{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T17:02:47Z","timestamp":1790960567807,"version":"4.1.0"},"reference-count":20,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2021,7,5]],"date-time":"2021-07-05T00:00:00Z","timestamp":1625443200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Tooth loss represents a diffused pathologic condition affecting the worldwide population. Risk factors have been identified in both general features (smoking, diabetes, economic status) and local tooth-related factors (caries, periodontitis). In this retrospective study, we examined the data of 366 patients with a large number of remaining teeth (\u226525) undergoing maintenance therapy in order to identify specific risk factors for tooth loss. The number of remaining teeth, number of non-vital teeth, and number of occlusal units were investigated for their correlation with tooth loss. The mean follow-up of patients was 9.2 years (range 5 to 14). Statistically significant risk factors for tooth loss were identified as number of remaining teeth at baseline (p = 0.05), number of occlusal units (p = 0.03), and number of non-vital teeth in posterior regions (p &lt; 0.001). Multiple logistic regression showed that the number of occlusal units and number of non-vital teeth in the posterior regions were significantly associated with a greater risk of tooth loss (odds ratio 1.88 and 3.17, respectively). These results confirm that not only the number of remaining teeth, but also their vital or non-vital status and the distribution between the anterior and posterior regions influence the long-term survival.<\/jats:p>","DOI":"10.3390\/ijerph18137174","type":"journal-article","created":{"date-parts":[[2021,7,5]],"date-time":"2021-07-05T04:18:21Z","timestamp":1625458701000},"page":"7174","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Risk Factors for Tooth Loss in Patients with \u226525 Remaining Teeth Undergoing Mid-Long-Term Maintenance: A Retrospective Study"],"prefix":"10.3390","volume":"18","author":[{"given":"Hiroo","family":"Kawahara","sequence":"first","affiliation":[{"name":"Department of Stomatognathic Function and Occlusal Reconstruction, Graduate School of Biomedical Sciences, Tokushima University, 3-18-15 Tokushima, Tokushima 770-8504, Japan"},{"name":"Kawahara Dental Clinic, 1-128 Muneshige, Mima, Tokushima 771-2104, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miho","family":"Inoue","sequence":"additional","affiliation":[{"name":"Department of Stomatognathic Function and Occlusal Reconstruction, Graduate School of Biomedical Sciences, Tokushima University, 3-18-15 Tokushima, Tokushima 770-8504, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7079-5596","authenticated-orcid":false,"given":"Kazuo","family":"Okura","sequence":"additional","affiliation":[{"name":"Department of Stomatognathic Function and Occlusal Reconstruction, Graduate School of Biomedical Sciences, Tokushima University, 3-18-15 Tokushima, Tokushima 770-8504, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masamitsu","family":"Oshima","sequence":"additional","affiliation":[{"name":"Department of Stomatognathic Function and Occlusal Reconstruction, Graduate School of Biomedical Sciences, Tokushima University, 3-18-15 Tokushima, Tokushima 770-8504, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1069-2605","authenticated-orcid":false,"given":"Yoshizo","family":"Matsuka","sequence":"additional","affiliation":[{"name":"Department of Stomatognathic Function and Occlusal Reconstruction, Graduate School of Biomedical Sciences, Tokushima University, 3-18-15 Tokushima, Tokushima 770-8504, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,7,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1111\/cdoe.12391","article-title":"Tooth loss is a complex measure of oral disease: Determinants and methodological considerations","volume":"46","author":"Haworth","year":"2018","journal-title":"Community Dent. Oral Epidemiol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1186\/1477-7525-8-126","article-title":"Tooth loss and oral health-related quality of life: A systematic review and meta-analysis","volume":"8","author":"Gerritsen","year":"2010","journal-title":"Health Qual. Life Outcomes"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1177\/0022034513490168","article-title":"Global burden of oral conditions in 1990-2010: A systematic analysis","volume":"92","author":"Marcenes","year":"2013","journal-title":"J. Dent. Res."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1111\/j.1600-051X.2011.01811.x","article-title":"Tooth loss in periodontally treated patients: A long-term study of periodontal disease and root caries","volume":"39","author":"Ravald","year":"2012","journal-title":"J. Clin. Periodontol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1590\/0103-6440201701476","article-title":"Tooth Loss in Patients under Periodontal Maintenance in a Private Practice: A Retrospective Study","volume":"28","author":"Stadler","year":"2017","journal-title":"Braz. Dent. J."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Passarelli, P.C., Pagnoni, S., Piccirillo, G.B., Desantis, V., Benegiamo, M., Liguori, A., Papa, R., Papi, P., Pompa, G., and D\u2019Addona, A. (2020). Reasons for Tooth Extractions and Related Risk Factors in Adult Patients: A Cohort Study. Int J. Environ. Res. Public Health, 17.","DOI":"10.3390\/ijerph17072575"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1111\/jcpe.13336","article-title":"Dose-dependent effect of smoking and smoking cessation on periodontitis-related tooth loss during 10\u201347 years periodontal maintenance\u2014A retrospective study in compliant cohort","volume":"47","author":"Troiano","year":"2020","journal-title":"J. Clin. Periodontol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1590\/1980-5497201500020006","article-title":"Contextual socioeconomic determinants of tooth loss in adults and elderly: A systematic review","volume":"18","author":"Barbato","year":"2015","journal-title":"Rev. Bras. Epidemiol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e12392","DOI":"10.1111\/jicd.12392","article-title":"Risk factors for tooth loss in adult Japanese dental patients: 8020 Promotion Foundation Study","volume":"10","author":"Saito","year":"2019","journal-title":"J. Investig. Clin. Dent."},{"key":"ref_10","first-page":"105","article-title":"Tooth loss in adults: Factors associated with the position and number of lost teeth","volume":"53","author":"Gondinho","year":"2019","journal-title":"Rev. Saude Publica"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Saito, M., Shimazaki, Y., Fukai, K., Furuta, M., Aida, J., Ando, Y., Miyazaki, H., and Kambara, M. (2020). A multilevel analysis of the importance of oral health instructions for preventing tooth loss: The 8020 Promotion Foundation Study of Japanese Dental Patients. BMC Oral Health, 20.","DOI":"10.1186\/s12903-020-01319-9"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"11","DOI":"10.2209\/tdcpublication.57.11","article-title":"Tooth Loss in Problem-oriented, Irregular, and Regular Attenders at Dental Offices","volume":"57","author":"Yoshino","year":"2016","journal-title":"Bull. Tokyo Dent. Coll."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Fushida, S., Kosaka, T., Kida, M., Kokubo, Y., Watanabe, M., Higashiyama, A., Miyamoto, Y., Ono, T., and Ikebe, K. (2020). Decrease in posterior occlusal support area can accelerate tooth loss: The Suita study. J. Prosthodont. Res.","DOI":"10.2186\/jpr.JPR_D_20_00005"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"223","DOI":"10.2209\/tdcpublication.2016-0044","article-title":"Number of Non-vital Teeth as Indicator of Tooth Loss during 10-year Maintenance: A Retrospective Study","volume":"58","author":"Suzuki","year":"2017","journal-title":"Bull. Tokyo Dent. Coll"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Kawahara, H., Inoue, M., Okura, K., Oshima, M., and Matsuka, Y. (2020). Risk Factors for Tooth Loss in Patients Undergoing Mid-Long-Term Maintenance: A Retrospective Study. Int. J. Environ. Res. Public Health, 17.","DOI":"10.3390\/ijerph17176258"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1111\/j.1600-0528.2005.00233.x","article-title":"Cariogram\u2014A multifactorial risk assessment model for a multifactorial disease","volume":"33","author":"Bratthall","year":"2005","journal-title":"Community Dent. Oral Epidemiol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1002\/j.0022-0337.2005.69.5.tb03939.x","article-title":"The Oral Health Information Suite (OHIS): Its use in the management of periodontal disease","volume":"69","author":"Page","year":"2005","journal-title":"J. Dent. Educ."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.jpor.2015.12.008","article-title":"Ten-year longitudinal study on the state of dentition and subjective masticatory ability in community-dwelling elderly people","volume":"60","author":"Sato","year":"2016","journal-title":"J. Prosthodont. Res."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1111\/j.1752-7325.2005.tb02792.x","article-title":"Root canal filled versus non-root canal filled teeth: A retrospective comparison of survival times","volume":"65","author":"Caplan","year":"2005","journal-title":"J. Public Health Dent."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Preda, C., Butera, A., Pelle, S., Pautasso, E., Chiesa, A., Esposito, F., Oldoini, G., Scribante, A., Genovesi, A.M., and Cosola, S. (2021). The Efficacy of Powered Oscillating Heads vs. Powered Sonic Action Heads Toothbrushes to Maintain Periodontal and Peri-Implant Health: A Narrative Review. Int. J. Environ. Res. Public Health, 18.","DOI":"10.3390\/ijerph18041468"}],"container-title":["International Journal of Environmental Research and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-4601\/18\/13\/7174\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:25:56Z","timestamp":1760163956000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-4601\/18\/13\/7174"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,5]]},"references-count":20,"journal-issue":{"issue":"13","published-online":{"date-parts":[[2021,7]]}},"alternative-id":["ijerph18137174"],"URL":"https:\/\/doi.org\/10.3390\/ijerph18137174","relation":{},"ISSN":["1660-4601"],"issn-type":[{"value":"1660-4601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,5]]}}}