{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T10:52:47Z","timestamp":1770461567726,"version":"3.49.0"},"reference-count":280,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2021,6,28]],"date-time":"2021-06-28T00:00:00Z","timestamp":1624838400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Although cancer is traditionally considered a genetic disease, the epigenetic abnormalities, including DNA hypermethylation, histone deacetylation, and\/or microRNA dysregulation, have been demonstrated as a hallmark of cancer. Compared with gene mutations, aberrant epigenetic changes occur more frequently, and cellular epigenome is more susceptible to change by environmental factors. Excess cancer risks are positively associated with exposure to occupational and environmental chemical carcinogens, including those from gasoline combustion exhausted in vehicles. Of note, previous studies proposed particulate matter index (PMI) as a measure for gasoline sooting tendency, and showed that, compared with the other molecules in gasoline, 1,2,4\u2013Trimethylbenzene, 2\u2013methylnaphthalene and toluene significantly contribute to PMI of the gasoline blends. Mechanistically, both epigenome and genome are important in carcinogenicity, and the genotoxicity of chemical agents has been thoroughly studied. However, less effort has been put into studying the epigenotoxicity. Moreover, as the blending of ethanol into gasoline substitutes for carcinogens, like benzene, toluene, xylene, butadiene, and polycyclic aromatic hydrocarbons, etc., a reduction of secondary aromatics has been achieved in the atmosphere. This may lead to diminished cancer initiation and progression through altered cellular epigenetic landscape. The present review summarizes the most important findings in the literature on the association between exposures to carcinogens from gasoline combustion, cancer epigenetics and the potential epigenetic impacts of biofuels.<\/jats:p>","DOI":"10.3390\/ijerph18136930","type":"journal-article","created":{"date-parts":[[2021,6,28]],"date-time":"2021-06-28T22:43:06Z","timestamp":1624920186000},"page":"6930","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["An Assessment on Ethanol-Blended Gasoline\/Diesel Fuels on Cancer Risk and Mortality"],"prefix":"10.3390","volume":"18","author":[{"given":"Steffen","family":"Mueller","sequence":"first","affiliation":[{"name":"Energy Resources Center, The University of Illinois at Chicago, Chicago, IL 60607, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gail","family":"Dennison","sequence":"additional","affiliation":[{"name":"The Hormel Institute, University of Minnesota, Austin, MN 55912, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shujun","family":"Liu","sequence":"additional","affiliation":[{"name":"The Hormel Institute, University of Minnesota, Austin, MN 55912, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,6,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Rossner, P., Cervena, T., Vojtisek\u2013Lom, M., Vrbova, K., Ambroz, A., Novakova, Z., Elzeinova, F., Margaryan, H., Beranek, V., and Pechout, M. (2019). The Biological Effects of Complete Gasoline Engine Emissions Exposure in a 3D Human Airway Model (MucilAir(TM)) and in Human Bronchial Epithelial Cells (BEAS\u20132B). Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20225710"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.mrrev.2007.08.003","article-title":"Air pollution combustion emissions: Characterization of causative agents and mechanisms associated with cancer, reproductive, and cardiovascular effects","volume":"636","author":"Lewtas","year":"2007","journal-title":"Mutat. Res. Mutat. Res."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"24192","DOI":"10.1007\/s11356-018-2476-2","article-title":"Effect of anhydrous ethanol\/gasoline blends on performance and exhaust emissions of spark-ignited non-road engines","volume":"25","author":"Ribeiro","year":"2018","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1093\/mutage\/get042","article-title":"Genotoxicity biomarkers associated with exposure to traffic and near-road atmospheres: A review","volume":"28","author":"DeMarini","year":"2013","journal-title":"Mutagenesis"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"3803","DOI":"10.1021\/acs.chemrev.5b00067","article-title":"Formation of Urban Fine Particulate Matter","volume":"115","author":"Zhang","year":"2015","journal-title":"Chem. Rev."},{"key":"ref_6","first-page":"367","article-title":"The contribution of outdoor air pollution sources to premature mortality on a global scale","volume":"525","author":"Lelieveld","year":"2015","journal-title":"Nat. Cell Biol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.envint.2014.12.007","article-title":"Populations potentially exposed to traffic\u2013related air pollution in seven world cities","volume":"78","author":"Su","year":"2015","journal-title":"Environ. Int."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.envres.2016.11.015","article-title":"Traffic\u2013derived particulate matter exposure and histone H3 modification: A repeated measures study","volume":"153","author":"Zheng","year":"2017","journal-title":"Environ. Res."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/S0140-6736(00)02653-2","article-title":"Public-health impact of outdoor and traffic-related air pollution: A European assessment","volume":"356","author":"Kaiser","year":"2000","journal-title":"Lancet"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1289\/ehp.1002353","article-title":"Lung Cancer Incidence and Long-Term Exposure to Air Pollution from Traffic","volume":"119","author":"Andersen","year":"2011","journal-title":"Environ. Heal. Perspect."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1289\/ehp.9587","article-title":"A Case\u2013Control Analysis of Exposure to Traffic and Acute Myocardial Infarction","volume":"115","author":"Tonne","year":"2007","journal-title":"Environ. Heal. Perspect."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1289\/ehp.1510089","article-title":"Exposure to Traffic-Related Air Pollution in Relation to Progression in Physical Disability among Older Adults","volume":"124","author":"Weuve","year":"2016","journal-title":"Environ. Heal. Perspect."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.envint.2018.12.052","article-title":"Children environmental exposure to particulate matter and polycyclic aromatic hydrocarbons and biomonitoring in school environments: A review on indoor and outdoor exposure levels, major sources and health impacts","volume":"124","author":"Oliveira","year":"2019","journal-title":"Environ. Int."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"927","DOI":"10.3109\/10715762.2012.663084","article-title":"Hazardous components and health effects of atmospheric aerosol particles: Reactive oxygen species, soot, polycyclic aromatic compounds and allergenic proteins","volume":"46","author":"Shiraiwa","year":"2012","journal-title":"Free Radic Res."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1021\/acs.chemrestox.9b00035","article-title":"Population\u2013Based Analysis of DNA Damage and Epigenetic Effects of 1,3\u2013Butadiene in the Mouse","volume":"32","author":"Lewis","year":"2019","journal-title":"Chem. Res. Toxicol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1136\/oemed-2017-104987","article-title":"Associations between occupational exposure to benzene, toluene and xylene and risk of lung cancer in Montreal","volume":"75","author":"Warden","year":"2018","journal-title":"Occup. Environ. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1016\/S1470-2045(17)30832-X","article-title":"Carcinogenicity of benzene","volume":"18","author":"Loomis","year":"2017","journal-title":"Lancet Oncol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1136\/oemed-2018-105058","article-title":"Occupational exposure to benzene, toluene, xylene and styrene and risk of prostate cancer in a population-based study","volume":"75","author":"Parent","year":"2018","journal-title":"Occup. Environ. Med."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Sha, Y., Zhou, W., Yang, Z., Zhu, X., Xiang, Y., Li, T., Zhu, D., and Yang, X. (2014). Changes in Poly(ADP-Ribosyl)ation Patterns in Workers Exposed to BTX. PLoS One, 9.","DOI":"10.1371\/journal.pone.0106146"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.mrrev.2008.10.001","article-title":"Improving prediction of chemical carcinogenicity by considering multiple mechanisms and applying toxicogenomic approaches","volume":"681","author":"Guyton","year":"2009","journal-title":"Mutat. Res. Mutat. Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1093\/toxsci\/kfv040","article-title":"Polycyclic Aromatic Hydrocarbons: From Metabolism to Lung Cancer","volume":"145","author":"Moorthy","year":"2015","journal-title":"Toxicol. Sci."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Mizumoto, A., Ohashi, S., Hirohashi, K., Amanuma, Y., Matsuda, T., and Muto, M. (2017). Molecular Mechanisms of Acetaldehyde-Mediated Carcinogenesis in Squamous Epithelium. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18091943"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1093\/toxsci\/kfu191","article-title":"Epigenetic events determine tissue-specific toxicity of inhalational exposure to the genotoxic chemical 1,3-butadiene in male C57BL\/6J mice","volume":"142","author":"Chappell","year":"2014","journal-title":"Toxicol. Sci."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"3401","DOI":"10.3892\/mmr.2016.4955","article-title":"Benzene exposure is associated with epigenetic changes","volume":"13","author":"Fenga","year":"2016","journal-title":"Mol. Med. Rep."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"S9","DOI":"10.1186\/1476-069X-10-S1-S9","article-title":"Occupational cancer in developed countries","volume":"10","author":"Blair","year":"2011","journal-title":"Environ. Health"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/S0140-6736(77)90074-5","article-title":"Leukaemia in benzene workers","volume":"2","author":"Infante","year":"1977","journal-title":"Lancet"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1196\/annals.1371.081","article-title":"Benzene exposure and multiple myeloma: A detailed meta\u2013analysis of benzene cohort studies","volume":"1076","author":"Infante","year":"2006","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"12483","DOI":"10.1074\/jbc.RA119.008666","article-title":"Benzoquinone, a leukemogenic metabolite of benzene, catalytically inhibits the protein tyrosine phosphatase PTPN2 and alters STAT1 signaling","volume":"294","author":"Duval","year":"2019","journal-title":"J. Biol. Chem."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2647","DOI":"10.1002\/ijc.32202","article-title":"Residential ambient benzene exposure in the United States and subsequent risk of hematologic malignancies","volume":"145","author":"Teras","year":"2019","journal-title":"Int. J. Cancer"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1093\/carcin\/bgy042","article-title":"Adductomic signatures of benzene exposure provide insights into cancer induction","volume":"39","author":"Grigoryan","year":"2018","journal-title":"Carcinogenesis"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Chen, J., Zheng, Z., Chen, Y., Li, J., Qian, S., Shi, Y., Sun, L., Han, Y., Zhang, S., and Yu, K. (2016). Histone Deacetylase Inhibitors Trichostatin A and MCP30 Relieve Benzene\u2013Induced Hematotoxicity via Restoring Topoisomerase IIalpha. PLoS One, 11.","DOI":"10.1371\/journal.pone.0153330"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.toxlet.2019.12.028","article-title":"Up\u2013regulation of DNMT3b contributes to HOTAIRM1 silencing via DNA hypermethylation in cells transformed by long\u2013term exposure to hydroquinone and workers exposed to benzene","volume":"322","author":"Zhang","year":"2020","journal-title":"Toxicol. Lett."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/s00204-018-2333-6","article-title":"Benzene metabolite 1,2,4\u2013benzenetriol changes DNA methylation and histone acetylation of erythroid\u2013specific genes in K562 cells","volume":"93","author":"Yu","year":"2019","journal-title":"Arch. Toxicol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.mrfmmm.2015.06.011","article-title":"Environmental and chemotherapeutic agents induce breakage at genes involved in leukemia\u2013causing gene rearrangements in human hematopoietic stem\/progenitor cells","volume":"779","author":"Thys","year":"2015","journal-title":"Mutat. Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1093\/carcin\/bgr297","article-title":"Current understanding of the mechanism of benzene\u2013induced leukemia in humans: Implications for risk assessment","volume":"33","author":"McHale","year":"2012","journal-title":"Carcinogenesis"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1158\/0008-5472.CAN-06-2995","article-title":"Changes in DNA methylation patterns in subjects exposed to low\u2013dose benzene","volume":"67","author":"Bollati","year":"2007","journal-title":"Cancer Res."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1158\/1055-9965.EPI-06-1057","article-title":"Benzene exposure and risk of non\u2013Hodgkin lymphoma","volume":"16","author":"Smith","year":"2007","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1002\/1097-0142(19880801)62:3<635::AID-CNCR2820620332>3.0.CO;2-3","article-title":"A population\u2013based case\u2013control study of childhood leukemia in Shanghai","volume":"62","author":"Shu","year":"1988","journal-title":"Cancer"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/S1047-2797(03)00037-1","article-title":"Occupational history and exposure and the risk of adult leukemia in Shanghai","volume":"13","author":"Adegoke","year":"2003","journal-title":"Ann. Epidemiol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1097\/01.ede.0000082001.05563.e0","article-title":"Leukemia risk associated with low\u2013level benzene exposure","volume":"14","author":"Glass","year":"2003","journal-title":"Epidemiology"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.cbi.2005.03.006","article-title":"Health Watch exposure estimates: Do they underestimate benzene exposure?","volume":"153\u2013154","author":"Glass","year":"2005","journal-title":"Chem. Biol. Interact."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1126\/science.1102443","article-title":"Hematotoxicity in workers exposed to low levels of benzene","volume":"306","author":"Lan","year":"2004","journal-title":"Science"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"2875","DOI":"10.3390\/ijerph9082875","article-title":"Leukemia and benzene","volume":"9","author":"Snyder","year":"2012","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1002\/(SICI)1097-0274(199603)29:3<227::AID-AJIM2>3.0.CO;2-N","article-title":"A cohort study of cancer among benzene\u2013exposed workers in China: Overall results","volume":"29","author":"Yin","year":"1996","journal-title":"Am. J. Ind. Med."},{"key":"ref_45","first-page":"1349","article-title":"Mortality among benzene\u2013exposed workers in China","volume":"104","author":"Hayes","year":"1996","journal-title":"Environ. Health Perspect."},{"key":"ref_46","first-page":"1339","article-title":"An expanded cohort study of cancer among benzene\u2013exposed workers in China. Benzene Study Group","volume":"104","author":"Yin","year":"1996","journal-title":"Environ. Health Perspect."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1146\/annurev.pa.36.040196.003041","article-title":"Breast cancer and environmental risk factors: Epidemiological and experimental findings","volume":"36","author":"Wolff","year":"1996","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1002\/em.10068","article-title":"Identification of mammary carcinogens in rodent bioassays","volume":"39","author":"Bennett","year":"2002","journal-title":"Environ. Mol. Mutagen."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"2635","DOI":"10.1002\/cncr.22653","article-title":"Chemicals causing mammary gland tumors in animals signal new directions for epidemiology, chemicals testing, and risk assessment for breast cancer prevention","volume":"109","author":"Rudel","year":"2007","journal-title":"Cancer"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"4467","DOI":"10.3892\/mmr.2016.5791","article-title":"Occupational exposure to carcinogens: Benzene, pesticides and fibers","volume":"14","author":"Falzone","year":"2016","journal-title":"Mol. Med. Rep."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.mrrev.2016.03.004","article-title":"Epigenetic alterations induced by genotoxic occupational and environmental human chemical carcinogens: A systematic literature review","volume":"768","author":"Chappell","year":"2016","journal-title":"Mutat. Res. Rev. Mutat. Res."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1002\/ijc.30593","article-title":"Occupational exposure to solvents and bladder cancer: A population\u2013based case control study in Nordic countries","volume":"140","author":"Hadkhale","year":"2017","journal-title":"Int. J. Cancer"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"215","DOI":"10.5271\/sjweh.426","article-title":"Risk of premenopausal breast cancer in association with occupational exposure to polycyclic aromatic hydrocarbons and benzene","volume":"25","author":"Petralia","year":"1999","journal-title":"Scand. J. Work Environ. Health"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1177\/030089160909500102","article-title":"Exposure to benzene and risk of breast cancer among shoe factory workers in Italy","volume":"95","author":"Costantini","year":"2009","journal-title":"Tumori"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1080\/00313029400169711","article-title":"Xylene: Its toxicity, measurement of exposure levels, absorption, metabolism and clearance","volume":"26","author":"Langman","year":"1994","journal-title":"Pathology"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1016\/j.scitotenv.2017.10.152","article-title":"Human cancer risk estimation for 1,3\u2013butadiene: An assessment of personal exposure and different microenvironments","volume":"616\u2013617","author":"Huy","year":"2018","journal-title":"Sci. Total Environ."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1289\/ehp.9086149","article-title":"Cancer risk assessment of 1,3\u2013butadiene","volume":"86","author":"Cote","year":"1990","journal-title":"Environ. Health Perspect."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.cbi.2015.06.009","article-title":"A comprehensive review of occupational and general population cancer risk: 1,3\u2013Butadiene exposure\u2013response modeling for all leukemia, acute myelogenous leukemia, chronic lymphocytic leukemia, chronic myelogenous leukemia, myeloid neoplasm and lymphoid neoplasm","volume":"241","author":"Sielken","year":"2015","journal-title":"Chem. Biol. Interact."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1093\/carcin\/16.2.157","article-title":"Mechanistic data indicate that 1,3\u2013butadiene is a human carcinogen","volume":"16","author":"Melnick","year":"1995","journal-title":"Carcinogenesis"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1289\/ehp.1002910","article-title":"Epigenetic alterations in liver of C57BL\/6J mice after short\u2013term inhalational exposure to 1,3\u2013butadiene","volume":"119","author":"Koturbash","year":"2011","journal-title":"Environ. Health Perspect."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"2476","DOI":"10.1038\/s41598-018-20616-6","article-title":"Occupational Exposure to Polycyclic Aromatic Hydrocarbons and Elevated Cancer Incidence in Firefighters","volume":"8","author":"Stec","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1289\/ehp.961041166","article-title":"Polycyclic aromatic hydrocarbons and cancer in man","volume":"104","author":"Mastrangelo","year":"1996","journal-title":"Environ. Health Perspect."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Zhang, C., Luo, Y., Zhong, R., Law, P.T.Y., Boon, S.S., Chen, Z., Wong, C.H., and Chan, P.K.S. (2019). Role of polycyclic aromatic hydrocarbons as a co\u2013factor in human papillomavirus\u2013mediated carcinogenesis. BMC Cancer, 19.","DOI":"10.1186\/s12885-019-5347-4"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1002\/em.22187","article-title":"The effects of acetaldehyde exposure on histone modifications and chromatin structure in human lung bronchial epithelial cells","volume":"59","author":"Chen","year":"2018","journal-title":"Environ. Mol. Mutagen."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s12263-009-0154-1","article-title":"Acetaldehyde as an underestimated risk factor for cancer development: Role of genetics in ethanol metabolism","volume":"5","author":"Seitz","year":"2010","journal-title":"Genes Nutr."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1111\/j.1360-0443.2009.02516.x","article-title":"Carcinogenicity of acetaldehyde in alcoholic beverages: Risk assessment outside ethanol metabolism","volume":"104","author":"Lachenmeier","year":"2009","journal-title":"Addiction"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1006\/faat.1996.2283","article-title":"Chronic toxicity and carcinogenicity studies of 2\u2013methylnaphthalene in B6C3F1 mice","volume":"36","author":"Murata","year":"1997","journal-title":"Fundam. Appl. Toxicol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"470","DOI":"10.4271\/2013-01-1635","article-title":"An Overview of the Effects of Ethanol\u2013Gasoline Blends on SI Engine Performance, Fuel Efficiency, and Emissions","volume":"6","author":"Stein","year":"2013","journal-title":"SAE Int. J. Engines"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"4059","DOI":"10.1021\/es061776o","article-title":"Effects of fuel ethanol content and volatility on regulated and unregulated exhaust emissions for the latest technology gasoline vehicles","volume":"41","author":"Durbin","year":"2007","journal-title":"Environ. Sci. Technol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"11853","DOI":"10.1021\/acs.est.6b02606","article-title":"Bioethanol Blending Reduces Nanoparticle, PAH, and Alkyl\u2013 and Nitro\u2013PAH Emissions and the Genotoxic Potential of Exhaust from a Gasoline Direct Injection Flex\u2013Fuel Vehicle","volume":"50","author":"Munoz","year":"2016","journal-title":"Environ. Sci. Technol."},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Comunian, S., Dongo, D., Milani, C., and Palestini, P. (2020). Air Pollution and Covid\u201319: The Role of Particulate Matter in the Spread and Increase of Covid\u201319\u2019s Morbidity and Mortality. Int. J. Environ. Res. Public Health, 17.","DOI":"10.3390\/ijerph17124487"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"16213","DOI":"10.1038\/s41598-020-73197-8","article-title":"Impact of meteorological conditions and air pollution on COVID\u201319 pandemic transmission in Italy","volume":"10","author":"Lolli","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/j.matt.2020.09.014","article-title":"Is Particulate Matter of Air Pollution a Vector of Covid\u201319 Pandemic?","volume":"3","author":"Barakat","year":"2020","journal-title":"Matter"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"114465","DOI":"10.1016\/j.envpol.2020.114465","article-title":"Can atmospheric pollution be considered a co\u2013factor in extremely high level of SARS\u2013CoV\u20132 lethality in Northern Italy?","volume":"261","author":"Conticini","year":"2020","journal-title":"Environ. Pollut."},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Wu, X., Nethery, R.C., Sabath, B.M., Braun, D., and Dominici, F. (2020). Exposure to air pollution and COVID\u201319 mortality in the United States: A nationwide cross\u2013sectional study. MedRxiv.","DOI":"10.1101\/2020.04.05.20054502"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1038\/ncponc0354","article-title":"DNA methylation and gene silencing in cancer","volume":"2","author":"Baylin","year":"2005","journal-title":"Nat. Clin. Pract. Oncol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/nrc1799","article-title":"Epigenetic gene silencing in cancer\u2014A mechanism for early oncogenic pathway addiction?","volume":"6","author":"Baylin","year":"2006","journal-title":"Nat. Rev. Cancer"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/nature21687","article-title":"ENL links histone acetylation to oncogenic gene expression in acute myeloid leukaemia","volume":"543","author":"Wan","year":"2017","journal-title":"Nature"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.ccr.2008.04.018","article-title":"Genetic and epigenetic silencing of microRNA\u2013203 enhances ABL1 and BCR\u2013ABL1 oncogene expression","volume":"13","author":"Bueno","year":"2008","journal-title":"Cancer Cell"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.csbj.2016.05.005","article-title":"MicroRNAs and oncogenic transcriptional regulatory networks controlling metabolic reprogramming in cancers","volume":"14","author":"Pinweha","year":"2016","journal-title":"Comput. Struct. Biotechnol. J."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1038\/nrc1997","article-title":"MicroRNA signatures in human cancers","volume":"6","author":"Calin","year":"2006","journal-title":"Nat. Rev. Cancer"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1038\/nrc3932","article-title":"MicroRNA biogenesis pathways in cancer","volume":"15","author":"Lin","year":"2015","journal-title":"Nat. Rev. Cancer"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/nrd.2016.246","article-title":"MicroRNA therapeutics: Towards a new era for the management of cancer and other diseases","volume":"16","author":"Rupaimoole","year":"2017","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1038\/nrg.2016.134","article-title":"A network\u2013biology perspective of microRNA function and dysfunction in cancer","volume":"17","author":"Bracken","year":"2016","journal-title":"Nat. Rev. Genet."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1038\/s41580-019-0143-1","article-title":"The roles of DNA, RNA and histone methylation in ageing and cancer","volume":"20","author":"Michalak","year":"2019","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.gendis.2018.06.003","article-title":"Epigenetic mechanisms as a new approach in cancer treatment: An updated review","volume":"5","author":"Fardi","year":"2018","journal-title":"Genes Dis."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/nrc2876","article-title":"Covalent histone modifications\u2013\u2013miswritten, misinterpreted and mis\u2013erased in human cancers","volume":"10","author":"Chi","year":"2010","journal-title":"Nat. Rev. Cancer"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1038\/nrg2005","article-title":"Cancer epigenomics: DNA methylomes and histone\u2013modification maps","volume":"8","author":"Esteller","year":"2007","journal-title":"Nat. Rev. Genet."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1186\/s13059-019-1870-5","article-title":"Epigenetic modifications of histones in cancer","volume":"20","author":"Zhao","year":"2019","journal-title":"Genome Biol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1038\/nrc.2016.82","article-title":"Metabolic control of epigenetics in cancer","volume":"16","author":"Kinnaird","year":"2016","journal-title":"Nat. Rev. Cancer"},{"key":"ref_91","first-page":"757","article-title":"Tumour metabolism: When metabolic and epigenetic states converge","volume":"16","author":"Dart","year":"2016","journal-title":"Nat. Rev. Cancer"},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Arand, J., Spieler, D., Karius, T., Branco, M.R., Meilinger, D., Meissner, A., Jenuwein, T., Xu, G., Leonhardt, H., and Wolf, V. (2012). In vivo control of CpG and non\u2013CpG DNA methylation by DNA methyltransferases. PLoS Genet., 8.","DOI":"10.1371\/journal.pgen.1002750"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"9899","DOI":"10.1021\/bi047634t","article-title":"De novo methylation of nucleosomal DNA by the mammalian Dnmt1 and Dnmt3A DNA methyltransferases","volume":"44","author":"Gowher","year":"2005","journal-title":"Biochemistry"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.tibs.2014.05.002","article-title":"New concepts in DNA methylation","volume":"39","author":"Jeltsch","year":"2014","journal-title":"Trends Biochem. Sci."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1182\/blood.V97.5.1172","article-title":"Expression of DNA methyltransferases DNMT1, 3A, and 3B in normal hematopoiesis and in acute and chronic myelogenous leukemia","volume":"97","author":"Mizuno","year":"2001","journal-title":"Blood"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"6919","DOI":"10.1038\/onc.2017.305","article-title":"A regulatory circuit composed of DNA methyltransferases and receptor tyrosine kinases controls lung cancer cell aggressiveness","volume":"36","author":"Yan","year":"2017","journal-title":"Oncogene"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1038\/leu.2016.349","article-title":"Fatty acid\u2013binding protein FABP4 mechanistically links obesity with aggressive AML by enhancing aberrant DNA methylation in AML cells","volume":"31","author":"Yan","year":"2017","journal-title":"Leukemia"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"5494","DOI":"10.18632\/oncotarget.2131","article-title":"A nucleolin\u2013DNMT1 regulatory axis in acute myeloid leukemogenesis","volume":"5","author":"Shen","year":"2014","journal-title":"Oncotarget"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1016\/j.addr.2012.08.004","article-title":"Epigenetics advancing personalized nanomedicine in cancer therapy","volume":"64","author":"Liu","year":"2012","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"6411","DOI":"10.1182\/blood-2008-07-170589","article-title":"MicroRNA\u201329b induces global DNA hypomethylation and tumor suppressor gene reexpression in acute myeloid leukemia by targeting directly DNMT3A and 3B and indirectly DNMT1","volume":"113","author":"Garzon","year":"2009","journal-title":"Blood"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"489","DOI":"10.3389\/fonc.2019.00489","article-title":"DNA Methylation Readers and Cancer: Mechanistic and Therapeutic Applications","volume":"9","author":"Mahmood","year":"2019","journal-title":"Front. Oncol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"2749","DOI":"10.3892\/ol.2020.11836","article-title":"Expression and clinical significance of methyl\u2013CpG binding domain protein 2 in high\u2013grade serous ovarian cancer","volume":"20","author":"Gong","year":"2020","journal-title":"Oncol. Lett."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1139\/o05-035","article-title":"Methyl\u2013CpG\u2013binding proteins in cancer: Blaming the DNA methylation messenger","volume":"83","author":"Ballestar","year":"2005","journal-title":"Biochem. Cell Biol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.ccr.2012.09.009","article-title":"Aberrant overexpression of IL\u201315 initiates large granular lymphocyte leukemia through chromosomal instability and DNA hypermethylation","volume":"22","author":"Mishra","year":"2012","journal-title":"Cancer Cell"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"2424","DOI":"10.1056\/NEJMoa1005143","article-title":"DNMT3A mutations in acute myeloid leukemia","volume":"363","author":"Ley","year":"2010","journal-title":"New Engl. J. Med."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"18480","DOI":"10.1074\/jbc.M114.633693","article-title":"The DNA Methyltransferase DNMT1 and Tyrosine\u2013Protein Kinase KIT Cooperatively Promote Resistance to 5\u2013Aza\u20132\u2019\u2013deoxycytidine (Decitabine) and Midostaurin (PKC412) in Lung Cancer Cells","volume":"290","author":"Yan","year":"2015","journal-title":"J. Biol. Chem."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"2364","DOI":"10.1182\/blood-2007-08-110171","article-title":"Bortezomib induces DNA hypomethylation and silenced gene transcription by interfering with Sp1\/NF\u2013kappaB\u2013dependent DNA methyltransferase activity in acute myeloid leukemia","volume":"111","author":"Liu","year":"2008","journal-title":"Blood"},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Yan, F., Pang, J., Peng, Y., Molina, J.R., Yang, P., and Liu, S. (2016). Elevated Cellular PD1\/PD\u2013L1 Expression Confers Acquired Resistance to Cisplatin in Small Cell Lung Cancer Cells. PLoS One, 11.","DOI":"10.1371\/journal.pone.0162925"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1038\/leu.2017.307","article-title":"A vicious loop of fatty acid\u2013binding protein 4 and DNA methyltransferase 1 promotes acute myeloid leukemia and acts as a therapeutic target","volume":"32","author":"Yan","year":"2018","journal-title":"Leukemia"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"6254","DOI":"10.1158\/1078-0432.CCR-17-0235","article-title":"Inactivation of Receptor Tyrosine Kinases Reverts Aberrant DNA Methylation in Acute Myeloid Leukemia","volume":"23","author":"Shen","year":"2017","journal-title":"Clin. Cancer Res."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1038\/leu.2015.56","article-title":"AML1\/ETO cooperates with HIF1alpha to promote leukemogenesis through DNMT3a transactivation","volume":"29","author":"Gao","year":"2015","journal-title":"Leukemia"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1038\/s41467-018-03058-6","article-title":"Heritable DNA methylation marks associated with susceptibility to breast cancer","volume":"9","author":"Joo","year":"2018","journal-title":"Nature Commun."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/gm325","article-title":"DNA methylation signatures for breast cancer classification and prognosis","volume":"4","author":"Szyf","year":"2012","journal-title":"Genome Med."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.molonc.2010.04.002","article-title":"The epigenetics of breast cancer","volume":"4","author":"Jovanovic","year":"2010","journal-title":"Mol. Oncol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1038\/s41467-017-00510-x","article-title":"DNA methylation at enhancers identifies distinct breast cancer lineages","volume":"8","author":"Fleischer","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"233","DOI":"10.4048\/jbc.2018.21.e41","article-title":"The Epigenetics of Triple\u2013Negative and Basal\u2013Like Breast Cancer: Current Knowledge","volume":"21","author":"Temian","year":"2018","journal-title":"J. Breast Cancer"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1002\/cncr.22087","article-title":"Elevated mRNA levels of DNA methyltransferase\u20131 as an independent prognostic factor in primary nonsmall cell lung cancer","volume":"107","author":"Kim","year":"2006","journal-title":"Cancer"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.lungcan.2006.10.022","article-title":"Alteration of DNA methyltransferases contributes to 5\u2019CpG methylation and poor prognosis in lung cancer","volume":"55","author":"Lin","year":"2007","journal-title":"Lung Cancer"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"5807","DOI":"10.1158\/0008-5472.CAN-09-4161","article-title":"Dysregulation of p53\/Sp1 control leads to DNA methyltransferase\u20131 overexpression in lung cancer","volume":"70","author":"Lin","year":"2010","journal-title":"Cancer Res."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"2459","DOI":"10.1038\/s41467-020-16295-5","article-title":"Genetic and epigenetic intratumor heterogeneity impacts prognosis of lung adenocarcinoma","volume":"11","author":"Hua","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"3079","DOI":"10.1038\/onc.2015.359","article-title":"DNMT3A mutations mediate the epigenetic reactivation of the leukemogenic factor MEIS1 in acute myeloid leukemia","volume":"35","author":"Ferreira","year":"2016","journal-title":"Oncogene"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"5824","DOI":"10.1182\/blood-2011-07-367961","article-title":"Mutant DNMT3A: A marker of poor prognosis in acute myeloid leukemia","volume":"119","author":"Ribeiro","year":"2012","journal-title":"Blood"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1038\/leu.2011.44","article-title":"Recurrent DNMT3A mutations in patients with myelodysplastic syndromes","volume":"25","author":"Walter","year":"2011","journal-title":"Leukemia"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1038\/nrc3895","article-title":"DNMT3A in haematological malignancies","volume":"15","author":"Yang","year":"2015","journal-title":"Nat. Rev. Cancer"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1038\/leu.2014.124","article-title":"DNMT3A and IDH mutations in acute myeloid leukemia and other myeloid malignancies: Associations with prognosis and potential treatment strategies","volume":"28","author":"Im","year":"2014","journal-title":"Leukemia"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1016\/j.leukres.2012.05.012","article-title":"Decreased DNA methylation in acute myeloid leukemia patients with DNMT3A mutations and prognostic implications of DNA methylation","volume":"36","author":"Hajkova","year":"2012","journal-title":"Leuk. Res."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/nature25477","article-title":"Structural basis for DNMT3A\u2013mediated de novo DNA methylation","volume":"554","author":"Zhang","year":"2018","journal-title":"Nature"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1101\/gad.276568.115","article-title":"Role of TET enzymes in DNA methylation, development, and cancer","volume":"30","author":"Rasmussen","year":"2016","journal-title":"Genes Dev."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1126\/science.1210597","article-title":"Tet proteins can convert 5\u2013methylcytosine to 5\u2013formylcytosine and 5\u2013carboxylcytosine","volume":"333","author":"Ito","year":"2011","journal-title":"Science"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1038\/cr.2011.189","article-title":"Generation and replication\u2013dependent dilution of 5fC and 5caC during mouse preimplantation development","volume":"21","author":"Inoue","year":"2011","journal-title":"Cell Res."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1126\/science.1210944","article-title":"Tet\u2013mediated formation of 5\u2013carboxylcytosine and its excision by TDG in mammalian DNA","volume":"333","author":"He","year":"2011","journal-title":"Science"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.cell.2011.03.022","article-title":"Hydroxylation of 5\u2013methylcytosine by TET1 promotes active DNA demethylation in the adult brain","volume":"145","author":"Guo","year":"2011","journal-title":"Cell"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1038\/nature12750","article-title":"TET enzymes, TDG and the dynamics of DNA demethylation","volume":"502","author":"Kohli","year":"2013","journal-title":"Nature"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"2662","DOI":"10.4161\/cc.10.16.17093","article-title":"Emerging roles of TET proteins and 5\u2013hydroxymethylcytosines in active DNA demethylation and beyond","volume":"10","author":"Guo","year":"2011","journal-title":"Cell Cycle"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/nrg.2017.33","article-title":"TET\u2013mediated active DNA demethylation: Mechanism, function and beyond","volume":"18","author":"Wu","year":"2017","journal-title":"Nat. Rev. Genet."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s13073-015-0134-6","article-title":"TET proteins and the control of cytosine demethylation in cancer","volume":"7","author":"Scourzic","year":"2015","journal-title":"Genome Med."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"3803","DOI":"10.1182\/blood-2011-02-339747","article-title":"TET2 mutation is an unfavorable prognostic factor in acute myeloid leukemia patients with intermediate\u2013risk cytogenetics","volume":"118","author":"Chou","year":"2011","journal-title":"Blood"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"2289","DOI":"10.1056\/NEJMoa0810069","article-title":"Mutation in TET2 in myeloid cancers","volume":"360","author":"Delhommeau","year":"2009","journal-title":"New Engl. J. Med."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"e472","DOI":"10.1038\/bcj.2016.82","article-title":"Number and type of TET2 mutations in chronic myelomonocytic leukemia and their clinical relevance","volume":"6","author":"Patnaik","year":"2016","journal-title":"Blood Cancer J."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.tig.2014.07.005","article-title":"Connections between TET proteins and aberrant DNA modification in cancer","volume":"30","author":"Huang","year":"2014","journal-title":"Trends Genet."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"11994","DOI":"10.1073\/pnas.1310656110","article-title":"TET1 plays an essential oncogenic role in MLL\u2013rearranged leukemia","volume":"110","author":"Huang","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1038\/onc.2012.67","article-title":"Tumor development is associated with decrease of TET gene expression and 5\u2013methylcytosine hydroxylation","volume":"32","author":"Yang","year":"2013","journal-title":"Oncogene"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1038\/leu.2011.326","article-title":"Landscape of TET2 mutations in acute myeloid leukemia","volume":"26","author":"Weissmann","year":"2012","journal-title":"Leukemia"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"4316","DOI":"10.1172\/JCI129317","article-title":"Tumor suppressor TET2 promotes cancer immunity and immunotherapy efficacy","volume":"129","author":"Xu","year":"2019","journal-title":"J. Clin. Invest."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"3909610","DOI":"10.1155\/2020\/3909610","article-title":"TET1 is a Tumor Suppressor That Inhibits Papillary Thyroid Carcinoma Cell Migration and Invasion","volume":"2020","author":"Yu","year":"2020","journal-title":"Int. J. Endocrinol."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1158\/0008-5472.CAN-18-1234","article-title":"p53\u2013Suppressed Oncogene TET1 Prevents Cellular Aging in Lung Cancer","volume":"79","author":"Filipczak","year":"2019","journal-title":"Cancer Res."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"553","DOI":"10.3389\/fgene.2019.00553","article-title":"TET Upregulation Leads to 5\u2013Hydroxymethylation Enrichment in Hepatoblastoma","volume":"10","author":"Rivas","year":"2019","journal-title":"Front. Genet."},{"key":"ref_148","doi-asserted-by":"crossref","unstructured":"Wang, R., Gao, X., and Yu, L. (2019). The prognostic impact of tet oncogene family member 2 mutations in patients with acute myeloid leukemia: A systematic\u2013review and meta\u2013analysis. BMC Cancer, 19.","DOI":"10.1186\/s12885-019-5602-8"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1200\/JCO.2011.39.2886","article-title":"TET2 mutations in acute myeloid leukemia (AML): Results from a comprehensive genetic and clinical analysis of the AML study group","volume":"30","author":"Gaidzik","year":"2012","journal-title":"J. Clin. Oncol."},{"key":"ref_150","doi-asserted-by":"crossref","unstructured":"Yang, L., Yu, S.J., Hong, Q., Yang, Y., and Shao, Z.M. (2015). Reduced Expression of TET1, TET2, TET3 and TDG mRNAs Are Associated with Poor Prognosis of Patients with Early Breast Cancer. Plos One, 10.","DOI":"10.1371\/journal.pone.0133896"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1186\/s13148-019-0713-2","article-title":"Air pollution and DNA methylation: Effects of exposure in humans","volume":"11","author":"Rider","year":"2019","journal-title":"Clin. Epigenetics"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.18632\/oncotarget.13622","article-title":"Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study","volume":"8","author":"Jiang","year":"2017","journal-title":"Oncotarget"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/srep00275","article-title":"Particulate matter Air Pollution induces hypermethylation of the p16 promoter Via a mitochondrial ROS\u2013JNK\u2013DNMT1 pathway","volume":"2","author":"Soberanes","year":"2012","journal-title":"Sci. Rep."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0092-8674(00)00118-5","article-title":"Signaling to chromatin through histone modifications","volume":"103","author":"Cheung","year":"2000","journal-title":"Cell"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.4161\/epi.21975","article-title":"Histone phosphorylation: A chromatin modification involved in diverse nuclear events","volume":"7","author":"Rossetto","year":"2012","journal-title":"Epigenetics"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"4858","DOI":"10.1128\/MCB.05631-11","article-title":"A peek into the complex realm of histone phosphorylation","volume":"31","author":"Banerjee","year":"2011","journal-title":"Mol. Cell Biol."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.molcel.2008.02.014","article-title":"Histone ubiquitination: Triggering gene activity","volume":"29","author":"Weake","year":"2008","journal-title":"Mol. Cell"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1038\/s41467-018-03895-5","article-title":"Functional crosstalk between histone H2B ubiquitylation and H2A modifications and variants","volume":"9","author":"Wojcik","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/S0092-8674(02)00798-5","article-title":"Histone methylation: Dynamic or static?","volume":"109","author":"Bannister","year":"2002","journal-title":"Cell"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/ncb1076","article-title":"Histone H3 lysine 4 methylation patterns in higher eukaryotic genes","volume":"6","author":"Schneider","year":"2004","journal-title":"Nat. Cell Biol."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/nature04835","article-title":"ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression","volume":"442","author":"Shi","year":"2006","journal-title":"Nature"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1126\/science.1074973","article-title":"Regulation of heterochromatic silencing and histone H3 lysine\u20139 methylation by RNAi","volume":"297","author":"Volpe","year":"2002","journal-title":"Science"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1126\/science.1076997","article-title":"Role of histone H3 lysine 27 methylation in Polycomb\u2013group silencing","volume":"298","author":"Cao","year":"2002","journal-title":"Science"},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/nrn3427","article-title":"Histone acetylation: Molecular mnemonics on the chromatin","volume":"14","author":"Graff","year":"2013","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/S0968-0004(97)01016-5","article-title":"Histone acetylation: Chromatin in action","volume":"22","author":"Wade","year":"1997","journal-title":"Trends Biochem. Sci."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/j.tibs.2016.05.008","article-title":"The Metabolic Impact on Histone Acetylation and Transcription in Ageing","volume":"41","author":"Peleg","year":"2016","journal-title":"Trends Biochem. Sci."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"a019521","DOI":"10.1101\/cshperspect.a019521","article-title":"Histone Modifications and Cancer","volume":"8","author":"Audia","year":"2016","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"26","DOI":"10.3389\/fonc.2012.00026","article-title":"Histone ubiquitination and deubiquitination in transcription, DNA damage response, and cancer","volume":"2","author":"Cao","year":"2012","journal-title":"Front. Oncol"},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"11414","DOI":"10.18632\/oncotarget.23356","article-title":"Role of novel histone modifications in cancer","volume":"9","author":"Shanmugam","year":"2018","journal-title":"Oncotarget"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"293","DOI":"10.3892\/br.2016.574","article-title":"Role of several histone lysine methyltransferases in tumor development","volume":"4","author":"Li","year":"2016","journal-title":"Biomed. Rep."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1093\/bfgp\/els065","article-title":"Cancers with wrong HATs: The impact of acetylation","volume":"12","author":"Schneider","year":"2013","journal-title":"Brief. Funct. Genom."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"5420","DOI":"10.1038\/sj.onc.1210610","article-title":"Histone deacetylases and cancer","volume":"26","author":"Glozak","year":"2007","journal-title":"Oncogene"},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"4062","DOI":"10.1091\/mbc.e08-02-0139","article-title":"HDAC4 promotes growth of colon cancer cells via repression of p21","volume":"19","author":"Wilson","year":"2008","journal-title":"Mol. Biol. Cell"},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1177\/1947601912475079","article-title":"The Roles of SIRT1 in Cancer","volume":"4","author":"Lin","year":"2013","journal-title":"Genes Cancer"},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.canlet.2008.08.016","article-title":"HDAC family: What are the cancer relevant targets?","volume":"277","author":"Witt","year":"2009","journal-title":"Cancer Lett."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S1535-6108(03)00165-X","article-title":"Histone deacetylase inhibitors in cancer therapy: Is transcription the primary target?","volume":"4","author":"Johnstone","year":"2003","journal-title":"Cancer Cell"},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"4192","DOI":"10.1038\/s41467-019-12222-5","article-title":"Histone deacetylase 11 inhibition promotes breast cancer metastasis from lymph nodes","volume":"10","author":"Leslie","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1172\/JCI69738","article-title":"New and emerging HDAC inhibitors for cancer treatment","volume":"124","author":"West","year":"2014","journal-title":"J. Clin. Invest."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"263","DOI":"10.2217\/fon.11.2","article-title":"Rational therapeutic combinations with histone deacetylase inhibitors for the treatment of cancer","volume":"7","author":"Thurn","year":"2011","journal-title":"Future Oncol."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"187","DOI":"10.2174\/1568011033482440","article-title":"The interaction of histone deacetylase inhibitors and DNA methyltransferase inhibitors in the treatment of human cancer cells","volume":"3","author":"Zhu","year":"2003","journal-title":"Curr. Med. Chem. Anticancer. Agents"},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1126\/science.1201662","article-title":"The leukemogenicity of AML1\u2013ETO is dependent on site\u2013specific lysine acetylation","volume":"333","author":"Wang","year":"2011","journal-title":"Science"},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/S0092-8674(00)82001-2","article-title":"The transcriptional coactivators p300 and CBP are histone acetyltransferases","volume":"87","author":"Ogryzko","year":"1996","journal-title":"Cell"},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1038\/nrd772","article-title":"Histone\u2013deacetylase inhibitors: Novel drugs for the treatment of cancer","volume":"1","author":"Johnstone","year":"2002","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.drudis.2009.06.008","article-title":"Histone acetyl transferases as emerging drug targets","volume":"14","author":"Dekker","year":"2009","journal-title":"Drug Discov. Today"},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"2391","DOI":"10.1158\/1535-7163.MCT-07-0159","article-title":"Characterization of novel inhibitors of histone acetyltransferases","volume":"6","author":"Eliseeva","year":"2007","journal-title":"Mol. Cancer Ther"},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/s13148-016-0225-2","article-title":"Histone acetyltransferases: Challenges in targeting bi\u2013substrate enzymes","volume":"8","author":"Wapenaar","year":"2016","journal-title":"Clin. Epigenetics"},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/0092-8674(93)90529-Y","article-title":"The C. elegans heterochronic gene lin\u20134 encodes small RNAs with antisense complementarity to lin\u201314","volume":"75","author":"Lee","year":"1993","journal-title":"Cell"},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/nrc1840","article-title":"Oncomirs\u2013microRNAs with a role in cancer","volume":"6","author":"Slack","year":"2006","journal-title":"Nat. Rev. Cancer"},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"4051","DOI":"10.1038\/sj.emboj.7600385","article-title":"MicroRNA genes are transcribed by RNA polymerase II","volume":"23","author":"Lee","year":"2004","journal-title":"EMBO J."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"5228","DOI":"10.1038\/s41467-018-07657-1","article-title":"Pan\u2013cancer characterisation of microRNA across cancer hallmarks reveals microRNA\u2013mediated downregulation of tumour suppressors","volume":"9","author":"Dhawan","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.ccr.2007.09.020","article-title":"Epigenetic silencing of the myelopoiesis regulator microRNA\u2013223 by the AML1\/ETO oncoprotein","volume":"12","author":"Fazi","year":"2007","journal-title":"Cancer Cell"},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1182\/blood-2012-07-444729","article-title":"Epigenetic silencing of microRNA\u2013193a contributes to leukemogenesis in t(8;21) acute myeloid leukemia by activating the PTEN\/PI3K signal pathway","volume":"121","author":"Li","year":"2013","journal-title":"Blood"},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"39994","DOI":"10.18632\/oncotarget.18127","article-title":"An AML1\u2013ETO\/miR\u201329b\u20131 regulatory circuit modulates phenotypic properties of acute myeloid leukemia cells","volume":"8","author":"Zaidi","year":"2017","journal-title":"Oncotarget"},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.ccr.2010.03.008","article-title":"Sp1\/NFkappaB\/HDAC\/miR\u201329b regulatory network in KIT\u2013driven myeloid leukemia","volume":"17","author":"Liu","year":"2010","journal-title":"Cancer Cell"},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"2324","DOI":"10.1038\/leu.2014.133","article-title":"Notch and NF\u2013kB signaling pathways regulate miR\u2013223\/FBXW7 axis in T\u2013cell acute lymphoblastic leukemia","volume":"28","author":"Kumar","year":"2014","journal-title":"Leukemia"},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1158\/0008-5472.CAN-05-3632","article-title":"Rapid alteration of microRNA levels by histone deacetylase inhibition","volume":"66","author":"Scott","year":"2006","journal-title":"Cancer Res."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1111\/j.1742-4658.2011.08089.x","article-title":"MicroRNAs and epigenetics","volume":"278","author":"Sato","year":"2011","journal-title":"FEBS J."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.4161\/cbt.6.8.4486","article-title":"DNA methylation regulates MicroRNA expression","volume":"6","author":"Han","year":"2007","journal-title":"Cancer Biol. Ther."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"24R","DOI":"10.1203\/pdr.0b013e3180457684","article-title":"Epigenetics and microRNAs","volume":"61","author":"Chuang","year":"2007","journal-title":"Pediatr. Res."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.arr.2014.04.005","article-title":"MicroRNA expression altered by diet: Can food be medicinal?","volume":"17","author":"Palmer","year":"2014","journal-title":"Ageing Res. Rev."},{"key":"ref_201","first-page":"1","article-title":"Diet and lifestyle factors associated with miRNA expression in colorectal tissue","volume":"10","author":"Slattery","year":"2017","journal-title":"Pharmgenomics Pers. Med."},{"key":"ref_202","doi-asserted-by":"crossref","unstructured":"Landrier, J.F., Derghal, A., and Mounien, L. (2019). MicroRNAs in Obesity and Related Metabolic Disorders. Cells, 8.","DOI":"10.3390\/cells8080859"},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"017007","DOI":"10.1289\/EHP1447","article-title":"Fine Particulate Air Pollution and the Expression of microRNAs and Circulating Cytokines Relevant to Inflammation, Coagulation, and Vasoconstriction","volume":"126","author":"Chen","year":"2018","journal-title":"Environ. Health Perspect."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.3892\/or.2013.2351","article-title":"Downregulation of microRNA\u201334 induces cell proliferation and invasion of human mesothelial cells","volume":"29","author":"Tanaka","year":"2013","journal-title":"Oncol. Rep."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"4965","DOI":"10.1158\/1078-0432.CCR-10-3040","article-title":"Epigenetic silencing of microRNA\u201334b\/c plays an important role in the pathogenesis of malignant pleural mesothelioma","volume":"17","author":"Kubo","year":"2011","journal-title":"Clin. Cancer Res."},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"e194","DOI":"10.1038\/mtna.2014.47","article-title":"Mir\u201334: A new weapon against cancer?","volume":"3","author":"Misso","year":"2014","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"7390","DOI":"10.1158\/0008-5472.CAN-06-0800","article-title":"MicroRNA\u2013cancer connection: The beginning of a new tale","volume":"66","author":"Calin","year":"2006","journal-title":"Cancer Res."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1146\/annurev.med.59.053006.104707","article-title":"MicroRNAs in Cancer","volume":"60","author":"Garzon","year":"2009","journal-title":"Annu. Rev. Med."},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"330","DOI":"10.6026\/97320630002330","article-title":"Oncomirs: The potential role of non\u2013coding microRNAs in understanding cancer","volume":"2","author":"Manikandan","year":"2008","journal-title":"Bioinformation"},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1038\/s41598-020-58072-w","article-title":"Simultaneous downregulation of miR\u201321 and upregulation of miR\u20137 has anti\u2013tumor efficacy","volume":"10","author":"Bhere","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_211","doi-asserted-by":"crossref","unstructured":"Sochor, M., Basova, P., Pesta, M., Dusilkova, N., Bartos, J., Burda, P., Pospisil, V., and Stopka, T. (2014). Oncogenic microRNAs: miR\u2013155, miR\u201319a, miR\u2013181b, and miR\u201324 enable monitoring of early breast cancer in serum. BMC Cancer, 14.","DOI":"10.1186\/1471-2407-14-448"},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"13944","DOI":"10.1073\/pnas.0506654102","article-title":"miR\u201315 and miR\u201316 induce apoptosis by targeting BCL2","volume":"102","author":"Cimmino","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"345","DOI":"10.3892\/ijo.2016.3811","article-title":"Molecular mechanisms and clinical applications of miR\u201322 in regulating malignant progression in human cancer","volume":"50","author":"Wang","year":"2017","journal-title":"Int. J. Oncol."},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1038\/gt.2011.79","article-title":"Developing therapeutic microRNAs for cancer","volume":"18","author":"Bader","year":"2011","journal-title":"Gene Ther."},{"key":"ref_215","doi-asserted-by":"crossref","unstructured":"Zealy, R.W., Wrenn, S.P., Davila, S., Min, K.W., and Yoon, J.H. (2017). MicroRNA\u2013binding proteins: Specificity and function. Wiley Interdiscip. Rev. RNA, 8.","DOI":"10.1002\/wrna.1414"},{"key":"ref_216","doi-asserted-by":"crossref","unstructured":"Hoareau\u2013Aveilla, C., and Meggetto, F. (2017). Crosstalk between microRNA and DNA Methylation Offers Potential Biomarkers and Targeted Therapies in ALK\u2013Positive Lymphomas. Cancers, 9.","DOI":"10.3390\/cancers9080100"},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"7894","DOI":"10.3748\/wjg.v20.i24.7894","article-title":"DNA methylation, microRNAs, and their crosstalk as potential biomarkers in hepatocellular carcinoma","volume":"20","author":"Anwar","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.3892\/ol.2017.5593","article-title":"Reciprocal regulation between microRNAs and epigenetic machinery in colorectal cancer","volume":"13","author":"Wang","year":"2017","journal-title":"Oncol. Lett."},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1080\/15592294.2016.1273308","article-title":"Mutual regulation of microRNAs and DNA methylation in human cancers","volume":"12","author":"Wang","year":"2017","journal-title":"Epigenetics"},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1016\/j.cellsig.2013.05.013","article-title":"The epigenetic feedback loop between DNA methylation and microRNAs in fibrotic disease with an emphasis on DNA methyltransferases","volume":"25","author":"Sun","year":"2013","journal-title":"Cell Signal."},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.neuint.2014.03.012","article-title":"The interplay between microRNAs and histone deacetylases in neurological diseases","volume":"77","author":"Bourassa","year":"2014","journal-title":"Neurochem. Int."},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/nature15252","article-title":"Tet2 is required to resolve inflammation by recruiting Hdac2 to specifically repress IL\u20136","volume":"525","author":"Zhang","year":"2015","journal-title":"Nature"},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.molcel.2016.12.013","article-title":"Acetylation Enhances TET2 Function in Protecting against Abnormal DNA Methylation during Oxidative Stress","volume":"65","author":"Zhang","year":"2017","journal-title":"Mol. Cell"},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1038\/77124","article-title":"DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F\u2013responsive promoters","volume":"25","author":"Robertson","year":"2000","journal-title":"Nat. Genet."},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1158\/0008-5472.CAN-04-4532","article-title":"Interplay of RUNX1\/MTG8 and DNA methyltransferase 1 in acute myeloid leukemia","volume":"65","author":"Liu","year":"2005","journal-title":"Cancer Res."},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1124\/jpet.106.118406","article-title":"Targeting AML1\/ETO\u2013histone deacetylase repressor complex: A novel mechanism for valproic acid\u2013mediated gene expression and cellular differentiation in AML1\/ETO\u2013positive acute myeloid leukemia cells","volume":"321","author":"Liu","year":"2007","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1126\/science.1227166","article-title":"Suppression of oxidative stress by beta\u2013hydroxybutyrate, an endogenous histone deacetylase inhibitor","volume":"339","author":"Shimazu","year":"2013","journal-title":"Science"},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1126\/science.1226603","article-title":"Influence of threonine metabolism on S\u2013adenosylmethionine and histone methylation","volume":"339","author":"Locasale","year":"2013","journal-title":"Science"},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1056\/NEJM198809013190901","article-title":"Genetic alterations during colorectal\u2013tumor development","volume":"319","author":"Vogelstein","year":"1988","journal-title":"New Engl. J. Med."},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/carcin\/bgp220","article-title":"Epigenetics in cancer","volume":"31","author":"Sharma","year":"2010","journal-title":"Carcinogenesis"},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1111\/j.1749-6632.2003.tb05976.x","article-title":"Epigenetics in carcinogenesis and cancer prevention","volume":"983","author":"Jones","year":"2003","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"5462","DOI":"10.1038\/sj.onc.1205606","article-title":"DNA methylation and breast carcinogenesis","volume":"21","author":"Widschwendter","year":"2002","journal-title":"Oncogene"},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/5947","article-title":"Cancer epigenetics comes of age","volume":"21","author":"Jones","year":"1999","journal-title":"Nature Genet."},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/leu.2013.242","article-title":"Origins of aberrant DNA methylation in acute myeloid leukemia","volume":"28","author":"Schoofs","year":"2014","journal-title":"Leukemia"},{"key":"ref_235","first-page":"84","article-title":"Global DNA methylation and low\u2013level exposure to benzene","volume":"103","author":"Fustinoni","year":"2012","journal-title":"Med. Lav."},{"key":"ref_236","doi-asserted-by":"crossref","first-page":"3366","DOI":"10.3892\/mmr.2017.6383","article-title":"Epigenetic alterations and occupational exposure to benzene, fibers, and heavy metals associated with tumor development","volume":"15","author":"Salemi","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"ref_237","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1097\/MOP.0b013e32832925cc","article-title":"Epigenetics and environmental chemicals","volume":"21","author":"Baccarelli","year":"2009","journal-title":"Curr. Opin. Pediatr."},{"key":"ref_238","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.taap.2017.12.002","article-title":"Aberrant promoter methylation in genes related to hematopoietic malignancy in workers exposed to a VOC mixture","volume":"339","author":"Guo","year":"2018","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_239","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.cbi.2009.12.028","article-title":"Methylation and expression analysis of tumor suppressor genes p15 and p16 in benzene poisoning","volume":"184","author":"Xing","year":"2010","journal-title":"Chem. Biol. Interact."},{"key":"ref_240","doi-asserted-by":"crossref","unstructured":"Zheng, M., Lin, F., Hou, F., Li, G., Zhu, C., Xu, P., Xing, C., and Wang, Q. (2017). Association between Promoter Methylation of Gene ERCC3 and Benzene Hematotoxicity. Int. J. Environ. Res. Public Health, 14.","DOI":"10.3390\/ijerph14080921"},{"key":"ref_241","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.toxlet.2010.03.005","article-title":"Methylation of PARP\u20131 promoter involved in the regulation of benzene\u2013induced decrease of PARP\u20131 mRNA expression","volume":"195","author":"Gao","year":"2010","journal-title":"Toxicol. Lett."},{"key":"ref_242","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.toxlet.2011.02.020","article-title":"Decreased topoisomerase IIalpha expression and altered histone and regulatory factors of topoisomerase IIalpha promoter in patients with chronic benzene poisoning","volume":"203","author":"Yu","year":"2011","journal-title":"Toxicol. Lett."},{"key":"ref_243","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.envpol.2017.11.042","article-title":"Enhanced H3K4me3 modifications are involved in the transactivation of DNA damage responsive genes in workers exposed to low\u2013level benzene","volume":"234","author":"Li","year":"2018","journal-title":"Environ. Pollut."},{"key":"ref_244","doi-asserted-by":"crossref","first-page":"27058","DOI":"10.3390\/ijms161126001","article-title":"Benzene\u2013Induced Aberrant miRNA Expression Profile in Hematopoietic Progenitor Cells in C57BL\/6 Mice","volume":"16","author":"Wei","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"ref_245","doi-asserted-by":"crossref","first-page":"403","DOI":"10.21037\/jtd.2016.02.56","article-title":"Analysis of plasma microRNA expression profiles in a Chinese population occupationally exposed to benzene and in a population with chronic benzene poisoning","volume":"8","author":"Liu","year":"2016","journal-title":"J. Thorac. Dis."},{"key":"ref_246","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1080\/1354750X.2019.1652348","article-title":"MicroRNAs as biomarkers of harmful environmental and occupational exposures: A systematic review","volume":"24","author":"Kotsyfakis","year":"2019","journal-title":"Biomarkers"},{"key":"ref_247","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/s00204-017-2033-7","article-title":"Down\u2013regulation of miRNA\u2013451a and miRNA\u2013486\u20135p involved in benzene\u2013induced inhibition on erythroid cell differentiation in vitro and in vivo","volume":"92","author":"Liang","year":"2018","journal-title":"Arch. Toxicol."},{"key":"ref_248","doi-asserted-by":"crossref","first-page":"22648","DOI":"10.1007\/s11356-020-08614-6","article-title":"PARP1\u2013DNMT1\u2013CTCF complex and the apoptotic\u2013induced factor mRNA expressions in workers occupationally exposed to benzene","volume":"27","author":"Habieb","year":"2020","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"ref_249","first-page":"1365","article-title":"An epidemiologic study of early biologic effects of benzene in Chinese workers","volume":"104","author":"Rothman","year":"1996","journal-title":"Environ. Health Perspect."},{"key":"ref_250","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.ygeno.2007.05.003","article-title":"Identification of human cell responses to benzene and benzene metabolites","volume":"90","author":"Gillis","year":"2007","journal-title":"Genomics"},{"key":"ref_251","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1002\/tox.21795","article-title":"Modulation of microRNA expression by volatile organic compounds in mouse lung","volume":"29","author":"Wang","year":"2014","journal-title":"Environ. Toxicol."},{"key":"ref_252","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.tiv.2017.02.020","article-title":"Comparative analysis of microRNA and mRNA expression profiles in cells and exosomes under toluene exposure","volume":"41","author":"Lim","year":"2017","journal-title":"Toxicol. In Vitro"},{"key":"ref_253","doi-asserted-by":"crossref","first-page":"518","DOI":"10.3923\/pjbs.2020.518.525","article-title":"Hypermethylation in Gene Promoters Are Induced by Chronic Exposure to Benzene, Toluene, Ethylbenzene and Xylenes","volume":"23","author":"Silvestre","year":"2020","journal-title":"Pak. J. Biol. Sci."},{"key":"ref_254","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.envres.2015.12.014","article-title":"Association analysis of toluene exposure time with high\u2013throughput mRNA expressions and methylation patterns using in vivo samples","volume":"146","author":"Hong","year":"2016","journal-title":"Environ. Res."},{"key":"ref_255","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.taap.2015.04.016","article-title":"CYP2E1 epigenetic regulation in chronic, low\u2013level toluene exposure: Relationship with oxidative stress and smoking habit","volume":"286","author":"Baccarelli","year":"2015","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_256","doi-asserted-by":"crossref","first-page":"e12937","DOI":"10.1111\/adb.12937","article-title":"Adolescent chronic intermittent toluene inhalation dynamically regulates the transcriptome and neuronal methylome within the rat medial prefrontal cortex","volume":"26","author":"Dick","year":"2021","journal-title":"Addict. Biol."},{"key":"ref_257","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.neulet.2010.12.004","article-title":"Repeated toluene exposure modifies the acetylation pattern of histones H3 and H4 in the rat brain","volume":"489","author":"Cruz","year":"2011","journal-title":"Neurosci. Lett."},{"key":"ref_258","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.pbb.2012.03.018","article-title":"Toluene impairs learning and memory, has antinociceptive effects, and modifies histone acetylation in the dentate gyrus of adolescent and adult rats","volume":"102","author":"Lamas","year":"2012","journal-title":"Pharmacol. Biochem. Behav."},{"key":"ref_259","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.toxrep.2019.01.001","article-title":"Circulating microRNAs as potential biomarkers of occupational exposure to low dose organic solvents","volume":"6","author":"Sisto","year":"2019","journal-title":"Toxicol. Rep."},{"key":"ref_260","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/j.toxrep.2020.05.006","article-title":"Occupational exposure to volatile organic compounds affects microRNA profiling: Towards the identification of novel biomarkers","volume":"7","author":"Sisto","year":"2020","journal-title":"Toxicol. Rep."},{"key":"ref_261","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1289\/ehp.1104056","article-title":"Prenatal exposure to polycyclic aromatic hydrocarbons, benzo[a]pyrene\u2013DNA adducts, and genomic DNA methylation in cord blood","volume":"120","author":"Herbstman","year":"2012","journal-title":"Environ. Health Perspect."},{"key":"ref_262","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.envint.2016.12.009","article-title":"Prenatal airborne polycyclic aromatic hydrocarbon exposure, LINE1 methylation and child development in a Chinese cohort","volume":"99","author":"Lee","year":"2017","journal-title":"Environ. Int."},{"key":"ref_263","doi-asserted-by":"crossref","first-page":"067005","DOI":"10.1289\/EHP2773","article-title":"Exposure to Polycyclic Aromatic Hydrocarbons and Accelerated DNA Methylation Aging","volume":"126","author":"Li","year":"2018","journal-title":"Environ. Health Perspect."},{"key":"ref_264","doi-asserted-by":"crossref","unstructured":"Ma, Y., Lu, Z., Wang, L., and Qiang, M. (2019). Correlation of Internal Exposure Levels of Polycyclic Aromatic Hydrocarbons to Methylation of Imprinting Genes of Sperm DNA. Int. J. Environ. Res. Public Health, 16.","DOI":"10.3390\/ijerph16142606"},{"key":"ref_265","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.chemosphere.2012.11.077","article-title":"Epigenetic markers of exposure to polycyclic aromatic hydrocarbons in Mexican brickmakers: A pilot study","volume":"91","author":"Barretta","year":"2013","journal-title":"Chemosphere"},{"key":"ref_266","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1002\/ijc.24492","article-title":"Global and gene\u2013specific promoter methylation changes are related to anti\u2013B[a]PDE\u2013DNA adduct levels and influence micronuclei levels in polycyclic aromatic hydrocarbon\u2013exposed individuals","volume":"125","author":"Pavanello","year":"2009","journal-title":"Int. J. Cancer"},{"key":"ref_267","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1158\/1055-9965.EPI-11-0784","article-title":"CpG site\u2013specific hypermethylation of p16INK4alpha in peripheral blood lymphocytes of PAH\u2013exposed workers","volume":"21","author":"Yang","year":"2012","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"ref_268","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1007\/s10552-015-0672-7","article-title":"Polycyclic aromatic hydrocarbon (PAH)\u2013DNA adducts and breast cancer: Modification by gene promoter methylation in a population\u2013based study","volume":"26","author":"White","year":"2015","journal-title":"Cancer Causes Control."},{"key":"ref_269","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.envres.2015.11.033","article-title":"Sources of polycyclic aromatic hydrocarbons are associated with gene\u2013specific promoter methylation in women with breast cancer","volume":"145","author":"White","year":"2016","journal-title":"Environ. Res."},{"key":"ref_270","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.envres.2016.05.043","article-title":"Polycyclic aromatic hydrocarbons are associated with insulin receptor substrate 2 methylation in adipose tissues of Korean women","volume":"150","author":"Kim","year":"2016","journal-title":"Environ. Res."},{"key":"ref_271","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1039\/C6TX00112B","article-title":"Specific histone modifications were associated with the PAH\u2013induced DNA damage response in coke oven workers","volume":"5","author":"Zhang","year":"2016","journal-title":"Toxicol. Res."},{"key":"ref_272","doi-asserted-by":"crossref","first-page":"e24","DOI":"10.1097\/JOM.0000000000000564","article-title":"Polycyclic Aromatic Hydrocarbons\u2013Associated MicroRNAs and Heart Rate Variability in Coke Oven Workers","volume":"58","author":"Huang","year":"2016","journal-title":"J. Occup. Environ. Med."},{"key":"ref_273","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1002\/mc.22175","article-title":"Regulation of p53\u2013targeting microRNAs by polycyclic aromatic hydrocarbons: Implications in the etiology of multiple myeloma","volume":"54","author":"Gordon","year":"2015","journal-title":"Mol. Carcinog."},{"key":"ref_274","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1016\/j.cell.2017.05.045","article-title":"Dynamic RNA Modifications in Gene Expression Regulation","volume":"169","author":"Roundtree","year":"2017","journal-title":"Cell"},{"key":"ref_275","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.ccell.2016.11.017","article-title":"FTO Plays an Oncogenic Role in Acute Myeloid Leukemia as a N6\u2013Methyladenosine RNA Demethylase","volume":"31","author":"Li","year":"2017","journal-title":"Cancer Cell"},{"key":"ref_276","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1038\/s41422-018-0034-6","article-title":"RNA N(6)\u2013methyladenosine modification in cancers: Current status and perspectives","volume":"28","author":"Deng","year":"2018","journal-title":"Cell Res."},{"key":"ref_277","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.cell.2017.11.031","article-title":"R\u20132HG Exhibits Anti\u2013tumor Activity by Targeting FTO\/m(6)A\/MYC\/CEBPA Signaling","volume":"172","author":"Su","year":"2018","journal-title":"Cell"},{"key":"ref_278","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1038\/s41422-018-0097-4","article-title":"A dynamic N(6)\u2013methyladenosine methylome regulates intrinsic and acquired resistance to tyrosine kinase inhibitors","volume":"28","author":"Yan","year":"2018","journal-title":"Cell Res."},{"key":"ref_279","doi-asserted-by":"crossref","first-page":"3816","DOI":"10.1093\/nar\/gkaa048","article-title":"The m6A reader YTHDF1 promotes ovarian cancer progression via augmenting EIF3C translation","volume":"48","author":"Liu","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"ref_280","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1038\/s41556-018-0174-4","article-title":"M(6)A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer","volume":"20","author":"Liu","year":"2018","journal-title":"Nat. Cell Biol."}],"container-title":["International Journal of Environmental Research and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-4601\/18\/13\/6930\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:26:17Z","timestamp":1760163977000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-4601\/18\/13\/6930"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,28]]},"references-count":280,"journal-issue":{"issue":"13","published-online":{"date-parts":[[2021,7]]}},"alternative-id":["ijerph18136930"],"URL":"https:\/\/doi.org\/10.3390\/ijerph18136930","relation":{},"ISSN":["1660-4601"],"issn-type":[{"value":"1660-4601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,28]]}}}