{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T22:42:01Z","timestamp":1774737721385,"version":"3.50.1"},"reference-count":31,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2021,6,23]],"date-time":"2021-06-23T00:00:00Z","timestamp":1624406400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007771","name":"Medical University of Silesia","doi-asserted-by":"publisher","award":["PCN-1-003\/K\/0\/K"],"award-info":[{"award-number":["PCN-1-003\/K\/0\/K"]}],"id":[{"id":"10.13039\/100007771","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Clinical studies have been performed to evaluate the thermal response of topical hyperbaric oxygen therapy (THBOT) in patients suffering from hard-to-heal wounds diagnosed as venous leg ulcers located on their lower extremities. It was found that this therapy leads to a temperature decrease in areas around the wound. Moreover, a minor temperature differentiation between all areas was seen in the third period of topical hyperbaric oxygen therapy (THBOT) that may suggest that microcirculation and thermoregulation improvement start the healing process. On the other hand, the results of the conducted studies seem to prove that thermal imaging may provide a safe and effective method of analyzing wound healing of hard-to-heal wounds being treated with THBOT. This is the first study that tries to show the possibilities of a very new method by evaluating treatment of hard-to-heal wounds using thermal imaging, similar to the hyperbaric oxygen therapy effects evaluated by thermal imaging and described previously. However, the first clinical results showed a decrease in temperature due to the THBOT session and some qualitative similarities in the decrease in temperature differentiation between the studied areas and the temperature effects obtained due to hyperbaric oxygen therapy.<\/jats:p>","DOI":"10.3390\/ijerph18136737","type":"journal-article","created":{"date-parts":[[2021,6,23]],"date-time":"2021-06-23T04:33:28Z","timestamp":1624422808000},"page":"6737","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Thermal Effects of Topical Hyperbaric Oxygen Therapy in Hard-to-Heal Wounds\u2014A Pilot Study"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1325-0098","authenticated-orcid":false,"given":"Teresa","family":"Kasprzyk-Kucewicz","sequence":"first","affiliation":[{"name":"Faculty of Science and Technology, University of Silesia, 40-007 Katowice, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3998-7677","authenticated-orcid":false,"given":"Armand","family":"Cholewka","sequence":"additional","affiliation":[{"name":"Faculty of Science and Technology, University of Silesia, 40-007 Katowice, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beata","family":"Englisz-Jurgielewicz","sequence":"additional","affiliation":[{"name":"Faculty of Science and Technology, University of Silesia, 40-007 Katowice, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Romualda","family":"Mucha","sequence":"additional","affiliation":[{"name":"Department and Clinic of Internal Medicine, Angiology and Physical Medicine, Specialistic Hospital No. 2 in Bytom, Batorego 15 St., 41-902 Bytom, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3366-5183","authenticated-orcid":false,"given":"Micha\u0142","family":"Relich","sequence":"additional","affiliation":[{"name":"Faculty of Science and Technology, University of Silesia, 40-007 Katowice, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marek","family":"Kawecki","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Technical-Humanistic Academy, 43-300 Bielsko-Bia\u0142a, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karolina","family":"Siero\u0144","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine, School of Health Sciences in Katowice, Medical University of Silesia, Medyk\u00f3w Street 12, 40-752 Katowice, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrycja","family":"Onak","sequence":"additional","affiliation":[{"name":"Med Holding S.A. Specialist Hospital Named after prof. E. Micha\u0142owski, Strzelecka 9 St., 40-073 Katowice, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6939-9898","authenticated-orcid":false,"given":"Agata","family":"Stanek","sequence":"additional","affiliation":[{"name":"Department and Clinic of Internal Medicine, Angiology and Physical Medicine, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Batorego 15 St., 41-902 Bytom, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,6,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Pocock, G., Richards, C.D., and Richards, D.A. (2017). The respiratory system. Human Physiology, Oxford University Press. [5th ed.].","DOI":"10.1093\/hesc\/9780198737223.003.0017"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Herman, I.P. (2016). 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