{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T01:56:18Z","timestamp":1760234178189,"version":"build-2065373602"},"reference-count":43,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2021,4,22]],"date-time":"2021-04-22T00:00:00Z","timestamp":1619049600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>The effectiveness of direct oral anticoagulants (DOAC) is non-inferior to vitamin K antagonists (VKA) to treat atrial fibrillation and venous thromboembolism (VTE). In this cross-sectional study, we compared older persons taking DOACs to those taking VKAs. We included ambulatory individuals \u226580 years, affiliated to Mutualit\u00e9 Sociale Agricole of Burgundy, who were refunded for a medical prescription in September 2017. The demographic conditions, registered chronic diseases (RCD), and number and types of prescribed drugs were compared in the DOAC group and VKA group. Of the 3190 included individuals, 1279 (40%) were prescribed DOACs and 1911 (60%) VKAs. Individuals taking VKAs were older than those taking DOACs (87.11 vs. 86.35 years). In the DOAC group, there were more women (51.92% vs. 48.25%) (p = 0.043), less RCD (89.60% vs. 92.73%) (p = 0.002), less VTE (1.80% vs. 6.59%), less severe heart failure (58.09% vs. 67.87%), less severe hypertension (18.22% vs. 23.60%), less severe kidney diseases (1.49% vs. 3.82%), and fewer drugs per prescription (6.15 vs. 6.66) (p &lt; 0.01 for all). The DOAC group were also less likely to be taking angiotensin receptor blockers (10.79% vs. 13.97%), furosemide (40.81% vs. 49.66%) or digoxin (10.32% vs. 13.66%) than the VKA group (p = 0.009, p &lt; 0.001, and p = 0.005). DOACs were less prescribed than VKAs. Individuals taking VKAs were older and had more severe comorbidities and more drugs per prescription than those taking DOACs.<\/jats:p>","DOI":"10.3390\/ijerph18094443","type":"journal-article","created":{"date-parts":[[2021,4,22]],"date-time":"2021-04-22T13:59:14Z","timestamp":1619099954000},"page":"4443","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Direct Oral Anticoagulants versus Vitamin K Antagonists in Patients Aged 80 Years and Older"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5518-9803","authenticated-orcid":false,"given":"Patrick","family":"Manckoundia","sequence":"first","affiliation":[{"name":"\u201cP\u00f4le Personnes \u00c2g\u00e9es\u201d, Hospital of Champmaillot, University Hospital, 21079 Dijon, France"},{"name":"INSERM U-1093, Cognition, Action and Sensorimotor Plasticity, University of Burgundy Franche-Comt\u00e9, 21000 Dijon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gilles","family":"Nuemi","sequence":"additional","affiliation":[{"name":"Department of Medical Information, University Hospital, 21079 Dijon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arthur","family":"Hacquin","sequence":"additional","affiliation":[{"name":"\u201cP\u00f4le Personnes \u00c2g\u00e9es\u201d, Hospital of Champmaillot, University Hospital, 21079 Dijon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Didier","family":"Menu","sequence":"additional","affiliation":[{"name":"\u201cMutualit\u00e9 Sociale Agricole\u201d of Burgundy, 21079 Dijon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cl\u00e9mentine","family":"Rosay","sequence":"additional","affiliation":[{"name":"\u201cP\u00f4le Personnes \u00c2g\u00e9es\u201d, Hospital of Champmaillot, University Hospital, 21079 Dijon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00e9r\u00e9mie","family":"Vovelle","sequence":"additional","affiliation":[{"name":"\u201cP\u00f4le Personnes \u00c2g\u00e9es\u201d, Hospital of Champmaillot, University Hospital, 21079 Dijon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentine","family":"Nuss","sequence":"additional","affiliation":[{"name":"\u201cP\u00f4le Personnes \u00c2g\u00e9es\u201d, Hospital of Champmaillot, University Hospital, 21079 Dijon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camille","family":"Baudin-Senegas","sequence":"additional","affiliation":[{"name":"\u201cP\u00f4le Personnes \u00c2g\u00e9es\u201d, Hospital of Champmaillot, University Hospital, 21079 Dijon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7140-8415","authenticated-orcid":false,"given":"J\u00e9r\u00e9my","family":"Barben","sequence":"additional","affiliation":[{"name":"\u201cP\u00f4le Personnes \u00c2g\u00e9es\u201d, Hospital of Champmaillot, University Hospital, 21079 Dijon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4408-554X","authenticated-orcid":false,"given":"Alain","family":"Putot","sequence":"additional","affiliation":[{"name":"\u201cP\u00f4le Personnes \u00c2g\u00e9es\u201d, Hospital of Champmaillot, University Hospital, 21079 Dijon, France"},{"name":"Physiopathologie et Epid\u00e9miologie C\u00e9r\u00e9bro-Cardiovasculaires (PEC2), University of Burgundy and Franche Comt\u00e9, 21000 Dijon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,4,22]]},"reference":[{"key":"ref_1","first-page":"222","article-title":"Cross-national Disparities in Sex Differences in Life Expectancy with and without Frailty","volume":"43","author":"Fouweather","year":"2013","journal-title":"Age. 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