{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T21:07:56Z","timestamp":1791320876712,"version":"4.3.1"},"reference-count":122,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2021,5,20]],"date-time":"2021-05-20T00:00:00Z","timestamp":1621468800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Of 218 million working children worldwide, many are suspected to be exposed to hazardous chemicals. This review aims to synthesize reported evidence over the last two decades on chemical exposure and adverse health consequences in children labourers in low- and middle-income Countries (LMIC). Included studies investigated health outcomes related to chemical exposures among child labourers aged 5\u201318 in LMIC. Twenty-three papers were selected for review, focusing on pesticides (n = 5), solvents (n = 3), metals (n = 13) and persistent organic pollutants (POPs) (n = 2). Adverse health effects identified among child labourers included abnormal biomarkers, for example elevated blood and urine chemical concentrations, neurobehavioural deficits and neurological symptoms, mental health issues, oxidative stress and DNA damage, poor growth, asthma, and hypothyroidism. Workplace exposure to chemicals has pernicious health effects on child labourers. Large research gaps exist, in particular for long-term health impacts through chronic conditions and diseases with long latencies. A sizeable disease burden in later life is likely to be directly attributable to chemicals exposures. We urge national and international agencies concerned with child labour and occupational health, to prioritize research and interventions aiming to reduce noxious chemical exposures in workplaces where children are likely to be present.<\/jats:p>","DOI":"10.3390\/ijerph18105496","type":"journal-article","created":{"date-parts":[[2021,5,20]],"date-time":"2021-05-20T11:45:57Z","timestamp":1621511157000},"page":"5496","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["The Health Impacts of Hazardous Chemical Exposures among Child Labourers in Low- and Middle-Income Countries"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6500-6281","authenticated-orcid":false,"given":"Natasha B.","family":"Scott","sequence":"first","affiliation":[{"name":"LSHTM Alumni, London SW1V 4LS, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola S.","family":"Pocock","sequence":"additional","affiliation":[{"name":"Lumos Foundation, London EC3R 8NB, UK"},{"name":"Gender Violence &amp; Health Centre, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,5,20]]},"reference":[{"key":"ref_1","unstructured":"ILO (2020, August 06). Convention C182\u2014Worst Forms of Child Labour Convention, 1999 (No. 182). Available online: https:\/\/www.ilo.org\/dyn\/normlex\/en\/f?p=NORMLEXPUB:12100:0::NO::P12100_ILO_CODE:C182."},{"key":"ref_2","unstructured":"ILO (2017). Global Estimates of Child Labour: Results and Trends, 2012\u20132016, ILO."},{"key":"ref_3","unstructured":"ILO (2011). Children in Hazardous Work: What We Know, What We Need to Do, ILO."},{"key":"ref_4","unstructured":"Avis, W. (2017). Data on the Prevalence of the Worst Forms of Child Labour, Institute of Development Studies. K4D Helpdesk Report."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"17","DOI":"10.4103\/ipj.ipj_105_14","article-title":"Challenges and perspectives of child labor","volume":"27","author":"Filip","year":"2018","journal-title":"Ind. Psychiatry J."},{"key":"ref_6","unstructured":"WHO (2020, August 06). Protecting Children\u2019s Health in a Changing Environment. Report of the 5th Ministerial Conference on Health and the Environment. Available online: http:\/\/www.euro.who.int\/en\/publications\/abstracts\/protecting-childrens-health-in-a-changing-environment.-report-of-the-fifth-ministerial-conference-on-environment-and-health."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1179\/oeh.2010.16.2.195","article-title":"The unique developmental considerations of youth-related work injuries","volume":"16","author":"Sudhinaraset","year":"2010","journal-title":"Int. J. Occup. Environ. Health"},{"key":"ref_8","unstructured":"Organisation for Economic Co-Operation and Development (2020, September 07). The Costs and Benefits of Regulating Chemicals. Available online: http:\/\/www.oecd.org\/environment\/tools-evaluation\/sacame.htm."},{"key":"ref_9","unstructured":"World Health Organization (2006). Principles for Evaluating Health Risks in Children Associated with Exposure to Chemicals, World Health Organization."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"O\u2019Donnell, O., Van Doorslaer, E., and Rosati, F.C. (2002). Child Labour and Health: Evidence and Research Issues. SSRN Electron. J.","DOI":"10.2139\/ssrn.1780320"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"e1765","DOI":"10.1542\/peds.2012-2758","article-title":"Council on Environmental Health Pesticide Exposure in Children","volume":"130","author":"Roberts","year":"2012","journal-title":"Pediatrics"},{"key":"ref_12","unstructured":"United Nations (2010). Mining and Quarrying. Industrial Commodity Statistics Yearbook 2010, United Nations Publications."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1038\/jes.2012.64","article-title":"Exposures of lead to adolescent workers in battery recycling workshops and surrounding communities","volume":"22","author":"Shah","year":"2012","journal-title":"J. Expo. Sci. Environ. Epidemiol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1093\/tropej\/fmr002","article-title":"Assessment of Impact on Health of Children Working in the Garbage Dumping Site in Dhaka, Bangladesh","volume":"57","author":"Lahiry","year":"2011","journal-title":"J. Trop. Pediatr."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1289\/ehp.10713","article-title":"Polybrominated Diphenyl Ethers (PBDEs) and Bioaccumulative Hydroxylated PBDE Metabolites in Young Humans from Managua, Nicaragua","volume":"116","author":"Athanasiadou","year":"2008","journal-title":"Environ. Health Perspect."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1177\/0748233711409483","article-title":"Blood chromium levels of children working in gem-polishing industries in India","volume":"28","author":"Tiwari","year":"2011","journal-title":"Toxicol. Ind. Health"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/S1474-4422(13)70278-3","article-title":"Neurobehavioural effects of developmental toxicity","volume":"13","author":"Grandjean","year":"2014","journal-title":"Lancet Neurol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"613","DOI":"10.4103\/1735-1995.165971","article-title":"A systematic review on the effects of environmental exposure to some organohalogens and phthalates on early puberty","volume":"20","author":"Kelishadi","year":"2015","journal-title":"J. Res. Med Sci."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.scitotenv.2004.01.017","article-title":"Scalp hair analysis as a tool in assessing human exposure to heavy metals (S. Domingos mine, Portugal)","volume":"327","author":"Pereira","year":"2004","journal-title":"Sci. Total Environ."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1002\/bdrc.20029","article-title":"Embryonic and fetal programming of physiological disorders in adulthood","volume":"72","author":"Lau","year":"2004","journal-title":"Birth Defects Res. Part C Embryo Today Rev."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Buralli, R.J., Dultra, A.F., and Ribeiro, H. (2020). Respiratory and Allergic Effects in Children Exposed to Pesticides\u2014A Systematic Review. Int. J. Environ. Res. Public Health, 17.","DOI":"10.3390\/ijerph17082740"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1177\/074823379901500110","article-title":"Immunotoxicity of pesticides: A review","volume":"15","author":"Blakley","year":"1999","journal-title":"Toxicol. Ind. Health"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1289\/ehp.6115","article-title":"Children\u2019s health and the environment: Public health issues and challenges for risk assessment","volume":"112","author":"Landrigan","year":"2004","journal-title":"Environ. Health Perspect."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1179\/oeh.2000.6.1.55","article-title":"Child Labor and Health: Problems and Perspectives","volume":"6","author":"Fassa","year":"2000","journal-title":"Int. J. Occup. Environ. Health"},{"key":"ref_25","first-page":"449","article-title":"Occupational Injuries and Deaths among Younger Workers\u2014United States, 1998\u20132007","volume":"59","author":"Estes","year":"2010","journal-title":"Morb. Mortal. Wkly. Rep."},{"key":"ref_26","first-page":"451","article-title":"Identifying Critical Windows of Exposure for Children\u2019s Health","volume":"108","author":"Selevan","year":"2000","journal-title":"Environ. Health Perspect."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1177\/0972150914564419","article-title":"Poverty, Educational Failure and the Child-Labour Trap: The Indian Experience","volume":"16","author":"Sasmal","year":"2015","journal-title":"Glob. Bus. Rev."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"281","DOI":"10.2190\/HS.40.2.h","article-title":"Unemployment, Informal Work, Precarious Employment, Child Labor, Slavery, and Health Inequalities: Pathways and Mechanisms","volume":"40","author":"Muntaner","year":"2010","journal-title":"Int. J. Health Serv."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.ssci.2018.11.024","article-title":"Occupational safety and health interventions to protect young workers from hazardous work\u2014A scoping review","volume":"113","author":"Ijaz","year":"2019","journal-title":"Saf. Sci."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1001\/archpedi.155.6.704","article-title":"Adolescent Occupational Toxic Exposures","volume":"155","author":"Woolf","year":"2001","journal-title":"Arch. Pediatr. Adolesc. Med."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"106089","DOI":"10.1016\/j.envint.2020.106089","article-title":"The Effect of Occupational Exposure to Welding Fumes on Trachea, Bronchus and Lung Cancer: A Protocol for a Systematic Review and Meta-Analysis from the WHO\/ILO Joint Estimates of the Work-Related Burden of Disease and Injury","volume":"145","author":"Pega","year":"2001","journal-title":"Environ. Int."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0048-9697(01)00762-8","article-title":"A longitudinal study of the effects of long-term exposure to lead among lead battery factory workers in Taiwan (1989\u20131999)","volume":"279","author":"Hsiao","year":"2001","journal-title":"Sci. Total Environ."},{"key":"ref_33","unstructured":"International Occupational Safety and Health Information Centre (2016, March 12). 2011. Chemical Exposure Limits. Available online: https:\/\/www.ilo.org\/safework\/info\/publications\/WCMS_151534."},{"key":"ref_34","unstructured":"Health and Safety Executive (2020). EH4O\/2005 Workplace Exposure Limits, Stationery Office."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Rothenberg, S.J. (2008). Blood Lead Levels in Children. Environ. Health Perspect., 116.","DOI":"10.1289\/ehp.11636"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1007\/s00038-018-1075-9","article-title":"Child labour and health: A systematic review","volume":"63","author":"Kuimi","year":"2018","journal-title":"Int. J. Public Health"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"271","DOI":"10.2105\/AJPH.2005.066829","article-title":"The Health Impact of Child Labor in Developing Countries: Evidence From Cross-Country Data","volume":"97","author":"Roggero","year":"2007","journal-title":"Am. J. Public Health"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1093\/pubmed\/fdy018","article-title":"Child labor and health: A systematic literature review of the impacts of child labor on child\u2019s health in low- and middle-income countries","volume":"41","author":"Ibrahim","year":"2019","journal-title":"J. Public Health"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Shendell, D.G., Noomnual, S., Chishti, S., Allacci, M.S., and Madrigano, J. (2016). Exposures Resulting in Safety and Health Concerns for Child Laborers in Less Developed Countries. J. Environ. Public Health, 3985498.","DOI":"10.1155\/2016\/3985498"},{"key":"ref_40","unstructured":"(2021, April 12). New World Bank Country Classifications by Income Level: 2020\u20132021. Available online: https:\/\/blogs.worldbank.org\/opendata\/new-world-bank-country-classifications-income-level-2020-2021."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Moher, D., Liberati, A., Tetzlaff, J., Altman, D.G., and The PRISMA Group (2009). Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement. PLoS Med., 6.","DOI":"10.1371\/journal.pmed.1000097"},{"key":"ref_42","unstructured":"OSHA (2020, July 25). Occupational Chemical Database. Occupational Safety and Health Administration, Available online: https:\/\/www.osha.gov\/chemicaldata\/."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1136\/adc.2003.048819","article-title":"Biomarkers in paediatric research and practice","volume":"90","author":"Lanphear","year":"2005","journal-title":"Arch. Dis. Child."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/S0003-4878(99)00045-9","article-title":"Identification of determinants of pesticide exposure among Kenyan agricultural workers using empirical modelling","volume":"43","author":"Kromhout","year":"1999","journal-title":"Ann. Occup. Hyg."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/carcin\/20.1.1","article-title":"The light at the end of the tunnel for chemical-specific biomarkers: Daylight or headlight?","volume":"20","author":"Groopman","year":"1999","journal-title":"Carcinogenesis"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1136\/oem.2008.044933","article-title":"Retrospective exposure assessment in environmental epidemiology","volume":"66","author":"Rushton","year":"2009","journal-title":"Occup. Environ. Med."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.neuro.2013.09.003","article-title":"Neurodevelopmental effects in children associated with exposure to organophosphate pesticides: A systematic review","volume":"39","author":"Lucero","year":"2013","journal-title":"Neurotoxicology"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1183\/20734735.0021711","article-title":"Spirometry: Step by step","volume":"8","author":"Moore","year":"2012","journal-title":"Breathe"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.beem.2013.10.003","article-title":"Pitfalls in the measurement and interpretation of thyroid function tests","volume":"27","author":"Koulouri","year":"2013","journal-title":"Best Pract. Res. Clin. Endocrinol. Metab."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1096\/fj.02-0752rev","article-title":"Oxidative DNA damage: Mechanisms, mutation, and disease","volume":"17","author":"Cooke","year":"2003","journal-title":"FASEB J."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/0014-4827(88)90265-0","article-title":"A simple technique for quantitation of low levels of DNA damage in individual cells","volume":"175","author":"Singh","year":"1988","journal-title":"Exp. Cell Res."},{"key":"ref_52","unstructured":"Critical Appraisal Skills Programme (2020, July 25). 2018. Home\u2014CASP\u2014Critical Appraisal Skills Programme. CASP Systematic Review Checklist. Available online: https:\/\/casp-uk.net\/."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"e011458","DOI":"10.1136\/bmjopen-2016-011458","article-title":"Development of a critical appraisal tool to assess the quality of cross-sectional studies (AXIS)","volume":"6","author":"Downes","year":"2016","journal-title":"BMJ Open"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Liberati, A., Altman, D.G., Tetzlaff, J., Mulrow, C., G\u00f8tzsche, P.C., Ioannidis, J.P.A., Clarke, M., Devereaux, P.J., Kleijnen, J., and Moher, D. (2009). The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: Explanation and elaboration. PLoS Med., 6.","DOI":"10.2427\/5768"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"13117","DOI":"10.3390\/ijerph111213117","article-title":"Chlorpyrifos Exposure and Respiratory Health among Adolescent Agricultural Workers","volume":"11","author":"Callahan","year":"2014","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Ismail, A.A., Bonner, M.R., Hendy, O., Rasoul, G.A., Wang, K., Olson, J.R., and Rohlman, D.S. (2017). Comparison of neurological health outcomes between two adolescent cohorts exposed to pesticides in Egypt. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0172696"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1177\/0748233713485883","article-title":"Occupational and Environmental Lead Exposure to Adolescent Workers in Battery Recycling Workshops","volume":"31","author":"Kazi","year":"2015","journal-title":"Toxicol. Ind. Health"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"137549","DOI":"10.1016\/j.scitotenv.2020.137549","article-title":"Occupational exposure of lead and cadmium on adolescent and adult workers of battery recycling and welding workshops: Adverse impact on health","volume":"720","author":"Baloch","year":"2020","journal-title":"Sci. Total Environ."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1289\/ehp.1104678","article-title":"Adverse Health Effects of Child Labor: High Exposure to Chromium and Oxidative DNA Damage in Children Manufacturing Surgical Instruments","volume":"120","author":"Sughis","year":"2012","journal-title":"Environ. Health Perspect."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/j.neuro.2008.06.009","article-title":"Effects of Occupational Pesticide Exposure on Children Applying Pesticides","volume":"29","author":"Mechael","year":"2008","journal-title":"Neurotoxicology"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1111\/1471-0528.15199","article-title":"Randomised controlled trials\u2014the gold standard for effectiveness research","volume":"125","author":"Hariton","year":"2018","journal-title":"BJOG Int. J. Obstet. Gynaecol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.ntt.2006.09.028","article-title":"Age related effects of pesticide exposure on neurobehavioral performance of adolescent farm workers in Brazil","volume":"29","author":"Eckerman","year":"2007","journal-title":"Neurotoxicol. Teratol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1007\/s11011-014-9565-9","article-title":"Characterizing exposures and neurobehavioral performance in Egyptian adolescent pesticide applicators","volume":"29","author":"Rohlman","year":"2014","journal-title":"Metab. Brain Dis."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1016\/j.neuro.2009.08.003","article-title":"Neurobehavioral Impairment in Children Occupationally Exposed to Mixed Organic Solvents","volume":"30","author":"Saddik","year":"2009","journal-title":"Neurotoxicology"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/S0161-813X(03)00053-6","article-title":"Evidence of Neurotoxicity in Working Children in Lebanon","volume":"24","author":"Saddik","year":"2003","journal-title":"Neurotoxicology"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1177\/003335490512000614","article-title":"The Effects of Solvent Exposure on Memory and Motor Dexterity in Working Children","volume":"120","author":"Saddik","year":"2005","journal-title":"Public Health Rep."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1136\/oem.2004.015503","article-title":"Health of children working in small urban industrial shops","volume":"62","author":"Nuwayhid","year":"2005","journal-title":"Occup. Environ. Med."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"e2976","DOI":"10.1097\/MD.0000000000002976","article-title":"Environmental and Occupational Lead Exposure Among Children in Cairo, Egypt","volume":"95","author":"Moawad","year":"2016","journal-title":"Medicine"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1177\/0748233717754163","article-title":"Lead induced oxidative DNA damage in battery-recycling child workers from Bangladesh","volume":"34","author":"Arif","year":"2018","journal-title":"Toxicol. Ind. Health"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.envres.2005.10.002","article-title":"The effect of long-term low-dose lead exposure on thyroid function in adolescents","volume":"101","author":"Dundar","year":"2006","journal-title":"Environ. Res."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.envres.2008.01.009","article-title":"Mercury as a serious health hazard for children in gold mining areas","volume":"107","author":"Lettmeier","year":"2008","journal-title":"Environ. Res."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.envpol.2017.04.026","article-title":"Health hazards of child labor in the leather products and surgical instrument manufacturing industries of Sialkot, Pakistan","volume":"226","author":"Junaid","year":"2017","journal-title":"Environ. Pollut."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.ijheh.2014.02.002","article-title":"Metal exposure in schoolchildren and working children. A urinary biomonitoring study from Lahore, Pakistan","volume":"217","author":"Sughis","year":"2014","journal-title":"Int. J. Hyg. Environ. Health"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1579\/0044-7447(2006)35[109:POPICW]2.0.CO;2","article-title":"Persistent Organochlorine Pollutants in Children Working at a Waste-Disposal Site and in Young Females with High Fish Consumption in Managua, Nicaragua","volume":"35","author":"Cuadra","year":"2006","journal-title":"AMBIO"},{"key":"ref_75","unstructured":"American Conference of Governmental Industrial Hygienists (2006). TLVs and BEIs: Based on the Documentation of the Threshold Limit Values for Chemical Substances and Physical Agents & Biological Exposure Indices, ACGIH."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1080\/15459624.2011.601710","article-title":"Review: Lead Exposure in Battery Manufacturing and Recycling in Developing Countries and Among Children in Nearby Communities","volume":"8","author":"Gottesfeld","year":"2011","journal-title":"J. Occup. Environ. Hyg."},{"key":"ref_77","unstructured":"Rees, N., and Fuller, R. (2020). The Toxic Truth: Children\u2019 s Exposure to Lead Pollution Undermines a Generation of Future Potential, UNICEF."},{"key":"ref_78","unstructured":"ILO (2020, September 23). Work-Related Fatalities Reach 2 Million Annually. Available online: https:\/\/www.ilo.org\/global\/about-the-ilo\/newsroom\/news\/WCMS_007789\/lang--en\/index.htm."},{"key":"ref_79","unstructured":"International Agency for Research on Cancer (2021). Arsenic, Metals, Fibres and Dusts: A Review of Human Carcinogens\u2014Part C, WHO."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1080\/00984100290071018","article-title":"Is hexavalent chromium carcinogenic via ingestion? A weight-of-evidence review","volume":"65","author":"Proctor","year":"2002","journal-title":"J. Toxicol. Environ. Health Part A"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1574-695X.2002.tb00596.x","article-title":"Effects of chromium on the immune system","volume":"34","author":"Shrivastava","year":"2002","journal-title":"FEMS Immunol. Med. Microbiol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1136\/oemed-2019-105786","article-title":"Cancer incidence among workers with blood lead measurements in two countries","volume":"76","author":"Steenland","year":"2019","journal-title":"Occup. Environ. Med."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/s10552-019-01140-y","article-title":"Cancer incidence in the Agricultural Health Study after 20 years of follow-up","volume":"30","author":"Lerro","year":"2019","journal-title":"Cancer Causes Control"},{"key":"ref_84","unstructured":"WHO (2020, September 13). Lead Poisoning and Health. Available online: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/lead-poisoning-and-health."},{"key":"ref_85","unstructured":"WHO (2020, September 13). Exposure to Cadmium: A Major Public Health Concern. Preventing Disease Through Healthy Environments, 3\u20136. Available online: http:\/\/www.who.int\/ipcs\/features\/cadmium.pdf."},{"key":"ref_86","first-page":"460508","article-title":"Mercury Toxicity and Treatment: A Review of the Literature","volume":"2012","author":"Bernhoft","year":"2011","journal-title":"J. Environ. Public Health"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1111\/andr.12178","article-title":"Burden of disease and costs of exposure to endocrine disrupting chemicals in the European Union: An updated analysis","volume":"4","author":"Trasande","year":"2016","journal-title":"Andrology"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1007\/s00787-016-0864-z","article-title":"Child labour in low- and middle-income countries and its consequences for mental health: A systematic literature review of epidemiologic studies","volume":"25","author":"Sturrock","year":"2016","journal-title":"Eur. Child Adolesc. Psychiatry"},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Campion, J. (2019). Public Mental Health: Evidence, Practice and Commissioning, Royal Society for Public Health.","DOI":"10.1007\/978-3-319-70554-5_31"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/j.neuro.2012.01.004","article-title":"Neurobehavioral and neurodevelopmental effects of pesticide exposures","volume":"33","author":"London","year":"2012","journal-title":"Neurotoxicology"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1002\/em.20419","article-title":"Multipronged evaluation of genotoxicity in Indian petrol-pump workers","volume":"49","author":"Pandey","year":"2008","journal-title":"Environ. Mol. Mutagen."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/s11356-008-0087-z","article-title":"Chromosomal aberrations and DNA damage in human populations exposed to the processing of electronics waste","volume":"16","author":"Liu","year":"2008","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0002-9149(02)03144-2","article-title":"Role of oxidative stress in atherosclerosis","volume":"91","author":"Harrison","year":"2003","journal-title":"Am. J. Cardiol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/35041687","article-title":"Oxidants, oxidative stress and the biology of ageing","volume":"408","author":"Finkel","year":"2000","journal-title":"Nature"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1093\/aje\/kwx224","article-title":"Childhood Residential and Agricultural Pesticide Exposures in Relation to Adult-Onset Rheumatoid Arthritis in Women","volume":"187","author":"Parks","year":"2018","journal-title":"Am. J. Epidemiol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1289\/ehp.02110563","article-title":"Economic gains resulting from the reduction in children\u2019s exposure to lead in the United States","volume":"110","author":"Grosse","year":"2002","journal-title":"Environ. Health Perspect."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1093\/jeea\/jvz059","article-title":"Perverse Consequences of Well Intentioned Regulation: Evidence from India\u2019s Child Labor Ban","volume":"18","author":"Bharadwaj","year":"2019","journal-title":"J. Eur. Econ. Assoc."},{"key":"ref_98","unstructured":"(2020, December 02). The Consequences of Banning Child Labor. Available online: https:\/\/blogs.worldbank.org\/developmenttalk\/consequences-banning-child-labor."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/BF01537339","article-title":"Children\u2019s participation in household labor: Child socialization versus the need for household labor","volume":"21","author":"Blair","year":"1992","journal-title":"J. Youth Adolesc."},{"key":"ref_100","unstructured":"O\u2019Kane, C., Barros, O., and Meslaoui, N. (2017). It\u2019s Time to Talk!\u2014Children\u2019s Views on Children\u2019s Work, Terre des Hommes."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1177\/0907568299006001003","article-title":"Combatting Child Labour","volume":"6","author":"Woodhead","year":"1999","journal-title":"Childhood"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1093\/heapol\/16.1.21","article-title":"Early entrance to the job market and its effect on adult health: Evidence from Brazil","volume":"16","author":"Kassouf","year":"2001","journal-title":"Health Policy Plan."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.worlddev.2018.05.001","article-title":"Effects of public policy on child labor: Current knowledge, gaps, and implications for program design","volume":"110","author":"Dammert","year":"2018","journal-title":"World Dev."},{"key":"ref_104","unstructured":"(2020, December 02). Home. Available online: http:\/\/www.mymeproject.org\/."},{"key":"ref_105","unstructured":"Schmidt, L., Garratt, A., and Fitzpatrick, R. (2000). Instruments for Mental Health: A Review Report from the Patient-reported Health Instruments Group to the Department of Health, Patient-Reported Health Instruments Group."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1023\/A:1016693417166","article-title":"Elementary school-aged children\u2019s reports of their health: A cognitive interviewing study","volume":"10","author":"Rebok","year":"2001","journal-title":"Qual. Life Res."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"43","DOI":"10.3922\/j.psns.2009.1.07","article-title":"Behavioral Observation Used to Estimate Pesticide Exposure for Farm Workers in Brazil","volume":"2","author":"Eckerman","year":"2009","journal-title":"Psychol. Neurosci."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1136\/oem.2008.041566","article-title":"Is farm-related job title an adequate surrogate for pesticide exposure in occupational cancer epidemiology?","volume":"66","author":"Macfarlane","year":"2009","journal-title":"Occup. Environ. Med."},{"key":"ref_109","unstructured":"CDC (2020, September 13). 2009. Fourth National Report on Human Exposure to Environmental Chemicals, Available online: https:\/\/www.cdc.gov\/exposurereport\/pdf\/fourthreport.pdf."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1289\/ehp.7917","article-title":"A Critical Review of Biomarkers Used for Monitoring Human Exposure to Lead: Advantages, Limitations, and Future Needs","volume":"113","author":"Barbosa","year":"2005","journal-title":"Environ. Health Perspect."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1016\/j.scitotenv.2010.11.033","article-title":"Biomonitorization of cadmium, chromium, manganese, nickel and lead in whole blood, urine, axillary hair and saliva in an occupationally exposed population","volume":"409","author":"Gil","year":"2011","journal-title":"Sci. Total Environ."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.envint.2008.09.003","article-title":"Non-invasive matrices in human biomonitoring: A review","volume":"35","author":"Esteban","year":"2009","journal-title":"Environ. Int."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1111\/j.1365-2214.2006.00702.x","article-title":"Exposure of young children working on Mexican tobacco plantations to organophosphorous and carbamic pesticides, indicated by cholinesterase depression","volume":"33","author":"Gamlin","year":"2007","journal-title":"Child Care Health Dev."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.neuro.2006.10.006","article-title":"Neurobehavioral Performance of Adult and Adolescent Agricultural Workers","volume":"28","author":"Rohlman","year":"2007","journal-title":"Neurotoxicology"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/s40572-015-0064-x","article-title":"Cumulative Chemical Exposures During Pregnancy and Early Development","volume":"2","author":"Mitro","year":"2015","journal-title":"Curr. Environ. Health Rep."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.shaw.2018.12.003","article-title":"Occupational Safety and Health Among Young Workers in the Nordic Countries: A Systematic Literature Review","volume":"10","author":"Hanvold","year":"2019","journal-title":"Saf. Health Work"},{"key":"ref_117","unstructured":"(2020, September 28). Haz-Map\u2014Hazardous Chemicals and Occupational Diseases Information. Available online: https:\/\/haz-map.com\/."},{"key":"ref_118","unstructured":"(2020, September 28). CISDOC Database. Available online: https:\/\/www.ilo.org\/dyn\/cisdoc2\/cismain.home?p_lang=en."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"105039","DOI":"10.1016\/j.envint.2019.105039","article-title":"RoB-SPEO: A tool for assessing risk of bias in studies estimating the prevalence of exposure to occupational risk factors from the WHO\/ILO Joint Estimates of the Work-related Burden of Disease and Injury","volume":"135","author":"Pega","year":"2020","journal-title":"Environ. Int."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"605","DOI":"10.2105\/AJPH.93.4.605","article-title":"Acute Pesticide-Related Illnesses Among Working Youths, 1988\u20131999","volume":"93","author":"Calvert","year":"2003","journal-title":"Am. J. Public Health"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1179\/oeh.2010.16.2.175","article-title":"Child labor and acute pesticide poisoning in Nicaragua: Failure to comply with children\u2019s rights","volume":"16","author":"Corriols","year":"2010","journal-title":"Int. J. Occup. Environ. Health"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1056\/NEJMp030025","article-title":"Exposure to Lead in Children\u2014How Low Is Low Enough?","volume":"348","author":"Rogan","year":"2003","journal-title":"N. Engl. J. Med."}],"container-title":["International Journal of Environmental Research and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-4601\/18\/10\/5496\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:04:57Z","timestamp":1760162697000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-4601\/18\/10\/5496"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,20]]},"references-count":122,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2021,5]]}},"alternative-id":["ijerph18105496"],"URL":"https:\/\/doi.org\/10.3390\/ijerph18105496","relation":{},"ISSN":["1660-4601"],"issn-type":[{"value":"1660-4601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,20]]}}}