{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T21:05:31Z","timestamp":1790629531558,"version":"4.1.0"},"reference-count":60,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2021,5,5]],"date-time":"2021-05-05T00:00:00Z","timestamp":1620172800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Hunan Province Technology Innovation Guidance Program Clinical Medical Technology Innovation Guidance Project","award":["2017SK50510, No. 97"],"award-info":[{"award-number":["2017SK50510, No. 97"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>(1) Backgrounds: Several studies have shown that the level of 25-hydroxyvitamin D (25(OH)D) could affect urticaria. The association of Vitamin D (VitD) with urticaria has not been well established. (2) Methods: The up-to-date meta-analysis was performed to synthesize the new findings. We performed a systematic search in PubMed, EMBASE, Web of Science, and Cochrane Database. We included the observational studies with the comparisons of 25(OH)D between urticarial populations and controls and clinical studies with the clinical severity of urticaria records. (3) Results: A meta-analysis of seventeen studies of urticaria group vs. controls revealed a mean difference of \u22129.35 ng\/mL (95% CI \u221212.27 to \u22126.44). There was also an association of urticaria with VitD deficiency. In the subgroup analysis of age and disease type, significant effects of 25(OH)D were found among adult and chronic urticarial populations. Six VitD supplementation trials showed a significant reduction in clinical urticarial score on intervention with VitD with the standard mean difference of \u22123.63 and \u22121.54 among randomized control studies and repeated measure trials, respectively. (4) Conclusions: The urticarial population, especially the adult chronic urticarial patients, may be associated with a high risk for lower serum 25(OH)D. VitD supplementations could result in a reduction of urticarial clinical symptoms.<\/jats:p>","DOI":"10.3390\/ijerph18094911","type":"journal-article","created":{"date-parts":[[2021,5,5]],"date-time":"2021-05-05T11:06:01Z","timestamp":1620212761000},"page":"4911","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Effects of Serum Vitamin D Levels and Vitamin D Supplementation on Urticaria: A Systematic Review and Meta-Analysis"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4710-087X","authenticated-orcid":false,"given":"Yajia","family":"Li","sequence":"first","affiliation":[{"name":"Department of Dermatology, Xiangya Hospital, Central South University, Changsha 410008, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziqin","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Spine Surgery, Xiangya Hospital, Central South University, Changsha 410008, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Xiangya Hospital, Central South University, Changsha 410008, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4816-4613","authenticated-orcid":false,"given":"Qiangxiang","family":"Li","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Geriatric Disorders of Xiangya Hospital, Central South University (Sub-center of Ningxia), Yinchuan 750001, China"},{"name":"Ningxia Geriatric Disease Clinical Research Center, People\u2019s Hospital of Ningxia Hui Autonomous Region, Yinchuan 750001, China"},{"name":"Hunan People\u2019s Hospital, Department of Hunan Institute of Geriatrics, Changsha 410002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Xiangya Hospital, Central South University, Changsha 410008, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,5,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1111\/all.13397","article-title":"The EAACI\/GA\u00b2LEN\/EDF\/WAO guideline for the definition, classification, diagnosis and management of urticaria","volume":"73","author":"Zuberbier","year":"2018","journal-title":"Allergy"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1111\/all.14037","article-title":"Prevalence of chronic urticaria in children and adults across the globe: Systematic review with meta-analysis","volume":"75","author":"Fricke","year":"2020","journal-title":"Allergy"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1111\/ijd.12109","article-title":"Clinical and laboratory features of chronic idiopathic urticaria in the elderly","volume":"52","author":"Magen","year":"2013","journal-title":"Int. J. Dermatol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"522","DOI":"10.4168\/aair.2016.8.6.522","article-title":"Plasma Levels of Matrix Metalloproteinase-9 in Children With Chronic Spontaneous Urticaria","volume":"8","author":"Dilek","year":"2016","journal-title":"Allergy Asthma Immunol. Res."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1056\/NEJM199506293322608","article-title":"Chronic urticaria","volume":"332","author":"Greaves","year":"1995","journal-title":"N. Engl. J. Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.iac.2016.08.004","article-title":"Biologics in Chronic Urticaria","volume":"37","author":"Bulkhi","year":"2017","journal-title":"Immunol Allergy Clin. N. Am."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1097\/ACI.0000000000000636","article-title":"Clinically significant differences in patient-reported outcomes evaluations in chronic spontaneous urticaria","volume":"20","author":"Baiardini","year":"2020","journal-title":"Curr. Opin. Allergy Clin. Immunol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1111\/j.1398-9995.2011.02580.x","article-title":"Recommendations for assessing patient-reported outcomes and health-related quality of life in patients with urticaria: A GA (2) LEN taskforce position paper","volume":"66","author":"Baiardini","year":"2011","journal-title":"Allergy"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1038\/jid.2008.380","article-title":"Vitamin D receptor and coactivators SRC2 and 3 regulate epidermis-specific sphingolipid production and permeability barrier formation","volume":"129","author":"Oda","year":"2009","journal-title":"J. Investig. Dermatol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1189\/jlb.1011523","article-title":"Age and low levels of circulating vitamin D are associated with impaired innate immune function","volume":"91","author":"Amado","year":"2012","journal-title":"J. Leukoc. Biol."},{"key":"ref_11","first-page":"951946","article-title":"Vitamin D and Its Role as a Protective Factor in Allergy","volume":"2014","author":"Hoxha","year":"2014","journal-title":"Int. Sch. Res. Not."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.biocel.2010.10.011","article-title":"Vitamin D (3) signalling to mast cells: A new regulatory axis","volume":"43","author":"Yu","year":"2011","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1189\/jlb.0506322","article-title":"VDR-dependent regulation of mast cell maturation mediated by 1,25-dihydroxyvitamin D3","volume":"81","author":"Baroni","year":"2007","journal-title":"J. Leukoc. Biol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1111\/j.1399-3038.2010.01093.x","article-title":"Childhood acute urticaria in northern and southern Europe shows a similar epidemiological pattern and significant meteorological influences","volume":"22","author":"Konstantinou","year":"2011","journal-title":"Pediatr. Allergy Immunol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1136\/oem.2002.006809","article-title":"Climate and the prevalence of symptoms of asthma, allergic rhinitis, and atopic eczema in children","volume":"61","author":"Weiland","year":"2004","journal-title":"Occup. Environ. Med."},{"key":"ref_16","first-page":"85","article-title":"Vitamin D level among Egyptian patients with chronic spontaneous urticaria and its relation to severity of the disease","volume":"21","author":"Sheha","year":"2014","journal-title":"Egypt J. Immunol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s12948-017-0078-z","article-title":"Amelioration of patients with chronic spontaneous urticaria in treatment with vitamin D supplement","volume":"15","author":"Ariaee","year":"2017","journal-title":"Clin. Mol. Allergy"},{"key":"ref_18","first-page":"438","article-title":"Vitamin D and Autoimmune Diseases: Is Vitamin D Receptor (VDR) Polymorphism the Culprit?","volume":"19","author":"Bizzaro","year":"2017","journal-title":"Isr. Med. Assoc. J."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1093\/qjmed\/hcx223","article-title":"Evaluation of 1,25-dihydroxyvitamin D3 pathway in patients with chronic urticaria","volume":"111","author":"Abdi","year":"2018","journal-title":"QJM"},{"key":"ref_20","unstructured":"SACN (2018, October 21). Vitamin D and Health, Available online: https:\/\/www.gov.uk\/government\/groups\/scientific-advisory-committee-on-nutrition."},{"key":"ref_21","first-page":"389","article-title":"The association between serum vitamin D levels and urticaria: A meta-analysis of observational studies","volume":"153","author":"Wang","year":"2018","journal-title":"G. Ital. Dermatol. Venereol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.jaad.2018.02.033","article-title":"Vitamin D deficiency in patients with chronic and acute urticaria: A systematic review and meta-analysis","volume":"79","author":"Tsai","year":"2018","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_23","unstructured":"(2021, January 12). The Newcastle-Ottawa Scale (NOS) for Assessing the Quality if Nonrandomized Studies in Meta-Analyses. Available online: http:\/\/www.ohri.ca\/programs\/clinical_epidemiology\/oxford.htm."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0197-2456(95)00134-4","article-title":"Assessing the quality of reports of randomized clinical trials: Is blinding necessary?","volume":"17","author":"Jadad","year":"1996","journal-title":"Control. Clin. Trials."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"3271","DOI":"10.1016\/j.arthro.2018.10.002","article-title":"Research Pearls: How Do We Establish the Level of Evidence?","volume":"34","author":"Hohmann","year":"2018","journal-title":"Arthroscopy"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.jaci.2010.04.040","article-title":"Reduced vitamin D levels in adult subjects with chronic urticaria","volume":"126","author":"Thorp","year":"2010","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_27","first-page":"81","article-title":"Is high prevalence of vitamin D deficiency evidence for asthma and allergy risks?","volume":"43","author":"Ehlayel","year":"2011","journal-title":"Eur. Ann. Allergy Clin. Immunol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"e115-8","DOI":"10.1515\/cclm-2013-1014","article-title":"25-Hydroxy vitamin D levels in chronic urticaria and its correlation with disease severity from a tertiary care centre in South India","volume":"52","author":"Chandrashekar","year":"2014","journal-title":"Clin. Chem. Lab. Med."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1476-9255-11-2","article-title":"Relationship between vitamin D status and the inflammatory state in patients with chronic spontaneous urticaria","volume":"11","author":"Grzanka","year":"2014","journal-title":"J. Inflamm. (Lond.)"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"e983685","DOI":"10.4161\/derm.29727","article-title":"Vitamin D supplements improve urticaria symptoms and quality of life in chronic spontaneous urticaria patients: A prospective case-control study","volume":"8","author":"Boonpiyathad","year":"2016","journal-title":"Dermatoendocrinology"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"926167","DOI":"10.1155\/2015\/926167","article-title":"Association between Micronutrient Levels and Chronic Spontaneous Urticaria","volume":"2015","author":"Wu","year":"2015","journal-title":"Biomed. Res. Int."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s40413-015-0066-z","article-title":"Chronic urticaria merits serum vitamin D evaluation and supplementation; a randomized case control study","volume":"8","author":"Rasool","year":"2015","journal-title":"World Allergy Organ. J."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"163","DOI":"10.3109\/09546634.2015.1079297","article-title":"Does replacement of vitamin D reduce the symptom scores and improve quality of life in patients with chronic urticaria?","volume":"27","author":"Kocaturk","year":"2016","journal-title":"J. Dermatolog. Treat."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"423","DOI":"10.5021\/ad.2015.27.4.423","article-title":"Vitamin D as a Marker for Disease Severity in Chronic Urticaria and Its Possible Role in Pathogenesis","volume":"27","author":"Woo","year":"2015","journal-title":"Ann. Dermatol."},{"key":"ref_35","first-page":"222","article-title":"Vitamin D deficiency in chronic idiopathic urticaria","volume":"14","author":"Movahedi","year":"2015","journal-title":"Iran J. Allergy Asthma. Immunol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.aller.2016.04.007","article-title":"Serum vitamin D levels decrease in children with acute urticaria","volume":"44","author":"Ozdemir","year":"2016","journal-title":"Allergol. Immunopathol. (Madr.)"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"212","DOI":"10.4168\/aair.2017.9.3.212","article-title":"Prevalence and Risk Factors of Urticaria With a Focus on Chronic Urticaria in Children[J]","volume":"9","author":"Lee","year":"2017","journal-title":"Allergy Asthma Immunol Res."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"170","DOI":"10.4103\/idoj.IDOJ_74_17","article-title":"Serum Levels of 25-hydroxyvitamin D in Chronic Urticaria and its Association with Disease Activity: A Case Control Study","volume":"9","author":"Rather","year":"2018","journal-title":"Indian Dermatol. Online J."},{"key":"ref_39","first-page":"675","article-title":"25-hydroxyvitamin D levels are low but not associated with disease activity in chronic spontaneous urticaria and depression","volume":"121","author":"Vurgun","year":"2020","journal-title":"Bratisl. Lek. Listy."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Mohamed, A.A., Hussein, M.S., Salah, E.M., Eldemery, A., Darwish, M.M., Ghaith, D.M., Attala, R.A., and Borolossy, R. (2020). Efficacy and safety of active vitamin D supplementation in chronic spontaneous urticaria patients. J. Dermatolog. Treat., 1\u20136.","DOI":"10.1080\/09546634.2020.1762838"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"250","DOI":"10.5114\/ada.2020.94843","article-title":"Associations between vitamin D receptor gene polymorphisms and chronic spontaneous urticaria in Chinese Han population","volume":"37","author":"Ma","year":"2020","journal-title":"Postepy. Dermatol. Alergol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.anai.2014.01.010","article-title":"Beneficial role for supplemental vitamin D3 treatment in chronic urticaria: A randomized study","volume":"112","author":"Rorie","year":"2014","journal-title":"Ann. Allergy Asthma Immunol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cca.2020.01.003","article-title":"Effect of vitamin D supplementation on clinical outcome and biochemical profile in South Indian population with vitamin D-deficient chronic urticarial\u2014A randomized double-blind placebo controlled trial","volume":"504","author":"Mony","year":"2020","journal-title":"Clin. Chim. Acta"},{"key":"ref_44","unstructured":"Nabavizadeh, S.H., Alyasin, S., Esmaeilzadeh, H., Mosavat, F., and Ebrahimi, N. The effect of vitamin D add-on therapy on the improvement of quality of life and clinical symptoms of patients with chronic spontaneous urticaria. Asian Pac. J. Allergy Immunol., 2020."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Miraglia del Giudice, M., Indolfi, C., and Strisciuglio, C. (2017, January 10\u201312). Vitamin D: Immunomodulatory Aspects. J. Clin. Gastroenterol. 2018, 52 (Suppl 1). Proceedings of the 9th Probiotics, Prebiotics and New Foods, Nutraceuticals and Botanicals for Nutrition & Human and Microbiota Health Meeting, Rome, Italy.","DOI":"10.1097\/MCG.0000000000001112"},{"key":"ref_46","unstructured":"(2008). Time for more vitamin D. Missing out on the \u201csunshine vitamin\u201d has consequences for more than just bone health. Harv. Womens Health Watch., 16, 1\u20133."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1210\/jcem-67-2-373","article-title":"Influence of season and latitude on the cutaneous synthesis of vitamin D3: Exposure to winter sunlight in Boston and Edmonton will not promote vitamin D3 synthesis in human skin","volume":"67","author":"Webb","year":"1988","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1093\/ajcn\/79.3.362","article-title":"Vitamin D: Importance in the prevention of cancers, type 1 diabetes, heart disease, and osteoporosis","volume":"79","author":"Holick","year":"2004","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1002\/jcb.10338","article-title":"Vitamin D: A millenium perspective","volume":"88","author":"Holick","year":"2003","journal-title":"J. Cell Biochem."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1678s","DOI":"10.1093\/ajcn\/80.6.1678S","article-title":"Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease","volume":"80","author":"Holick","year":"2004","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"EFSA Panel on Dietetic Products N, Allergies (2012). Scientific Opinion on the Tolerable Upper Intake Level of vitamin D. EFSA J., 10, 2813.","DOI":"10.2903\/j.efsa.2012.2813"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"E447","DOI":"10.1210\/jc.2010-2230","article-title":"Vitamin D(3) is more potent than vitamin D(2) in humans","volume":"96","author":"Heaney","year":"2011","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.3945\/ajcn.112.046110","article-title":"Comparison of vitamin D(2) and vitamin D(3) supplementation in increasing serum 25-hydroxyvitamin D status: A systematic review and meta-analysis","volume":"96","author":"MacDonald","year":"2012","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1111\/imr.12029","article-title":"Metabolic control of the Treg\/Th17 axis","volume":"252","author":"Barbi","year":"2013","journal-title":"Immunol. Rev."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.autrev.2013.12.004","article-title":"Th17 and regulatory T cell balance in autoimmune and inflammatory diseases","volume":"13","author":"Noack","year":"2014","journal-title":"Autoimmun. Rev."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.1002\/eji.201040391","article-title":"IL-6: Regulator of Treg\/Th17 balance","volume":"40","author":"Kimura","year":"2010","journal-title":"Eur. J. Immunol."},{"key":"ref_57","first-page":"3395","article-title":"1alpha,25-dihydroxyvitamin D3 inhibits anti-CD40 plus IL-4-mediated IgE production in vitro","volume":"32","author":"Heine","year":"2002","journal-title":"Eur. J. Immunol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.1002\/art.22722","article-title":"Association between serum vitamin D metabolite levels and disease activity in patients with early inflammatory polyarthritis","volume":"56","author":"Patel","year":"2007","journal-title":"Arthritis Rheum."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1476-9255-5-10","article-title":"Serum tumor necrosis factor-alpha concentrations are negatively correlated with serum 25(OH)D concentrations in healthy women","volume":"5","author":"Peterson","year":"2008","journal-title":"J. Inflamm. (Lond.)"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1111\/j.1749-6632.2003.tb06057.x","article-title":"Tolerogenic dendritic cells induced by vitamin D receptor ligands enhance regulatory T cells inhibiting autoimmune diabetes","volume":"987","author":"Adorini","year":"2003","journal-title":"Ann. N. Y. Acad. Sci."}],"container-title":["International Journal of Environmental Research and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-4601\/18\/9\/4911\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T05:57:15Z","timestamp":1760162235000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-4601\/18\/9\/4911"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,5]]},"references-count":60,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2021,5]]}},"alternative-id":["ijerph18094911"],"URL":"https:\/\/doi.org\/10.3390\/ijerph18094911","relation":{},"ISSN":["1660-4601"],"issn-type":[{"value":"1660-4601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,5]]}}}