{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T15:03:59Z","timestamp":1788793439266,"version":"build-2803163510"},"reference-count":78,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2021,6,25]],"date-time":"2021-06-25T00:00:00Z","timestamp":1624579200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Several available studies have already analyzed the systemic effects of endocrine-disrupting chemicals (EDCs) on fertile woman and neonatal outcomes, but little is still known in humans about the precise mechanisms of interference of these compounds with the endometrial receptivity. There is consistent evidence that continuous and prolonged exposure to EDCs is a risk factor for reduced fertility and fecundity in women. Preliminary studies on mammalian models provide robust evidence about this issue and could help gynecologists worldwide to prevent long term injury caused by EDCs on human fertility. In this systematic review, we aimed to systematically summarize all available data about EDC effects on blastocyst endometrial implantation. We performed a systematic review using PubMed\u00ae\/MEDLINE\u00ae to summarize all in vivo studies, carried out on mice models, analyzing the molecular consequences of the prolonged exposure of EDC on the implantation process. 34 studies carried out on mouse models were included. Primary effects of EDC were a reduction of the number of implantation sites and pregnancy rates, particularly after BPA and phthalate exposure. Furthermore, the endometrial expression of estrogen (ER) and progesterone receptors (PR), as well as their activation pathways, is compromised after EDC exposure. Finally, the expression of the primary endometrial markers of receptivity (such as MUC1, HOXA10, Inn and E-cadherin) after EDC contact was analyzed. In conclusion EDC deeply affect blastocyst implantation in mouse model. Several players of the implantation mechanism are strongly influenced by the exposure to different categories of EDC.<\/jats:p>","DOI":"10.3390\/ijerph18136840","type":"journal-article","created":{"date-parts":[[2021,6,25]],"date-time":"2021-06-25T11:07:40Z","timestamp":1624619260000},"page":"6840","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Effects of Endocrine-Disrupting Chemicals on Endometrial Receptivity and Embryo Implantation: A Systematic Review of 34 Mouse Model Studies"],"prefix":"10.3390","volume":"18","author":[{"given":"Donatella","family":"Caserta","sequence":"first","affiliation":[{"name":"Gynecology Division, Department of Medical and Surgical Sciences and Translational Medicine, Sant\u2019Andrea University Hospital, Sapienza University of Rome, Via di Grottarossa 1035, 00189 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavia","family":"Costanzi","sequence":"additional","affiliation":[{"name":"Gynecology Division, Department of Medical and Surgical Sciences and Translational Medicine, Sant\u2019Andrea University Hospital, Sapienza University of Rome, Via di Grottarossa 1035, 00189 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Paola","family":"De Marco","sequence":"additional","affiliation":[{"name":"Gynecology Division, Department of Medical and Surgical Sciences and Translational Medicine, Sant\u2019Andrea University Hospital, Sapienza University of Rome, Via di Grottarossa 1035, 00189 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa","family":"Di Benedetto","sequence":"additional","affiliation":[{"name":"Gynecology Division, Department of Medical and Surgical Sciences and Translational Medicine, Sant\u2019Andrea University Hospital, Sapienza University of Rome, Via di Grottarossa 1035, 00189 Rome, Italy"},{"name":"PhD Program in \u201cTranslational Medicine and Oncology\u201d, Department of Medical and Surgical Sciences and Translational Medicine, Psychology and Medicine Faculty, Sapienza University of Rome, Via di Grottarossa 1035, 00189 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleonora","family":"Matteucci","sequence":"additional","affiliation":[{"name":"Gynecology Division, Department of Medical and Surgical Sciences and Translational Medicine, Sant\u2019Andrea University Hospital, Sapienza University of Rome, Via di Grottarossa 1035, 00189 Rome, Italy"},{"name":"PhD Program in \u201cTranslational Medicine and Oncology\u201d, Department of Medical and Surgical Sciences and Translational Medicine, Psychology and Medicine Faculty, Sapienza University of Rome, Via di Grottarossa 1035, 00189 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Assorgi","sequence":"additional","affiliation":[{"name":"Gynecology Division, Department of Medical and Surgical Sciences and Translational Medicine, Sant\u2019Andrea University Hospital, Sapienza University of Rome, Via di Grottarossa 1035, 00189 Rome, Italy"},{"name":"PhD Program in \u201cTranslational Medicine and Oncology\u201d, Department of Medical and Surgical Sciences and Translational Medicine, Psychology and Medicine Faculty, Sapienza University of Rome, Via di Grottarossa 1035, 00189 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Clara","family":"Pacilli","sequence":"additional","affiliation":[{"name":"Gynecology Division, Department of Medical and Surgical Sciences and Translational Medicine, Sant\u2019Andrea University Hospital, Sapienza University of Rome, Via di Grottarossa 1035, 00189 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aris Raad","family":"Besharat","sequence":"additional","affiliation":[{"name":"Gynecology Division, Department of Medical and Surgical Sciences and Translational Medicine, Sant\u2019Andrea University Hospital, Sapienza University of Rome, Via di Grottarossa 1035, 00189 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filippo","family":"Bellati","sequence":"additional","affiliation":[{"name":"Gynecology Division, Department of Medical and Surgical Sciences and Translational Medicine, Sant\u2019Andrea University Hospital, Sapienza University of Rome, Via di Grottarossa 1035, 00189 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilary","family":"Ruscito","sequence":"additional","affiliation":[{"name":"Gynecology Division, Department of Medical and Surgical Sciences and Translational Medicine, Sant\u2019Andrea University Hospital, Sapienza University of Rome, Via di Grottarossa 1035, 00189 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,6,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1093\/humrep\/dem046","article-title":"International estimates of infertility prevalence and treatment-seeking: Potential need and demand for infertility medical care","volume":"22","author":"Boivin","year":"2007","journal-title":"Hum. Reprod."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"16.e1","DOI":"10.1016\/j.fertnstert.2008.09.046","article-title":"A public health focus on infertility prevention, detection, and management","volume":"93","author":"Macaluso","year":"2010","journal-title":"Fertil. Steril."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1016\/j.fertnstert.2009.09.009","article-title":"International Committee for Monitoring Assisted Reproductive Technology (ICMART) and the World Health Organization (WHO) revised glossary of ART terminology","volume":"92","author":"Adamson","year":"2009","journal-title":"Fertil. Steril."},{"key":"ref_4","first-page":"39","article-title":"Infertility in the Global South: Raising awareness and generating insights for policy and practice","volume":"9","author":"Gerrits","year":"2017","journal-title":"Facts Views Vis. ObGyn"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"6","DOI":"10.4172\/2325-9795.1000121","article-title":"Epidemiology and Etiology of Infertility in Iran, Systematic Review and Meta-Analysis","volume":"2","author":"Parsanezhad","year":"2013","journal-title":"J. Womens Health Issues Care"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1056\/NEJMra000763","article-title":"Implantation and the Survival of Early Pregnancy","volume":"345","author":"Norwitz","year":"2001","journal-title":"N. Engl. J. Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1053\/beog.2000.0116","article-title":"The cell biological basis of human implantation","volume":"14","author":"Aplin","year":"2000","journal-title":"Best Pr. Res. Clin. Obstet. Gynaecol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1136\/bmj.321.7272.1301","article-title":"The endometrium and embryo implantation","volume":"321","author":"Horne","year":"2000","journal-title":"BMJ"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.fertnstert.2019.02.009","article-title":"What exactly is endometrial receptivity?","volume":"111","author":"Lessey","year":"2019","journal-title":"Fertil. Steril."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/1477-7827-2-48","article-title":"Trophoblast-uterine interactions at implantation","volume":"2","author":"Aplin","year":"2004","journal-title":"Reprod. Biol. Endocrinol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1093\/humrep\/14.suppl_2.17","article-title":"MUC-1 glycosylation in endometrium: Possible roles of the apical glycocalyx at implantation","volume":"14","author":"Aplin","year":"1999","journal-title":"Hum. Reprod."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1210\/er.2003-0020","article-title":"Molecular Cues to Implantation","volume":"25","author":"Dey","year":"2004","journal-title":"Endocr. Rev."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/nrg1808","article-title":"Roadmap to embryo implantation: Clues from mouse models","volume":"7","author":"Wang","year":"2006","journal-title":"Nat. Rev. Genet."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.cytogfr.2009.07.001","article-title":"Leukemia inhibitory factor and interleukin-11: Critical regulators in the establishment of pregnancy","volume":"20","author":"Paiva","year":"2009","journal-title":"Cytokine Growth Factor Rev."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"3639","DOI":"10.1210\/endo.136.8.7628404","article-title":"Expression and steroid hormonal control of Muc-1 in the mouse uterus","volume":"136","author":"Surveyor","year":"1995","journal-title":"Endocrinology"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1095\/biolreprod64.2.590","article-title":"Human Endometrial Mucin MUC1 Is Up-Regulated by Progesterone and Down-Regulated In Vitro by the Human Blastocyst1","volume":"64","author":"Meseguer","year":"2001","journal-title":"Biol. Reprod."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1172\/JCI1597","article-title":"HOXA10 is expressed in response to sex steroids at the time of implantation in the human endometrium","volume":"101","author":"Taylor","year":"1998","journal-title":"J. Clin. Investig."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"119","DOI":"10.5653\/cerm.2011.38.3.119","article-title":"Role of endometrial immune cells in implantation","volume":"38","author":"Lee","year":"2011","journal-title":"Clin. Exp. Reprod. Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0009-2797(97)03767-8","article-title":"Estrogenic effects of nonylphenol on pS2, ER and MUC1 gene expression in human breast cancer cells-MCF-7","volume":"104","author":"Ren","year":"1997","journal-title":"Chem. Interact."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1093\/humupd\/dmm025","article-title":"Impact of endocrine disruptor chemicals in gynaecology","volume":"14","author":"Caserta","year":"2007","journal-title":"Hum. Reprod. Updat."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1289\/ehp.1306695","article-title":"State of the Science of Endocrine Disruptors","volume":"121","author":"Birnbaum","year":"2013","journal-title":"Environ. Health Perspect."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/S0300-483X(02)00468-7","article-title":"Hazard identification and risk assessment of endocrine disrupting chemicals with regard to developmental effects","volume":"181","author":"Mantovani","year":"2002","journal-title":"Toxicology"},{"key":"ref_23","first-page":"73","article-title":"Endocrine disruptor compounds and their role in the developmental programming of the repro-ductive axis","volume":"59","author":"Zambrano","year":"2007","journal-title":"Rev. Investig. Clin."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1002\/bdrc.21137","article-title":"The effect of maternal exposure to endocrine disrupting chemicals on fetal and neonatal development: A review on the major concerns","volume":"108","author":"Mallozzi","year":"2016","journal-title":"Birth Defects Res. Part C Embryo Today Rev."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1080\/09513590.2018.1473362","article-title":"Maternal exposure to endocrine disruptors and placental transmission: A pilot study","volume":"34","author":"Caserta","year":"2018","journal-title":"Gynecol. Endocrinol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"e81","DOI":"10.1016\/j.fertnstert.2007.12.036","article-title":"Science linking environmental contaminant exposures with fertility and reproductive health impacts in the adult female","volume":"89","author":"Mendola","year":"2008","journal-title":"Fertil. Steril."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1095\/biolreprod.109.078543","article-title":"Effects of Neonatal Exposure to Bisphenol A on Steroid Regulation of Vascular Endothelial Growth Factor Expression and Endothelial Cell Proliferation in the Adult Rat Uterus1","volume":"82","author":"Bosquiazzo","year":"2010","journal-title":"Biol. Reprod."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"5848","DOI":"10.1210\/en.2008-0651","article-title":"Developmental Exposure to Bisphenol A Impairs the Uterine Response to Ovarian Steroids in the Adult","volume":"149","author":"Varayoud","year":"2008","journal-title":"Endocrinology"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1210\/en.2009-1037","article-title":"Neonatal Exposure to Bisphenol A Alters Rat Uterine Implantation-Associated Gene Expression and Reduces the Number of Implantation Sites","volume":"152","author":"Varayoud","year":"2011","journal-title":"Endocrinology"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.reprotox.2015.01.011","article-title":"Developmental exposure to bisphenol A alters the differentiation and functional response of the adult rat uterus to estrogen treatment","volume":"52","author":"Vigezzi","year":"2015","journal-title":"Reprod. Toxicol."},{"key":"ref_31","first-page":"28","article-title":"Disrupted Organization of RFamide Pathways in the Hypothalamus Is Associated with Advanced Puberty in Female Rats Neonatally Exposed to bisphenol A","volume":"87","author":"Todd","year":"2012","journal-title":"Biol. Reprod."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1095\/biolreprod.109.078261","article-title":"Neonatal Bisphenol-A Exposure Alters Rat Reproductive Development and Ovarian Morphology Without Impairing Activation of Gonadotropin-Releasing Hormone Neurons","volume":"81","author":"Adewale","year":"2009","journal-title":"Biol. Reprod."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Tran, D.N., Jung, E.-M., Ahn, C., Lee, J.-H., Yoo, Y.-M., and Jeung, E.-B. (2018). Effects of Bisphenol A and 4-tert-Octylphenol on Embryo Implantation Failure in Mouse. Int. J. Environ. Res. Public Health, 15.","DOI":"10.20944\/preprints201805.0256.v1"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/j.fertnstert.2017.12.003","article-title":"Environmentally relevant levels of bisphenol A affect uterine decidualization and embryo implantation through the estrogen receptor\/serum and glucocorticoid-regulated kinase 1\/epithelial sodium ion channel \u03b1-subunit pathway in a mouse model","volume":"109","author":"Yuan","year":"2018","journal-title":"Fertil. Steril."},{"key":"ref_35","first-page":"1","article-title":"Bisphenol A exposure during early pregnancy impairs uterine spiral artery remodeling and provokes intrauterine growth restriction in mice","volume":"8","author":"Meyer","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.reprotox.2010.06.006","article-title":"Bisphenol-A exposure during the period of blastocyst implantation alters uterine morphology and perturbs measures of estrogen and progesterone receptor expression in mice","volume":"30","author":"Berger","year":"2010","journal-title":"Reprod. Toxicol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1210\/en.2015-2031","article-title":"Chronic Exposure to Bisphenol A Affects Uterine Function During Early Pregnancy in Mice","volume":"157","author":"Li","year":"2016","journal-title":"Endocrinology"},{"key":"ref_38","first-page":"434","article-title":"Preimplantation exposure to bisphenol A (BPA) affects embryo transport, preimplantation embryo development, and uterine receptivity in mice","volume":"32","author":"Xiao","year":"2011","journal-title":"Reprod. Toxicol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.reprotox.2017.02.009","article-title":"Perinatal administration of bisphenol A alters the expression of tight junction proteins in the uterus and reduces the implantation rate","volume":"69","author":"Morimoto","year":"2017","journal-title":"Reprod. Toxicol."},{"key":"ref_40","first-page":"20035","article-title":"Bisphenol a influences blastocyst implantation via regulating integrin \u03b23 and trophinin expression levels","volume":"8","author":"Pan","year":"2015","journal-title":"Int. J. Clin. Exp. Med."},{"key":"ref_41","first-page":"8720","article-title":"Inhibitory effects of preimplantation exposure to bisphenol-A on blastocyst devel-opment and implantation","volume":"8","author":"Pan","year":"2015","journal-title":"Int. J. Clin. Exp. Med."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.cbi.2015.05.012","article-title":"Stress lowers the threshold dose at which bisphenol A disrupts blastocyst implantation, in conjunction with decreased uterine closure and e-cadherin","volume":"237","author":"Borman","year":"2015","journal-title":"Chem. Interact."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.reprotox.2019.04.005","article-title":"Parental perinatal exposure to bisphenol A reduces the threshold to disrupt blastocyst implantation via decreasing talin, occudin and E-cadherin levels","volume":"86","author":"Morimoto","year":"2019","journal-title":"Reprod. Toxicol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.reprotox.2012.09.008","article-title":"Disruption of blastocyst implantation by triclosan in mice: Impacts of repeated and acute doses and combination with bisphenol-A","volume":"34","author":"Crawford","year":"2012","journal-title":"Reprod. Toxicol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.reprotox.2008.06.007","article-title":"Impact of acute bisphenol-A exposure upon intrauterine implantation of fertilized ova and urinary levels of progesterone and 17\u03b2-estradiol","volume":"26","author":"Berger","year":"2008","journal-title":"Reprod. Toxicol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1002\/jbm.a.30029","article-title":"Reproductive toxic effect of bisphenol A dimethacrylate in mice","volume":"69","author":"Darmani","year":"2004","journal-title":"J. Biomed. Mater. Res."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"2611","DOI":"10.1016\/S0024-3205(01)01341-8","article-title":"Evaluation of developmental toxicity in rats exposed to the environmental estrogen bisphenol A during pregnancy","volume":"69","author":"Kim","year":"2001","journal-title":"Life Sci."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.jhazmat.2012.09.038","article-title":"Effects of DEHP on endometrial receptivity and embryo implantation in pregnant mice","volume":"241","author":"Li","year":"2012","journal-title":"J. Hazard. Mater."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0890-6238(99)00066-0","article-title":"Effects of dibutyl phthalate on reproductive function in pregnant and pseudopregnant rats","volume":"14","author":"Ema","year":"2000","journal-title":"Reprod. Toxicol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S0890-6238(01)00131-9","article-title":"Effects of monobutyl phthalate on reproductive function in pregnant and pseudopregnant rats","volume":"15","author":"Ema","year":"2001","journal-title":"Reprod. Toxicol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1177\/1933719117711258","article-title":"Effect of 2,3\u2032,4,4\u2032,5-Pentachlorobiphenyl Exposure on Endometrial Receptivity and the Methylation of HOXA10","volume":"25","author":"Qu","year":"2017","journal-title":"Reprod. Sci."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.fct.2014.04.021","article-title":"Exposure of mice to benzo(a)pyrene impairs endometrial receptivity and reduces the number of implantation sites during early pregnancy","volume":"69","author":"Zhao","year":"2014","journal-title":"Food Chem. Toxicol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.mce.2014.11.028","article-title":"Neonatal exposure to low doses of endosulfan induces implantation failure and disrupts uterine functional differentiation at the pre-implantation period in rats","volume":"401","author":"Milesi","year":"2015","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.reprotox.2017.12.001","article-title":"Effect of beta-cypermethrin exposure on embryo implantation in mice","volume":"76","author":"Zhou","year":"2018","journal-title":"Reprod. Toxicol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1002\/jat.3922","article-title":"In utero and lactational exposure to triclocarban: Reproductive effects on female rat offspring","volume":"40","author":"Costa","year":"2019","journal-title":"J. Appl. Toxicol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.bbrc.2020.04.051","article-title":"In vitro and in vivo impairment of embryo implantation by commonly used fungicide Mancozeb","volume":"527","author":"Akthar","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1111\/j.1365-2605.2007.00838.x","article-title":"Endocrine-disrupting properties in vivo of widely used azole fungicides","volume":"31","author":"Taxvig","year":"2008","journal-title":"Int. J. Androl."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1038\/nm.3012","article-title":"Mechanisms of implantation: Strategies for successful pregnancy","volume":"18","author":"Cha","year":"2012","journal-title":"Nat. Med."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"11162","DOI":"10.1073\/pnas.90.23.11162","article-title":"Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene","volume":"90","author":"Lubahn","year":"1993","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/B978-0-12-800095-3.00010-9","article-title":"Long-Lasting Effects of Neonatal Bisphenol A Exposure on the Implantation Process","volume":"94","author":"Varayoud","year":"2014","journal-title":"Vitam. Horm."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mce.2017.05.028","article-title":"Uterine ER\u03b1 epigenetic modifications are induced by the endocrine disruptor endosulfan in female rats with impaired fertility","volume":"454","author":"Milesi","year":"2017","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1210\/me.2015-1142","article-title":"Uterine Epithelial Estrogen Receptor-\u03b1 Controls Decidualization via a Paracrine Mechanism","volume":"29","author":"Pawar","year":"2015","journal-title":"Mol. Endocrinol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1080\/10520295.2017.1305500","article-title":"A morphological study of uterine alterations in mice due to exposure to cadmium","volume":"92","author":"Weller","year":"2017","journal-title":"Biotech. Histochem."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1002\/bdrb.20147","article-title":"NTP-CERHR expert panel report on the reproductive and developmental toxicity of bisphenol A","volume":"83","author":"Chapin","year":"2008","journal-title":"Birth Defects Res. Part B Dev. Reprod. Toxicol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"11119","DOI":"10.1002\/jcp.27762","article-title":"Benzo(a)pyrene inhibits endometrial cell apoptosis in early pregnant mice via the WNT5A pathway","volume":"234","author":"Yi","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"135945","DOI":"10.1016\/j.scitotenv.2019.135945","article-title":"Cypermethrin exposure during perinatal period affects fetal development and impairs reproductive functions of F1 female rats","volume":"707","author":"Singh","year":"2020","journal-title":"Sci. Total. Environ."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1095\/biolreprod55.5.1098","article-title":"Spatial and Temporal Analyses of Integrin and Muc-1 Expression in Porcine Uterine Epithelium and Trophectoderm in Vivo","volume":"55","author":"Bowen","year":"1996","journal-title":"Biol. Reprod."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"4441","DOI":"10.1074\/jbc.M111.286138","article-title":"Studies Using an in Vitro Model Show Evidence of Involvement of Epithelial-Mesenchymal Transition of Human Endometrial Epithelial Cells in Human Embryo Implantation","volume":"287","author":"Uchida","year":"2012","journal-title":"J. Biol. Chem."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.reprotox.2007.03.006","article-title":"Effects of some endocrine disruptors on the proliferation and viability of human endometrial endothelial cells in vitro","volume":"23","author":"Bredhult","year":"2007","journal-title":"Reprod. Toxicol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"2006","DOI":"10.1210\/me.2004-0388","article-title":"Chromatin Immunoprecipitation Analysis of Gene Expression in the Rat Uterusin Vivo: Estrogen-Induced Recruitment of Both Estrogen Receptor \u03b1 and Hypoxia-Inducible Factor 1 to the Vascular Endothelial Growth Factor Promoter","volume":"19","author":"Kazi","year":"2005","journal-title":"Mol. Endocrinol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1093\/humupd\/dml004","article-title":"Endometrial receptivity markers, the journey to successful embryo implantation","volume":"12","author":"Achache","year":"2006","journal-title":"Hum. Reprod. Updat."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1210\/er.2014-1045","article-title":"Cyclic Decidualization of the Human Endometrium in Reproductive Health and Failure","volume":"35","author":"Gellersen","year":"2014","journal-title":"Endocr. Rev."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"017","DOI":"10.1055\/s-0029-1242989","article-title":"Endometrial Decidualization: Of Mice and Men","volume":"28","author":"Ramathal","year":"2010","journal-title":"Semin. Reprod. Med."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"R109","DOI":"10.1530\/JOE-17-0023","article-title":"Exposure to endocrine disruptors during adulthood: Consequences for female fertility","volume":"233","author":"Rattan","year":"2017","journal-title":"J. Endocrinol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1093\/humupd\/dmy032","article-title":"Program collaborators for Environmental influences on Child Health Outcomes Exposure to non-persistent chemicals in consumer products and fecundability: A systematic review","volume":"25","author":"Hipwell","year":"2018","journal-title":"Hum. Reprod. Updat."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1289\/ehp.1104307","article-title":"Urinary Bisphenol A Concentrations and Implantation Failure among Women Undergoing in Vitro Fertilization","volume":"120","author":"Ehrlich","year":"2012","journal-title":"Environ. Health Perspect."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2013\/510703","article-title":"Correlation of Endocrine Disrupting Chemicals Serum Levels and White Blood Cells Gene Expression of Nuclear Receptors in a Population of Infertile Women","volume":"2013","author":"Caserta","year":"2013","journal-title":"Int. J. Endocrinol."},{"key":"ref_78","first-page":"460","article-title":"Sexually dimorphic sterility phenotypes in HoxalO-deficient mice","volume":"374","author":"Satokata","year":"1995","journal-title":"Nat. Cell Biol."}],"container-title":["International Journal of Environmental Research and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-4601\/18\/13\/6840\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:24:17Z","timestamp":1760163857000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-4601\/18\/13\/6840"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,25]]},"references-count":78,"journal-issue":{"issue":"13","published-online":{"date-parts":[[2021,7]]}},"alternative-id":["ijerph18136840"],"URL":"https:\/\/doi.org\/10.3390\/ijerph18136840","relation":{},"ISSN":["1660-4601"],"issn-type":[{"value":"1660-4601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,25]]}}}