{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T19:57:04Z","timestamp":1788292624422,"version":"build-2803163510"},"reference-count":29,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2021,6,19]],"date-time":"2021-06-19T00:00:00Z","timestamp":1624060800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["GINOP-2.3.2-15-2016-00062"],"award-info":[{"award-number":["GINOP-2.3.2-15-2016-00062"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004895","name":"European Social Fund","doi-asserted-by":"publisher","award":["EFOP-3.6.1-16-2016-00022"],"award-info":[{"award-number":["EFOP-3.6.1-16-2016-00022"]}],"id":[{"id":"10.13039\/501100004895","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003825","name":"Magyar Tudom\u00e1nyos Akad\u00e9mia","doi-asserted-by":"publisher","award":["J\u00e1nos Bolyai Research Scholarship"],"award-info":[{"award-number":["J\u00e1nos Bolyai Research Scholarship"]}],"id":[{"id":"10.13039\/501100003825","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012550","name":"Nemzeti Kutat\u00e1si, Fejleszt\u00e9si \u00e9s Innovaci\u00f3s Alap","doi-asserted-by":"publisher","award":["\u00daNKP-20-5"],"award-info":[{"award-number":["\u00daNKP-20-5"]}],"id":[{"id":"10.13039\/501100012550","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015498","name":"Ministry for Innovation and Technology","doi-asserted-by":"publisher","award":["TKP2020-IKA-04"],"award-info":[{"award-number":["TKP2020-IKA-04"]}],"id":[{"id":"10.13039\/501100015498","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Sarcopenia, defined as loss of muscle mass and strength, develops gradually with aging or after chronic disease. Efforts are ongoing to identify the best interventions that can slow down or stop sarcopenia. Nutrition-based interventions and exercise therapy may be beneficial; however, pharmacotherapy also could play a role. The effect of ACE inhibitors on physical performance is controversial. The present study investigates the impact of functional training on sarcopenia in the presence or absence of ACEi in elderly females. A total of 35 women over 65 years of age were selected for two groups on the basis that they were taking ACEi (n = 18) or not (n = 17). All subjects conducted a training program two times a week for 6 months. We examined various factors related to sarcopenia. After completing the short physical performance battery (SPPB) test, we found a significant improvement after 6 months of functional training. SPPB values of the ACEi group were significantly lower at the beginning of the study; however, we observed no difference between the SPPB results of the two groups after the training period. We conducted further studies to measure posture and spine mobility. Our Schober and Cobra test results revealed significantly improved spine mobility (both flexor and extensor) in both groups after 6 months of training. Furthermore, the grip strength of the hands, studied by an electric dynamometer, was significantly improved in both groups at the end of the training period. Our results indicated that functional training may improve body composition and muscle strength in patients diagnosed with sarcopenia. Furthermore, ACEi may be a helpful additional therapy in older adult patients suffering from severe sarcopenia.<\/jats:p>","DOI":"10.3390\/ijerph18126594","type":"journal-article","created":{"date-parts":[[2021,6,20]],"date-time":"2021-06-20T22:00:02Z","timestamp":1624226402000},"page":"6594","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Effects of Functional Training on Sarcopenia in Elderly Women in the Presence or Absence of ACE Inhibitors"],"prefix":"10.3390","volume":"18","author":[{"given":"Marianna","family":"Mile","sequence":"first","affiliation":[{"name":"Institute of Sport Sciences, University of Debrecen, 4032 Debrecen, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e1szl\u00f3","family":"Balogh","sequence":"additional","affiliation":[{"name":"Institute of Sport Sciences, University of Debrecen, 4032 Debrecen, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e1bor","family":"Papp","sequence":"additional","affiliation":[{"name":"Institute of Sport Sciences, University of Debrecen, 4032 Debrecen, Hungary"},{"name":"Department of Internal Medicine, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f3zsef M\u00e1rton","family":"Pucsok","sequence":"additional","affiliation":[{"name":"Institute of Sport Sciences, University of Debrecen, 4032 Debrecen, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krisztina","family":"Szab\u00f3","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilla","family":"Barna","sequence":"additional","affiliation":[{"name":"Institute of Sport Sciences, University of Debrecen, 4032 Debrecen, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zolt\u00e1n","family":"Csiki","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Istv\u00e1n","family":"Lekli","sequence":"additional","affiliation":[{"name":"Institute of Healthcare Industry, University of Debrecen, 4032 Debrecen, Hungary"},{"name":"Department of Pharmacology, Faculty of Pharmacy, University of Debrecen, 4032 Debrecen, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,6,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1152\/physrev.00061.2017","article-title":"Sarcopenia: Aging-related loss of muscle mass and function","volume":"99","author":"Larsson","year":"2019","journal-title":"Physiol. Rev."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1093\/ageing\/afq034","article-title":"Sarcopenia: European consensus on definition and diagnosis: Report of the European Working Group on Sarcopenia in Older People","volume":"39","author":"Baeyens","year":"2010","journal-title":"Age Ageing"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s13063-017-2390-9","article-title":"Leucine and ACE inhibitors as therapies for sarcopenia (LACE trial): Study protocol for a randomised controlled trial","volume":"19","author":"Band","year":"2018","journal-title":"Trials"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1007\/s40266-016-0396-8","article-title":"Angiotensin-converting enzyme inhibitors and parameters of sarcopenia: Relation to muscle mass, strength and function: Data from the Berlin Aging Study-II (BASE-II)","volume":"33","author":"Spira","year":"2016","journal-title":"Drugs Aging"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1503\/cmaj.061339","article-title":"Effect of perindopril on physical function in elderly people with functional impairment: A randomized controlled trial","volume":"177","author":"Sumukadas","year":"2007","journal-title":"CMAJ"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1111\/j.1532-5415.2004.52265.x","article-title":"Antihypertensive medications and differences in muscle mass in older persons: The Health, Aging and Body Composition Study","volume":"52","author":"Onder","year":"2004","journal-title":"J. Am. Geriatr. Soc."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1007\/s40266-018-0566-y","article-title":"Pharmacological interventions to improve muscle mass, muscle strength and physical performance in older people: An umbrella review of systematic reviews and meta-analyses","volume":"35","author":"Beckwee","year":"2018","journal-title":"Drugs Aging"},{"key":"ref_8","first-page":"224","article-title":"TRX Suspension Training: A New Functional Training Approach for Older Adults\u2014Development, Training Control and Feasibility","volume":"8","author":"Gaedtke","year":"2015","journal-title":"Int. J. Exerc. Sci."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"3237","DOI":"10.1589\/jpts.27.3237","article-title":"Effect of proprioceptive neuromuscular facilitation integration pattern and swiss ball training on pain and balance in elderly patients with chronic back pain","volume":"27","author":"Young","year":"2015","journal-title":"J. Phys. Ther. Sci."},{"key":"ref_10","first-page":"410","article-title":"Validation and use of performance measures of functioning in a non-disabled older population: MacArthur studies of successful aging","volume":"6","author":"Guralnik","year":"1994","journal-title":"Aging (Milano)"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"85","DOI":"10.11005\/jbm.2020.27.2.85","article-title":"Measurement and Interpretation of Handgrip Strength for Research on Sarcopenia and Osteoporosis","volume":"27","author":"Lee","year":"2020","journal-title":"J. Bone Metab."},{"key":"ref_12","unstructured":"Clarkson, H.M. (2000). Musculoskeletal Assessment: Joint Range of Motion and Manual Muscle Strength, Lippincott Williams & Wilkins."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/BF03324691","article-title":"Relationship between the occiput-wall distance and physical performance in the elderly: A cross sectional study","volume":"19","author":"Pedone","year":"2007","journal-title":"Aging Clin. Exp. Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1093\/gerona\/gls221","article-title":"Efficacy of whey protein supplementation on resistance exercise-induced changes in lean mass, muscle strength, and physical function in mobility-limited older adults","volume":"68","author":"Chale","year":"2013","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.jamda.2012.05.020","article-title":"Protein supplementation increases muscle mass gain during prolonged resistance-type exercise training in frail elderly people: A randomized, double-blind, placebo-controlled trial","volume":"13","author":"Tieland","year":"2012","journal-title":"J. Am. Med. Dir. Assoc."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1007\/s12603-018-1090-9","article-title":"Effects of resistance exercise training on cognitive function and physical performance in cognitive frailty: A randomized controlled trial","volume":"22","author":"Yoon","year":"2018","journal-title":"J. Nutr. Health Aging"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1519\/JPT.0000000000000105","article-title":"Influences of resistance training on physical function in older, obese men and women with sarcopenia","volume":"41","author":"Stoever","year":"2018","journal-title":"J. Geriatr. Phys. Ther."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Moriyama, Y., Hara, M., Aratani, S., Ishikawa, H., Kono, K., and Tamaki, M. (2019). The association between six month intra-dialytic resistance training and muscle strength or physical performance in patients with maintenance hemodialysis: A multicenter retrospective observational study. BMC Nephrol., 20.","DOI":"10.1186\/s12882-019-1375-1"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.cger.2016.08.002","article-title":"Pathogenesis and management of sarcopenia","volume":"33","author":"Dhillon","year":"2017","journal-title":"Clin. Geriatr. Med."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1002\/jcsm.12411","article-title":"Sarcopenia and its association with falls and fractures in older adults: A systematic review and meta-analysis","volume":"10","author":"Yeung","year":"2019","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1007\/s12603-016-0843-6","article-title":"Prospective associations of low muscle mass and function with 10-year falls risk, incident fracture and mortality in community-dwelling older adults","volume":"21","author":"Balogun","year":"2017","journal-title":"J. Nutr. Health Aging"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1111\/j.1532-5415.2005.53257.x","article-title":"Type and intensity of activity and risk of mobility limitation: The mediating role of muscle parameters","volume":"53","author":"Visser","year":"2005","journal-title":"J. Am. Geriatr. Soc."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1093\/gerona\/glt142","article-title":"Do ACE inhibitors improve the response to exercise training in functionally impaired older adults? A randomized controlled trial","volume":"69","author":"Sumukadas","year":"2014","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/S1043-2760(00)00310-6","article-title":"The ACE I\/D polymorphism and human physical performance","volume":"11","author":"Woods","year":"2000","journal-title":"Trends Endocrinol. Metab."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1589\/jpts.28.547","article-title":"Angiotensin-II blockage, muscle strength, and exercise capacity in physically independent older adults","volume":"28","author":"Coelho","year":"2016","journal-title":"J. Phys. Ther. Sci."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1007\/s40266-016-0417-7","article-title":"ACE inhibitors and sarcopenia: Covering all the BASEs?","volume":"33","author":"Springer","year":"2016","journal-title":"Drugs Aging"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.2174\/138161206777442137","article-title":"Effects of ACE inhibitors on skeletal muscle","volume":"12","author":"Onder","year":"2006","journal-title":"Curr. Pharm. Des."},{"key":"ref_28","first-page":"12","article-title":"Regular exercise may restore certain age-related alterations of adaptive immunity and rebalance immune regulation","volume":"16","author":"Papp","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1111\/j.1532-5415.2012.04045.x","article-title":"Angiotensin-converting enzyme inhibitor use by older adults is associated with greater functional responses to exercise","volume":"60","author":"Buford","year":"2012","journal-title":"J. Am. Geriatr. Soc."}],"container-title":["International Journal of Environmental Research and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-4601\/18\/12\/6594\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:18:58Z","timestamp":1760163538000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-4601\/18\/12\/6594"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,19]]},"references-count":29,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2021,6]]}},"alternative-id":["ijerph18126594"],"URL":"https:\/\/doi.org\/10.3390\/ijerph18126594","relation":{},"ISSN":["1660-4601"],"issn-type":[{"value":"1660-4601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,19]]}}}