{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T15:27:49Z","timestamp":1783351669365,"version":"3.54.6"},"reference-count":42,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2021,5,14]],"date-time":"2021-05-14T00:00:00Z","timestamp":1620950400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Proper hemodynamic management is necessary among post-cardiac arrest patients to improve survival. We aimed to investigate the effects of PiCCO\u2122-guided (pulse index contour cardiac output) hemodynamic management on mortality in post-resuscitation therapy. In this longitudinal analysis of 63 comatose patients after successful cardiopulmonary resuscitation cooled to 32\u201334 \u00b0C, 33 patients received PiCCO\u2122, and 30 were not monitored with PiCCO\u2122. Primary and secondary outcomes were 30 day and 1 year mortality. Kaplan\u2013Meier curves and log-rank tests were used to assess differences in mortality among the groups. Interaction effects to disentangle the relationship between patient\u2019s condition, PiCCO\u2122 application, and mortality were assessed by means of Chi-square tests and logistic regression models. A 30 day mortality was significantly higher among PiCCO\u2122 patients, while 1 year mortality was marginally higher. More severe patient condition per se was not the cause of higher mortality rate in the PiCCO\u2122 group. Patients in better health conditions (without ST-elevation myocardial infarction, without cardiogenic shock, without intra-aortic balloon pump device, or without stroke in prior history) had worse outcomes with PiCCO\u2122-guided therapy. Catecholamine administration worsened both 30 day and 1 year mortality among all patients. Our analysis showed that there was a complex interaction relationship between PiCCO\u2122-guided therapy, patients\u2019 condition, and 30 day mortality for most conditions.<\/jats:p>","DOI":"10.3390\/ijerph18105223","type":"journal-article","created":{"date-parts":[[2021,5,14]],"date-time":"2021-05-14T10:54:22Z","timestamp":1620989662000},"page":"5223","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["An Interaction Effect Analysis of Thermodilution-Guided Hemodynamic Optimization, Patient Condition, and Mortality after Successful Cardiopulmonary Resuscitation"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2012-1136","authenticated-orcid":false,"given":"Enik\u0151","family":"Kov\u00e1cs","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology and Intensive Therapy, Semmelweis University, H-1428 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9ria Anna","family":"Gyarmathy","sequence":"additional","affiliation":[{"name":"Medical Department, EpiConsult Biomedical Consulting and Medical Communication Agency, Dover, DE 19901, USA"},{"name":"Department of Epidemiology, Johns Hopkins University, Baltimore, MD 21218, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7232-9698","authenticated-orcid":false,"given":"D\u00e1vid","family":"Pilecky","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III, Klinikum Passau, 94032 Passau, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Fekete-Gy\u0151r","sequence":"additional","affiliation":[{"name":"Anaesthetics Department, Hillingdon Hospital, London UB 8 3NN, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zs\u00f3fia","family":"Szak\u00e1l-T\u00f3th","sequence":"additional","affiliation":[{"name":"Heart and Vascular Center, Semmelweis University, H-1428 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e1szl\u00f3","family":"Gell\u00e9r","sequence":"additional","affiliation":[{"name":"Heart and Vascular Center, Semmelweis University, H-1428 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9254-2189","authenticated-orcid":false,"given":"Bal\u00e1zs","family":"Hauser","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Intensive Therapy, Semmelweis University, H-1428 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e1nos","family":"G\u00e1l","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Intensive Therapy, Semmelweis University, H-1428 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e9la","family":"Merkely","sequence":"additional","affiliation":[{"name":"Heart and Vascular Center, Semmelweis University, H-1428 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Endre","family":"Zima","sequence":"additional","affiliation":[{"name":"Heart and Vascular Center, Semmelweis University, H-1428 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,5,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.resuscitation.2019.12.042","article-title":"Survival after out-of-hospital cardiac arrest in Europe\u2014Results of the EuReCa TWO study","volume":"148","author":"Grasner","year":"2020","journal-title":"Resuscitation"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.resuscitation.2020.02.044","article-title":"Out-of-hospital cardiac arrest across the World: First report from the International Liaison Committee on Resuscitation (ILCOR)","volume":"152","author":"Kiguchi","year":"2020","journal-title":"Resuscitation"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.resuscitation.2015.07.015","article-title":"European Resuscitation Council Guidelines for Resuscitation 2015: Section 2. 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