese Injury Prevention and Safety Promotion Association, Taipei 11490, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4576-9900","authenticated-orcid":false,"given":"Chi-Hsiang","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Medical Research, Tri-Service General Hospital, National Defense Medical Center, Taipei 11490, Taiwan"},{"name":"School of Public Health, National Defense Medical Center, Taipei 11490, Taiwan"},{"name":"Taiwanese Injury Prevention and Safety Promotion Association, Taipei 11490, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chih-Yuan","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Cardiovascular Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei 11490, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0215-3193","authenticated-orcid":false,"given":"Shih-Hung","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei 11490, Taiwan"},{"name":"Department of Physiology and Biophysics, Graduate Institute of Physiology, National Defense Medical Center, Taipei 11490, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,4,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.1016\/S0140-6736(12)61729-2","article-title":"Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990\u20132010: A systematic analysis for the Global Burden of Disease Study 2010","volume":"380","author":"Vos","year":"2012","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1001\/jama.291.4.427","article-title":"Migraine as a risk factor for subclinical brain lesions","volume":"291","author":"Kruit","year":"2004","journal-title":"JAMA"},{"key":"ref_3","first-page":"33","article-title":"Migraine and cerebrovascular disease: Still a dangerous connection?","volume":"39","author":"Agostoni","year":"2018","journal-title":"Neurol. 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