{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T20:32:25Z","timestamp":1770237145350,"version":"3.49.0"},"reference-count":31,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2021,6,17]],"date-time":"2021-06-17T00:00:00Z","timestamp":1623888000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007397","name":"Univerzita Karlova v Praze","doi-asserted-by":"publisher","award":["PROGRES Q40\/13"],"award-info":[{"award-number":["PROGRES Q40\/13"]}],"id":[{"id":"10.13039\/100007397","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003243","name":"Ministerstvo Zdravotnictv\u00ed Cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["MH CZ - DRO (UHHK, 00179906)"],"award-info":[{"award-number":["MH CZ - DRO (UHHK, 00179906)"]}],"id":[{"id":"10.13039\/501100003243","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Introduction: Oral lichen planus (OLP) is a chronic inflammatory disease with an unknown etiology rating among oral potentially malignant disorder. The aim of the study was to determine the epidemiological and clinical characteristics of the patients with OLP and rate of malignant transformation. Patients and methods: Data were obtained from the medical records of 271 patients referred to the Oral Medicine Unit at the University Hospital in Hradec Kr\u00e1lov\u00e9 diagnosed with oral lichen planus in the period of 2003\u20132020. The records were retrospectively analyzed. The following clinical data were retrieved from the medical charts: gender, age, systemic diseases, alcohol and tobacco consumption, localization\/clinical appearance of lesions, distribution of the lesions, presence of the symptoms, treatment provided and malignant transformation. Results: A total of 271 charts of patients with confirmed diagnosis of OLP were retrospectively analyzed, of whom, 66.4% (180\/271) were women and 33.6% (91\/271) were men. The mean age of the patients was 56.0 (18.2\u201385.0) years. The median follow-up of all patients was 15.2 months. Overall, 2 patients (2\/271, 0.74%) meeting the above-mentioned criteria for malignant transformation were identified during the follow-up period. Both patients suffered from erosive type OLP and developed squamous cell carcinoma of the tongue. Conclusions: This retrospective study is in concordance with other studies showing the similar profile and clinical features of the patients with OLP. Malignant transformation rate was 0.74%.<\/jats:p>","DOI":"10.3390\/ijerph18126525","type":"journal-article","created":{"date-parts":[[2021,6,17]],"date-time":"2021-06-17T11:20:26Z","timestamp":1623928826000},"page":"6525","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["The Characteristics of Patients with Oral Lichen Planus and Malignant Transformation\u2014A Retrospective Study of 271 Patients"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0212-4328","authenticated-orcid":false,"given":"Vladim\u00edra","family":"Radochov\u00e1","sequence":"first","affiliation":[{"name":"Department of Dentistry, Faculty of Medicine and University Hospital in Hradec Kr\u00e1lov\u00e9, Charles University, Sokolsk\u00e1 581, 50005 Hradec Kr\u00e1lov\u00e9, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8346-1835","authenticated-orcid":false,"given":"Romana","family":"Koberov\u00e1 Ivan\u010dakov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Dentistry, Faculty of Medicine and University Hospital in Hradec Kr\u00e1lov\u00e9, Charles University, Sokolsk\u00e1 581, 50005 Hradec Kr\u00e1lov\u00e9, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8119-0640","authenticated-orcid":false,"given":"Ond\u0159ej","family":"Heneberk","sequence":"additional","affiliation":[{"name":"Department of Dentistry, Faculty of Medicine and University Hospital in Hradec Kr\u00e1lov\u00e9, Charles University, Sokolsk\u00e1 581, 50005 Hradec Kr\u00e1lov\u00e9, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Radovan","family":"Slez\u00e1k","sequence":"additional","affiliation":[{"name":"Department of Dentistry, Faculty of Medicine and University Hospital in Hradec Kr\u00e1lov\u00e9, Charles University, Sokolsk\u00e1 581, 50005 Hradec Kr\u00e1lov\u00e9, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,6,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1007\/s00403-016-1667-2","article-title":"Oral lichen planus: A literature review and update","volume":"308","author":"Alrashdan","year":"2016","journal-title":"Arch. 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