{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:17:29Z","timestamp":1788308249667,"version":"build-2803163510"},"reference-count":110,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2021,5,6]],"date-time":"2021-05-06T00:00:00Z","timestamp":1620259200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100014440","name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades","doi-asserted-by":"publisher","award":["PGC2018-099117-B-C21"],"award-info":[{"award-number":["PGC2018-099117-B-C21"]}],"id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Inhibitory control deficit and impulsivity and compulsivity behaviours are present in different psychopathological disorders such as addiction, obsessive-compulsive disorders and schizophrenia, among others. Social relationships in humans and animals are governed by social organization rules, which modulate inhibitory control and coping strategies against stress. Social stress is associated with compulsive alcohol and drug use, pointing towards a determining factor in an increased vulnerability to inhibitory control deficit. The goal of the present review is to assess the implication of social stress and dominance on the vulnerability to develop impulsive and\/or compulsive spectrum disorders, with the aid of the information provided by animal models. A systematic search strategy was carried out on the PubMed and Web of Science databases, and the most relevant information was structured in the text and tables. A total of 34 studies were recruited in the qualitative synthesis. The results show the role of social stress and dominance in increased drug and alcohol use, aggressive and impulsive behaviour. Moreover, the revised studies support the role of Dopaminergic (DA) activity and the alterations in the dopaminergic D1\/D2 receptors as key factors in the development of inhibitory control deficit by social stress.<\/jats:p>","DOI":"10.3390\/ijerph18094953","type":"journal-article","created":{"date-parts":[[2021,5,6]],"date-time":"2021-05-06T11:10:27Z","timestamp":1620299427000},"page":"4953","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The Role of Social Stress in the Development of Inhibitory Control Deficit: A Systematic Review in Preclinical Models"],"prefix":"10.3390","volume":"18","author":[{"given":"Luc\u00eda","family":"S\u00e1nchez-Salvador","sequence":"first","affiliation":[{"name":"Department of Psychology and Health Research Center (CEINSA), Almeria University-ceiA3, 04120 Almeria, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1ngeles","family":"Prados-Pardo","sequence":"additional","affiliation":[{"name":"Department of Psychology and Health Research Center (CEINSA), Almeria University-ceiA3, 04120 Almeria, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Mart\u00edn-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Department of Psychology and Health Research Center (CEINSA), Almeria University-ceiA3, 04120 Almeria, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Olmedo-C\u00f3rdoba","sequence":"additional","affiliation":[{"name":"Department of Psychology and Health Research Center (CEINSA), Almeria University-ceiA3, 04120 Almeria, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santiago","family":"Mora","sequence":"additional","affiliation":[{"name":"Department of Psychology and Health Research Center (CEINSA), Almeria University-ceiA3, 04120 Almeria, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarita","family":"Moreno","sequence":"additional","affiliation":[{"name":"Department of Psychology and Health Research Center (CEINSA), Almeria University-ceiA3, 04120 Almeria, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,5,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/j.neuron.2011.01.020","article-title":"Impulsivity, Compulsivity, and Top-Down Cognitive Control","volume":"69","author":"Dalley","year":"2011","journal-title":"Neuron"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.tics.2011.11.009","article-title":"Neurocognitive endophenotypes of impulsivity and compulsivity: Towards dimensional psychiatry","volume":"16","author":"Robbins","year":"2012","journal-title":"Trends Cogn. Sci."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.neuron.2019.01.046","article-title":"Obsessive-Compulsive Disorder: Puzzles and Prospects","volume":"102","author":"Robbins","year":"2019","journal-title":"Neuron"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1093\/ijnp\/pyx088","article-title":"Mapping Compulsivity in the DSM-5 Obsessive Compulsive and Related Disorders: Cognitive Domains, Neural Circuitry, and Treatment","volume":"21","author":"Fineberg","year":"2018","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"American Psychiatric Association (2013). Diagnostic and Statistical Manual of Mental Disorders, APA. [5th ed.].","DOI":"10.1176\/appi.books.9780890425596"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1007\/s13679-016-0208-9","article-title":"Parent-Child Interaction, Self-Regulation, and Obesity Prevention in Early Childhood","volume":"5","author":"Anderson","year":"2016","journal-title":"Curr. Obes. Rep."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.cpr.2016.01.001","article-title":"The interaction between reinforcement and inhibitory control in ADHD: A review and research guidelines","volume":"44","author":"Ma","year":"2016","journal-title":"Clin. Psychol. Rev."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1038\/s41593-018-0246-6","article-title":"Volitional social interaction prevents drug addiction in rat models","volume":"21","author":"Venniro","year":"2018","journal-title":"Nat. Neurosci."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1002\/da.20506","article-title":"Quality of life and functional impairment in obsessive-compulsive disorder: A comparison of patients with and without comorbidity, patients in remission, and healthy controls","volume":"26","author":"Huppert","year":"2009","journal-title":"Depress. Anxiety"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Rodriguez-Salgado, B., Dolengevich-Segal, H., Arrojo-Romero, M., Castelli-Candia, P., Navio-Acosta, M., Perez-Rodriguez, M.M., Saiz-Ruiz, J., and Baca-Garcia, E. (2006). Perceived quality of life in obsessive-compulsive disorder: Related factors. BMC Psychiatry, 6.","DOI":"10.1186\/1471-244X-6-20"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1177\/0145445508327444","article-title":"Neither saints nor wolves in disguise: Ambivalent interpersonal attitudes and behaviors in obsessive-compulsive disorder","volume":"22","author":"Moritz","year":"2009","journal-title":"Behav. Modif."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1017\/S1352465812000574","article-title":"Interpersonal Ambivalence in Obsessive-Compulsive Disorder","volume":"41","author":"Moritz","year":"2013","journal-title":"Behav. Cogn. Psychother."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1037\/0893-164X.18.2.91","article-title":"Measuring College Students\u2019 Motives for Playing Drinking Games","volume":"18","author":"Johnson","year":"2004","journal-title":"Psychol. Addict. Behav."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1353\/csd.2019.0000","article-title":"Undergraduate Men\u2019s Alcohol Consumption: Masculine Norms, Ethnic Identity, and Social Dominance Orientation","volume":"60","author":"Radimer","year":"2019","journal-title":"J. Coll. Stud. Dev."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1037\/0090-5550.53.1.39","article-title":"Men with serious injuries: Relations among masculinity, age, and alcohol use","volume":"53","author":"Good","year":"2008","journal-title":"Rehabil. Psychol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0018-506X(02)00037-5","article-title":"Are subordinates always stressed? A comparative analysis of rank differences in cortisol levels among primates","volume":"43","author":"Abbott","year":"2003","journal-title":"Horm. Behav."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0165-6147(97)01115-2","article-title":"The role of stress in drug self-administration","volume":"19","author":"Piazza","year":"1998","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"538","DOI":"10.15288\/jsa.1995.56.538","article-title":"Stress, vulnerability and adult alcohol relapse","volume":"56","author":"Brown","year":"1995","journal-title":"J. Stud. Alcohol"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1037\/0021-843X.105.2.166","article-title":"Escalated substance use: A longitudinal grouping analysis from early to middle adolescence","volume":"105","author":"Wills","year":"1996","journal-title":"J. Abnorm. Psychol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s00213-010-1916-6","article-title":"The role of early life stress as a predictor for alcohol and drug dependence","volume":"214","author":"Enoch","year":"2011","journal-title":"Psychopharmacology"},{"key":"ref_21","first-page":"54","article-title":"Factores psicosociales asociados con el abuso y la dependencia de drogas entre adolescentes: An\u00e1lisis bivariados de un estudio de casos y controles","volume":"27","author":"Negrete","year":"2004","journal-title":"Salud Ment."},{"key":"ref_22","unstructured":"Mazur, A. (2005). Biosociology of Dominance and Deference, Rowman & Littlefield Publishers."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1126\/science.1209951","article-title":"Bidirectional Control of Social Hierarchy by Synaptic Efficacy in Medial Prefrontal Cortex","volume":"334","author":"Wang","year":"2011","journal-title":"Science"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1007\/s002130050133","article-title":"Activational effects of social stress on IV cocaine self-administration in rats","volume":"128","author":"Miczek","year":"1996","journal-title":"Psychopharmacology"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/s00441-013-1636-4","article-title":"Animal models of social avoidance and social fear","volume":"354","author":"Toth","year":"2013","journal-title":"Cell Tissue Res."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1016\/j.physbeh.2011.12.013","article-title":"Impulsivity and aggressive behavior in Roman high and low avoidance rats: Baseline differences and adolescent social stress induced changes","volume":"105","author":"Coppens","year":"2012","journal-title":"Physiol. Behav."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1002\/ab.21527","article-title":"Aggression and aspects of impulsivity in wild-type rats","volume":"40","author":"Coppens","year":"2014","journal-title":"Aggress. Behav."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/0031-9384(71)90139-9","article-title":"Excessive water intake in captive Norway rats with scar-markings","volume":"7","author":"Boice","year":"1971","journal-title":"Physiol. Behav."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s12640-014-9498-4","article-title":"Enhanced Aggressive Behaviour in a Mouse Model of Depression","volume":"27","author":"Yang","year":"2015","journal-title":"Neurotox. Res."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.bbr.2015.10.049","article-title":"Chronic mild stress in submissive mice: Marked polydipsia and social avoidance without hedonic deficit in the sucrose preference test","volume":"298","author":"Gross","year":"2016","journal-title":"Behav. Brain Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1007\/s00213-015-4122-8","article-title":"Social dominance in rats: Effects on cocaine self-administration, novelty reactivity and dopamine receptor binding and content in the striatum","volume":"233","author":"Jupp","year":"2016","journal-title":"Psychopharmacology"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/0091-3057(95)02137-X","article-title":"Selective effects of 8-OH-DPAT on social competition in the rat","volume":"54","author":"Woodall","year":"1996","journal-title":"Pharmacol. Biochem. Behav."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/BF02691361","article-title":"Effects of stress on defensive aggression and dominance in a water competition test","volume":"29","author":"Lucion","year":"1994","journal-title":"Integr. Physiol. Behav. Sci."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s00213-010-2139-6","article-title":"Social defeat stress in rats: Escalation of cocaine and \u201cspeedball\u201d binge self-administration, but not heroin","volume":"215","author":"Cruz","year":"2011","journal-title":"Psychopharmacology"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1007\/s002130100858","article-title":"Repeated social-defeat stress, cocaine or morphine","volume":"158","author":"Covington","year":"2001","journal-title":"Psychopharmacology"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s00213-009-1584-6","article-title":"Two modes of intense cocaine bingeing: Increased persistence after social defeat stress and increased rate of intake due to extended access conditions in rats","volume":"206","author":"Quadros","year":"2009","journal-title":"Psychopharmacology"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/s00213-007-0712-4","article-title":"Social defeat stress, sensitization, and intravenous cocaine self-administration in mice","volume":"192","author":"Yap","year":"2007","journal-title":"Psychopharmacology"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1002\/dev.21800","article-title":"Adolescent social stress and social context influence the intake of ethanol and sucrose in male rats soon and long after the stress exposures","volume":"61","author":"Marcolin","year":"2019","journal-title":"Dev. Psychobiol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.alcohol.2019.08.003","article-title":"The effects of social instability stress and subsequent ethanol consumption in adolescence on brain and behavioral development in male rats","volume":"82","author":"Marcolin","year":"2020","journal-title":"Alcohol"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.physbeh.2017.02.010","article-title":"Chronic social instability increases anxiety-like behavior and ethanol preference in male Long Evans rats","volume":"173","author":"Roeckner","year":"2017","journal-title":"Physiol. Behav."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1097\/00008877-200109000-00004","article-title":"Short or continuous social stress: Suppression of continuously available ethanol intake in subordinate rats","volume":"12","author":"Tachi","year":"2001","journal-title":"Behav. Pharmacol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/0091-3057(87)90502-8","article-title":"Social structure and ethanol consumption in the laboratory rat","volume":"28","author":"Blanchard","year":"1987","journal-title":"Pharmacol. Biochem. Behav."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.pbb.2010.02.017","article-title":"Acute novel stressors modify ethanol intake of psychosocially stressed rats","volume":"95","author":"Pohorecky","year":"2010","journal-title":"Pharmacol. Biochem. Behav."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/0091-3057(83)90237-X","article-title":"Alcohol-preferring rats in colonies show withdrawal, inactivity, and lowered dominance","volume":"18","author":"Ellison","year":"1983","journal-title":"Pharmacol. Biochem. Behav."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1134\/S0012496610010084","article-title":"The influence of social conditions on the development of ethanol preference in rats","volume":"430","author":"Filatova","year":"2010","journal-title":"Dokl. Biol. Sci."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"441","DOI":"10.3109\/10253890.2012.754419","article-title":"Increased anxiety, voluntary alcohol consumption and ethanol-induced place preference in mice following psychosocial stress","volume":"16","author":"Bahi","year":"2013","journal-title":"Stress"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1007\/BF02245112","article-title":"Social-status and voluntary alcohol-consumption in mice-interaction with stress","volume":"108","author":"Lister","year":"1992","journal-title":"Psychopharmacology"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/0031-9384(91)90511-L","article-title":"Social success and voluntary ethanol-consumption in mice of C57BL\/6J and CBA\/LAC strains","volume":"50","author":"Kudryavtseva","year":"1991","journal-title":"Physiol. Behav."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/0091-3057(91)90297-F","article-title":"Social-behavior, dominance, and social deprivation of rats determine drug choice","volume":"38","author":"Wolffgramm","year":"1991","journal-title":"Pharmacol. Biochem. Behav."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.euroneuro.2006.01.002","article-title":"Anxiety and ethanol consumption in victorious and defeated mice; effect of kappa-opioid receptor activation","volume":"16","author":"Kudryavtseva","year":"2006","journal-title":"Eur. Neuropsychopharmacol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1097\/00008877-199912000-00007","article-title":"Behavioural consequences of repeated social defeat in the mouse: Preliminary evaluation of a potential animal model of depression","volume":"10","author":"Keeney","year":"1999","journal-title":"Behav. Pharmacol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s00213-006-0536-7","article-title":"The impact of moderate daily alcohol consumption on aggression and the formation of dominance hierarchies in rats","volume":"189","author":"Duncan","year":"2006","journal-title":"Psychopharmacology"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.pbb.2012.01.010","article-title":"Amphetamine modifies ethanol intake of psychosocially stressed male rats","volume":"101","author":"Pohorecky","year":"2012","journal-title":"Pharmacol. Biochem. Behav."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/0091-3057(95)00193-X","article-title":"The development of opiate addiction in the rat","volume":"53","author":"Heyne","year":"1996","journal-title":"Pharmacol. Biochem. Behav."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.bbr.2013.10.023","article-title":"Differential effects of chronic fluoxetine on the behavior of dominant and subordinate naked mole-rats","volume":"258","author":"Mongillo","year":"2014","journal-title":"Behav. Brain Res."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Endo, T., Kakeyama, M., Uemura, Y., Haijima, A., Okuno, H., Bito, H., and Tohyama, C. (2012). Executive Function Deficits and Social-Behavioral Abnormality in Mice Exposed to a Low Dose of Dioxin in Utero and via Lactation. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0050741"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.neuroscience.2011.09.008","article-title":"Adolescent social defeat increases adult amphetamine conditioned place preference and alters D2 dopamine receptor expression","volume":"197","author":"Burke","year":"2011","journal-title":"Neuroscience"},{"key":"ref_58","first-page":"324","article-title":"The Roles of Dopamine D1 Receptor on the Social Hierarchy of Rodents and Nonhuman Primates","volume":"20","author":"Yamaguchi","year":"2017","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1126\/science.1137073","article-title":"Nucleus Accumbens D2\/3 Receptors Predict Trait Impulsivity and Cocaine Reinforcement","volume":"315","author":"Dalley","year":"2007","journal-title":"Science"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1176\/appi.ajp.2012.11091421","article-title":"Cognitive dysfunction and Anxious-impulsive Personality Traits are Endophenotypes for Drug Dependence","volume":"169","author":"Ersche","year":"2012","journal-title":"Am. J. Psychiatry"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"473","DOI":"10.15288\/jsad.2016.77.473","article-title":"Impulsive Personality and Alcohol Use: Bidirectional Relations Over One Year","volume":"77","author":"Kaiser","year":"2016","journal-title":"J. Stud. Alcohol Drugs"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0166-4328(96)00181-7","article-title":"Social isolation increases aggressive behaviour and alters the effects of diazepam in the rat social interaction test","volume":"75","author":"Wongwitdecha","year":"1996","journal-title":"Behav. Brain Res."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00213-008-1173-0","article-title":"The role of impulsive behavior in drug abuse","volume":"200","author":"Perry","year":"2008","journal-title":"Psychopharmacology"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.neuroscience.2007.09.034","article-title":"Individual differences in offensive aggression in golden hamsters: A model of reactive and impulsive aggression?","volume":"150","author":"Cervantes","year":"2007","journal-title":"Neuroscience"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.beproc.2014.10.013","article-title":"Adolescent social defeat disturbs adult aggression-related impulsivity in wild-type rats","volume":"108","author":"Coppens","year":"2014","journal-title":"Behav. Process."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.pbb.2003.10.021","article-title":"Effects of morphine and cocaine in mice with stable high aggressive and nonaggressive behavioral strategy","volume":"77","author":"Vekovischeva","year":"2004","journal-title":"Pharmacol. Biochem. Behav."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/nn798","article-title":"Social dominance in monkeys: Dopamine D2 receptors and cocaine self-administration","volume":"5","author":"Morgan","year":"2002","journal-title":"Nat. Neurosci."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.biopsych.2012.03.002","article-title":"Social dominance in female monkeys: Dopamine receptor function and cocaine reinforcement","volume":"72","author":"Nader","year":"2012","journal-title":"Biol. Psychiatry"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1037\/0893-164X.21.4.462","article-title":"Social dominance mediates the association of testosterone and neurobehavioral disinhibition with risk for substance use disorder","volume":"21","author":"Tarter","year":"2007","journal-title":"Psychol. Addict. Behav."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.physbeh.2004.10.002","article-title":"A single social defeat induces short-lasting behavioral sensitization to amphetamine","volume":"83","author":"Wasilewski","year":"2005","journal-title":"Physiol. Behav."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1007\/s00213-020-05486-z","article-title":"Long-term impact of acute restraint stress on heroin self-administration, reinstatement, and stress reactivity","volume":"237","author":"Carter","year":"2020","journal-title":"Psychopharmacology"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.pnpbp.2016.04.016","article-title":"Up-regulation of histone acetylation induced by social defeat mediates the conditioned rewarding effects of cocaine","volume":"70","author":"Montesinos","year":"2016","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1111\/adb.12301","article-title":"Effects of repeated social defeat on adolescent mice on cocaine-induced CPP and self-administration in adulthood: Integrity of the blood-brain barrier","volume":"22","author":"Aguilar","year":"2017","journal-title":"Addict. Biol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.bbr.2014.05.040","article-title":"Subchronic and mild social defeat stress accelerates food intake and body weight gain with polydipsia-like features in mice","volume":"270","author":"Goto","year":"2014","journal-title":"Behav. Brain Res."},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Goto, T., and Toyoda, A. (2015). A Mouse Model of Subchronic and Mild Social Defeat Stress for Understanding Stress-induced Behavioral and Physiological Deficits. J. Vis. Exp., 52973.","DOI":"10.3791\/52973"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.jsat.2014.02.002","article-title":"The association between social stressors and drug use\/hazardous drinking among former prison inmates","volume":"47","author":"Calcaterra","year":"2014","journal-title":"J. Subst. Abus. Treat."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"56","DOI":"10.14200\/jrm.2012.1.1005","article-title":"Addiction: Childhood Trauma, Stress and the Biology of Addiction","volume":"1","year":"2012","journal-title":"J. Restor. Med."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1111\/j.1530-0277.2006.00077.x","article-title":"Alcohol-Related Social Consequences in Castille and Leon, Spain","volume":"30","author":"Alvarez","year":"2006","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/S0031-9384(03)00211-7","article-title":"Fluoxetine treatment decreases territorial aggression in a coral reef fish","volume":"79","author":"Perreault","year":"2003","journal-title":"Physiol. Behav."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1002\/ab.21797","article-title":"Acute fluoxetine differently affects aggressive display in zebrafish phenotypes","volume":"45","author":"Barbosa","year":"2019","journal-title":"Aggress. Behav."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"51","DOI":"10.2466\/02.13.PR0.110.1.51-62","article-title":"Decreased aggressive and locomotor behaviors in Betta splendens after exposure to fluoxetine","volume":"110","author":"Kohlert","year":"2012","journal-title":"Psychol. Rep."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"19850","DOI":"10.1038\/srep19850","article-title":"Acute fluoxetine exposure alters crab anxiety-like behaviour, but not aggressiveness","volume":"6","author":"Hamilton","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1007\/s10695-016-0329-9","article-title":"Acute fluoxetine treatment increases aggressiveness in juvenile matrinx\u00e3 (Brycon amazonicus)","volume":"43","author":"Wolkers","year":"2017","journal-title":"Fish Physiol. Biochem."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1037\/a0029761","article-title":"Repeated fluoxetine administration during adolescence stimulates aggressive behavior and alters serotonin and vasopressin neural development in hamsters","volume":"126","author":"Ricci","year":"2012","journal-title":"Behav. Neurosci."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1089\/cap.2008.055","article-title":"Efficacy and Safety of Fluoxetine in Preschool Children with Obsessive-Compulsive Disorder","volume":"19","author":"Coskun","year":"2009","journal-title":"J. Child Adolesc. Psychopharmacol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1097\/00004583-200212000-00014","article-title":"Fluoxetine in Children and Adolescents with OCD: A Placebo-Controlled Trial","volume":"41","author":"Liebowitz","year":"2002","journal-title":"J. Am. Acad. Child Adolesc. Psychiatry"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1017\/S0033291703007682","article-title":"Neuropsychological performance of OCD patients before and after treatment with fluoxetine: Evidence for persistent cognitive deficits","volume":"33","author":"Nielen","year":"2003","journal-title":"Psychol. Med."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.bbr.2018.04.011","article-title":"Reserpine-induced depression is associated in female, but not in male, adolescent rats with heightened, fluoxetine-sensitive, ethanol consumption","volume":"348","author":"Ruiz","year":"2018","journal-title":"Behav. Brain Res."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/0091-3057(88)90137-2","article-title":"Effects of Ro 15-4513, fluoxetine and desipramine on the intake of ethanol, water and food by the alcohol-preferring (P) and -nonpreferring (NP) lines of rats","volume":"30","author":"McBride","year":"1988","journal-title":"Pharmacol. Biochem. Behav."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1097\/00004850-199409000-00004","article-title":"Fluoxetine attenuates alcohol intake and desire to drink","volume":"9","author":"Naranjo","year":"1994","journal-title":"Int. Clin. Psychopharmacol."},{"key":"ref_91","first-page":"789","article-title":"Disruption of paired-associate learning in rat offspring perinatally exposed to dioxins","volume":"88","author":"Kakeyama","year":"2014","journal-title":"Arch. Toxicol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0892-0362(02)00186-1","article-title":"Impaired cued delayed alternation behavior in adult rat offspring following exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin on gestation day 15","volume":"24","author":"Markowski","year":"2002","journal-title":"Neurotoxicol. Teratol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1097\/00008571-199706000-00007","article-title":"Genetic differences in alcohol drinking preference between inbred strains of mice","volume":"7","author":"He","year":"1997","journal-title":"Pharmacogenetics"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.envint.2019.04.051","article-title":"Human prenatal exposure to polychlorinated biphenyls (PCBs) and risk behaviors in adolescence","volume":"129","author":"Dickerson","year":"2019","journal-title":"Environ. Int."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/0741-8329(94)90093-0","article-title":"Alcohol drinking in rats treated with 5,7-dihydroxytryptamine: Effect of 8-OH-DPAT and tropisetron (ICS 205-930)","volume":"11","author":"Jankowska","year":"1994","journal-title":"Alcohol"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s00213-003-1395-0","article-title":"5-HT1A agonists: Alcohol drinking in rats and squirrel monkeys","volume":"167","author":"Miczek","year":"2003","journal-title":"Psychopharmacology"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.alcohol.2011.07.007","article-title":"Effects of fenfluramine, 8-OH-DPAT, and tryptophan-enriched diet on the high-ethanol intake by rats bred for susceptibility to stress","volume":"45","author":"West","year":"2011","journal-title":"Alcohol"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/0306-4603(93)90028-8","article-title":"Morphine and human aggression","volume":"18","author":"Berman","year":"1993","journal-title":"Addict. Behav."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1097\/00004850-199007000-00005","article-title":"The Effects of Codeine on Human Aggressive Responding","volume":"5","author":"Spiga","year":"1990","journal-title":"Int. Clin. Psychopharmacol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1159\/000324065","article-title":"Addiction and Brain Reward and Antireward Pathways","volume":"30","author":"Gardner","year":"2011","journal-title":"Adv. Psychosom. Med."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"152","DOI":"10.3389\/fncir.2013.00152","article-title":"Dopamine signaling in reward-related behaviors","volume":"7","author":"Baik","year":"2013","journal-title":"Front. Neural Circuits"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"924","DOI":"10.3389\/fphar.2017.00924","article-title":"Activation of Dopamine D1-D2 Receptor Complex Attenuates Cocaine Reward and Reinstatement of Cocaine-Seeking through Inhibition of DARPP-32, ERK, and \u0394FosB","volume":"8","author":"Hasbi","year":"2018","journal-title":"Front. Pharmacol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1038\/sj.npp.1301062","article-title":"Addiction-related alterations in D1 and D2 dopamine receptor behavioral responses following chronic cocaine self-administration","volume":"32","author":"Edwards","year":"2007","journal-title":"Neuropsychopharmacology"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/0741-8329(93)90037-O","article-title":"Effects of D1 and D2 dopamine receptor agents on ethanol consumption in the high-alcohol-drinking (HAD) line of rats","volume":"10","author":"Dyr","year":"1993","journal-title":"Alcohol"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1007\/s00429-020-02059-w","article-title":"In vivo reduction of striatal D1R by RNA interference alters expression of D1R signaling -related proteins and enhances methamphetamine addiction in male rats","volume":"225","author":"Kreisler","year":"2020","journal-title":"Brain Struct. Funct."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1016\/j.biopsych.2011.06.033","article-title":"Response Perseveration in Stimulant Dependence Is Associated with Striatal Dysfunction and Can Be Ameliorated by a D2\/3 Receptor Agonist","volume":"70","author":"Ersche","year":"2011","journal-title":"Biol. Psychiatry"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"2337","DOI":"10.1007\/s00213-019-05325-w","article-title":"Computational modelling reveals contrasting effects on reinforcement learning and cognitive flexibility in stimulant use disorder and obsessive-compulsive disorder: Remediating effects of dopaminergic D2\/3 receptor agents","volume":"236","author":"Kanen","year":"2019","journal-title":"Psychopharmacology"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1001\/archpsyc.1992.01820110045007","article-title":"Naltrexone and Coping Skills Therapy for Alcohol Dependence","volume":"49","author":"Jaffe","year":"1992","journal-title":"Arch. Gen. Psychiatry"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1001\/archpsyc.1992.01820110040006","article-title":"Naltrexone in the Treatment of Alcohol Dependence","volume":"49","author":"Volpicelli","year":"1992","journal-title":"Arch. Gen. Psychiatry"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1176\/ajp.140.9.1219","article-title":"Naloxone administration in obsessive-compulsive disorder: Report of two cases","volume":"140","author":"Insel","year":"1983","journal-title":"Am. J. Psychiatry"}],"container-title":["International Journal of Environmental Research and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-4601\/18\/9\/4953\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T05:57:41Z","timestamp":1760162261000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-4601\/18\/9\/4953"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,6]]},"references-count":110,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2021,5]]}},"alternative-id":["ijerph18094953"],"URL":"https:\/\/doi.org\/10.3390\/ijerph18094953","relation":{},"ISSN":["1660-4601"],"issn-type":[{"value":"1660-4601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,6]]}}}